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Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells
Wang, Chun-Hua,Shyu, Rong-Yaun,Wu, Chang-Chieh,Chen, Mao-Liang,Lee, Ming-Cheng,Lin, Yi-Yin,Wang, Lu-Kai,Jiang, Shun-Yuan,Tsai, Fu-Ming Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.6
The tazarotene-induced gene 1 (TIG1) protein is a retinoidinducible growth regulator and is considered a tumor suppressor. Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis. Ectopic DNAJC8 expression induced the translocation of pyruvate kinase M2 (PKM2) into the nucleus, subsequently inducing glucose transporter 1 (GLUT1) expression to promote glucose uptake. Silencing either DNAJC8 or PKM2 alleviated the upregulation of GLUT1 expression and glucose uptake induced by ectopic DNAJC8 expression. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. In conclusion, TIG1 acts as a pivotal repressor of DNAJC8 to enhance glucose uptake by partially regulating PKM2 translocation.
Chung-Chieh Wang,Nan-Chou Su,Jou-Ping Hou,이동인 한국기상학회 2018 Asia-Pacific Journal of Atmospheric Sciences Vol.54 No.3
The forecast of summertime afternoon convection by numerical weather prediction models is highly challenging because of its weak dynamical forcing, small scale, and low predictability. To assess such an ability for future improvement, we evaluated the performance of the 2.5-km Cloud-Resolving Storm Simulator (CReSS) in predicting afternoon convection in Taiwan under weak synoptic conditions during the summers (May–October) of 2011 and 2012. For a total of 89 target days, daily CReSS forecasts in three ranges, starting at 0000 UTC (0800 LST) on the same day (D0), the day before (D-1), and 2 days before (D-2), were examined. With regard to the occurrence of afternoon convection anywhere in Taiwan, the predictive skill of the model was considerably high, as evidenced by the threat score (TS) and post-agreement (PA) of D0 (D-1) forecasts reaching 0.75 and 0.90 (0.50 and 0.79), respectively.While the score values decrease when Taiwan is divided into four regions (i.e., the forecast must be in the correct region to be considered a hit), the TS and PA for D0 (D-2) forecasts remain respectable at 0.44 and 0.73 (0.29 and 0.59). Among the four regions, the TS (0.48–0.65) and PA (0.77–0.83) for Central Taiwan are the highest with the best predictive skill. Overall, while the prediction of afternoon convection in the correct region is challenging, the 2.5-km CReSS model has considerable skill (TS ~ 0.30) even 2 days in advance, and can provide useful guidance for afternoon convection in Taiwan.
王瑞傑(Jui Chieh Wang) 중앙대학교 중앙사학연구소 2007 중앙사론 Vol.25 No.-
The author puts great emphasis on discussing distinguishing features of historical description inside the “Shierji”, The Twelve Records(十二紀), by examining the accounts on the Three Dynasties (the Xia Dynasty, the Shang Dynasty, the Zhou Dynasty) after explaining the background, intention and content of the Lushichunqiu, The Spring and Autumn Annals(呂氏春秋). In addition to synthesizing different schools of thought, the “Shierji” largely quoted people’s achievements for more persuasiveness. Besides reflecting the thought and argumentation, “Shierji” offers certain value for reference in understanding history of the Three Dynasties.
Shih-Ming Wang,Ji-Jun Lin,Zhe-Zhi Ye,Shambaljamts Tsooj,Chun-Chieh Wang 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
To perform an accurate micro machining process, accurate alignment of the micro cutter with respect to the local coordinate frame for machining is essential. Due to the fragility of the micro tool, traditional cutter alignment method used in industry is no longer proper for micro machining. Utilizing machine vision technology with 2 CCDs, a micro tool positioning error measurement and auto-compensation method and system were proposed. In the measurement method, Power Law Method was first used to enhance the image taken by a CCD. Canny Edge Method and image projection method were then used to identify the contours of the cutter and the workpiece from the image. Finally, the position errors of the cutter were determined through calculating the number of pixels between the cutter and the workpiece. The proposed error compensation system can automatically generate NC codes which will accurately re-locate the cutter based on the measured position errors . Experiments were conducted on a micro machine tool, and the results have shown that the y-dir. positioning error of the cutter was significantly improved from -0.025 mm to 0.001 mm, and the total machining error was reduced from -0.02 mm to -0.001 mm.
Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells
Chun-Hua Wang,Rong-Yaun Shyu,Chang-Chieh Wu,Mao-Liang Chen,Ming-Cheng Lee,Yi-Yin Lin,Lu-Kai Wang,Shun-Yuan Jiang,Fu-Ming Tsai 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.6
The tazarotene-induced gene 1 (TIG1) protein is a retinoid-inducible growth regulator and is considered a tumor suppressor. Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis. Ectopic DNAJC8 expression induced the translocation of pyruvate kinase M2 (PKM2) into the nucleus, subsequently inducing glucose transporter 1 (GLUT1) expression to promote glucose uptake. Silencing either DNAJC8 or PKM2 alleviated the upregulation of GLUT1 expression and glucose uptake induced by ectopic DNAJC8 expression. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. In conclusion, TIG1 acts as a pivotal repressor of DNAJC8 to enhance glucose uptake by partially regulating PKM2 translocation.
王瑞傑(Jui-chieh Wang) 중앙대학교 중앙사학연구소 2008 중앙사론 Vol.27 No.-
This article with Book of Odes(詩經)for example chooses Zhu Xi ‘s Collection of Poetry(詩集傳)to discuss. The reason that chooses Collection of Poetry,is mainly because it was the book that the gentleman person studied Book of Odes primer later the Southern Song Dynasty; secondly, in the compiling of official Confucian classics or the civil academic study, Zhu Xi s book also had rather important status, up to now, even if the people of our time arrange the poetry annotations of the Book of Odes , all have also scraped together about the credible view of the Zhu Xi’s book. Therefore, through author’s studying insight, this article hopes that can know the application value of Zhu Xi’s Collection of Poetry in taking pre?Qin history researcht, to cause the people of our time to utilize Book of Odes as the historical data, can as far as possible reduce the error.