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( Da-hye Ju ),( Sang Jin Ha ),( Hyeyeon Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: The aim of the current study was to examine the prevalence and time interval of metabolic syndrome development among women with hypertensive disorders of pregnancy compared to those of women with a normal delivery using big data analysis of a customized database using a National Health Insurance System data registry and to compare the prevalence of MS components between the HDP group and the normal delivery group. Methods: Data from 2002 to 2012 from the National Health Insurance Research Database in Korea was used to compare women diagnosed with HDP with those with a normal singleton pregnancy. The women who had medical checkups between 2009 and 2016 were assessed for MS. Using the customized DB, we conducted a trajectory analysis of MS development in our cohort. Results: Between 2002 and 2012, there were a total of 4723541 deliveries. Among the women who were analyzed, a total of 305919 underwent a medical examination from 2009 to 2016. MS was diagnosed in 47459 cases (22%). MS was found in 20.3% of the women in the normal group and 37.1% of the women in the HDP group. The time to MS development in women who had experienced pregnancy complicated by HDP was significantly shorter than that of women who did not experience HDP (6.6 ± 3.4 years vs 8.2 ± 3.4 years, p<0.0001). Women with a history of HDP had significantly increased odds of developing MS (OR 1.23; 95% CI, 1.12-1.35) and elevated systolic blood pressure strongly contributed the increased odds of developing MS in the HDP group (OR 1.644; 95% CI, 1.610-1.678). Conclusion: Our findings suggest that HDP increases the risk of MS development in later life and that MS develops in a shorter period of time in women with HDP than in those with a normal delivery. Women with HDP should be intensively checked for the components of MS.
재발성 또는 지속성 상피성 난소암에서의 Docetaxel 요법의 효용성 및 독성
주다혜 ( Da Hye Ju ),김용만 ( Yong Man Kim ),김민균 ( Min Gyun Kim ),김유진 ( Eu Gene Kim ),김대연 ( Dae Yeon Kim ),서대식 ( Dae Sik Seo ),김종혁 ( Jong Hyeok Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.11
Objective: The aim of this study is to determine the efficacy and toxicity of docetaxel in patients with recurrent or persistent epithelial ovarian cancer, previously treated with paclitaxel and platinum combination chemotherapy. Methods: Forty patients with recurrent or persistent epithelial ovarian cancer, had been treated with docetaxel combination chemotherapy at Asan Medical Center from May 1989 to December 2006. They received docetaxel (75 mg/m2) only or docetaxel (75 mg/m2) and platinum (carboplatin AUC5 or cisplatin 75 mg/m2) on day 1. The administration was repeated every 3 or 4 weeks. The response of patients was evaluated with CA-125 response criteria and RECIST criteria. The toxicities were defined according to the NCI common toxicity criteria. Results: Twenty patients had been evaluated by RECIST criteria and twenty patients had been evaluated by CA-125 response criteria. The overall response rate was 35% (14/40). Eleven patients were belonged to complete response (CR), and three patients were belonged to partial response (PR). The mean response duration (RD) was 11.29 months (4 to 20.7 months) and the mean time to progression (TTP) was 6.91 months (1 to 23 months). The response rate in the platinum-sensitive patients was 38.7% but in the platinum-resistant patients was 22.2%. The platinum-sensitive patients showed more favorable response rate, but that was not significant statistically. Heavily treated group, more than three prior regimens were used, had poor outcome. The common toxicities were alopecia and gastrointestinal toxicities (anorexia and nausea). Bone marrow suppression was the most serious drug toxicity, however, it was tolerable. Conclusion: The docetaxel is a considerable 2nd line chemotherapy with acceptable efficacy and toxicity in patients with recurrent or persistent epithelial ovarian cancer previously treated with paclitaxel and platinum combination chemotherapy.
Aryl diester들에 존재하는 methoxycarbonylmethylester group의 상대적 반응성에 관한 연구
정혜진, 채수연, 표수진, 김다미,이유빈, 최의진, 김진주, 남궁성건 서울여자대학교 자연과학연구소 2016 자연과학연구논문집 Vol.28 No.-
The aryl diesters (1-3) and (8A) were prepared to investigate efficiency of methoxycarbonylmethyl (MCM) group as both protecting group specific for carboxylic acids and activating group for several functional group transformation reactions. MCM ester was very stable under strongly acidic condition and easily deprotected to its acid under mild basic condition. MCM ester of diclofenac (5B) proved to be one of activated esters through base-promoted cyclization reaction. MCM ester was also effective for transesterification reaction and reduction under the presented reaction conditions. Finally, MCM ester was not reactive to pri- and sec-aliphatic amines.
Da In Kim,Ju Hyang Park,Hojun Seo,Sang Gi Hong,Hye Ji Kim,Hyungju Ahn,Jongbok Kim,문건대,Dong Choon Hyun 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.82 No.-
This work demonstrates the fabrication of cationic polymer particles with controllable and complexstructures for the high immobilization of noble-metal nanoparticles (NPs). The fabrication involves theuse of a cationic extra monomer to synthesize polystyrene (PS) solid spheres with cationic character,followed by their transformation into complex-structured particles via the phase separation route in aseeded dispersion polymerization. Control of the phase separation enables the formation of PS particleswith cage- and bowl-like shapes as well as hollow structures. The large surface areas of the complex-structured particles, as theoretically calculated using simple models, and the electrostatic attractionbetween them and the negatively charged noble-metal NPs, as experimentally observed, allow the highimmobilization of noble-metal NPs onto their surfaces.