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Costs of illness and quality of life in patients with systemic lupus erythematosus in South Korea
Cho, JH,Chang, SH,Shin, NH,Choi, BY,Oh, HJ,Yoon, MJ,Lee, EY,Lee, EB,Lee, TJ,Song, YW SAGE Publications 2014 Lupus Vol.23 No.9
<P><B>Objective</B></P><P>To assess the costs of illness, health-related quality of life (HRQOL) and their associated factors in patients with systemic lupus erythematosus (SLE) in South Korea.</P><P><B>Method</B></P><P>Two hundred and one patients with SLE were enrolled at the Rheumatology clinic of Seoul National University Hospital. Direct, indirect and total costs and HRQOL were measured using hospital electronic data and face-to-face interview. Socio-demographic and clinical factors associated with cost of illness and HRQOL were analyzed using multiple regression and multivariate logistic regression.</P><P><B>Results</B></P><P>The average total cost of illness was estimated to be KRW 9.82 million (US $ 8993) per year, of which 41.6% was accounted for by direct costs and 58.4% by indirect costs. In multivariate regression, patients with renal involvement and those with depression incurred an average increment in annual total costs of 37.6% (<I>p</I> = 0.050) and 49.1% (<I>p</I> = 0.024), respectively, and an average increment in annual direct costs of 26.4% (<I>p</I> = 0.050) and 43.3% (<I>p</I> = 0.002), respectively, compared with patients without renal involvement and depression, respectively. In addition, disease damage was positively associated with an average increment in annual total and direct costs (55.3%, <I>p</I> = 0.006; 33.3%, <I>p</I> = 0.013, respectively), and the occurrence of indirect costs (OR 2.21, 1.09–4.88). There was no significant difference in HRQOL between patients with and without renal involvement (0.655 vs. 0.693, <I>p</I> = 0.203)</P><P><B>Conclusion</B></P><P>Renal involvement, depression, and disease damage were major factors associated with higher total and medical costs for patients with SLE in South Korea. Effective treatment of renal disorders and depression may reduce the high economic burden of SLE.</P>
SEMM방식의 골반경 자궁적출술 ( CISH ) 300 예에 대한 임상적 연구
조진호(JH Cho),이정노(JN Lee),김인현(IH Kim),김경률(KL Kim),정창조(CJ Chung),김종욱(JW Kim),신명철(MC Shin) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5
Laparoscopic hysterectomy, introduced by Reich et al in 1988, has proven to be an effective alternative to abdominal hysterectomy for women. Several modalities were introduced by some laparoscopists, among which the supracervical modality was particularly suitable for laparoscopic surgery because it has some advantages. The surpracervical hysterectomy requires less dissection of the bladder and the technique minimally alters the anatomy and integrity of the pelvic floor and vagina, therefore the risk of bleeding, surgical injuries to the bladder, ureters and lower intestinal tract were decreased. These factors may be responsible for the apparently less compromised bladder and sexual Function and decreased long term morbidity. The purpose of the study described below was to show that laparoscopic supracervical hysterectomy can be performed safely with minimal morbidity, and to establish the validity of replacing the vast majority of traditional abdominal hysterectomies. During the period October, 1992-June, 1996, 300 women underwent Classical Intrafascial SEMM Hysterectomy(CISH) at Cha Hospital, Seoul, Korea and KyungHee Bundang Cha Hosptial, Seongnam, Korea. Most common age groups were 41~50, and average age of patients was 43.2 years old. Most common parity groups was 2, and average parity was 2.4. Myoma and adenomyosis of uterus were common preoperative surgical indications. Most common uterine size was 8~10 weeks gestational size. The common operation time ranged from 151~180 minutes with a mean of 156 minutes. The common Hgb loss range was 1.5~1.0gm/dl, and average was 0.78gm/dl. The common hospitalization period were 5~6 day with a mean of 5.9days. The complications were 23 cases, among which intra and postoperative bleeding were most common.
35 세 이하에서 발생된 자궁경부암조직의 인유두종 바이러스 16 형 및 18 형에 의한 종양억제 유전인자 p53 의 동태변화
신정환(JH Shin),조삼현(SH Cho),황윤영(YY Hwang),조수현(SH Cho),유중배(JB Yoo),문형(H Moon),이재억(JA Lee),조율희(YH Cho) 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.3
To evaluate the influence of human papillomavirus to the modulation of p53 in younger ptients with the uterine carvical carcinoma, comparative analysis was undertaken with the clinical variants. The prevalence and types of human papillomavirus was obtained by means of 2 steps polymerase chain reactions with the primers of HPV L1 consensus, type 16 and 18 E6specific primers and confirmed by southern blot hybridization. The status of p53 was evaluated with the 2 steps nested ploymerase chain reation-single strand conformation polymorphism/direct sequencing with the primers of p53 exon 4,5-6,7,8-9, and their nested primers of exon 4,5,6,7,8 and 9 from the biopsy specimens of the 20 patients less than 36 years lod(study group) and 10 patients over 45 years old(control group). The incidence of lymph node metastases in the study group was higher than that of control group(35% in study group vs. 30% in control group) in spite of less advanced FIGO stage and 85% in 3-year survival in the study group. The prevalence rate and types of human papillomavirus were 16/20(80%), 14/16(87.5%) with type 16, 2 with type 18 in the former, and 9/10, type 16 only in the latter. There was one missense mutation in the younger patient group and one splicing mutation in the older patient group B ; the missense mutation revealed a transition from C to T of the 2nd base in the codon 189 of exon 4, and splicing mutation was found to delete 51 bases at the junction between intron 5 and 6. The clinical end results of the two cases with mutation of p53 were all recurrence within a year following the combined modalities with the induction chemotherapy and subseqint radical hysterectomy and paraaortic, pelvic lymph node dissection. These suggest that the HPV could not modulate tumor suppressor gene p53 universally in patient with cervical carcinoma with no relation to the age factor. However, the sequential research whether the products in cancer cell to induce stabilization of p53 is present or not, and the flow cytometric analysis for
이준형(JH Lee),박정희(JH Park),박종두(JD Park),강유미(YM Kang),조태일(TI Cho) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.8
A diagnosis of leiomyosarcoma of the ovary was made in a 49 year old female presenting with abdominal pain and palpable mass. On clinical examination, a hard, large mass was found occupying the pelvic cavity. We experienced this infrequent malignant tumor. The authors report this case with the clinicopathologic findings and brief review of literature.
태아수종을 동반한 Klinefelter증후군 태아 1 예
조진호(JH Cho),조은미(EM Cho),이정노(JN Lee),김병성(BS Kim),계정웅(CW Kay),장성운(SW Chang) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.7
Nonimmune hydrops fetalis(NIHF) is a heterogenous disorder resulting from a vast number of underlying pathologies. Chromsomal abnormalities underlie a large percentage of cases of NIHF in most series. There are many reports identifying the association of Turner syndrome and Trisomy 21, 18, 13 with NIHF, but few reports about Klinefelter syndrome. In this article, we experienced a case of Klinefelter syndrome combined with hydrops fetalis and report the case with brief review of literature.
조장형(JH CHO),원영수(YS WON),조규수(KS CHO) 한국자동차공학회 1998 한국자동차공학회 춘 추계 학술대회 논문집 Vol.1998 No.5_1
A 3-dimensional flow analysis in a muffler considering pulsating pressure of exhaust gas has been conducted to provide a pressure data for noise reduction. The CFD analysis of a unit area of porous materials also conducted for determining the permeability of perforated inlet pipe and baffle plates. The pulsating velocity of exhaust gas was assumed for three case conditions. The STAR-CD S/W used for the three dimensional unsteady state CFD analysis in a muffler. The pulsating pressure amplitude was decreased in an outlet pipe of muffler. About 80% pressure drop was obtained between inlet pipe and out pipe. For a practical application, temperature calculation in a muffler has to conducts.<br/>
조준형(JH Cho),차순도(SD Cha),이태성(TS Lee),조치흠(CH Cho),백원기(WK Baek),서성일(SI Seo),서민호(MH Seo) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11
Human papillomavirus(HPV) infection is one of the common sexual transmitted infections in Korea, and evidence that HPV plays a central role in the development of cervical cancer and its precusors is growing. HPV is a small, double stranded, non-enveloped DNA virus that infe-cts epithelial cells, replicates within their nuclei, and causes hyperproliferative lesions. HPV ty-pe 16 and 18 are most strongly associated with high-grade lesion and cancer of the cervix. HPV DNA is integrated into the genome of the host cell in most invasive cancers. Integration usually results in disruption of the viral transcriptional regulatory circuit, which may faciliate cell proliferation by allowing deregulated expression of the viral oncogenes E6 and E7. The high risk HPV E6 protein can form complex with tumor suppressor protein p53 and faciliate the rapid degradation of p53 via the ubiquitin dependent proteolytic system. The high risk E7 protein bi-nds pRB related proteins and then displaces E2F like transcription factors from pRB related proteins. By inactivating p53 and pRB, HPV can induce proliferation of infected cells. In order to elucidate the association between HPV infection and the expression of cyclin genes in cervical cancers, we studied the prevalence of HPV infection and the expression level of cyclin genes(cyclin A, B, C, D1 and E) in nine cervical cancer samples. The presence of HPV infection was examined by RT-PCR and restriction enzyme analysis. HPV was detected in all cases(9/9);HPV type 16 was detected in 6 cases, HPV type 18 in 2 cases and an unknown type was detected in one case. The expression level of cyclin genes were evaluated by semiquantitative RT-PCR method. Expression of examined cyclin genes(cyclin A, B, C, D1 and E) were increased in all cancer tissues, and cyclin B and C expression were remarkably increased. There are no differences of expression levels of cyclins depending on infected HPV types.