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지하채굴공동 안정성 해석을 위한 암반등급 분류법의 비교 연구
양훈재,고진석 조선대학교 생산기술연구소 2007 生産技術硏究 Vol.29 No.2
It is compared with the stability of pillar to make a selection of numehcal analysis by Hoek-Brown Model and Mohr-Coulomb Model at FDM analysis and so presented proper formation model. The RMi system is based on defined inherent parameters of the rock mass and is obtained by combining the compressive strength of intact rock and a jointing parameter and an improved method to determine the constants m and s in the Hoek-Brown failure chterion for rock masses. By using numehcal analysis program for the accuracy of constants m, s calculated by RMi in Hoek-Brown failure criteron also compared with the constants calculated by RMR. The reliability of constants calculated by RMi is confirmed. The result of analysis to select proper numehcal analysis model on this study site is comparatively high stress level and Hoek-Brown model is possible for a safe design. The parameter calculated by RMi is almost equal to the parameter calculated by RMR.
정상 성인에 경구 투여한 Cefixime 두 정제의 생물학적 동등성 비교
강진양,서성훈,이경태,문창훈,강진한,이동건,최정현,신완식 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.4
목적 : 식품의약안전청 고시 제 1998-86호(1998. 8.26) "생물학적 동등성 시험 기준"에 의하여 섹심 캅셀(시험약, 한국유나이트제약)과 슈프락스 캅셀(대조약, 동아제약)의 생물학적 동등성을 비교 검토하였다. 방법 : 2×2 라틴 방격법에 따라 건강한 성인 남성 지원자 20명에게 cefixime 100㎎씩 경구투여하였다. 약제투여 후 12시간까지 일정간격으로 채혈하였고 각 피험자들의 혈중약물농도 데이터로부터 구한 Area under the concentration (AUC), C_(max), T_(max) 등의 생체이용률 파라미터에 대해 통계학적으로 고찰하여 두 제제간의 생물학적 동등성을 평가하였다. 결과 : AUC, C_(max), T_(max)에 대한 평균값의 차가 각각 1.26%, 3.73%, 6.21%로서 모두 대조약의 20% 이내에 들어 생물학적 동등성 판정기준의 전제조건을 만족하였다. 분산분석 결과 AUC, C_(max), T_(max)의 각 비교 항목에 있어서 모두 유의수준 α=0.05의 군/순서효과 검정에서 F비가 F 분석표의 한계값보다 작아 교차시험이 제대로 이루어졌음을 확인할 수 있었으며, AUC, C_(max), T_(max) 각 비교항목에 있어서 유의수준 α=0.05에서 대조약에 대한 최소검출차(Δ)가 각각 17.74%, 17.05%, 15.67%로 모두 20% 이내이었으며, 검출력(1-β)도 모두 0.8 이상으로 나타나 생물학적 동등성 판정기준을 만족시켰다. 또 AUC, C_(max), T_(max) 각 비교항목에 있어서 대조약에 대한 생체이용률 차이의 신뢰한계(δ)가 ±20% 이내이어야 한다는 생물학적 동등성 판정기준을 모두 만족시켰다. 결론 : 이상의 실험결과로 시험약은 대조약에 대하여 생물학적 동등성 평가항목인 AUC, C_(max), T_(max)에서 모두 판정기준을 만족시켜 시험약은 대조약과 생물학적으로 동등하다고 사료된다. Background : The study was designed to compare the bioeqivalence between the test (CEXIME®. United Korea. Co., Ltd) and control (SUPRAX®. Dong-a Pharm. Co.. Ltd) capsules of cefixime. Methods : Twenty. healthy, male volunteers completed the study Each subject ingested single dose (100 ㎍) of the control and test drugs in 2?2 crossover design with a week drug-free interval between the doses. Blood samples were collected serially up to 12 hours and plasma concentrations of cefixime were measured by high-performance liquid chromatography with UV detection. A non-compartmental approach was used for analysis of the concentration-time data. Results : The area under the curve (AUC), the maximum concentration of drug (C_(max)). and time to reach C_(max)(T_(max)) did not show any significant difference between the two preparations by ANOVA. The mean differences of AUC, C_(max), and T_(max) were within 20% of the control drug, those were 1.26%. 3.73%. and 6.21%. respectively. The confidence limits of three parameters were satisfied the bioeqivalence criteria. Conclusion : These results suggest that the test drug was bioequivalent with the control drug.
골분진과 섬유소 접합물을 이용한 두안면부 골결손의 치료
권성택,박양수,김진환 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3
In the field of plastic surgery, various forms of craniofacial bone defects may be encountered under such conditions as trauma, congenieal defect, and postoperative condition. Until now, autogenous bone graft, processed homograft or heterograft, and alloplastic implants have been used for the reconstruction of those defecrs. Although each method has its own pros and cons, autogenous bone graft is most widely used because of its high survival rate, low postoperative complication rate, and longterm stability, Recently, the calvarium has become the favorite source of autogenous bone graft since it has many advantages. However, it is not easy to fabricate bone graft to fit in the defect accurately, paricularly for cystic or irregularly shaped depressions of craniofacial bone defects. In 1970, Shehadi reported the use of calvarial bone dust in reconstruction of cranial defects. Bone dust is harvested easily and in reasonably sufficient amount, but has not been used widely due to problems in fixation and survival rate. In our previous study, authors experimentally proved that a miture of fibrin sealant and autogenous bone dust plays an effective role to form a new bone in bone healing process. Fibrin controls bleeding, serves as a surface for adherence and degranulation of platelets, and accelerates would healing in general. In the healing process of bone grafting, fibrin trellis is known to contribute to osteoconduction and osteoinduction by supplying moving channels for undifferentiated mesechymal cells and bone morphogenic protein. Clinically, authors successfully treated 7 cases of craniofacial bony defects using bone dust and fibrin sealant and concluded as follows ; 1. Bone dust is easy to harvest in sufficient amount and is useful in reconstruction of various forms of bony defects. 2. Bone dust can be easily fixed when mixed with fibrin sealant. 3. Fibrin sealant stimulates bone union of bone dust graft. 4. Bone dust can also be harvested simultaneously when harvesting calvarial bone graft and be used in various craniofacial reconstruction as mixture with fibrin sealant.