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키랄 HPLC를 이용한 원료 및 제제로부터 클로르페니라민 광학이성질체의 분석
조종운,김경태,이은주,홍정희,채규한,이은실,강종성 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
Chlorpheniramine(CPM) is an antiallergic drug with H1 antihistamine properties. The molecule has an asymmetric carbon, hence, two stereoisomers, d- and l-CPM, are available. It was reported that d-CPM showed higher antihistaminic effect than l-CPM, which was eliminated slower than d-CPM in CYP2D6 metabolism. The method of chiral separation for CPM enantimers was developed and the validated method was then applied to the quality control of raw materials and pharmaceutical formulations of CPM. The chiral analysis was carried out on a chiral stationary phase, Chiralcel OJ-H (0.46 × 15 cm, 5 μm), with the mobile phase of hexane : ethanol : diethylamine (98 : 2 : 0.1, v/v/v) in 0.3 ml/min. The eluent was monitored at UV 262 nm. The validation studies were carried out according to ICH requirements. The mean concentration of l-CPM in racemic raw materials and formulations were 42.8~53.5%, while those of d-CPM were 44.2~56.0%, and total mean concentration of dl-CPM was 91.4~108.5%. All commercially available samples showed good results within KP range, except some pharmaceutical formulations containing dextromethorphan due to the incomplete separation of d-CPM, dextromethorphan and l-CPM.
Effects of Nelumbinis Semen on Contractile Dysfunction in Ischemic and Reperfused Rat Heart
Jong-Hoon Kim,강문규,Chongwoon Cho,정환석,Chang-Woon Kang,Shoukat Parvez,배현수 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.9
Nelumbinis Semen (NS), or lotus seed, is one of the most well-known traditional herbal medicines and is frequently used to treat cardiovascular symptoms in Korea. The anti-ischemic effects of NS on ischemia-induced isolated rat heart were investigated through analyses of changes in blood pressure, aortic flow, coronary flow, and cardiac output. The subjects in this study were divided into two groups: a control, untreated ischemia-induced group, and an ischemia-induced group treated with NS. There were no significant differences in perfusion pressure, aortic flow, coronary flow and cardiac output between the groups before ischemia was induced. The supply of oxygen and buffer was stopped for ten minutes to induce ischemia in isolated rat hearts, and NS was administered during ischemia induction. NS treatment significantly prevented decreases in perfusion pressure, aortic flow, coronary flow and cardiac output under ischemic conditions (p<0.01). In addition, the mechanism of the anti-ischemic effects of NS was also examined through quantitation of intracellular calcium content in rat neonatal cardiomyocytes. NS significantly prevented intracellular calcium increases induced by isoproterenol (p<0.01). These results suggest that NS has distinct anti-ischemic effects through calcium antagonism.
Kang, Moonkyu,Kim, Jong-Hoon,Cho, Chongwoon,Chung, Hwan-Suck,Yoon, You-Sik,Lee, Youngseop,Hong, Moochang,Shin, Minkyu,Bae, Hyunsu Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.3
<P><I>Acori graminei Rhizoma</I> is one of the best-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Asian countries. The anti-ischemic effect of <I>Acori graminei Rhizoma</I> on ischemia-induced isolated rat heart was investigated through analysis of changes in perfusion pressure, aortic flow, coronary flow, and cardiac output. The subjects in this study were divided into two groups, an ischemia-induced group without any treatment (I), and an ischemia-induced group with <I>Acori graminei Rhizoma</I> treatment (I+AGR). There were no significant differences in perfusion pressure, aortic flow, coronary flow, or cardiac output between the two groups before ischemia was induced. The supply of oxygen and buffer was stopped for 10 min to induce ischemia in isolated rat hearts, and <I>Acori graminei Rhizoma</I> was administered while inducing ischemia. The data showed that <I>Acori graminei Rhizoma</I> treatment significantly prevented decreases in perfusion pressure, aortic flow, coronary flow, and cardiac output under an ischemic condition. In addition, hemodynamics (except heart rate) of the AGR-treated group was significantly recovered 60 min after reperfusion compared to the control group, (systolic aortic pressure: 85.5% <I>vs.</I> 62.5%, aortic flow volume: 68.1% <I>vs.</I> 49.4%, coronary flow volume: 86.8% <I>vs.</I> 60.1%, and cardiac output: 73.1% <I>vs.</I> 54.1%, <I>p</I><0.01). These results suggest that <I>Acori graminei Rhizoma</I> has distinct anti-ischemic effects.</P>
Kang, Moonkyu,Shin, Dongwon,Oh, Jung-Wan,Cho, Chongwoon,Lee, Hwa-Jin,Yoon, Dong-Won,Lee, Sang-Moon,Yun, Jung-Hwan,Choi, Hyun,Park, Seongkyu,Shin, Minkyu,Hong, Moochang,Bae, Hyunsu Institute for Advanced Research in Asian Science a 2005 The American journal of Chinese medicine Vol.33 No.2
<P>Nelumbinis Semen is a well-known traditional herbal medicine frequently used in treatment of depression in many Asian countries. In this study, its anti-depression effects in rats were investigated by comparing the test results of those treated with Nelumbinis Semen to those treated with other herbal anti-depressants, including Rehmanniae Radix Preparat, Corni Fructus, Lycii Fructus, Pinelliae Rhizoma and Hypericum Perforatum. In order to induce depression-like symptoms, the animals were placed under chronic mild stress in the form of overnight illumination for 2 consecutive days. They were treated with the respective herbal extract and forced swimming tests were conducted afterwards. The anti-depression effects of each extract were then evaluated based on a measured index, which consisted of struggling time, first latency and first rest duration. These test results show that Nelumbinis Semen provides greater anti-depression effects than the other herbal extracts. Specifically, only the rats treated with Nelumbinis Semen showed significant increases in struggling time (43.9%, p < 0.005, p = 0.0037) and in first latency time (90.2%, p < 0.05, p = 0.0116). However, the first rest duration for Nelumbinis Semen treated rats was not significantly different from the other rats. It appears that Nelumbinis Semen provides even greater anti-depression effects than Hypericum Perforatum (commonly referred to as St. John's Wort, perhaps the most widely used natural antidepressant today). The anti-depression effects of Nelumbinis Semen might be due to the modulation of the amount of neurotransmitters involved in depression.</P>
Effects of Yukmijihwang-tang Derivatives (YMJd) on Ibotenic Acid-Induced Amnesia in the Rat
Kang, Moonkyu,Kim, Ji-Hyun,Cho, Chongwoon,Lee, Kwang-Yeun,Shin, Minkyu,Hong, Moochang,Shim, Insop,Bae, Hyunsu Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.7
<P>The present study investigates the effects of Yukmijihwang-tang Derivatives (YMJd) on learning and memory through the Morris water maze task and the central cholinergic system of rats with excitotoxic medial septum (MS) lesion. In the water maze test, the animals were trained to find a platform in a fixed position for 6 d and then received a 60-s probe trial in which the platform was removed from the pool on the 7th day. Ibotenic lesion of the MS showed the impaired performance in the Morris water maze test and severe cell losses in the MS, as indicated by decreased choline acetyltransferase-immunoreactivity in the medial septum. Daily administrations of YMJd (100 mg/kg, i.p.) for 21 consecutive days produced significant reversals of ibotenic acid-induced deficit in learning and memory. These treatments also reduced the loss of choline acetyltransferase (ChAT) immunoreactivity in the MS induced by ibotenic acid. These results suggest that impairments of spatial learning and memory might be attributable to the degeneration of septohippocampal cholinergic (SHC) neurons and that YMJd treatment ameliorated learning and memory deficits partly due through neuroprotective effects on the central acetylcholine system. Our studies suggest that YMJd might be useful in the treatment of Alzheimer's disease.</P>
CHUNG, Hwan-Suck,KANG, Moonkyu,CHO, Chongwoon,PARVEZ, Shoukat,PARK, Chong-heong,KIM, Dongwoo,OH, Joonghwan,KIM, Hongyeoul,SHIN, Minkyu,HONG, Moochang,KIM, Yangseok,BAE, Hyunsu WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, the efTect of MC on lipopolysaccharide (LPS) and rccombinant interferon-gamma(rIF)-indiiced productioii ofnitric oxide (NO) and tumor necrosis factor (TNFγ)-aIpha were examined using mouse perituneal macrophages. MC inhibited the LPS/rIFN-γ-induced expression of inducible nitric oxide synthase (iNOS) and TNF-alpha release. To clarify the mechanism involved, the effect of MC on the activation of nuclear factor (NF)-kappaB was examined. The LPS/rIFN-γ-induced activation of NF-kappaB was almost completely blocked by MC at 0.5 mg/ml. These findings demonstrate that the inhibition of the LPS/rlFN-γ-induced production of NO and TNF-atpha by MC is due to the inhibition of NF-kappaB activation.
Kang, Moonkyu,Kim, Jong-Hoon,Cho, Chongwoon,Chung, Hwan-Suck,Kang, Chang-Woon,Kim, Yangseok,Shin, Minkyu,Hong, Moochang,Bae, Hyunsu WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Aurantii Fructus (AF) is one of the most well-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Korea. The anti-ischemic effects of AF on ischemia-induced isolated rat heart were investigated through analyses of changes in perfusion pressure, aortic flow, coronary How, and cardiac output. The subjects in this study were divided into two groups: an ischemia-induced group without any treatment, and an ischemia-induced group with AF treatment. There were no significant differences in perfusion pressure, aortic How, coronary flow. and cardiac output between them before ischcmia was induced. The supply of oxygen and buffer was stopped for 10 min to induce ischemia in isolated rat hearts, and AF was administered during ischemia induction. AF treatment significantly prevented decreases in perfusion pressure, aortic How, coronary flow, and cardiac output under ischemic conditions (P<0.01).These results suggest that AF has distinct anti-ischemic effects through recovery of contractile dysfunction in ischemic heart.