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Kwon, Yo Han,Woo, Sang‐,Wook,Jung, Hye‐,Ran,Yu, Hyung Kyun,Kim, Kitae,Oh, Byung Hun,Ahn, Soonho,Lee, Sang‐,Young,Song, Seung‐,Wan,Cho, Jaephil,Shin, Heon‐,Cheol,Kim, Je Y WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.38
<P>The first ever demonstration of a cable‐type lithium ion battery architecture with outstanding omni‐directional flexibility is described by Je Young Kim, Heon‐Cheol Shin, and co‐workers on page 5192. The Front Cover image illustrates the unique battery architecture comprising a skeleton frame surrounding an empty space, that is, a hollow‐spiral anode with a multi‐helical structure. This design enables the battery to reliably power an LED screen or an MP3 player even under severe mechanical twisting and bending. </P>
Improved cycle performance of annealed Si/Ni/Cu film electrodes
Cho, Gyu-Bong,Noh, Jung-Pil,Bae, Sang-Ho,Kim, Ji-Heon,Lee, Jung-Goo,Kim, Ki-Won Royal Swedish Academy of Sciences 2010 Physica scripta Vol.2010 No.t139
<P>Electrochemical properties of Si/Ni/Cu film electrodes were investigated with different Ni film thicknesses (50–600 nm) and annealing temperatures (200–500 °C). The morphology of amorphous Si film was considerably affected by surface features of the Ni under-layer. The best cycle performance of 90.2% retention after 70 cycles was obtained from Si/Ni/Cu film with 300 nm thick Ni film and after 400 °C annealing. For the annealed Si/Ni/Cu electrode, the surface morphology (protrusions) and the formation of compounds among Si, Ni and Cu prohibited the volume expansion of Si during the charge–discharge process and enhanced adhesion between films and substrate, respectively.</P>
The virtual asthma guideline e-learning program: learning effectiveness and user satisfaction
( Sung-yoon Kang ),( Sae-hoon Kim ),( Yong-eun Kwon ),( Tae-bum Kim ),( Hye-kyung Park ),( Heung-woo Park ),( Yoon-seok Chang ),( Young-koo Jee ),( Hee-bom Moon ),( Kyung-up Min ),( Sang-heon Cho ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.3
Background/Aims: Effective educational tools are important for increasing adherence to asthma guidelines and clinical improvement of asthma patients. We developed a computer-based interactive education program for asthma guideline named the Virtual Learning Center for Asthma Management (VLCAM). We evaluated the usefulness of program in terms of its effects on user awareness of asthma guideline and level of satisfaction. Methods: Physicians-in-training at tertiary hospitals in Korea were enrolled in a cross-sectional questionnaire survey. The e-learning program on asthma guideline was conducted over a 2-week period. We investigated changes in the awareness of asthma guideline using 35-item self-administered questionnaire aiming at assessing physicians’ knowledge, attitude, and practice. Satisfaction with the program was scored on 4-point Likert scales. Results: A total of 158 physicians-in-training at six tertiary hospitals completed the survey. Compared with baseline, the overall awareness obtained from the scores of knowledge, attitude, and practice was improved significantly. Participants were satisfied with the VLCAM program in the following aspects: helpfulness, convenience, motivation, effectiveness, physicians’ confidence, improvement of asthma management, and willingness to recommend. All items in user satisfaction questionnaires received high scores over 3 points. Moreover, the problem-based learning with a virtual patient received the highest user satisfaction among all parts of the program. Conclusions: Our computer-based e-learning program is useful for improving awareness of asthma management. It could improve adherence to asthma guidelines and enhance the quality of asthma care.
Cho, Nam H.,Ahn, Chang Ho,Moon, Joon Ho,Kwak, Soo Heon,Choi, Sung Hee,Lim, Soo,Park, Kyong Soo,Metzger, Boyd E.,Jang, Hak C. Wolters Kluwer Health 2016 Medicine Vol.95 No.35
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Metabolic syndrome (MetS) is an established predisposing condition for type 2 diabetes mellitus (T2DM). However, it is not thoroughly evaluated whether MetS increases the risk of T2DM in women with a previous history of gestational diabetes mellitus (GDM) who already at high risk of T2DM compared with the general population. We investigated the impact of MetS on the development of postpartum diabetes in women with a history of GDM.</P><P>This was a multicenter, prospective cohort study of women diagnosed with GDM. The follow-up evaluations, including the oral glucose tolerance test, were completed at 6 weeks postpartum and annually thereafter. MetS was diagnosed at the initial postpartum evaluation according to the revised criteria of the National Cholesterol Education Program-Adult Treatment Panel III. The risk of developing type 2 diabetes (T2DM) in the follow-up period was analyzed based on the presence of MetS, and the adjusted risk was calculated using a Cox proportional hazards model.</P><P>A total of 412 women without diabetes at the initial postpartum evaluation participated in the annual follow-up for median 3.8 years. MetS was prevalent in 66 (19.2%) women at the initial postpartum evaluation. The incidences of diabetes in women with and without MetS were 825 and 227 per 10,000 person-years, respectively (<I>P</I> < 0.001). The presence of MetS was an independent risk factor for T2DM, with a hazard ratio (HR) of 2.23 (95% confidence interval 1.04–5.08) in multivariate analysis after adjustment for clinical and metabolic parameters. When we considered MetS and impaired fasting glucose (IFG) separately, women with MetS, IFG, or both had an increased risk of T2DM, with HRs of 4.17, 4.36, and 6.98, respectively.</P><P>The presence of MetS during the early postpartum period is an independent risk factor for the development of T2DM in women with a previous history of GDM.</P></▼2>
Newly developed method for mouse olfactory behavior tests using an automatic video tracking system
Cho, Hyung-Ju,Lee, Yong Hyuk,Kim, Bo Ra,Kim, Hong-Kyung,Chung, Hyo Jin,Park, Sang Chul,Seong, Je Kyung,Yoon, Joo-Heon,Kim, Chang-Hoon Elsevier 2018 Auris, nasus, larynx Vol.45 No.1
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>The mouse is the most popular animal model in olfactory research. Behavior tests with odorants are essential for determining olfactory phenotype. To the best of our knowledge, the mouse olfactory behavior test has not been standardized, making the results vulnerable to inter-observer variation. We sought to develop a new mouse olfactory behavior test assessed by an automatic video tracking system with minimal inter-observer variation.</P> <P><B>Methods</B></P> <P>A video-tracking system was used to automatically track mouse behavior in standard breeding cages with C57BL/6N mice. We tested two odorants (peanut butter for the preference test, 2MB acid for the avoidance test) and distilled water (for a control). Mouse behavior was recorded for 3min and analyzed. For the preference test, investigation time was measured. For the avoidance test, time spent in sectors away from the odorant zone was measured. To confirm our experimental settings, we also evaluated an anosmia mouse model prepared with intranasal administration of ZnSO<SUB>4</SUB>.</P> <P><B>Results</B></P> <P>All strains of mice showed reproducible behavior patterns of preference or avoidance for the odorants. The anosmia mouse model, as expected, failed to show an olfactory ability for preference or avoidance, and this was well-matched by histologic changes caused by the ZnSO<SUB>4</SUB> treatment. The automatic video tracking system successfully tracked and automatically calculated mouse behavior with good reproducibility.</P> <P><B>Conclusion</B></P> <P>Our olfactory behavior test offers a simple and accurate method to evaluate olfactory function in mice. This test can be utilized as a possible standard method to search for features of olfactory phenotypes in mice.</P>
Protective effect of 4,4'-diaminodiphenylsulfone against paraquat-induced mouse lung injury
Cho, Sung-Chun,Rhim, Ji-Heon,Choi, Hae-Ri,Son, Young-Hoon,Lee, Seok-Jin,Song, Kye-Yong,Park, Sang Chul Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.9
Although 4,4'-diaminodiphenylsulfone (DDS, dapsone) has been used to treat several dermatologic conditions, including Hansen disease, for the past several decades, its mode of action has remained a topic of debate. We recently reported that DDS treatment significantly extends the lifespan of the nematode $C.$ $elegans$ by decreasing the generation of reactive oxygen species. Additionally, in $in$ $vitro$ experiments using non-phagocytic human fibroblasts, we found that DDS effectively counteracted the toxicity of paraquat (PQ). In the present study, we extended our work to test the protective effect of DDS against PQ $in$ $vivo$ using a mouse lung injury model. Oral administration of DDS to mice significantly attenuated the lung tissue damage caused by subsequent administration of PQ. Moreover, DDS reduced the local expression of mRNA transcripts encoding inflammation-related molecules, including endothelin-1 (ET-1), macrophage inflammatory protein-$1{\alpha}$ (MIP-$1{\alpha}$), and transforming growth factor-${\beta}$ (TGF-${\beta}$). In addition, DDS decreased the PQ-induced expression of NADPH oxidase mRNA and activation of protein kinase $C{\mu}$ ($PKC{\mu}$). DDS treatment also decreased the PQ-induced generation of superoxide anions in mouse lung fibroblasts. Taken together, these data suggest the novel efficacy of DDS as an effective protective agent against oxidative stress-induced tissue damages.
Current practice for diagnosing immediate drug hypersensitivity reactions in Korea
( Sung-yoon Kang ),( Min-suk Yang ),( Woo-jung Song ),( Sang-heon Cho ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.0
Background/Aims: Skin (STs) and drug provocation (DPTs) tests are essential for identifying the culprit drugs causing drug hypersensitivity reactions (DHRs). Several protocols have been developed for the identification of some culprit drugs, but they are neither thoroughly validated nor standardized. Furthermore, language barriers may impede the exchange of information necessary for test standardization. Methods: We searched the Korean literature for articles on drug hypersensitivity published from 1933 to 2016 using the KoreaMed search engine and archives of Korean journals. We reviewed and rated all articles according to the description of STs and DPTs. Results: Of the 632 articles obtained in our initial search, 34 had adequate descriptions of 15 STs and 22 DPTs. Up to 27 healthy control subjects in STs were enrolled to determine non-irritating concentrations. The concentrations used for intradermal tests were commonly a 1/10 dilution of those used for skin prick tests. The interpretations of the STs were mostly similar among researchers. For DPTs, most procedures were single-arm open-label tests of various drugs. The initial dose ranged from a quarter dose to a single therapeutic dose, depending on the severity of the original hypersensitivity reaction. The interval between doses was usually 30 to 60 minutes, and a positive reaction usually occurred within twice the time of the original reaction. Conclusions: Efforts to distribute information are necessary to standardize protocols and better understand DHRs.