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Adaptation through horizontal gene transfer in the cryptoendolithic red alga Galdieria phlegrea
Qiu, H.,Price, D.C.,Weber, A.P.M.,Reeb, V.,Chan Yang, E.,Lee, J.M.,Kim, S.Y.,Yoon, H.S.,Bhattacharya, D. Current Biology Ltd ; Elsevier Science Ltd 2013 Current biology Vol.23 No.19
Thriving in the hot, acidic, and metal-rich environments associated with geothermal areas is possible for only a few eukaryotes, with the Cyanidiophytina red algae (Cyanidium, Galdieria, and Cyanidioschyzon) being a famous example. These unicellular taxa can live in pH 0-4 and temperatures reaching up to 56<SUP>o</SUP>C [1,2]. Because Cyanidiophytina is sister to a vast array of mesophilic red algae (the Rhodophytina), such as the unicellular Porphyridium and the seaweed Chondrus[3], the genetic basis of their adaptation to extreme environments is of great interest from both the perspective of biotechnology and of evolution. The recently completed 13.7 Mbp genome sequence from the hot-spring dwelling Galdieria sulphuraria demonstrated that horizontal gene transfer (HGT) from prokaryotic sources provided this taxon with remarkable metabolic versatility (e.g., glycerol metabolism) and the ability to survive in its hostile environment (e.g., genes to detoxify mercury and arsenic) [4]. To explore the role of HGT in other members of this genus, we generated an 11.4 Mbp draft genome assembly from the sister taxon G. phlegrea DBV 009 [5]. In contrast to G. sulphuraria, this species is adapted to dry habitats near fumaroles such as fissures between rocks or cryptoendolithic environments [5,6]. Here, we provide evidence for extensive gene loss in the common ancestor of Cyanidiophytina that includes the eukaryote-derived loci required for urea utilization. Surprisingly, we find that G. phlegrea has regained the complete set of genes required for urea hydrolysis through HGT from eubacteria. The unlinked nature of these genes is likely explained by multiple gene transfers that resulted in assembly of the pathway in G. phlegrea. Our study demonstrates that genome reduction, a common outcome in eukaryotes for adaptation to a specialized niche, can be ameliorated by the gain of once lost, or novel functions through HGT.
Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma
Yang, Y.,Kelly, P.,Shaffer, A.L.,Schmitz, R.,Yoo, H.M.,Liu, X.,Huang, D.W.,Webster, D.,Young, R.M.,Nakagawa, M.,Ceribelli, M.,Wright, G.W.,Yang, Y.,Zhao, H.,Yu, X.,Xu, W.,Chan, W.C.,Jaffe, E.S.,Gascoy Cell Press 2016 CANCER CELL Vol.29 No.4
Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the CARD11-MALT1-BCL10 (CBM) adapter complex to activate IκB kinase (IKK) and the classical NF-κB pathway. Here we show that the CBM complex includes the E3 ubiquitin ligases cIAP1 and cIAP2, which are essential mediators of BCR-dependent NF-κB activity in ABC DLBCL. cIAP½ attach K63-linked polyubiquitin chains on themselves and on BCL10, resulting in the recruitment of IKK and the linear ubiquitin chain ligase LUBAC, which is essential for IKK activation. SMAC mimetics target cIAP½ for destruction, and consequently suppress NF-κB and selectively kill BCR-dependent ABC DLBCL lines, supporting their clinical evaluation in patients with ABC DLBCL.
Cyanophora paradoxa Genome Elucidates Origin of Photosynthesis in Algae and Plants
Price, D. C.,Chan, C. X.,Yoon, H. S.,Yang, E. C.,Qiu, H.,Weber, A. P. M.,Schwacke, R.,Gross, J.,Blouin, N. A.,Lane, C.,Reyes-Prieto, A.,Durnford, D. G.,Neilson, J. A. D.,Lang, B. F.,Burger, G.,Steiner American Association for the Advancement of Scienc 2012 Science Vol.335 No.6070
AN EVALUATION OF THE SOLAR RADIO BURST LOCATOR (SRBL) AT OVRO
HwangBo, J.E.,Bong, Su-Chan,Cho, K.S.,Moon Y.J.,Lee, D.Y.,Park, Y.D.,Gary Dale E.,Dougherty Brian L. The Korean Astronomical Society 2005 Journal of The Korean Astronomical Society Vol.38 No.4
The Solar Radio Burst Locator (SRBL) is a spectrometer that can observe solar microwave bursts over a wide band (0.1-18 GHz) as well as detect the burst locations without interferometry or mechanical scanning. Its prototype has been operated at Owens Valley Radio Observatory (OVRO) since 1998. In this study, we have evaluated the capability of the SRBL system in flux and radio burst location measurements. For this, we consider 130 microwave bursts from 2000 to 2002. The SRBL radio fluxes of 53 events were compared with the fluxes from USAF/RSTN and the burst locations of 25 events were compared with the optical flare locations. From this study, we found: (1) there is a relatively good correlation (r = 0.9) between SRBL flux and RSTN flux; (2) the mean location error is about 8.4 arcmin and the location error (4.7 arcmin) of single source events is much smaller than that (14.9 arcmin) of multiple source events; (3) the minimum location error usually occurred just after the starting time of burst, mostly within 10 seconds; (4) there is a possible anti-correlation (r = -0.4) between the pointing error of SRBL antenna and the location error. The anti-correlation becomes more evident (r=-0.9) for 6 strong single source events associated with X-class flares. Our results show that the flux measurement of SRBL is consistent with that of RSTN, and the mean location error of SRBL is estimated to be about 5 arcmin for single source events.
Haar Cascade와 DNN 기반의 실시간 얼굴 표정 및 음성 감정 분석기 구현
유찬영(Chan-Young Yu),서덕규(Duck-Kyu Seo),정유철(Yuchul Jung) 한국컴퓨터정보학회 2021 한국컴퓨터정보학회 학술발표논문집 Vol.29 No.1
본 논문에서는 인간의 표정과 목소리를 기반으로 한 감정 분석기를 제안한다. 제안하는 분석기들은 수많은 인간의 표정 중 뚜렷한 특징을 가진 표정 7가지를 별도의 클래스로 구성하며, DNN 모델을 수정하여 사용하였다. 또한, 음성 데이터는 학습 데이터 증식을 위한 Data Augmentation을 하였으며, 학습 도중 과적합을 방지하기 위해 콜백 함수를 사용하여 가장 최적의 성능에 도달했을 때, Early-stop 되도록 설정했다. 제안하는 표정 감정 분석 모델의 학습 결과는 val loss값이 0.94, val accuracy 값은 0.66이고, 음성 감정 분석모델의 학습 결과는 val loss 결과값이 0.89, val accuracy 값은 0.65로, OpenCV 라이브러리를 사용한 모델 테스트는 안정적인 결과를 도출하였다.