Clinical Characteristics, Genetic Features, and Long-Term Outcome of Wilson’s Disease in a Taiwanese Population: An 11-Year Follow-Up Study in a Taiwanese Population: An 11-Year Follow-Up Study

Chin-Hsien Lin 대한파킨슨병및이상운동질환학회 2023 Journal Of Movement Disorders Vol.16 No.2

Wilson’s disease (WD) is a rare genetic disorder of copper metabolism, and longitudinal follow-up studies are limited. We performed a retrospective analysis to determine the clinical characteristics and long-term outcomes in a large WD cohort.

Studies on the Processing Properties and Interactions Between Porcine Blood Proteins and Waxy Rice Starch During Making Porcine Blood Cake

Lin, Chin-Wen,Yang, Jeng-Huh,Chu, Hsien-Pin,Su, Ho-Ping,Chen, Hsiao-Ling,Huang, Chia-Cheong Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.3

The physiochemical properties and interactions between porcine blood and waxy rice were determined. Addition of calcium chloride (0.15%) improved acceptability of blood cake and increased the gelatinization degree of waxy rice. The water-holding capacity of porcine blood gel (blood/water=60/40, v/v), extent of absorption and gelatinization of waxy rice, and scanning electron microscopy showed that blood protein matrix and waxy rice are competitors for holding water in the cooking procedure. Non-haem iron content increased linearly (R=0.95) when heating temperature rose. The presence of blood proteins caused increasing of peak temperature (Tp) of gelatinization in differential scanning calorimetric thermal gram, The microstnlcture of plasma proteins and haemoglobin appeared continuous changes, and interacted with surface of waxy rice flour in terms of network and mosaic form, respectively. The electrophoretic patterns revealed an interaction between plasma proteins and waxy rice glutelin and haemoglobin when heated could be found at temperatures above $60^{\circ}C$.

Positive Symptoms in Antipsychotic-naïve Schizophrenia are Associated with Increased Body Mass Index after Treatment

Shih-Hsien Lin,Huai-Hsuan Tseng,Hsin Chun Tsai,Mei Hung Chi,I Hui Lee,Po See Chen,Kao Chin Chen,Yen Kuang Yang 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.1

Objective: Weight gain is an important risk factor for morbidity and mortality among patients with schizophrenia. We speculated that positive symptoms, related to dopaminergic hyperactivity and altered mesolimbic function, are associated with weight gain. Methods: Twenty-two antipsychotic-naïve, first-episode patients with schizophrenia were enrolled. The Positive and Negative Syndrome Scale was completed at enrollment and follow-up. Body mass index (BMI) was also measured. Results: The increase in BMI, after 6.04 ± 2.16 years of follow-up, was associated with positive symptoms, but not negative symptoms, before treatment with antipsychotics in antipsychotic-naïve patients with schizophrenia. Conclusion: This finding implied that dopaminergic hyperactivity could be an important factor to predict the treatment outcome. Body weight control is important for the health management of patients with schizophrenia with more severe positive symptoms.

FEM ANALYSIS AND EXPERIMENT VALIDATION ON MULTI-PASS FORGING OF TORX ROUND FLANGE BOLT

Shih-Hsien Lin,Dyi-Cheng Chen,Un-Chin Chai,Gow-Yi Tzou 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.5

This study aims at exploring the multi-pass forging of Torx Round Flange Bolt (automotive fastener) to simulate each pass forging process using FEM simulation. The software is used to carry out the simulation analysis. Constant shear friction is always assumed at the interface between die and workpiece to explore the effective stress, the effective strain, the velocity filed, and the forging force for each pass. Through the pass schedule plan and design based on FEM analysis, the four-pass forging process is designed to form the Torx Round Flange Bolt compared the five-pass forging. It is noted that the total forging force is 1204kN, so the 200 tons machinery in the factory can be chosen to manufacture this automotive fastener. The die stress analysis for each pass has been explored to realize whether the dies are damaged or not. The forming feasibility of Torx Round Flange Bolt can be performed by FEM simulation. All dies designs and forming results can be proposed to the dies manufacture so as to perform the realistic experiments. Comparisons between FEM and experiment for final product dimensions can be carried out. The maximum dimension error is just around 3.32% to show a good agreement with the experiment. The research results can provide to the industries as the references of establishment of multi-pass forging technology.

Altered gut microbiome and intestinal pathology in Parkinson’s disease

Han-Lin Chiang,Chin-Hsien Lin 대한파킨슨병및이상운동질환학회 2019 Journal Of Movement Disorders Vol.12 No.2

Parkinson’s disease (PD) is a common neurodegenerative disorder arising from an interplay between genetic and environmental risk factors. Studies have suggested that the pathological hallmarks of intraneuronal α-synuclein aggregations may start from the olfactory bulb and the enteric nervous system of the gut and later propagate to the brain via the olfactory tract and the vagus nerve. This hypothesis correlates well with clinical symptoms, such as constipation, that may develop up to 20 years before the onset of PD motor symptoms. Recent interest in the gut–brain axis has led to vigorous research into the gastrointestinal pathology and gut microbiota changes in patients with PD. In this review, we provide current clinical and pathological evidence of gut involvement in PD by summarizing the changes in gut microbiota composition and gut inflammation associated with its pathogenesis.

Study of Oil-Water Ratio and Flow Rate of MQL Fluid in High Speed Milling of Inconel 718

Yunn-Shiuan Liao,Chin-Hsi Liao,Hsien-Mou Lin 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.2

High speed milling of Inconel 718 by carbide tool aided by MQL of various oil-water ratios and flow rates of the fluid was investigated. Tool wear and cutting force were taken to assess the effectiveness of the fluids. The action of the fluid in machining Inconel 718 under MQL was also studied. EDX analysis of the rake face of the tool shows that the fluid has penetrated into the chiptool interface and works as the diffusion barrier as well. The results reveal that the amounts of fluid penetration and wetting area are essential for effective fluid action. Tool wear and cutting force are found to decrease with increasing flow rate of the fluid irrespective of oil-water ratio. But the improvements are negligible as compared with those resulted from the flow rates of 100 ml/ hr and 60 ml/hr. This can also be confirmed by the little difference of wetting area beyond the flow rate of 60 ml/hr. Based on this study, it is concluded that the most appropriate oil-water ratio and flow rate of the fluid used in MQL in high speed milling of Inconel 718 are 60:40 and 60 ml/hr, respectively.

Increase in Plasma Glucose Lowering Action of Rosiglitazone by Electroacupuncture at Bilateral Zusanli Acupoints (ST.36) in Rats

Hui-Ching Pai,Chung-Yuh Tzeng,Yu-Chen Lee,Chin-Hsien Chang,Jaung-Geng Lin,Juei-Tang Cheng,Shih-Liang Chang 사단법인약침학회 2009 Journal of Acupuncture & Meridian Studies Vol.2 No.2

Objectives: Hypoglycemia induced by electroacupuncture (EA) is due to an increase of insulin secretion and/or mediation of β-endorphin. We applied EA at the Zusanli (ST.36) acupuncture point (acupoint) in combination with rosiglitazone (TZD) administration to evaluate their effect on plasma glucose and to explore possible mechanisms of action. Methods: Thirty six normal adult Wistar rats were randomly divided into four groups: the 0.1 mg/kg TZD group (0.1TZD), 0.1 mg/kg TZD and EA group (0.1TZD + EA), EA group, and control group. In other experiments, streptozotocin was used to induce type 2 diabetes mellitus in neonatal rats; these were then randomly divided into a 0.1TZD group, 0.1TZD + EA group, and EA group and changes in plasma glucose and insulin concentrations evaluated. Results: A marked hypoglycemic response was observed in the normal rat 0.1TZD, 0.1TZD + EA and EA groups, with the response more significant in the 0.1TZD + EA group than in the 0.1TZD group. Among the diabetic animals, the hypoglycemic responses in the 0.1TZD + EA and EA groups were greater than in the 0.1TZD group. In both the normal and diabetic rats, insulin secretion was increased by EA or 0.1TZD + EA treatment, but not by 0.1TZD. Conclusions: The plasma glucose lowering action of rosiglitazone was increased by EA in both normal and diabetic rats, indicating that the application of EA may enhance the hypoglycemic action of this insulin sensitizer. Objectives: Hypoglycemia induced by electroacupuncture (EA) is due to an increase of insulin secretion and/or mediation of β-endorphin. We applied EA at the Zusanli (ST.36) acupuncture point (acupoint) in combination with rosiglitazone (TZD) administration to evaluate their effect on plasma glucose and to explore possible mechanisms of action. Methods: Thirty six normal adult Wistar rats were randomly divided into four groups: the 0.1 mg/kg TZD group (0.1TZD), 0.1 mg/kg TZD and EA group (0.1TZD + EA), EA group, and control group. In other experiments, streptozotocin was used to induce type 2 diabetes mellitus in neonatal rats; these were then randomly divided into a 0.1TZD group, 0.1TZD + EA group, and EA group and changes in plasma glucose and insulin concentrations evaluated. Results: A marked hypoglycemic response was observed in the normal rat 0.1TZD, 0.1TZD + EA and EA groups, with the response more significant in the 0.1TZD + EA group than in the 0.1TZD group. Among the diabetic animals, the hypoglycemic responses in the 0.1TZD + EA and EA groups were greater than in the 0.1TZD group. In both the normal and diabetic rats, insulin secretion was increased by EA or 0.1TZD + EA treatment, but not by 0.1TZD. Conclusions: The plasma glucose lowering action of rosiglitazone was increased by EA in both normal and diabetic rats, indicating that the application of EA may enhance the hypoglycemic action of this insulin sensitizer.