Reproduction and population dynamics of <i>Leptochela gracilis</i> (Decapoda: Pasiphaeidae) on the western coast of Korea, Yellow Sea

Oh, C.W.,Kim, J.Y.,Jeong, I.J.,Suh, H.L.,Cho, Y.K. Cambridge University Press 2006 Journal of the Marine Biological Association of th Vol.86 No.1

<P>Investigations were made on reproduction and population dynamics of <I>Leptochela gracilis</I> on the western coast of Korea, Yellow Sea, between May 2000 and October 2001. The egg volume was significantly larger at later egg stage than at early egg stage. Brood loss did not occur during the incubation period. Based on dry weight, the reproductive output (mass of incubating eggs/mass of female) averaged 0.18. The mature females first appeared in May, reached a peak in July and August, and then did not appear after September. The main breeding season was summer, although slightly different between the two years. A similar pattern could be found in monthly changes of gonadosomatic index (GSI), showing relatively higher GSI during the annual breeding season. A significant difference in ovarian dry weight between females with non-eyed eggs and eyed eggs indicates that ovarian maturation occurred during the embryonic development, suggesting that females were potentially consecutive breeders, capable of multiple spawning within a reproductive season. The size at which 50% of females were mature (CL50) was estimated as 7.63 mm carapace length. Females grew faster and reached a larger size at age than males (<I>L</I>∞=12.43 mm CL and <I>K</I>=0.90 y<SUP>−1</SUP> for females, and <I>L</I>∞=12.22 mm CL and <I>K</I>=0.58 y<SUP>−1</SUP> for males).</P>

Efficacy and safety findings from DREAM: a phase III study of DHP107 (oral paclitaxel) versus i.v. paclitaxel in patients with advanced gastric cancer after failure of first-line chemotherapy

Kang, Y.-K.,Ryu, M.-H.,Park, S.H.,Kim, J.G.,Kim, J.W.,Cho, S.-H.,Park, Y.-I.,Park, S.R.,Rha, S.Y.,Kang, M.J.,Cho, J.Y.,Kang, S.Y.,Roh, S.Y.,Ryoo, B.-Y.,Nam, B.-H.,Jo, Y.-W.,Yoon, K.-E.,Oh, S.C. Elsevier 2018 ANNALS OF ONCOLOGY Vol.29 No.5

<P>Conclusions: DHP107 as a second-line treatment of AGC was non-inferior to paclitaxel for PFS; other efficacy and safety parameters were comparable. DHP107 is the first oral paclitaxel with proven efficacy/safety for the treatment of AGC.</P>

Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough

Kim, T.-B.,Oh, S.-Y.,Park, H.-K.,Jeon, S.-G.,Chang, Y.-S.,Lee, K.-Y.,Cho, Y. S.,Chae, I.-H.,Kim, Y.-K.,Cho, S.-H.,Moon, H.-B.,Min, K.-U.,Kim, Y.-Y. Blackwell Publishing Ltd 2009 Journal of clinical pharmacy and therapeutics Vol.34 No.4

<P>Summary</P><P>Background and objective: </P><P>Treatment with angiotensin-converting enzyme (ACE) inhibitors can induce chronic cough in many patients. Genetic variations in the neurokinin 2 receptor gene (NK2R) are significantly associated with cough sensitivity to capsaicin.</P><P>Methods: </P><P>This study assessed the relationship between genetic polymorphisms in the NK2R gene and chronic cough in 91 patients taking ACE inhibitors. Patients included in the study did not have chest abnormalities, postnasal drip, gastroesophageal reflux or a recent history of upper respiratory infection.</P><P>Results: </P><P>We detected two single nucleotide polymorphisms in the NK2R gene (i.e., Gly231Glu and Arg375His). The allelic frequencies at amino acid 231 were 36·3% for Gly/Gly, 49·5% for Gly/Glu and 14·3% for Glu/Glu. The allelic frequencies at amino acid 375 were 74·7% for Arg/Arg, 24·2% for Arg/His and 1·1% for His/His. The prevalence of chronic cough in patients with the amino acid 231 genotype was 33·3% in Gly/Gly homozygotes, 24·4% in Gly/Glu heterozygotes and 0% in Glu/Glu homozygotes. There was a statistically significant association between chronic cough and the Glu/Glu allele (<I>P</I> = 0·028) when the data were analyzed with a recessive model. In addition, there was a significant inverse linear association between the number of Glu231 alleles and ACE inhibitor-related cough (<I>P </I>=<I> </I>0·026). The prevalence of chronic cough in patients with the amino acid 375 genotype was 22·1% in Arg/Arg homozygotes, 31·8% in Arg/His heterozygotes and 0% in His/His homozygotes, although none of these association were statistically significant.</P><P>Conclusion: </P><P>Our findings indicate that the Gly231Glu polymorphism is associated with a lower prevalence of ACE inhibitor-related cough.</P>

200 GeV/핵자 유황이온과 핵건판핵의 충돌에 의해 생성된 헬륨 파쇄핵의 극한파쇄 연구

김동철,송진섭,윤천실,정성헌,박인곤,김종오,김철수,김태연,이승희,조재희,천병구,김재률,김준원,김태익,박명렬,장한일,임인택 慶尙大學校 기초과학연구소 1992 基礎科學硏究所報 Vol.8 No.-

고에너지 중이온 원자핵과 핵건판의 충돌에서, 200GeV/핵자 유황이온에 의해 생성된 파쇄 헬륨핵(Z=2)의 실험실계의 방출각 분포는 표적핵에 무관한 회귀공식. dN=exp[a+k exp(η-y_b)]d[exp(η-y_b)]로 잘 표현된다. 여기에서 의사신속도 η=-ln[tan(θ/2)]이고, y_b는 실험실계의 입사입자(^32S)의 신속도이다. 이 공식에 의한 적합에서 k=-0.057±0.008로 얻어진다. 즉, 핵건판과 고에너지 중이온의 충돌에서 파쇄 헬륨핵의 exp(η-y_b)의 분포는 "극한파쇄" 현상을 잘 설명하고 있다. The angular distribution of emission angle θ of helium (Z=2) produced in the collisions of incident particles of 200 GeV/nucleon ^32S in nuclear emulsion is well expressed by dN=exp[a+k exp(η-y_b)]d[exp(η-y_b)] where the pseudorapidity is η=-ln[tan(θ/2)], the laboratory system primary rapidity is y_b, and k=-0.057+0.008. The shape of this frequency of occurrence distributions in terms of exp(η-y_b) attests to the validity of the concept of "limiting fragmentation" for helium projectile fragments produced in the projectile fragmentation regions of heavy ion collisions in nuclear emulsion.

Haplotypes for 12 Y-chromosomal STR loci in a Korean population (the central region)

Hwang, J.H.,Lee, H.,Lee, Y.A.,Han, M.S.,Kim, W.,Jin, I.,Cho, N.S. Elsevier Sequoia 2007 Forensic science international Vol.168 No.1

Haplotypes and allele frequencies of 12 STR loci included in the PowerPlex<SUP>(</SUP>R) Y system (DYS391, DYS389I, DYS439, DYS389II, DYS438, DYS437, DYS19, DYS392, DYS393, DYS390, and DYS385a/b) were obtained from a sample of 569 unrelated individuals living in the central region of Korea. A total of 473 haplotypes were observed in the 569 individuals studied, of which 426 (90.06%) were unique. The overall haplotype diversity for the 12 Y-STR loci was 0.9985, and the discrimination capacity was 0.8313. In DYS439, we found a new intermediate-sized allele that added an A at base 3 upstream from the repeat region's first GATA motif. The allele was named 11 (U3Ains) according to its sequence structure.

담낭염 환자에서의 99m Tc-HIDA Scan 의 진단적 의의

조보연,박난재,안일민,장연복,홍기석,윤용범,고창순 대한핵의학회 1981 핵의학 분자영상 Vol.15 No.2

Cholescintigraphic studies with Tc-99m-HIDA(dimethyl iminodiacetic acid) were performed in 22 cases of normal subjects, 21 of acute cholecystitis, 22 of chronic cholecystitis and 12 others, with the results of, 1) In normal control group, liver and intrahepatic biliary tree, CBD and gall bladder, and G-I tract appeared at 10, 20 and 30 minutes after intravenous injection of Tc-99m-HIDA respectively. 2) In acute cholecystitis, 20 among 21 cases showed non-visualization of gall bladder with the diagnostic accuracy, sensitivity and specificity of 98.290, 95.290 and 100% respectively. 3) In chronic cholecystitis, 5 among 12 cases showed non-visualization of gall bladder and remained 7 among 12 cases showed poor contraction of gall bladder (4), delayed visualization of gall bladder(l) and normal findings(2). 4) In the other disease group, the 12 cases which initially suspected as acute cholecystitis, revealed normal scan findings to exclude the cystic duct obstruction easily. With the above results, this scintigraphic procedure was found very rapid, accurate and easily available method for the determining of the cystic duct patency.

개체별 성장곡선 모수를 이용한 재래돼지와 랜드레이스종의 성장 특성에 관한 연구

조용민,윤호백,이영창,서강석,김시동,박영일 한국동물자원과학회 2001 한국축산학회지 Vol.43 No.6

축산기술연구소의 재래돼지 암수 각각 220두 및 192두와 랜드레이스종 암수 각각 91두 및 62두의 일령별 체중자료에 대하여 Gompertz 모형을 적용하여 개체별로 성장곡선 모수를 추정하였다. 측정시기(t)를 월령으로 변환하여 비선형회귀(NLIN) 방법으로 계산한 개체별 성숙체중(A) 추정치 평균은 재래돼지는 암수 각각 119.42±2.63㎏ 및 131.03±3.81㎏이었으며, 랜드레이스종은 각각 176.17±4.17㎏ 및 201.97±6.82㎏ 이었으며, 성숙률(k) 추정치 평균은 재래돼지는 암수 각각 0.3389±0.0085 및 0.3284±0.0067이었으며, 랜드레이스종은 0.3742±0.0068 및 0.3592±0.0085였다. 최대성장시기를 나타내는 변곡점(t_1)은 재래돼지는 암수 각각 4.63 및 4.86개월령이었으며, 랜드레이스종은 각각 4.31 및 4.56개월령으로 나타났다. 재래돼지는 랜드레이스종에 비하여 성장곡선의 성숙률(k)이 낮고 성숙체중(A)이 작고 변곡점에서의 최대성장률(∂W_t1/∂t)은 낮게 추정되었으며 이들 성장곡선 모수의 두 품종간 차이는 모두 통계적으로 유의성이 있었다. This study was conducted to estimate the growth curve parameters of Korean Native Pig(KNP) and Landrace breed and to compare their growth characteristics based on weight-age data from 220 females and 192 males of KNP and 91 females and 62 males of Landraces raised at N.L.R.I in Korea. Growth curve parameters were estimated from nonlinear regression using Gompertz model individually. Average mature weight(A) estimated for KNP were 119.42±2.63㎏ in females and 131.03±3.81㎏ in males. Average mature weight(A) estimated for Landraces were 176.17±4.17㎏ in females and 201.97±6.82㎏ in males. Average maturing rates(k) estimated for KNP were 0.3389±0.0085 in females and 0.3284±0.0067 in males, and the rates(k) estimated for Landraces were 0.3742±0.0068 in females and 0.3592±0.0085 in males. Average inflection points(t_1) showing maximum growth rate estimated for KNP were 4.63 month s of age in females and 4.86 months in male, and the points(t_1) estimated for Landraces were 4.31 months in females and 4.56 months in males. The results obtained in this study indicate that the KNP had significantly lower rates of maturing(k), smaller mature weights(A) and lower maximum growth rate at inflection point(∂W_t1/∂t) than the landrace breed.

Overexpression of PtrMYB119, a R2R3-MYB transcription factor from Populus trichocarpa, promotes anthocyanin production in hybrid poplar

Cho, J. S.,Nguyen, V. P.,Jeon, H. W.,Kim, M. H.,Eom, S. H.,Lim, Y. J.,Kim, W. C.,Park, E. J.,Choi, Y. I.,Ko, J. H. Oxford University Press 2016 Tree physiology Vol.36 No.9

<P>Anthocyanins are a group of colorful and bioactive natural pigments with important physiological and ecological functions in plants. We found an MYB transcription factor (PtrMYB119) from Populus trichocarpa that positively regulates anthocyanin production when expressed under the control of the CaMV 35S promoter in transgenic Arabidopsis. Amino acid sequence analysis revealed that PtrMYB119 is highly homologous to Arabidopsis PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT1), a well-known transcriptional activator of anthocyanin biosynthesis. Independently produced transgenic poplars overexpressing PtrMYB119 or PtrMYB120 (a paralogous gene to PtrMYB119) (i.e., 35S::PtrMYB119 and 35S::PtrMYB120, respectively) showed elevated accumulation of anthocyanins in the whole plants, including leaf, stem and even root tissues. Using a reverse-phase high-performance liquid chromatography, we confirmed that the majority of the accumulated anthocyanin in our transgenic poplar is cyanidin-3-O-glucoside. Gene expression analyses revealed that most of the genes involved in the anthocyanin biosynthetic pathway were highly upregulated in 35S::PtrMYB119 poplars compared with the nontransformed control poplar. Among these genes, expression of PtrCHS1 (Chalcone Synthase1) and PtrANS2 (Anthocyanin Synthase2), which catalyze the initial and last steps of anthocyanin biosynthesis, respectively, was upregulated by up to 350-fold. Subsequent transient activation assays confirmed that PtrMYB119 activated the transcription of both PtrCHS1 and PtrANS2. Interestingly, expression of MYB182, a repressor of both anthocyanin and proanthocyanidin (PA) biosynthesis, was largely suppressed in 35S::PtrMYB119 poplars, while expression of MYB134, an activator of PA biosynthesis, was not changed significantly. More interestingly, high-level accumulation of anthocyanins in 35S::PtrMYB119 poplars did not have an adverse effect on plant growth. Taken together, our results demonstrate that PtrMYB119 and PtrMYB120 function as transcriptional activators of anthocyanin accumulation in both Arabidopsis and poplar.</P>

TMAH-based wet surface pre-treatment for reduction of leakage current in AlGaN/GaN MIS-HEMTs

Yoon, Y.J.,Seo, J.H.,Cho, M.S.,Kang, H.S.,Won, C.H.,Kang, I.M.,Lee, J.H. Pergamon Press ; Elsevier Science Ltd 2016 Solid-state electronics Vol.124 No.-

The pre-passivation surface treatment process with tetramethylammonium hydroxide (TMAH)-based wet solution was proposed for the minimization of the leakage current (I<SUB>leak</SUB>) in AlGaN/GaN metal-insulator-semiconductor high electron mobility transistors (MIS-HEMTs). This process step contributes to the simultaneous decrease of the surface current (I<SUB>surf</SUB>) in the active region of device and mesa-isolated region by removing the surface states and traps related to nitrogen (N) vacancy, Ga-oxide, and dangling bonds. Using the surface treatment, the fabricated device achieves a lower off-state current (I<SUB>off</SUB>) of ~10<SUP>-12</SUP>A/mm, a higher on/off current ratio (I<SUB>on</SUB>/I<SUB>off</SUB>) of ~10<SUP>11</SUP>, a small subthreshold swing (SS) of 68.4mV/dec. The reduced I<SUB>leak</SUB> also improves breakdown voltage (BV). In addition, the interface trap density (D<SUB>it</SUB>) between the SiN layer and the AlGaN surface was extracted to evaluate the quality of the SiN/GaN interface, which showed that the treatment decreases the D<SUB>it</SUB> with reduction of the surface defects.

Thermodynamic behaviors of excitonic emission in ZnO nanorods grown by pulsed laser deposition

Lee, Y.,Lee, D.J.,Cho, H.D.,Yoon, I.T.,Shon, Y.,Lee, S. North-Holland 2017 Journal of luminescence Vol.190 No.-

We investigated the thermodynamic behaviors of the exciton emission in ZnO nanorods that had been grown by laser ablation. The ZnO nanorods exhibited a clear luminescence peak from the neutral donor-bound exciton (D<SUP>0</SUP>X), which persisted near room temperature. Through analyzing temperature-dependences of photoluminescence properties, we found out insignificant thermal-quenching of D<SUP>0</SUP>X, arising from the large donor binding energy (i.e., E<SUB>bD(NR)</SUB> ~ 51.1 +/- 7.3meV). A small discrepancy of E<SUB>bD(NR)</SUB> from ZnO bulks' values (i.e., E<SUB>bD(Bulk)</SUB> = 53 - 72meV) is associated with inhomogeneous thermal-broadening factors such as defect-scattering at the surface of the nanorod. Despite of inhomogeneous thermal-broadening, the ZnO nanorods still have a high luminescence efficiency because of the weak homogeneous thermal-broadening effect (i.e., low exciton-phonon coupling).