3T Multi Voxel Spectroscopy에서 SENSE와 NEX 변화에 따른 정상인 뇌 대사물질 변화 분석

성열훈,임재동,이재현,조성봉,우동철,최보영,Seong, Yeol-Hun,Rhim, Jae-Dong,Lee, Jae-Hyun,Cho, Sung-Bong,Woo, Dong-Chul,Choe, Bo-Young 한국의학물리학회 2008 의학물리 Vol.19 No.4

자기공명분광법(magnetic resonance spectroscopy: MRS)은 인체내 대사물질을 정량분석하여 병변의 조기진단 및 정밀진단에 도움을 주고 있으며, 최근 임상에 이용되고 있는 자기공명분광법은 single voxel spectroscopy (SVS) 기법과 multi voxel spectroscopy (MVS) 기법이 있다. 본 연구에서는 SENSE와 NEX를 변화시킨 multi voxel spectroscopy (MVS)의 데이터와 기존 single voxel spectroscopy (SVS)의 데이터를 비교 분석하여, 각각의 데이터의 유의성 차이를 평가하고자 하였다. 정상 성인 지원자 13명(남자: 5명, 여자: 8명, 평균 41세, 표준편차 11.65세)을 대상으로 chemical shift image (CSI)를 이용한 MVS검사를 시행하였다. 장비는 3.0T Achieva Release Version 2.1 (Philips Medical System, Netherland)을 이용하였고, 8 channel head coil을 사용하여 brain thalamus 부위에서 CSI spectrum을 1 slice 획득하였다. Scan parameter로는 FOV (field of view): $230{\times}184mm^2$, TR (time to repetition): 2000 msec, TE (time to echo): 288 msec, matrix: $15{\times}12$, VOI(view of interest): $110{\times}110mm^2$, voxel size: $15{\times}15{\times}15mm^3$로 하였다. SENSE factor (S)와 NEX (N)는 S1*N1, S2*N1, S2*N2, S3*N2로 변화하여 스펙트럼을 획득하였고, 각 scan time은 5분 54초, 3분 32초, 6분 20초, 4분 20초였다. 얻은 모든 MRS 데이터는 jMRUI 3.0 Version 프로그램에서 분석하였고, SENSE factor와 NEX를 변화시켜 얻은 MVS data 그룹들이 정상 성인 뇌 대사물질의 변화에 영향을 주는지 검증하기 위해 그룹 간에 ANOVA분석을 실행하여 P 값이 0.05보다 크게 나오면 그룹들 사이에 유의한 차이가 없다고 분석하였다. NAA/Cr과 Cho/Cr의 상대적 비율은 MV와 SVS사이에서는 유의한 차이가 없었다. 즉, SENSE factor와 NEX를 변화시켜 얻은 MVS data에서 정상 성인 뇌조직의 대사물질의 변화를 관찰한 결과, S1*N1의 NAA/Cr은 $1.45{\pm}0.03$, Cho/Cr은 $0.88{\pm}0.03$이고, S2*N1의 NAA/Cr은 $1.44{\pm}0.03$, Cho/Cr은 $0.87{\pm}0.05$, S2*N2의 NAA/Cr은 $1.43{\pm}0.02$, Cho/Cr은 $0.87{\pm}0.04$이며, S3*N2의 NAA/Cr은 $1.45{\pm}0.03$, Cho/Cr은 $0.87{\pm}0.03$으로 나타났다(F-value : 1.37, D.F : 3, P-value : 0.262). 그러나 데이터의 질을 측정하기 위한 MVS 데이터의 NAA Peak line-width는 SVS 데이터의 NAA Peak line-width 보다 약 3배 정도 넓었다. 본 연구에서는 MVS에서 SENSE factor와 NEX 값을 다양하게 변화시킨 MVS의 데이터와 SVS의 데이터가 큰 차이가 없음을 확인하였다. 즉, 어는 특정 부위의 뇌 조직의 대사물질은 MVS와 SVS 기법 모두 큰 차이가 없음을 확인할 수 있었다. 그러므로 MVS는 SVS보다 광범한 부위를 짧은 시간 안에 검사할 수 있으므로 매우 유용한 방법이라고 사료된다. To evaluate the metabolic changes in normal adult brains due to alterations SENSE and NEX (number of excitation) by multi voxel MR Spectroscopy at 3.0 Tesla. The study group was composed of normal volunteers (5 men and 8 women) with a mean ($\pm$ standard deviation) age of 41 (${\pm}11.65$). Their ages ranged from 28 to 61 years. MR Spectroscopy was performed with a 3.0T Achieva Release Version 2.0 (Philips Medical System-Netherlands). The 8 channel head coil was employed for MRS acquisition. The 13 volunteers underwent multi voxel spectroscopy (MVS) and single voxel spectroscopy (SVS) on the thalamus area with normally gray matter. Spectral parameters were as follows: 15 mm of thickness; 230 mm of FOV (field of view); 2000 msecs of repetition time (TR); 288 msecs of echo time (TE); $110{\times}110$ mm of VOI (view of interest); $15{\times}15{\times}15$ mm of voxel size. Multi voxel spectral parameters were made using specially in alteration of SENSE factor (1~3) and 1~2 of NEX. All MRS data were processed by the jMRUI 3.0 Version. There was no significant difference in NAA/Cr and Cho/Cr ratio between MVS and SVS likewise the previous results by Ross and coworkers in 1994. In addition, despite the alterations of SENSE factor and NEX in MVS, the metabolite ratios were not changed (F-value : 1.37, D.F : 3, P-value : 0.262). However, line-width of NAA peak in MVS was 3 times bigger than that in SVS. In the present study, we demonstrated that the alterations of SENSE factor and NEX were not critically affective to the result of metabolic ratios in the normal brain tissue.

서남해안 지방에서 발생한 Vibrio vulnificus 감염의 임상적 고찰

조남수,김춘호,김성중,김용배,조수형,안태훈 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: V. vulnificus infection in found between May and October when the man who has hepatic disorder or immunity disorder eats raw shellfish and it causes the systemic symptoms such as sudden fever, chilling, shock and stupor and local skin lesions like bleb and necrosis. This disease has 46∼61% of fatality rate in spite of intensive treatment. This study conducts the examination of history, epidemic study, ingesting raw fish and bacteriologic investigation in the patients with similar clinical symptoms to the above and examines the diagnostic dorrelations. Method: It is conducted with 31 cases who admitted at emergency medical center of Chosun University Hospital from May of 1995 to September of 1998 and are suspected to have V.vulnificus infection. It analyze bacteriologic examination, the survey of residence, eating raw shellfish, hepatic disorder, alcohol drinking habits and skin lesion. Results: 1) The rate of male and female is 15.5:1 and in the age, 18 cases are in fifties, seven are in forties and six are over sixties. 2) Clinically, V.vulnificus is detected in 20 of 31 cases which is suspected to have V.vulnificus infection and it is not detected in 5 cases. Other bacteria are detected in 6 cases and they include staphylococcus aureus, pseudomonas species, β-hemolytic streptococcus and E-coil. 3) In local distribution, Kohung has 10 cases, Shinan and Mokpo have six, Haenam and Kangjin have five, Yongkwang and Muan have five, Naju and Yongam have five and Kwangju has one. 4) Eating fishes and raw shellfishes is found in 31 cases. In the kind of shellfishes, eating raw clam is 10 cases, raw thin-shelled surf calm is 8 cases, raw oyster is 5 cases and sliced raw fish is 4 cases and pickled sea foods are 4 cases. 5) The cases with hepatic disorder are 23 and 15 cases with heavy alcohol drinking Carrier are included. The cases with Diabetic Mellitus are four and those with pulmonary tuberculosis are two. Two cases have not basal diseases. 6) On the opinion of skin lesion, 20 cases show vesicular necrosis, 7 cases have dendriform erythema, 3 cases have papule and one case doesn't show clear skin lesion. Conclusion: When V.vulnificus infection is detected, it is fatal and those who have hepatic disorder or heavy alcohol drinking habit must avoid eating fishes and shellfishes raw in summer. It is important to have emergency treatment for the patient whose V.vulnificus infection is suspected. It is considered that the administration of initial antibiotics is effective by generalizing the clinical symptom, epidemic opinion and patient history even before the results of bacteriologic confirmed.

직업성질환 감시체계의 계획과 관리

조수헌,홍윤철,임종한,장성실,천병철 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.1

직업성 질환에 관련된 다양한 진료를 체계적으로 수집하고 관리하여 직업성질환의 예방 목적으로 이를 활용하고 자하는 노력이 우리나라에서도 이제 다양한 방법으로 시도되고 있다. 최근의 자료 시스템의 구축과 관리 방법의 향상은 새로운 직업성 잘환감시방법을 개발하게 하여 직업성질환과 손상을 예 방하는데 크게 기여하고 있다. 우리나라에서도 기존의 산업보건사업의 성과를 계승하면서, 외국의 직업성질환 감시의 여러 경험을 비판적으로 수용하여 한국적인 직업성질환 감시 모델을 구축해야 할 것으로 생각된다. 자발적인 지역차원의 직업성질환 감시체계들이 틀을 잡아가고 있는 이 시점에서 본격적으로 직업성질환 감시체계 수립을 위한 전략과 구체적 방법론을 마련하고 공유하여야 할 필요가 있다. 이를 위하여 우리나라의 직업성질환 감시체계를 구축하는데 기초가 될 수 있는 직업성질환 감시체계의 계획과 관리에 대한 내용을 정리하였다. 이러한 감시체계를 우리나라에 정립하려는 노력들의 일환으로 최근 직업성질환감시연구회의 결성 및 각 지역의 직업성질환 감시체계의 운영 등이 조금씩 결실을 맺어가고 있어 간략히 소개하면 다음과 같다.첫째, 최근에 인천, 천안, 대전, 여천, 구미 등에서 지역단위의 직업성질환 감시체계를 구축하고 있고 한국산업안전공단에서는 특수건강진단과 작업환경측정 자료를 전산화하여 이를 직업성질환 감시에 사용하는 전국단위의 감시체계와 천식, 근골격계질환, 피부질환 등 질환별 감시체계 등이 시도되고 있다.둘째, 이러한 움직임은 과거에 비하여 한층 발전된 양상이고 바람직하지만 이제는 국가적 차원에서 직업성질환 감시체계를 어떻게 설정하고 조율할 지를 고민하고 계획하여야 할 때이다. 즉 한국산업안전공단과 지역단위 직업성질환 감시체계들의 역할분담과 상호 정보의 교류 등이 정리되어야 이를 바탕으로 유기적인 국가 직업성질환 감시체계가 구축될 수 있다.셋째, 이를 위하여서는 직업성질환 감시체계 구축의 방법론을 서로 교류하고 공유할 필요가 있으며 나아가서는 이를 표준화하여 기본적인 자료의 교류가 원활하게 이루어질 수 있도록 하여야 한다. 이러한 역할은 최근에 결성된 직업성질환감시연구회와 산업안전보건연구원, 그리고 대한산업의학회, 산업간호학회, 산업위생학회 등이 협력하여 학술적인 작업과 함께 실무적인 지침을 만들어나가도록 하는 것이 바람직할 것이다.

유산소성 운동이 노인남성들의 심폐기능과 혈중지질에 미치는 영향

조성봉,이상훈 東國專門大學 2002 金龜論叢 Vol.9 No.1

노인남성에 있어서 규칙적이고, 지속적인 유산소성 운동이 심폐기능을 증가시키고, 혈중지질의 영향을 줌으로써 노인남성의 성인병 및 노인성 질환의 예방은 물론 노년생활을 보다 건강하고 행복하게 보낼 수 있으리라 생각한다. 노인남성을 대상으로 HRmax 50-60%로 48주간 유산소성 운동을 통하여 노인남성의 심폐기능 및 혈중지질의 TG, TC, HDL-C, LDL-C에 미치는 영향을 규명하고자 하였다.

Aerobic dance를 사용한 3개월 간의 『운동+식사 프로그램』이 비만경향 여성의 형태 및 신체조성에 미치는 영향

육조영,김범수,이승훈,전혜령 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

The purpose of this study was to evaluate the effects of a weight-loss program in obese women. Sixty-seven subjects, aged 37.1±8.7 years, joined in the program that comprised diet and exercise prescription. The exercise prescription consisted of a 60-rnin aerobic dance(2d/wk) and self-selected, unsupervised aerobic exercise. The duration of this program was 3months. As a result, body mass and %fat significantly decreased from 61.9±8.4 to 59.1 ±8.3㎏ and from 30.7±7.5 to 26.6±7.0%(p<0.05), respectively. Fat-free mass(FFM) remained essentially unchanged (42.6±4.2 vs. 43.0±3.7㎏). About 10% of all subjects lost FFM by more than 2㎏, and accordingly, their energy yield was not enough to maintain FFM. Among the subjects who successfully reduced excess fat and maintained FFM no change in energy yield and reduction in upper body fat were found. Conversely, the subjects who could not maintain FFM lost lean tissue in lower limbs. It is suggested that our weight-loss program with exercise is useful in improving body composition and diet ingestion, and that particularly aerobic dance is considered available for reducing excess fat.

Glucocorticosteroid가 흉선 세포의 아형 및 핵산에 미치는 영향

문성록,이시은,장선일,조성경,정헌택 최신의학사 1991 最新醫學 Vol.34 No.1

부산 신평·장림공단지역의 대기오염물질 배출 특성

김상헌,정장표,김영태,조성훈 慶星大學校 環境問題硏究所 1995 環境硏報 Vol.5 No.1

Industrial growth and urban gravitation of the population etc. have seriously deteriorated the air quality which has adverse effect on human health and property, and the situation is more serious in industrial complex as well. Therefore, it is necessary to examine the pollutants emissions inventory to establish proper and comprehensive strategies for the reduction of pollutant levels. This study is aimed at investigating the characteristics of the pollutant emissions in the vicinity of Sinpyeung·Jangrim industrial complex in Pusan. The emission quantities of air pollutants were estimated by the grid(1㎞x1㎞), the source classification, and the time on the basis of the type and the amount per month of the fuel. The important results from this study were as followings: The average emission quantity(rate) of SO₂, TSP, NOx, CO and HC showed 1926.74 ton/yr(61.09 g/sec), 367.83 ton/yr(11.66 g/sec), 1440.64 ton/yr(45.68 g/sec), 4698.33 ton/yr(148.98 g/sec) and 447.15 ton/yr(14.18 g/sec), respectively. In case of SO₂and TSP, the emission quantities were majorly contributed by stationary source(point source and area source) whose contribution percentages were calculated as 65.8%, 30.6%. On the other hand, emission quantities of NOx, CO and HC were highly contributed by mobil source(line source) whose contribution percentages were calculated as 59.3%, 84.2% and 88.6%.

수정진동자를 이용한 계면활성제의 특성 분석

송성훈,박진영,이행자,조홍식,장상목 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.2

The phase transition phenomena and the phase separation phenomena of surfactants(SPES) are analyzed using QCA with resonant frequency and resonant resistance. The phase transition phenomena of SPES at 30℃ can be determined by measuring the resonant frequency and resonant resistance by lecithin coated on quartz crystal. The surfactants capacity of SPES can be analyzed by measuring the resonant frequency and resonant resistance of surfactants using QCA.

인슐린 비의존형 당뇨병 환자에서 혈장 Endothelin-1농도의 변화

신양수,조희충,김원식,국기용,김용화,정종훈,문철웅,배학연,양성훈 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

Endothelin(ET) is a 21-residue peptide originally isolated from the cultured porcine endothelial cells. There are at least three genes for endothelin:endothelin-1(ET-1), endothelin-2(ET-2), and endothelin-3(ET-3). Endothelins are present in various human biological fluids including plasma, urine, breast milk, and saliva and have been found elevated plasma ET concentrations in patients with diabetes mellitus, Patients undergoing maintenance hemodialysis due to chronic renal failure, patients with acute myocardial infarction, and patients with subarachnoid hemorrhage. Endothelial cell damage is suspected to occur in diabetic patients and may be one important cause of angiopathy, a major complication in diabetes mellitus. The elevation of ET in diabetic patients may be a marker of, and further exacerbate, their vascular disease. We measured the levels of ET-1 in plasma of 50 patients with non-insulin dependent diabetes mellitus(NIDDM) and 25 normal subjects by radioimmunoassay. The plasma ET-1 concentration (mean±S.D.) in NIDDM was 6.461 A2.510 f㏖/ ㎖, and was significantly higher than in normal subjects (4.567±1.155f㏖/㎖) (P<0.05). The plasma ET-1 concentration (mean±S.D.) in diabetic retinopathy group( 7.15±2.454 f㏖/ml) was significantly elevated than those in otherwise uncomplicated groups (5.348±2.390 f㏖/㎖)(P<0.01). The correlation between any clinical parameters and plasma ET-1 levels in NIDDM was not significant, In conclusion, this study suggest that the elevated levels of ET-1 in diabetic patients may be play a important role in the pathogenesis of diabetic complications.

연구개 및 구개수에 발생한 편평세포암종

이승호,이성훈,김기영,김창룡,박문성,류선열,조규승 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

Carcinoma of the mouth accounts for approximately 5% of all carcinomas occurring in man. Carcinoma of the oral cavity develops as a result of invasion of malignant epithelial cells through the normally intact basal cell layer into subcutaneous and submucosal tissuse. The sofe palate and uvula may be involved in oral cancer but are not common sites. Early lesions of soft palate carcinoma appear as red, white, or mixed changes in the mucosa. The earliest symptom is mild sore throat. Advanced lesions interfer with swallowing and may cause a voice change. Although surgical method of soft palate carcinoma is successful, prognosis is relatively poor to swallowing and speech problem. Occasionally marginal recurrence may be developed. This article reports a case of squamous cell carcinoma occurred unusually in the soft palate and uvula. The case was treated with neoadjuvant chemotherapy, local radicalexcision and postoperative irradiation. Patient was followed up for 2 years. There was no tumor recurrence. The overall result including function was satisfactory.