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- 저자 : Chonglin Tian (검색결과 2 건)
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Murine Model Study of a New Receptor-Targeted Tracer for Sentinel Lymph Node in Breast Cancer
Chonglin Tian,Xiao Sun,Bin-Bin Cong,Pengfei Qiu,Yongsheng Wang 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Purpose: Sentinel lymph node biopsy (SLNB), a critical staging and treatment step, has replaced axillary lymph node (LN) dissection as the standard staging procedure for early stage breast cancer patients with clinically negative axillary LNs. Hence, using a murine sentinel lymph node (SLN) model, we investigated the localization effect of the new receptor-targeted tracer, indocyanine green (ICG)-rituximab, on breast cancer SLNB. Methods: After establishing the murine SLN model, different doses of ICG-rituximab were subcutaneously injected into the hind insteps of BALB/c mice to determine the optimal dose and imaging time using continuous (> 3 hours) MDM-I fluorescence vasculature imaging. To explore the capacity of ICG-rituximab for sustained SLN localization with the optimal dose, MDM-I imaging was monitored at 6, 12, and 24 hours. Results: The popliteal LN was defined as the SLN for hindlimb lymphatic drainage, the iliac LN as the secondary, and the para-aortic or renal LN as the tertiary LNs. The SLN initial imaging and optimal imaging times were shortened with increased ICG-rituximab doses, and the imaging rates of the secondary and tertiary LNs increased accordingly. The optimal ICG dose was 0.12 μg, and its optimal imaging time was 34 minutes. After 24 hours, the SLN imaging rate remained 100%, while those of the secondary and the tertiary LNs increased from 0% (6 hours) and 0% (6 hours) to 10% (12 hours) and 10% (12 hours) to 20% (24 hours) and 10% (24 hours), respectively. Conclusion: ICG-rituximab localized to the SLN without imaging from the secondary or tertiary LNs within 6 hours. The optimal ICG dose was 0.12 μg, and the optimal interval for SLN detection was 34 minutes to 6 hours post-injection. This novel receptor-targeted tracer is of great value to clinical research and application.
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Zhibo Hao,Tian Tian,Shiqing Peng,Changchun Ge,Xinggang Li,Chonglin Jia,Chuan Guo,Qiang Zhu 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.8
A self-designed nickel-based superalloy, designated as FGH4096M, was prepared by selective laser melting (SLM). Differentheat treatments were performed to improve the mechanical properties of the SLM alloy through optimizing the microstructuresand the features of γ′ precipitates. Compared with the as-deposited alloy, the columnar grains with dendritic structuresand equiaxed structures were retained in the alloy after direct aging, but a large amount of tertiary γ′ phase precipitated,especially around the sub-grain boundaries, resulting in the highest tensile strength but the lowest elongation. During solidsolution and aging treatment (SSA), the recovery and recrystallization occurring in the alloy facilitated the grains to beequiaxed with the increase of solution temperature. For lower solution temperature (below 1100 ℃), the secondary γ′ precipitatesdecreased with the increase of solution temperature, while the tertiary γ′ precipitates from the subsequent agingprocess gradually increased; for higher solution temperature over 1100 ℃, exceeding the complete dissolution temperatureof the γ′ phase, only tertiary γ′ precipitates from the subsequent aging process were uniformly distributed in the alloy. Afterdouble solid solution (1170 ℃ + 1050 ℃) + aging heat treatment (DSSA), there were three sizes of γ′ precipitates in thealloy. In general, the SLM + SSA (1130 ℃) alloy obtained the best comprehensive properties, which could be related tothe homogenized microstructures and the uniform and dense distribution of single sized tertiary γ′ precipitates in the alloy.
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