Anti-inflammatory and analgesic activities of methanol extract of Triphala - a poly herbal formulation

D. Prabu,S. Kirubanandan,K. Ponnudurai,M. Nappinnai,Alin J.S. Jinu,S. Renganathan 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.4

Ayurveda, an ancient System of Indian Medicine, has recommended a number of drugs from indigenous plant sources for the treatment of inflammation. To evaluate the anti-inflammatory and analgesic activities of methanol extract of Triphala were investigated in Wister albino rats and mice. The methanol extract of Triphala were found to encompass substantial anti-inflammatory effect in acute and sub-acute models and analgesic effect. Animal models of carrageenan induced edema and cotton pellet induced granuloma in albino rats were used. Extract of 200 mg/kg shows significantly reduced paw edema. Analgesics activity of Triphala with 200 mg/kg shown by significant reduction of writhing. These report shows to support the use methanol extract of Triphala in relieving inflammation and pain. Ayurveda, an ancient System of Indian Medicine, has recommended a number of drugs from indigenous plant sources for the treatment of inflammation. To evaluate the anti-inflammatory and analgesic activities of methanol extract of Triphala were investigated in Wister albino rats and mice. The methanol extract of Triphala were found to encompass substantial anti-inflammatory effect in acute and sub-acute models and analgesic effect. Animal models of carrageenan induced edema and cotton pellet induced granuloma in albino rats were used. Extract of 200 mg/kg shows significantly reduced paw edema. Analgesics activity of Triphala with 200 mg/kg shown by significant reduction of writhing. These report shows to support the use methanol extract of Triphala in relieving inflammation and pain.

Anti-inflammatory and analgesic activities of methanol extract of Triphala - a poly herbal formulation

Prabu, D.,Kirubanandan, S.,Ponnudurai, K.,Nappinnai, M.,Jinu, Alin J.S.,Renganathan, S. Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.4

Ayurveda, an ancient System of Indian Medicine, has recommended a number of drugs from indigenous plant sources for the treatment of inflammation. To evaluate the anti-inflammatory and analgesic activities of methanol extract of Triphala were investigated in Wister albino rats and mice. The methanol extract of Triphala were found to encompass substantial anti-inflammatory effect in acute and sub-acute models and analgesic effect. Animal models of carrageenan induced edema and cotton pellet induced granuloma in albino rats were used. Extract of 200 mg/kg shows significantly reduced paw edema. Analgesics activity of Triphala with 200 mg/kg shown by significant reduction of writhing. These report shows to support the use methanol extract of Triphala in relieving inflammation and pain.

Hyperbranched polyester as a crosslinker in polyurethane formation: real-time monitoring using in situ FTIR

Dhevi, D. M.,Anand Prabu, A.,Kim, K. J. Springer Science + Business Media 2016 Polymer bulletin Vol.73 No.10

<P>Hyperbranched polymers find applications in many fields such as biomedical, catalysis, commercial coatings, etc., owing to their many advantages such as ease of synthesis, more number of end functional groups, and low solution/melt viscosity. In our study, a previously unreported synthesis of A(2) + AB(2) type hyperbranched polyester (HBP) of three different generations (HBP-G1 to HBP-G3) using phenyl dichlorophosphate as a core and 2,2-dimethylol propionic acid as a monomer was carried out, and characterized using spectral, physical and thermal analyses. In situ FTIR was used to study the one-shot curing reaction between hexamethylene diisocyanate, polyethylene glycol and HBP-G3 at 60 A degrees C for two different NCO/OH ratios (1.2316 and 2.1042). Lower NCO/OH ratio (1.2316) was found to obey the second order, thereby indicating the occurrence of primary reaction between -OH and -NCO groups, whereas higher NCO/OH ratio (2.1042) follows third order due to auto-catalytic effect of urethane resulting from its reaction with excess isocyanate group. Non-isothermal curing kinetics of PU formation using in situ FTIR was accomplished to determine the percentage of urethane content formed using Factor Analysis program for the first time. Based on the above data, further curing kinetics studies were carried out at three different isothermal (70, 90, and 110 A degrees C) temperatures for lower NCO/OH ratio sample to extract its thermodynamic parameters.</P>

FTIR studies on polymorphic control of PVDF ultrathin films by heat-controlled spin coater

Dhevi, D. M.,Prabu, A. A.,Kim, K. J. Springer Science + Business Media 2016 JOURNAL OF MATERIALS SCIENCE - Vol.51 No.7

<P>The performance of organic polymer-based memory devices based on polyvinylidene fluoride (PVDF) ultrathin films depends on the extent of its ferroelectric crystalline phase content. In the present study, the changes in polymorphs of PVDF ultrathin films prepared by using heat-controlled spin coater are examined. The polymorphic changes were analyzed by using FTIR-transmission (TS) and FTIR-grazing incidence reflection-absorption spectroscopy (GIRAS) as a function of varying (i) spin-coating temperatures (SCT-30 to 80 A degrees C), (ii) spin-coating substrates (KBr, ITO and Gold) and (iii) thermal treatments [as-cast (AC) at 30 A degrees C, annealed at 130 A degrees C (AN130) and melt (200 A degrees C)-slow cooled (MSC)] conditions. Compared to MSC samples, the AC and AN130 samples exhibited higher beta-crystalline (polar, all-trans) phase along with the complete absence of alpha-crystalline (non-polar, tgtg') phase at lower SCT-30 and 40 A degrees C irrespective of the substrates used, thereby avoiding the need of high-temperature SCT conditions. Among the three substrates used, FTIR-GIRAS data obtained using ITO and Gold substrates were more favored than the FTIR-TS data obtained using KBr window due to their real-time usage as the substrate for electronic applications.</P>

Deterioration in mechanical properties of glass fiber-reinforced nylon 6,6 composites by aqueous calcium chloride mixture solutions

Dhevi, D. Manjula,Choi, Chang Woo,Prabu, A. Anand,Kim, Kap Jin Wiley Subscription Services, Inc., A Wiley Company 2009 Polymer composites Vol.30 No.4

<P>In this article, nylon 6,6 (NY66) and glass fiber-(30 wt%) reinforced NY66 (GFNY66) specimens were immersed in various aqueous calcium chloride (aq. CaCl<SUB>2</SUB>) mixture solutions at different thermal conditions for varying intervals of time, and analyzed using attenuated total reflection-infrared (ATR-IR) spectroscopy, inductively coupled plasma (ICP), energy dispersive X-ray (EDX), gel permeation chromatography (GPC), and mechanical studies. ICP data revealed increasing concentration of absorbed Ca<SUP>2+</SUP> ions with increasing immersion time resulting in disruption of intra- and intermolecular H-bonding as confirmed using ATR-IR results. From EDX data, the ratio of Ca<SUP>2+</SUP> and Cl<SUP>−</SUP> ions absorbed by NY66 was calculated and found to follow its stoichiometric equivalence. GPC data exhibited less reduction in M<SUB>n</SUB> and M<SUB>w</SUB> for aq. CaCl<SUB>2</SUB>-treated NY66 specimens suggesting the absence of any significant chemical degradation, but the occurrence of only physical changes involving H-bond breakage and the formation of new C&n.dbond;O···Ca<SUP>2+</SUP> dative bond in NY66 matrix. The mechanical properties of GFNY66 samples treated with various types of aq. CaCl<SUB>2</SUB> solutions exhibited pronounced deterioration, possibly due to the interfacial failure between glass fiber and NY66 matrix. The results obtained from this study were quite useful toward understanding the degradation mechanism in NY66 and GFNY66 caused by various aq. CaCl<SUB>2</SUB> mixture solutions, and will be helpful in improving the mechanical properties of recycled NY66. POLYM. COMPOS., 2009. © 2008 Society of Plastics Engineers</P>

Intracellular cellobiose metabolism and its applications in lignocellulose-based biorefineries

Parisutham, Vinuselvi,Chandran, Sathesh-Prabu,Mukhopadhyay, Aindrila,Lee, Sung Kuk,Keasling, Jay D. Elsevier Applied Science 2017 Bioresource technology Vol.239 No.-

<P><B>Abstract</B></P> <P>Complete hydrolysis of cellulose has been a key characteristic of biomass technology because of the limitation of industrial production hosts to use cellodextrin, the partial hydrolysis product of cellulose. Cellobiose, a <I>β</I>-1,4-linked glucose dimer, is a major cellodextrin of the enzymatic hydrolysis (via endoglucanase and exoglucanase) of cellulose. Conversion of cellobiose to glucose is executed by <I>β</I>-glucosidase. The complete extracellular hydrolysis of celluloses has several critical barriers in biomass technology. An alternative bioengineering strategy to make the bioprocessing less challenging is to engineer microbes with the abilities to hydrolyze and assimilate the cellulosic-hydrolysate cellodextrin. Microorganisms engineered to metabolize cellobiose rather than the monomeric glucose can provide several advantages for lignocellulose-based biorefineries. This review describes the recent advances and challenges in engineering efficient intracellular cellobiose metabolism in industrial hosts. This review also describes the limitations of and future prospectives in engineering intracellular cellobiose metabolism.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The complete hydrolysis of cellulose by cellulase cocktail poses several critical barriers. </LI> <LI> The intracellular cellobiose assimilation has been considered as an alternative strategy. </LI> <LI> Engineering the industrial hosts for efficient cellobiose utilization would be advantageous. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>