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      • KCI등재

        Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan

        Ying-Cheng Chiang,Chi-An Chen,Chun-Ju Chiang,Tsui-Hsia Hsu,Ming-Chieh Lin,San-Lin You,Wen-Fang Cheng,Mei-Shu Lai 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.4

        Objective: To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. Methods: The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of these patients were analyzed. Results: Totally 9,491 patients were included in the study. The age-adjusted incidences of epithelial ovarian cancer were 1.01, 1.37, 2.37, 3.24, 4.18, and 6.33 per 100,000 person-years, respectively, in every 5-year period from 1979 to 2008. The age-specific incidence rates increased especially in serous, endometrioid and clear cell carcinoma, and the age of diagnosis decreased from sixty to fifty years old in the three decades. Patients with mucinous, endometrioid, or clear cell carcinoma had better long-term survival than patients with serous carcinoma (log rank test, p<0.001). Patients with undifferentiated carcinoma or carcinosarcoma had poorer survival than those with serous carcinoma (log rank test, p<0.001). The mortality risk of age at diagnosis of 30-39 was significantly higher than that of age of 70 years or more (test for trend, p<0.001). The mortality risk decreased from the period of 1996-1999 (hazard ratio [HR], 0.90; p=0.054) to the period after 2000 (HR, 0.74; p<0.001) as compared with that from the period of 1991-1995. Conclusion: An increasing incidence and decreasing age of diagnosis in epithelial ovarian cancer patients were noted. Histological type, age of diagnosis, and treatment period were important prognostic factors for epithelial ovarian carcinoma.

      • KCI등재

        Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

        An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

        Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.

      • A Cross-Cultural Comparative Study of Cultural Characteristics and Informa tion Search Behaviours of Business Travellers

        Che-Chao Chiang,Min-chi Chang,Po-Tsang Chen,Fu-Ming Chiang 세계문화관광학회 2010 Conference Proceedings Vol.11 No.0

        This study examines the information searching of business travelers and their behavior based on the cultural differences. Despite growing academic interest in business travel i n recent years, there has been little investigation of the information search behaviors of business travelers in a cross-culture context. The above themes are rational assumed that information search behaviour are necessary to understand. To address the identified gap s in the literature, the proposed relationships are examined and presented through using chi-square method with a survey sample. The research sample included Japanese, English and Chinese business travellers. A self-administrated questionnaire was distributed to 211 business travelers attending international conventions in Taipei. The research findings reveal that information preferences of business travelers are significantly differed from the three recognized groups in the case of Taiwan. Some significant differences in information search behaviors were recognized amongst the three recognized respondent groups. Marketing implications were also proposed and presented.

      • KCI등재후보

        Pull-Through Buddy Wire Technique for Endovascular Thrombectomy in Patients with Acute Ischemic Stroke: Technical Note

        Chiang Pin-Yi,Lin Yen-Heng,Huang Yu-Cheng,Lee Chung-Wei 대한신경중재치료의학회 2021 Neurointervention Vol.16 No.1

        Excessive tortuosity is a notable cause of failed endovascular thrombectomy for acute large-vessel occlusion stroke. Transcervical access (TCA) is a commonly proposed solution for overcoming this difficulty. However, the large-bore catheter usually used in TCA increases the risk of serious local complications. This paper presents a modified technique for TCA that uses a pull-through buddy wire (PTBW) to track a large-bore femoral guiding sheath (GS) into the carotid artery via a small carotid puncture site. The carotid puncture site can be easily managed through gentle manual compression. Two illustrative cases using this technique to deal with a large aortic arch and tortuous left common carotid artery are reported. In both cases, recanalization was achieved after successful GS placement. Using a PTBW is feasible in TCA.

      • KCI등재

        The Corrosion Behavior of Cold-Rolled 304 Stainless Steel In Salt Spray Environments

        Chiang, M.F.,Young, M.C.,Huang, J.Y. Korean Radioactive Waste Society 2011 방사성폐기물학회지 Vol.9 No.2

        염분분위기에서의 부식은 사용후핵연료의 중간저장 기간동안 304 스테인레스 강재 건식저장용기의 주 열화기구들 중 하나다. 본 연구에서는 감소정도가 서로 다른 냉연 304 스테인레스 강 시편들에 0.5wt.%의 염화나트륨 연무를 분사시키면서 느린 변형속도시험(SSRT)과 중성염 분사시험(NSS)을 $85^{\circ}C$와 $200^{\circ}C$ 에서 수행하였다. $85^{\circ}C$에서 2000 시간 동안 시험한 NSS시편의 무게 변화는 $200^{\circ}C$에서 시험한 시편의 무게 변화와 크게 달랐다. NSS 시편의 $85^{\circ}C$에서 무게 감량은 미미하였지만, 냉연 감소율이 증가함에 따라서 무게 변화는 점진적으로 감소하였다. $85^{\circ}C$와 $200^{\circ}C$에서 그리고 염분분사 환경에서 가볍게 냉연 가공된 시편의 SSRT 시험으로부터 얻은 항복강도와 극한 인장응력의 값은 공기 중의 값보다 약간 낮았다. 그러나 염분 분위기에서 부식으로 인한 20% 감소 냉연시편의 강도는 더 이상 변화하지 않았다. 예비결과는 냉연 304 스테인레스 강의 질과 성능이 건식저장용기의 제작을 위한 조건에 맞는다는 것을 증명하였다. 그러나 냉연 스테인레스 강의 장기적인 성능을 더 잘 이해하기 위해서는 염분분위기에서 이 재질의 부식거동에 관한 더 많은 연구가 필요하다. Saline corrosion is one of the major degradation mechanisms for stainless steel type 304 (SS304) dry storage cask during the spent fuel interim storage period. Slow strain rate test (SSRT) and neutral salt spray test (NSS) were performed at $85^{\circ}C$ and $200^{\circ}C$ with 0.5 wt% sodium chloride mist sprayed on the cold-rolled SS304 specimens of different degrees of reduction in this study. The weight changes of the NSS specimens tested at $85^{\circ}C$ for 2000 hours differed greatly from those at $200^{\circ}C$. The weight loss of NSS specimens was not significant at $85^{\circ}C$ but the weight gain decreased gradually with increasing the cold-rolled reduction. The yield strength (YS) and ultimate tensile stress (UTS) values obtained from the SSRT tests for lightly cold-rolled specimens in the salt spray environment at $85^{\circ}C$ and $200^{\circ}C$ are slightly lower than in air. But for those with 20% reductions, the specimen strengths were no longer changed by the saline corrosion. The preliminary results demonstrated that the quality and performance of cold-rolled SS304 is acceptable for fabrication of dry storage casks. However, more work on the corrosion behavior of cold-rolled stainless steel in the saline atmosphere is needed to better understand its long-term performance.

      • An Observer-based Fuzzy Neural Network Adaptive ILC for Nonlinear Systems

        Chiang-Ju Chien,Ying-Chung Wang 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10

        To deal with the iterative learning control problem for more general class of uncertain nonlinear systems using only output measurement, an observer based adaptive iterative learning control strategy using filtered fuzzy neural network was proposed in this paper. A model reference control technique is firstly presented to derive a state error observer for state estimation. A mixed time-domain and ..-domain representation is then used to develop an error model as a relative degree one stable system with some uncertain nonlinearities and filtered signals as the inputs. An averaging filter is also proposed to further transform the error model so that the AILC can be implemented without using differentiators. The main learning component of the controller is constructed by an filtered fuzzy neural network with the estimated state variables as network input. This main component performs as an approximator to compensate for the unknown system nonlinearities. Furthermore, a normalization signal is applied as a bounding function for designing a robust learning component in order to overcome the lumped uncertainties from function approximation error and state estimation error. Finally, a stabilization learning component is used to guarantee the boundedness of internal signals. Adaptive algorithms are derived to search for suitable parameters during each iteration since the optimal parameters for a good function approximation are in general unavailable. Based on a Lyapunov like analysis, we show that the output tracking error can converge, with all the internal signals bounded, to a small residual set whose level of magnitude depends on a design parameter. Simulation results also show the nice tracking performance with application to some practical nonlinear systems.

      • SCISCIESCOPUS

        A simple model for explaining muon-related anomalies and dark matter

        Chiang, Cheng-Wei,Okada, Hiroshi World Scientific Publishing 2019 International Journal of Modern Physics A Vol.34 No.20

        <P>We propose a model to explain several muon-related experimental anomalies and the abundance of dark matter. We introduce a vector-like exotic lepton that form an iso-doublet and three right-handed Majorana fermions as an iso-singlet. A real/complex scalar field is added as a dark matter candidate. We impose a global <TEX>$ U(1)_{\mu }$</TEX> symmetry under which fields associated with the SM muon are charged. To stabilize the dark matter, we impose a <TEX>$ Z_{2}$</TEX> (or <TEX>$ Z_{3}$</TEX>) symmetry under which the exotic lepton doublet and the real (or complex) scalar field are charged. We find that the model can simultaneously explain the muon anomalous magnetic dipole moment and the dark matter relic density in no conflict with any lepton flavor-violating/conserving observables, with some details depending upon whether the scalar field is real or complex. Besides, we extend the framework to the quark sector in a way similar to the lepton sector, and find that the recent anomalies associated with the <TEX>$ b \rightarrow s\mu ^{+}\mu ^{-}$</TEX> transition can also be accommodated while satisfying constraints such as the <TEX>$ B_{s(d)} \rightarrow \mu ^{+}\mu ^{-}$</TEX> decays and neutral meson mixings.</P>

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