한우 성별에 따른 등심의 육질특성 비교

최정석, 정동순, 최석현, 이상화, 김종희, 최양일 忠北大學校 農業科學硏究所 2011 農業科學硏究 Vol.27 No.4

-본문참고-

정신분열병 고위험군에서의 뇌영상 연구

최정석,권준수 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.5

The pafhophysiology of schizophrenia may be influenced by interaction of genetic, neurodevelopmental, environmental and/or psychological factors, which make it difficult to elucidate the etiology of the disorders through clinical phenomenology. Therefore it needs to find out endophenotypes specific to schizophrenia before onset of clinical expressions. Recently, many researchers have been concerned about subjects at high risk for schizophrenia genetically or clinically using neuroimaging techniques. In this review, we summarized neuroimaging findings performed on subjects at high risk for schizophrenia. In genetic high risk subjects, fronto-temporal abnormalities were observed, while clinical high risk subjects showed frontal abnormalities, suggestive of susceptibility markers to schizophrenia.

뉴로메드정(옥시라세탐 800㎎)에 대한 뉴라세탐정의 생물학적동등성

최성업,김종석,윤미경,김정일,박석,한상범,이재휘,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3

The purpose of the present study was designed to evaluate the bioequivalence of two oxiracetam tablets, Neuromed tablet (Korea Drug Co., reference drug) and Neuracetam tablet (Sam Jin Pharmaceutical Co., test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Release of oxiracetam from the tablet in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty-four healthy volunteers, 23.7 ± 2.4 year in age and 68.9 ± 6.2 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was performed. After oral administration of a tablet containing 800 ㎎ of oxiracetam, blood samples were taken at predetermined time intervals and concentrations of oxiracetam in plasma were determined using HPLC-MS-MS. The dissolution profiles of two formulations were very similar at all dissolution media. In addition, pharmacokinetic parameters such as AUCt, C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, and C_(max), untransformed T_(max). The results showed that the differences between two formulations based on the reference drug were 0.42%, 0.45% and -12.58% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log0.94 ~ log1.06 and log 0.90 - log 1.07 for AUCt and C_(max), respectively), indicating that Neuracetam tablet is bioequivalent to Neuromed tablet. The major pharmacokinetic parameters, AUCt, and C_(max), met the criteria set by KFDA for bioequivalence indicating that Neuracetam tablet is bioequivalent to Neuromed tablet.

넙치의 백화현상 규명에 관한 연구 : Ⅰ. 멜라닌 색소 생성에 미치는 효소와 기질의 영향 Ⅰ. Effects of Enzyme Activities and Substrates on Melanin Formation

최영준,강석중,조창환,명정구,김종현 國立統營水産專門大學 附設 水産科學硏究所 1990 수산과학연구소보고 Vol.2 No.-

멜라닌 색소의 생합성 과정에 관여하는 것으로 알려져 있는 효소 및 관련 인자와의 상관성을 검토하기 위하여 자연산 정상넙치와 양식산 백화넙치의 肉質과 表皮, 미립자 사료와 생물먹이인 Artemia 및 Rotifer에 대하여 단백질의 함량, 멜라닌 색소생성에 고나여하는 효소의 활성, 아미노산 조성 및 비타민A와 C의 함량을 비교하였다. 정상넙치表皮는 肉質에 비하여 단백질의 함량이 높았으나, 백화넙치인 경우는 대체로 비슷한 값이었다. 사료중의 단백질 함량은 미립자 사료 중 C1이 가장 높았다. catechal oxidase의 활성은 기질과 조효소 농도의 증가와 더불러 증가하였으며, 백화 유무에 관계없이 거의유사한 값으로 나타났다. 그리고 L-dopa oxidase활성도 동일한 결과였다. 정상넙치의 유리아미노산 함량은 백화개체에 비하여 높았으며, 表皮의 경우는 정상넙치가 백화너치에 비하여 7.5배 가량 높은 값을 나타내었다. 필수아미노산의 조성으로 비교했을 때, 미립자 사료는 Artemia와 Rotifer보다 우수한 단백질원이었다. 그리고 정상넙치의 함활아미노산의 함유량은 백화넙치의 6.3배에 달하였다. 비타민A는 정상 및 백화넙치의 肉質과 表皮에서 검출되지 않았으나 비타민C는 정상인 접치表皮가 백화넙치 表皮에 비해 약 7.8배였으며, 미립자 사료는 100.83mg/100ㅎ으로서 사료 중 가장 높았다. 따라서 넙치表皮의 멜라닌색소의 생성에는 기질인 방향족 아미노산과 함황아미노산이 큰 영향을 미치는 것으로 판단되었다. The albinic phenomenon of flat-fish (Paralichthys olivaceus) was investigated by measuring protein content, tyrosinase activity, amino acid composition, and contents of vitamin A and C. These materials in the flat-fish feed-stuff were also tested. The amount of skin protein was higher than that of muscle in normal flat-fish. Catechol and L-dopa oxidase activity did not differ between normal and albinic flat-fish. The free amino acid of skin in normal flat-fish was 7.5 times that in albinic one. Sulfur-containing amino acid in normal flat-fish was also 6.3 times that in albinic ones. Vitamin A was not detected in both of flat-fish. The content of vitamin C in normal flat-fish was 7.8 times that in albinic one. The contents of protein, sulfur-containing amino acid and Vitamin C in micro-encapsulated feed (one commercial feed in Japan) were the highest among the feed-stuff used in this experiment. The melanin formation of flat-fish skin was affected by substrates such as aromatic amino acid and cofactor such as sulfur amino acid.

실무개발자를 위한 BSD 소켓프로그래밍에 관한 연구

최대석,권중장,최재원 경성대학교 공학기술연구소 2002 공학기술연구지 Vol.9 No.-

네트워크 응용 프로그램을 개발하기 위해서는 Socket API를 많이 이용한다. Socket API를 이용해 정상적인 동작을 하는 것은 아주 쉽다. 그러나 실제 개발 과정에서 정상적인 상황이 아닌 여러 가지 비정상적인 오류에 처하게 됨에 따라 속수무책일 때가 많다. 따라서 본 논문에서 각 플랫폼별로 비정상적인 오류들의 사례 연구를 통하여 효율적인 응용시스템 개발에 도움을 주고자 한다.

갈바닉 전류를 이용한 철근부식 탐사기술에 관한 연구 : Part 2: 콘크리트에서 행한 전기화학적 시험 Part 2: Laboratory Electrochemical Testing of Sensors in Concrete

최윤석,박진택,김정구 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.1

The correlation between sensor output and the corrosion rate of steel bar was confirmed in concrete environment. Monitoring of open-circuit potential, linear polarization resistance (LPR) measurement and electrochemical impedance spectroscopy (EIS) were used to evaluate the corrosion behavior of steel bar embedded in concrete. Also, galvanic current measurements of designed sensors were conducted to obtain the charge of sensor embedded in concrete. In this study, the results of corrosion behavior of reinforcing steel showed a consistence among the data obtained by open-circuit potential monitoring, LPR and EIS measurements. Steel/copper sensor showed a good correlation in concrete environment between sensor output and corrosion rate of steel bar. However, there was no relationship between steel/stainless steel sensor output and corrosion rate of steel bar due to the low galvanic current output. Through the relationship between the steel/copper sensor output and the corrosion rate of reinforcing steel, real corrosion damage of the reinforcing steel can reliably be detected. (Received October 29, 2004)

SJO¨GREN'S SYNDROME 환자에게 즉시 임프란트 술식을 행한 치험례

최정환,손동석,이지연,이윤서,안선희,이재목 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The old edentulous patients experience xerostomia commonly. They have considerable difficulty in wearing tissue-supported prosthesis and high risk rate of caries. One of them is Sj□gren's syndrome patient. Sj□gren's syndrome is a chronic inflammatory autoimmune disorder that results in a lymphocyte-mediated destruction of exocrine glands. We planned to place implants immediately after extraction in this case of autoimmune disease. The advantages of immediate implant placement include considerable decrease in time from tooth extraction to placement of the final prosthesis, fewer surgical procedures, and better acceptance of the overall treatment plan. We present a case of Sj□gren's syndrome patient treated with immediate implant placement & immediate loading in anterior region and immediate implant placement in posterior region.

상수도 배관의 부식감지시스템 개발 (Ⅰ)

최윤석,김정구 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.10

In order to develop a new corrosion sensor for detecting and monitoring the corrosion of buried pipeline, sensor element design and the correlation of its output to corrosion rate of steel pipe itself were evaluated by laboratory test methods in synthetic groundwater. It uses well-known principles of galvanic corrosion and consists of two dissimilar metals (anode and cathode) installed on the buried pipeline. In this paper, two types of electrochemical probes were used: galvanic cells containing pipeline steel (CS)-copper (Cu) and pipeline steel (CS)-type 304 stainless steel (SS) couples. The corrosion behavior in synthetic groundwater for the different electrodes was investigated by potentiodynamic test. The galvanic corrosion test was accomplished by a zero resistance ammeter technique. Weight loss measurements were conducted to obtain the corrosion rates of pipeline steel in synthetic groundwater. The correlation between galvanic current and corrosion rate was obtained by galvanic current measurement and corrosion rate measurements. The results of the potentiodynamic test indicated that copper exhibited an active corrosion behavior, while stainless steel demonstrated spontaneous passivation. In galvanic corrosion tests, the galvanic current of copper-steel couple was higher than that of other couple. The comparison of the sensor output and corrosion rate revealed that a linear relationship was found between the probe current and the corrosion rate. Especially, a better linear quantitative relationship was found between the Cu-CS probe current and the weight loss data of the pipeline steel coupons. In addition, the Cu-CS probe is more suitable for high resistance soil than SS-CS probe, due to the high current output.

상수도 배관의 부식감지시스템 개발 (Ⅱ)

최윤석,신동호,김상현,김정구 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.4

In order to develop a new corrosion sensor for detecting and monitoring the corrosion of buried pipeline, the electrochemical property of sensors and the correlation of its output to corrosion rate of steel pipe, were evaluated by electrochemical methods in synthetic groundwater, two soils of varying resistivity (5,000 ohm-cm, 10,000 ohm-cm), and synthetic tap water. In this paper, two types of electrochemical probes were used: galvanic cells containing of pipeline steel-copper and pipeline steel-stainless steel (Type 304). The results of EIS measurement indicated that the sensor current was inversely related to sensor resistance, which was governed by the corrosion behavior of cathode. In galvanic corrosion tests, the galvanic current of Cu-CS probe was higher than that of SS-CS probe. The comparison of the sensor output and corrosion rates revealed that a linear relationship was found between the probe current and the corrosion rates. A good linear quantitative relationship was found between the Cu-CS probe current and the corrosion rate of pipeline steel coupons in the soil resistivity of 5,000 ohm-cm, and synthetic tap water. In the case of the soil resistivity of 10,000 ohm-cm, although the SS-CS probe showed a better linear correlation than that of Cu-CS probe, the Cu-CS probe is more suitable than SS-CS probe, due to the high current output. (Received February 1, 2005)

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.