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Lee, Yoox2010,Yong,Lee, Jix2010,Hoon,Cho, Jux2010,Young,Kim, Nax2010,Rae,Nam, Daex2010,Hyun,Choi, Inx2010,Suk,Nam, Ki Tae,Joo, Youngx2010,Chang WILEY‐VCH Verlag 2013 Advanced functional materials Vol.23 No.32
<P><B>Abstract</B></P><P>It remains a fundamental challenge in the development of stretchable electronics to understand how mechanical strain changes the electrical properties of materials. Although the piezoresistive behavior of poly(3,4‐ethylene‐ dioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) has been observed, its intrinsic origin is not yet fully understood because there are many extrinsic contributing factors and an experimental platform with which to assess such behavior has not been established. Here, systematic analysis shows that the matching Poisson's ratio and elastic modulus between PEDOT:PSS films and their underlying substrates is important in decoupling the factors that affect the material's piezoresistivity, allowing for tunable resistivity. Based on such a fundamental understanding, the conductivity of PEDOT:PSS can be controlled to be invariant and decrease as a function of applied tensile stress. Furthermore, a linear response of the resistivity with respect to mechanical strains of up to 60%, which has never before been realized, is shown. The irreversible conductivity enhancement is primarily caused by the coalescence‐induced growth of conductive PEDOT‐rich cores.</P>
Koo, Sukx2010,Jin,Hwang, Ki‐,Hwan,Jeon, Manx2010,Seok,Kim, Sungx2010,Hun,Lim, Jongsoo,Lee, Dongx2010,Guk,Cho, Namx2010,Gyu John Wiley Sons, Ltd 2014 Pest Management Science Vol.70 No.1
<P><B>Abstract</B></P><P><B>BACKGROUND</B></P><P><B>Selective control of annual bluegrass (<I>Poa annual</I> L.) has been difficult in turfgrasses. The potential of methiozolin in this area was investigated.</B></P><P><B>RESULTS</B></P><P><B>Methiozolin was safe on established zoysiagrass (<I>Zoysia japonica</I> Steud.), creeping bentgrass (<I>Agrostis palustris</I> Huds.), Kentucky bluegrass (<I>Poa pratensis</I> L.), and perennial ryegrass (<I>Lolium perenne</I> L.) at 1000 g ha<SUP>−1</SUP>, and controlled annual bluegrass with GR<SUB>50</SUB> values of 23, 52, 104, and 218 g ha<SUP>−1</SUP> at PRE, two‐, four‐ and eight‐leaf stage, respectively, in the greenhouse. When applied at early flowering, methiozolin suppressed >80% of annual bluegrass seed heads at 2000 g ha<SUP>−1</SUP>. <SUP>14</SUP>C‐Methiozolin was readily absorbed by both leaves and roots, but translocation was mainly acropetal. No herbicidal activity resulted from application to the leaf only; however, application to the soil surface only showed equivalent herbicidal activity to that of broadcast application to the leaf and soil. Methiozolin at 500 to 1000 g ha<SUP>−1</SUP> provided 80 to 100% control of annual bluegrass when applied in the fall with acceptable and temporary injury to creeping bentgrass, and about 60% control when applied in the spring with no bentgrass injury in the field.</B></P><P><B>CONCLUSION</B></P><P><B>Methiozolin is an excellent candidate for annual bluegrass management in turfgrasses. © 2013 Society of Chemical Industry</B></P>
Cho, Eunx2010,Seok,Lee, Kyungx2010,Tai,Kim, Junx2010,Mo,Lee, Six2010,Woo,Jeon, Hyeonx2010,Jeong,Lee, Seungx2010,Hwan,Hong, Ki‐,Chang,Kim, Taex2010,Hun John Wiley and Sons Inc. 2016 ANIMAL SCIENCE JOURNAL Vol.87 No.3
<P><B>Abstract</B></P><P>We identified a potential molecular marker associated with meat quality traits in the <I>myosin heavy chain 4</I>, <I>MYH4</I> gene of Landrace pigs. Sequencing revealed a single nucleotide polymorphism (SNP; g.‐1398G>T) in the 5' upstream region of <I>MYH4</I>. It was significantly associated with the number of type IIa muscle fibers and water‐holding capacity based on filter‐paper fluid uptake. The GG genotype groups had a greater number of type IIa fibers and a larger area composed of type IIa fibers than the other genotype group (<I>P</I> = 0.004 and <I>P</I> = 0.061, respectively). Expression level of <I>MYH4</I> gene in the genotype TT or GT was higher than in genotype of GG (<I>P</I> < 0.0001). The T allele may enhance expression level of <I>MYH4</I> gene and then the portion of IIb type fiber in the muscle be increased by the T allelle. Therefore, we suggest that the g.‐1398G>T in the 5' upstream region of the porcine <I>MYH4</I> may be used as a molecular marker for meat quality traits, although its functional effect is not defined yet.</P>
Park, Sunx2010,Mi,Park, Seungx2010,Ho,Ryu, Ki‐,Jun,Kim, Inx2010,Kyu,Han, Hyeontak,Kim, Hyox2010,Jin,Kim, Seonx2010,Hee,Hong, Keunx2010,Seok,Kim, Hyemin,Kim, Minju,Cho, Bok Im,Heo, Je Elsevier Science B.V. Amsterdam 2019 MOLECULAR ONCOLOGY Vol.13 No.5
<P>The epithelial–mesenchymal transition (EMT) plays a pivotal role in the conversion of early‐stage tumors into invasive malignancies. The transcription factor Snail, an extremely unstable protein whose subcellular levels are regulated by many E3 ubiquitin ligases, promotes EMT as well as associated pathological characteristics including migration, invasion, and metastasis. Through yeast two‐hybrid screening, we identified the carboxyl terminus of Hsc70‐interacting protein (CHIP) as a novel Snail ubiquitin ligase that interacts with Snail to induce ubiquitin‐mediated proteasomal degradation. Inhibition of CHIP expression increases Snail protein levels, induces EMT, and enhances <I>in vitro</I> migration and invasion as well as <I>in vivo</I> metastasis of ovarian cancer cells. In turn, Snail depletion abrogates all phenomena induced by CHIP depletion. Finally, Snail and CHIP expression is inversely correlated in ovarian tumor tissues. These findings establish the CHIP–Snail axis as a post‐translational mechanism of EMT and cancer metastasis regulation.</P>
In Situ Observation of Voltage‐Induced Multilevel Resistive Switching in Solid Electrolyte Memory
Choi, Sangx2010,Jun,Park, Gyeongx2010,Su,Kim, Ki‐,Hong,Cho, Soohaeng,Yang, Woox2010,Young,Li, Xiangx2010,Shu,Moon, Jungx2010,Hwan,Lee, Kyungx2010,Jin,Kim, Kinam WILEY‐VCH Verlag 2011 ADVANCED MATERIALS Vol.23 No.29
<P><B>Solid electrolyte memories</B> utilizing voltage‐induced resistance change display the capability of multilevel switching, but understanding of the microscopic switching mechanism has been left incomplete. Here, in situ TEM observation of voltage‐induced changes in the microstructure of a solid electrolyte memory is reported, revealing that the multilevel switching originates from the growth of multiple conducting filaments with nanometer‐sized diameter and spacing. </P>
Lee, Sungx2010,Eun,Kim, Yoox2010,Jin,Yahng, Seungx2010,Ah,Cho, Byungx2010,Sik,Eom, Ki‐,Sung,Lee, Seok,Min, Changx2010,Ki,Kim, Heex2010,Je,Cho, Seokx2010,Goo,Kim, Dongx2010,Wook,L Blackwell Publishing Ltd 2011 European journal of haematology Vol.87 No.6
<P><B>Abstract</B></P><P><I>Objective:</I> The aim of this study was to determine the optimum conditioning intensity for allogeneic stem cell transplantation (SCT) in young (age ≤50), lower‐risk (INT‐1 by IPSS) Myelodysplastic syndrome (MDS) patients without significant comorbidities (hematopoietic cell transplantation‐comorbidity index score ≤3). <I>Methods:</I> Transplant outcomes from 46 consecutive patients were retrospectively analyzed according to the conditioning intensity: reduced‐intensity conditioning (RIC; <I>n</I> = 14), intensified RIC by adding low‐dose total body irradiation (iRIC; <I>n</I> = 15), and myeloablative conditioning (MAC; <I>n</I> = 17). <I>Results:</I> After a median follow‐up of 73.7 months, RIC had a better 4‐yr overall survival (OS) (92.9%) compared with the iRIC (64.2%) or MAC (70.6%). Multivariate analysis showed that RIC was associated with improved OS compared with the MAC [relative risk (RR) of 0.08, <I>P </I>=<I> </I>0.022] because of a lower transplant‐related mortality (TRM) (RR, 0.08, <I>P </I>=<I> </I>0.035). iRIC failed to show survival benefits over the MAC (RR of 0.77, <I>P </I>=<I> </I>0.689) because of similarly high TRM (RR of 0.41, <I>P </I>=<I> </I>0.480). Cumulative incidence of acute and chronic graft‐versus‐host disease (GVHD) after RIC was higher, but GVHD‐specific survival was significantly better (RIC 100% vs. iRIC 45.7% vs. MAC, <I>P </I>=<I> </I>0.018). Relapse rate was not different among the three groups, but in the RIC group, azacitidine was available and useful for inducing remission in two patients. <I>Conclusion:</I> This study shows that RIC improved OS by directly lowering TRM and indirectly giving an additional chance for relapsed MDS in the era of hypomethylating treatment. RIC–SCT should be considered for relative healthy lower‐risk MDS patients.</P>
Lee, Sungx2010,Eun,Min, Changx2010,Ki,Yahng, Seungx2010,Ah,Cho, Byungx2010,Sik,Eom, Ki‐,Seong,Kim, Yoox2010,Jin,Kim, Heex2010,Je,Lee, Seok,Cho, Seokx2010,Goo,Kim, Dongx2010,Wook Blackwell Publishing Ltd 2011 European journal of haematology Vol.86 No.1
<P><B>Abstract</B></P><P>Osteolytic lesions with activated osteoclast (OC) and suppressed osteoblast (OB) activity are characteristics of myeloma bone lesion. Recently, it has been shown that bortezomib treatment enhances OB function. To evaluate the effect of bortezomib on myeloma bone lesions, we performed bone scans, where increased uptake of the radiopharmaceutical by OBs is associated with re‐building activity. Bortezomib treatment markedly enhanced bone metabolic activity and increased alkaline phosphatase levels, and decreased monoclonal protein levels. These findings suggest that bortezomib has potent anti‐myeloma activity and bone‐protecting effects, with enhanced OB function.</P>
Lee, Sungx2010,Eun,Park, Sung Soo,Jeon, Youngx2010,Woo,Yoon, Jaex2010,Ho,Cho, Byungx2010,Sik,Eom, Ki‐,Seong,Kim, Yoox2010,Jin,Lee, Seok,Min, Changx2010,Ki,Kim, Heex2010,Je,Cho, Seo John Wiley Sons, Inc. 2018 American journal of hematology Vol.93 No.11
<P><B>Abstract</B></P><P>This prospective study explored an optimal conditioning regimen to ensure engraftment with minimal toxicity in adult patients with severe aplastic anemia (SAA) who received haplo‐identical stem cell transplantation from a related mismatched donor (Haplo‐SCT). We explored a safe and sufficient dose of rabbit ATG (Thymoglobulin) in combination with 800 cGy total body irradiation (TBI) and fludarabine (Flu, 30 mg/m<SUP>2</SUP>/day) for 5 days using step‐by‐step dose de‐escalation. The dose of ATG was de‐escalated from 10 mg/kg (group 1), to 7.5 mg/kg (group 2), to 5 mg/kg (group 3), and the TBI dose was reduced to 600 cGy (group 4) beginning in October 2014. If one patient developed transplant‐related mortality (TRM) with engraftment in a group, we moved to the next lower dose group. Thirty‐four patients were enrolled in groups 1‐3 (<I>n</I> = 10) and 4 (<I>n</I> = 24). All patients achieved primary engraftment. The incidence of acute GVHD (grade ≥ 2) and chronic GVHD (≥ moderate) was 29.4% and 14.7%, respectively. With a median follow‐up of 56.6 and 21.8 months in groups 1‐3 and group 4, respectively, the 2‐year probability of overall survival (91.7% in group 4 vs 70% in groups 1‐3, <I>P</I> = 0.155) and GVHD‐free survival (78.4% in group 4 vs 50% in groups 1‐3, <I>P</I> = 0.115) was shown tended to be better in group 4. This study explored an optimal conditioning with step‐by‐step de‐escalation dosage of ATG and TBI to reduce TRM with sustained graft function. TBI‐600 cGy/Flu/intermediate‐dose ATG resulted in feasible outcomes of Haplo‐SCT for adult patients with SAA.</P>
Anti‐inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation
Kim, So Yong,Moon, Keunx2010,Ai,Jo, Heex2010,Yeon,Jeong, Sookyung,Seon, Seungx2010,Han,Jung, Eunyu,Cho, You Sook,Chun, Eunyoung,Lee, Ki‐,Young Nature Publishing Group 2012 Immunology and Cell Biology Vol. No.
<P>Oxidative stress is implicated in the pathogenesis of allergic asthma and remains an attractive target for the prevention of the disease. Herein, we investigated the anti‐inflammatory effects of apocynin, a NADPH oxidase (NOX) inhibitor, in both <I>in vitro</I> and <I>in vivo</I> allergen‐induced experimental asthma mediated by Th2 hyperresponsiveness. Apocynin showed potential antioxidant activities and inhibitory effects on the activation of redox‐sensitive transcription factors, such as NF‐κB and AP‐1, induced by pro‐inflammatory stimuli, such as TNF‐α, lipopolysaccharide and Poly I:C, and that inhibited the production of pro‐inflammatory cytokines, such as TNF‐α, IL‐1β and IL‐6. In <I>in vivo</I> experimental asthma model, moreover, apocynin significantly attenuated ovalbumin‐induced airway hyperresponsiveness and inflammation, as shown by the attenuation of total inflammatory cell and soluble product influx into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL‐4, IL‐5, IL‐12, IL‐13 and TNF‐α. Apocynin also significantly reduced lung inflammation in the tissues. Altogether, these results suggest that apocynin may be useful in the treatment of inflammatory diseases induced by oxidative stress through NOX activity.</P>
Cho, Seungho,Jang, Jix2010,Wook,Kong, Ki‐,jeong,Kim, Eun Sun,Lee, Kunx2010,Hong,Lee, Jae Sung WILEY‐VCH Verlag 2013 Advanced functional materials Vol.23 No.19
<P><B>Abstract</B></P><P>Mixed metal oxide (MMO) nanostructures co‐doped uniformly by carbon and nitrogen are synthesized for the first time by annealing a terephthalate‐intercalated layered double hydroxide (LDH) under ammonia gas flow. The interlayer gallery of LDH allows effective access of NH<SUB>3</SUB> and the carbon source to its crystal lattice for a uniform nitrogen and carbon doping. Such co‐doped MMO exhibit significantly red‐shifted absorption spectra to visible light region relative to pure MMO. Photoelectrochemical water oxidation and incident‐photon‐to‐current‐conversion efficiency of LDH‐derived photocatalysts demonstrate that all the visible light absorption caused by the anion doping contributes to the photocatalytic activity over the entire absorbed wavelength range of <610 nm. Density functional theory calculations of electronic structures are performed to elucidate the possibility of bandgap narrowing upon nitrogen and carbon co‐doping on MMO structures.</P>