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Tsai Li-Jen,Chung Chi-Hsiang,Lin Chien-Jung,Su Sheng-Chiang,Kuo Feng-Chih,Liu Jhih-Syuan,Chen Kuan-Chan,Ho Li-Ju,Kuo Chih-Chun,Chang Chun-Yung,Lin Ming-Hsun,Chu Nain-Feng,Lee Chien-Hsing,Hsieh Chang-H 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.2
Background: Diabetic patients are at high risk of developing cancer. Traditional Chinese medicine (TCM) has become increasingly popular as an adjuvant treatment for patients with chronic diseases, and some studies have identified its beneficial effect in diabetic patients with cancer. The purpoes of this study was to outline the potential of TCM to attenuate hospitalization and mortality rates in diabetic patients with carcinoma in situ (CIS). Methods: A total of 6,987 diabetic subjects with CIS under TCM therapy were selected from the National Health Insurance Research Database of Taiwan, along with 38,800 of 1:1 sex-, age-, and index year-matched controls without TCM therapy. Cox proportional hazard analysis was conducted to compare hospitalization and mortality rates during an average of 15 years of follow-up. Results: A total of 3,999/1,393 enrolled-subjects (28.62%/9.97%) had hospitalization/mortality, including 1,777/661 in the TCM group (25.43%/9.46%) and 2,222/732 in the control group (31.80%/10.48%). Cox proportional hazard regression analysis showed a lower rate of hospitalization and mortality for subjects in the TCM group (adjusted HR=0.536; 95% CI=0.367–0.780, P<0.001; adjusted HR=0.783; 95% CI=0.574– 0.974, P = 0.022). Kaplan-Meier analysis showed that the cumulative risk of hospitalization and mortality in the case and control groups was significantly different (log rank, P<0.001 and P = 0.011, respectively). Conclusions: Diabetic patients with CIS under TCM therapy were associated with lower hospitalization and mortality rates compared to those without TCM therapy. Thus, TCM application may reduce the burden of national medical resources.
Li, Chang-Zhi,Chien, Shang-Chieh,Yip, Hin-Lap,Chueh, Chu-Chen,Chen, Fang-Chung,Matsuo, Yutaka,Nakamura, Eiichi,Jen, Alex K.-Y. Royal Society of Chemistry 2011 Chemical communications Vol.47 No.36
<P>A facile synthesis was employed to make a 56π-electron methano-PC<SUB>61</SUB>BM with a very small 1,2-dihydromethano (CH<SUB>2</SUB>) group. This new fullerene derivative possesses high electron mobility (0.014 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>) and higher LUMO energy level (0.15 eV) than PC<SUB>61</SUB>BM. Bulk hetero-junction devices based on using poly(3-hexylthiophene) and methano-PC<SUB>61</SUB>BM as active layer exhibited better performance and thermal stability than those using the PC<SUB>61</SUB>BM analogue.</P> <P>Graphic Abstract</P><P>We have designed and synthesized a new 56π-electron methano-PC<SUB>61</SUB>BM using a very small and stable 1,2-dihydromethano (CH<SUB>2</SUB>) group. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc14446d'> </P>
Mitigation the Impact and Survive from Extreme Drought of Climate Change and Global Warming
Chien-Hsing Chu,Ching-yuan Lu,Chung-Yan Li,Fang-Lin Liao,Yu-Chi Lee 한국방재학회 2016 Journal of Disaster Management Vol.1 No.2
Tap Water is the lifeline of human existence. Due to the effect of the Climate Change, the world has experienced an uneven distribution of rainfall in recent years, cause of floods or droughts. A series drought broke out in Taipei city gave chance to protect our county and test our reliabilities to citizen. This developments but has also realize the agricultural water should cooperate effectively shift dial [2], active water conservation ordinance relaxed, provide valuable water resources. Water utilities in response to the challenges of extreme drought, should face the New thinking that the difference between the price of water upon request, considering distinguish the dry season and the rainy season in different water, and the water does not hike the basic livelihood of the people; to consider the idea of building “Our sponge cities sponge Taiwan”; avoid low tariff wasted water, or the use of reasonable price adjustments after yearly, water problems can be solved in Taipei area; contributed to the dry season to strengthen water conservation and carbon reduction to achieve the effect or open consumptive water use of large household[2] and strengthen told: the key to sustainable development of water resources, “NO WATER NO FUTURE”.
Flexural behavior of reinforced lightweight concrete beams under reversed cyclic loading
Li-Kai Chien,Yi-Hao Kuo,Chung-Ho Huang,How-Ji Chen,Ping-Hu Cheng 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.3
This paper presents the results of an experimental investigation on the flexural behavior of doubly reinforced lightweight concrete (R.L.C.) beams tested under cyclic loading. A total of 20 beam specimens were tested. Test results are presented in terms of ductility index, the degradation of strength and stiffness, and energy dissipation. The flexural properties of R.L.C. beam were compared to those of normal concrete (R.C.) beams. Test results show that R.L.C. beam with low and medium concrete strength (20, 40MPa) performed displacement ductility similar to the R.C. beam. The ductility can be improved by enhancing the concrete strength or decreasing the tension reinforcement ratio. Using lightweight aggregate in concrete is advantageous to the dynamic stiffness of R.L.C. beam. Enhancement of concrete strength and increase of reinforcement ratio will lead to increase of the stiffness degradation of beam. The energy dissipation of R.L.C beam, similar to R.C. beam, increase with the increase of tension reinforcement ratio. The energy dissipation of unit load cycle for smaller tension reinforcement ratio is relatively less than that of beam with higher reinforcement ratio.
Flexural behavior of reinforced lightweight concrete beams under reversed cyclic loading
Chien, Li-Kai,Kuo, Yi-Hao,Huang, Chung-Ho,Chen, How-Ji,Cheng, Ping-Hu Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.3
This paper presents the results of an experimental investigation on the flexural behavior of doubly reinforced lightweight concrete (R.L.C.) beams tested under cyclic loading. A total of 20 beam specimens were tested. Test results are presented in terms of ductility index, the degradation of strength and stiffness, and energy dissipation. The flexural properties of R.L.C. beam were compared to those of normal concrete (R.C.) beams. Test results show that R.L.C. beam with low and medium concrete strength (20, 40MPa) performed displacement ductility similar to the R.C. beam. The ductility can be improved by enhancing the concrete strength or decreasing the tension reinforcement ratio. Using lightweight aggregate in concrete is advantageous to the dynamic stiffness of R.L.C. beam. Enhancement of concrete strength and increase of reinforcement ratio will lead to increase of the stiffness degradation of beam. The energy dissipation of R.L.C beam, similar to R.C. beam, increase with the increase of tension reinforcement ratio. The energy dissipation of unit load cycle for smaller tension reinforcement ratio is relatively less than that of beam with higher reinforcement ratio.
Park, Yoon Jeong,Chang, Li‐,Chien,Liang, Jun Feng,Moon, Cheol,Chung, Chong‐,Pyoung,Yang, Victor C. Federation of American Society for Experimental Bi 2005 The FASEB Journal Vol.19 No.11
<P>Naturally derived, nontoxic peptides from protamine by the authors, termed low molecular weight protamines (LMWPs), possess high arginine content and carry significant sequence similarity to that of TAT, by far the most potent protein transduction domain peptide. Therefore, it was hypothesized that these LMWPs would also inherit the similar translocation activity across the cell membrane, which enables any impermeable species to be transduced into the cells. LMWPs were prepared by enzymatic digestion of protamine, examined their capability of transducing an impermeable protein toxin into the tumor cells by chemical conjugation, and determined cytotoxicity of transduced protein toxin (e.g., gelonin) against cancer cell lines and a tumor-bearing mouse. In vitro results showed that LMWPs could indeed translocate themselves into several mammalian cell lines as efficiently as TAT, thereby transducing impermeable gelonin into the cells by chemical conjugation. In vivo studies further confirmed that LMWP could carry an impermeable gelonin across the tumor mass and subsequently inhibit the tumor growth. In conclusion, the presence of equivalent cell translocation potency, absence of toxicity of peptide itself, and the suitability for low-cost production by simple enzymatic digestion could expand the range of clinical applications of LMWPs, including medical imaging and gene/protein therapies.</P>
Effects of post anneal for the INZO films prepared by ultrasonic spray pyrolysis
Lan, Wen-How,Li, Yue-Lin,Chung, Yu-Chieh,Yu, Cheng-Chang,Chou, Yi-Chun,Wu, Yi-Da,Huang, Kai-Feng,Chen, Lung-Chien Techno-Press 2014 Advances in nano research Vol.2 No.4
Indium-nitrogen co-doped zinc oxide thin films (INZO) were prepared on glass substrates in the atmosphere by ultrasonic spray pyrolysis. The aqueous solution of zinc acetate, ammonium acetate and different indium sources: indium (III) chloride and indium (III) nitrate were used as the precursors. After film deposition, different anneal temperature treatment as 350, 450, $550^{\circ}C$ were applied. Electrical properties as concentration and mobility were characterized by Hall measurement. The surface morphology and crystalline quality were characterized by SEM and XRD. With the activation energy analysis for both films, the concentration variation of the films at different heat treatment temperature was realized. Donors correspond to zinc related states dominate the conduction mechanism for these INZO films after $550^{\circ}C$ high temperature heat treatment process.
The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes
Yu-Chu Wang,Kung-Chao Chang,Bo-Wen Lin,Jenq-Chang Lee,Chien-Hsien Lai,Li-Jyuan Lin,Yun Yen,Chang-Shen Lin,Shiang-Jie Yang,Peng-Chan Lin,Chung-Ta Lee,Liang-Yi Hung 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Heterogeneous nuclear ribonucleoprotein (hnRNP) Q1, an RNA-binding protein, has been implicated in many posttranscriptional processes, including RNA metabolism and mRNA splicing and translation. However, the role of hnRNP Q1 in tumorigenesis remains unclear. We previously performed RNA immunoprecipitation (RIP)-seq analysis to identify hnRNP Q1-interacting mRNAs and found that hnRNP Q1 targets a group of genes that are involved in mitotic regulation, including Aurora-A. Here, we demonstrate that altering the hnRNP Q1 level influences the expression of the Aurora-A protein, but not its mRNA. Stimulation with epidermal growth factor (EGF) enhances both binding between hnRNP Q1 and Aurora-A mRNA as well as the efficacy of the hnRNP Q1-induced translation of Aurora-A mRNA. The EGF/hnRNP Q1-induced translation of Aurora-A mRNA is mediated by the mTOR and ERK pathways. In addition, we show that hnRNP Q1 up-regulates the translation of a group of spindle assembly checkpoint (SAC) genes. hnRNP Q1 overexpression is positively correlated with the levels of Aurora-A and the SAC genes in human colorectal cancer tissues. In summary, our data suggest that hnRNP Q1 plays an important role in regulating the expression of a group of cell cycle-related genes. Therefore, it may contribute to tumorigenesis by up-regulating the translation of these genes in colorectal cancer.