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RISS 인기검색어
- 검색키워드
- 저자 : Cong-Ju Li (검색결과 5 건)
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Efficacy and Safety of Bevacizumab in Chinese Patients with Metastatic Colorectal Cancer
Zhu, Li-Ming,Zhao, Ya-Zhen,Ju, Hai-Xing,Liu, Lu-Ying,Chen, Lei,Liu, Bi-Xia,Xu, Qi,Luo, Cong,Ying, Jie-Er,Yang, Yun-Shan,Zhong, Hai-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Objective: To evaluate the efficacy and safety of bevacizumab in the treatment of patients with metastatic colorectal cancer (mCRC). Methods: In a single-center, observational study of 91 Chinese patients with mCRC who received bevacizumab in combination with chemotherapy was conducted. Objective response rates (ORRs), progression-free survival (PFS), overall survival (OS) and adverse events were recorded, and the relationships between various clinical factors and PFS or OS were evaluated by Cox proportional hazards models. Results: Treatment with bevacizumab and chemotherapy was effective and tolerable. Univariate analysis showed that PFS and OS were significantly associated with the Eastern Cooperative Oncology Group performance status (ECOG-PS) score, duration of bevacizumab exposure, and whether chemotherapy was continued after discontinuation of bevacizumab treatment. A multivariate analysis showed that the duration of bevacizumab exposure and whether chemotherapy was continued after discontinuation of bevacizumab were independent prognostic factors for PFS and OS. Conclusion: In Chinese mCRC population, the shorter the duration of exposure to bevacizumab and chemotherapy, the worse the prognosis is.
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Peng, Yong,Guo, Cong-Shan,Li, Pan-Xia,Fu, Zhan-Zhao,Gao, Li-Ming,Di, Ya,Ju, Ya-Kun,Tian, Ru,Xue, Jia-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10
Background: The objective was to study the effect of Scutellaria baicalensis Georgi ethanol extracts (SBGE) on immune and anti-oxidant function in U14 tumor-bearing mice. Materials and Methods: U14 tumor-bearing mice were randomly divided into eight groups: a control group, a cyclophosphamide (CTX) group, three dose groups of SBGEI (high, medium, low), and three dose groups of SBGEII (high, medium, low). After two weeks, the thymus and spleen weight indices of mice bearing U14 cervical cancer were calculated. Enzyme linked immunosorbent assays (ELISA) was used to determine the levels of serum IL-2, TNF-${\alpha}$, IL-8, and PCNA. MDA activity and SOD activity in plasma were measured with detection kits. Results: In the SBGE groups, thymus weight and spleen weight indices of U14 tumor-bearing mice were significantly higher than in the control group or CTX group (p<0.05). Compared to control group, the levels of serum IL-2 and TNF-${\alpha}$ in U14 tumor-bearing mice increased significantly, whereas the contents of serum IL-8 and PCNA decreased (p<0.05). The activity of SOD increased with the growing dose of SBGE, while the activity of MDA decreased significantly in the highe-rdose groups of SBGE. Conclusions: These findings suggested that SBGE, especially at high dose, 1000 mg/kg, showed significant immune and anti-oxidant effects infU14 tumor-bearing mice, which might be the mechanisms of SBGE inhibition of tumor growth.
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Ruo Yu Meng,Cong Shan Li,Dan Hu,Soon-Gu Kwon,Hua Jin,Ok Hee Chai,Ju-Seog Lee,김수미 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.5
Hippo/YAP signaling hinders cancer progression. Inactivation of this pathway contributes to the development of esophageal cancer by activation of Akt. However, the possible interaction between Akt and Hippo/YAP pathways in esophageal cancer progression is unclear. In this study, we found that ursolic acid (UA) plus 3′3-diindolylmethane (DIM) efficiently suppressed the oncogenic Akt/Gsk-3β signaling pathway while activating the Hippo tumor suppressor pathway in esophageal cancer cells. Moreover, the addition of the Akt inhibitor LY294002 and the PI3K inhibitor 3-methyladenine enhanced the inhibitory effects of UA plus DIM on Akt pathway activation and further stimulated the Hippo pathway, including the suppression of YAP nuclear translocation in esophageal cancer cells. Silencing YAP under UA plus DIM conditions significantly increased the activation of the tumor suppressor PTEN in esophageal cancer cells, while decreasing p-Akt activation, indicating that the Akt signaling pathway could be down-regulated in esophageal cancer cells by targeting PTEN. Furthermore, in a xenograft nude mice model, UA plus DIM treatment effectively diminished esophageal tumors by inactivating the Akt pathway and stimulating the Hippo signaling pathway. Thus, our study highlights a feedback loop between the PI3K/Akt and Hippo signaling pathways in esophageal cancer cells, implying that a low dose of UA plus DIM could serve as a promising chemotherapeutic combination strategy in the treatment of esophageal cancer.
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Preparation of Petaloid TPEE@AlOOH Nanofibers with Cr (VI)-Removal Capacity
Jiao-Na Wang,Bin-Bin Jia,Cong-Ju Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.2
Hexavalent chromium (Cr (VI)) is a highly toxic pollutant which is harmful to marine organisms as well as humanity. Removing Cr (VI) from water is a hot-spot in environmental remediation. In this work, a novel kind of composite nanofibers membrane (thermal plastic elastomer ester (TPEE)@AlOOH) was first proposed by a simple method, based on a hybrid strategy composed of electrospinning and hydrothermal method. The obtained nanofibrous membrane was turned out to be a petaloid structure, which can enlarge the specific surface area of electrospun fibers. Furthermore, the Cr (VI) removal experiments suggested that the obtained nanofibrous membrane showed a high and fast efficiency, a stable recyclable property for the Cr (VI) removal. Therefore, such a novel nanofibrous membrane can be potentially widely used in Cr (VI) removal.
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An Empirical Analysis of Production Efficiency of Vegetable Industry in Hebei Province
Shuang-Yu Hu(호쌍우),Sung-Chan Kim(김성찬),Yu-Cong Sun(손우총),Zhi-Run Li(이지윤),Wen Ju(극문),Shi-Yong Piao(박세영),Jong-In Lee(이종인) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.8
중국 허베이성의 채소 산업의 발전은 이미 농민의 소득 증대를 촉진하는 중요한 경로로 되고 있으며 생태환경 오염, 자연 자원 부족 등 문제가 날로 심각해지는 상황에서 채소 산업의 고품질 발전을 실현하기 위해서는 반드시 채소산업의 생산효율을 제고함으로써 실현해야 한다. 농가의 생산성 제고를 위한 효율성 측정이 중요하다. 특히 효율성 계측시 농가의 자본투입, 토지투입 등 현실적 투입 고려가 필요하다. 본 연구는 국내외 연구 성과를 바탕으로 허베이성 2011-2018 채소 생산 투입량, 산출량 데이터, 맴퀴스트 지수와 DEA 모델을 바탕으로 허베이성 산업의 생산 효율성을 연구하였다. 효율성 계측 결과를 이용하여 비효율성의 원인을 규명하고, 농가 효율성 향상을 위한 대안을 제시한다. 분석을 통해 기술 진보 요인이 허베이성의 채소 생산능률의 증가에 영향을 미치는 중요한 원인이라는 것을 발견했다. 연구결과에 따라 본 연구는 채소 생산기술 수준을 제고하는 목적에 기초하여 허베이성 채소 생산의 구체적인 조건과 결합하여 채소 생산기술의 개발과 응용, 기계화 생산, 집약화 경영 발전 등 방면에서 상응하는 대책과 건의를 제기할 것이다. The development of the vegetable industry in Hebei province has become an important way to increase a farmer"s income. Under the background of increasingly serious problems, such as environmental pollution and the shortage of natural resources, it is necessary to improve the production efficiency of the vegetable industry to achieve high-quality development of the vegetable industry. Based on collating research results at home and abroad, this study selected the 2011-2018 vegetable production input and output data of Hebei Province. The production efficiency of Hebei Province"s industry was studied based on the Malmquist index and DEA model. The analysis showed that technological progress is an important factor in improving the vegetable production efficiency in Hebei Province. Based on the research results, the level of vegetable production technology, combined with the specific conditions of vegetable production in Hebei Province, can be improved by developing and applying vegetable production technology, mechanized production, and intensive management development.
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