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Piao, Chun Hua,Bui, Thi Tho,Song, Chang Ho,Shin, Hee Soon,Shon, Dong-Hwa,Chai, Ok Hee Elsevier 2017 Biochemical and biophysical research communication Vol.482 No.4
<P><B>Abstract</B></P> <P> <I>Trigonella foenum-graecum,</I> a member oldest medicinal plant in the fabaceae (legumes) family, is used as a herb, spice, and vegetable, and known for its olfactory, laxative, and galactogogue effects. However, the inhibitory effect of <I>Trigonella foenum-graecum</I> on allergic inflammatory response remains unclear, therefore, we investigated the precise role of <I>Trigonella foenum-graecum</I> in the allergic asthma and revealed the effects of <I>Trigonella foenum-graecum</I> in regulating airway inflammation and its possible mechanism. Allergic asthma was initiated in BALB/c mice by sensitized with OVA emulsified in aluminum on days 1 and 14, then aerosol challenged with OVA on days 27, 28 and 29. Some mice were administered <I>Trigonella foenum-graecum</I> by oral gavage before challenge. Then mice were evaluated for the presence of airway inflammation, production of allergen-specific cytokine response and lung pathology. <I>Trigonella foenum-graecum</I> significantly ameliorated the number of inflammatory cells in BALF and alleviated lung inflammation. It also reduced the collagen deposition and goblet cells. Meanwhile, <I>Trigonella foenum-graecum</I> treatment evidently decreased the high expression of Th2 cytokines and increased the Th1 cytokines in BALF and lung homogenates. <I>Trigonella foenum-graecum</I> showed a significant inhibition of serum IgE and anti-OVA IgG<SUB>1.</SUB> In this study, our data suggest that <I>Trigonella foenum-graecum</I> has a significant anti-inflammatory effect and it may prove to be an efficacious therapeutic regent on allergic asthma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The anti-inflammatory mechanisms of <I>Trigonella foenum-graecum</I> is proposed. </LI> <LI> The mechanism relies on suppressing proinflammatory cytokines and inflammatory cells. </LI> <LI> The <I>Trigonella foenum-graecum</I> may proves to be an efficacious therapeutic regent on allergic asthma. </LI> <LI> <I>Trigonella foenum-graecum</I> significantly ameliorated OVA-induced allergic asthma. </LI> </UL> </P>
Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model
Chun Hua Piao,Yan Jing Fan,Thi Van Nguyen,Zhen Nan Yu,Hee Soon Shin,Chang Ho Song,Ok Hee Chai 대한체질인류학회 2021 대한체질인류학회지 Vol.34 No.2
Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi on ovalbumin (OVA)-induced mouse asthma model. In this study, we examined the effect of F. amomi on OVA-induced asthma by analyzing Th1/Th2 cytokine production, histopathologic changes, and focusing on the NF-κB signaling. Oral administration of F. amomi reduced the number of inflammatory cells especially eosinophils and improved airway and pulmonary inflammation in the lungs of OVA-challenged mice. In addition, F. amomi significantly downregulated the overproduction of tumor necrosis factor-α, IL-1β, IL-4, IL-5 and the levels of OVA-specific both IgE and IgG1 and increased the secretion of interferon-γ and OVA-specific IgG2a. Moreover, F. amomi suppressed the increase of total NF-κB level and the phosphorylation of IκB-α and NF-κB by OVA. F. amomi may have therapeutic effect for allergic asthma by modulating Th1/Th2 cytokine imbalance and inhibiting NF-κB signaling activation.
Neuroprotective Effect of Wogonin: Potential Roles of Inflammatory Cytokines
Piao, Hua-Zi,Jin, Shun-Ai,Chun, Hyang-Sook,Lee, Jae-Chul,Kim, Won-Ki The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.9
Wogonin (5,7-dihydroxy-8-methoxyflavone), an active component originated from the root of Scutellaria baicalensis Georgi, has been reported to possess antioxidant and anti-inflamma-tory properties. In this study, we investigated the neuroprotective effect of wogonin in a focal cerebral ischemia rat model. Wogonin markedly reduced the infarct volume after 2 h middle cerebral artery occlusion followed by 22 h reperfusion. Wogonin decreased the production of nitric oxide and inflammatory cytokines such as TNF-$\alpha$ and IL-6 in lipopolisaccharide-stimu-lated microglial cells. While wogonin reduced the activity of NF-$textsc{k}$B, it did not change the activ-ity of mitogen-activated protein kinases family members, p38, ERK and JNK. The lipopolisaccharide-stimulated production of NO and cytokines was significantly blocked by vari-ous kinds of NF-$textsc{k}$B inhibitors such as N-acetyl cysteine, pyrrolidinedithiocarbamate and MG-132. The data may indicate that wogonin has neuroprotective effect by preventing the over-activation of microglial cells, possibly by inactivating NF-$textsc{k}$B signaling pathway