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한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
우성일,강동우,서한길,김봉조,이인상,정근화,박소영,정치영,이환철,정경천,손진욱,Woo, Sung-Il,Kang, Dong-Woo,Seo, Han-Gil,Kim, Bong-Jo,Lee, In-Sang,Jeong, Geun-Hoa,Park, So-Young,Jung, Chi-Yeong,Lee, Hwan-Cheol,Jeong, Kyeong-Cheon,Sohn, 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2
P450 CYP2D6 enzyme(=debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association of two genetic polymorphisms in the CYP2D6 gene, $CYP2D6^*4$ and $CYP2D6^*10$, with TD in Korean schizophrenic subjects. Subjects consisted of 71 Korean schizophrenics and TD was evaluated using the Abnormal Involuntary Movement Scale (AIMS). There were no statistically significant differences in the demographic variables of age, male to female percentage and the current antipsychotic(CPZ equivalent) dose between the group with TD and the group without TD. But the duration of antipsychotic drug exposure was significantly higher in the group without TD(p=0.000, by independent t-test). The mean AIMS score in the group with TD was $11.2{\pm}6.6$(S.D.). Genotypings for the presence of $CYP2D6^*4$ and $CYP2D6^*10$ were done using PCR amplifications and endonuclease digestions. There were no statistically significant genotypic and alleleic associations between TD and $CYP2D6^*4$(by chisquare tests), and between TD and $CYP2D6^*10$(by chi-square tests). These results indicate that the $CYP2D6^*4$ and $CYP2D6^*10$ polymorphisms have no significant roles in the causation of TD.
ENHANCED DISSOLUTION RATE OF BIPHENYL DIMETHYL DICARBOXYLATE USING SMEDDS
CHI, Sang-Cheol 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-
Biphenyl dimethyl dicarboxylate (DDB) has been used in the treatment of acute and chronic hepatitis. However, its bioavailability is only 20% due to the low solubility of the drug in water. In order to improve the solubility of DDB, a self-microemulsifying drug delivery system (SMEDDS) was developed and its dissolution rate and permeability rate, using Caco-2 cell monolayer, were evaluated. The DDB SMEDDS was optimized with the construction of pseudo-ternary phase diagrams. The formulation of choice consisted of 20% triacetin, Labrasol as the surfactant, and the combination of Transcutol, Cremophor RH 40 and Plurol Oleique CC 497 as the cosurfactant, with S/CoS of 1/2. Upon dilution with water, DDB SMEDDS resulted in O/W microemulsion with an average oil droplet size of 12nm. In vitro dissolution study of SMEDDS showed a significantly increased dissolution rate of DDB in water (>12 fold over DDB powder of tablet). O/W microemulsion containing 10 ug/ml of DDB resulted in 7.7 times higher permeability rate than the reference (2 ug/ml of DDB solution in transport medium), while O/W microemulsion containing 2 ug/ml of DDB did not increased the permeability rate significantly compared to the reference.
A Polymeric Micellar Carrier for the Solubilization of Biphenyl Dimethyl Dicarboxylate
Chi, Sang-Cheol,Yeom, Dae-Il,Kim, Sung-Chul,Park, Eun-Seok The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.2
A polymeric micelle drug delivery system was developed to enhance the solubility of poorly-water soluble drug, biphenyl dimethyl dicarboxylate, DDB. The block copolymers consisting of poly(D,L-lactide) (PLA) as the hydrophobic segment and methoxy poly(ethylene glycol) (mPEG) as the hydrophilic segment were synthesized and characterized by NMR, DSC and MALDI-TOF mass spectroscopy. The size of the polymeric micelles measured by dynamic light scattering showed a narrow monodisperse size distribution with the average diameter less than 50 nm. The MW of mPEG-PLA, 3000 (MW of mPEG, 2 K; MW of PLA, 1K), and the presence of hydrophilic and hydrophobic segments on the polymeric micelles were confirmed by MALDI-TOF mass spectroscopy and NMR, respectively. Polymeric micelle solutions of DDB were prepared by three different methods, i.e. the matrix method, emulsion method and dialysis method. In the matrix method, DDB solubility was reached to 13.29 mg/mL. The mPEG-PLA 2K-1K micelle system was compared with the poloxamer 407 micelle system for their critical micelle concentration, micelle size, solubilizing capacity, stability in dilution and physical state. DDB loaded-polymeric micelles prepared by the matrix method showed a significantly increased aqueous solubility (>5000 fold over intrinsic solubility) and were found to be superior to the poloxamer 407 micelles as a drug carrier.
Chi Young Shim,Eun Kyoung Kim,Dong‑Hyuk Cho,Jun‑Bean Park,Jeong‑Sook Seo,Jung‑Woo Son,In‑Cheol Kim,Sang‑Hyun Lee,Ran Heo,Hyun‑Jung Lee,Sahmin Lee,Byung Joo Sun,Se‑Jung Yoon,Sun Hwa Lee,Hyung Yoon Kim 한국심초음파학회 2024 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.32 No.-
This manuscript represents the official position of the Korean Society of Echocardiography on valvular heart diseases. This position paper focuses on the diagnosis and management of valvular heart diseases with referring to the guidelines recently published by the American College of Cardiology/American Heart Association and the European Society of Cardiology. The committee sought to reflect national data on the topic of valvular heart diseases published to date through a systematic literature search based on validity and relevance. In the part II of this article, we intend to present recommendations for diagnosis and treatment of mitral valve disease and tricuspid valve disease.
Morphological Development of Embryo, Larvae and Juvenile in Yellowtail Kingfish, Seriola lalandi
Sang Geun Yang,Sang Woo Hur,Seung Cheol Ji,Sang Gu Lim,Bong Seok Kim,Minhwan Jeong,Chi Hoon Lee,Young-Don Lee 한국발생생물학회 2016 발생과 생식 Vol.20 No.2
This study monitored the morphological development of embryo, larvae and juvenile yellowtail kingfish, Seriola lalandi, for their aquaculture. The fertilized eggs obtained by natural spawning were spherical shape and buoyant. Fertilized eggs were transparent and had one oil globule in the yolk, with an egg diameter of 1.35 ± 0.04 mm and an oil globule diameter of 0.32 ± 0.02 mm. The fertilized eggs hatched 67–75 h after fertilization in water at 20 ± 0.5°C. The total length (TL) of the hatched larvae was 3.62 ± 0.16 mm. During hatching, the larvae, with their mouth and anus not yet opened. The yolk was completely absorbed 3 days after hatching (DAH), while the TL of post-larvae was 4.72 ± 0.07 mm. At 40 DAH, the juveniles had grown to 30.44 ± 4.07 mm in TL, body depth increased, the body color changed to a black, yellow, and light gray-blue color, and 3–4 vertical stripes appeared. At 45 DAH, the juveniles were 38.67 ± 5.65 mm in TL and 10.10 ± 0.94 mm in body depth. The fish were green with a light orange color, with 7 faint green-brown stripes on the sides of their body. At 87 DAH, the juveniles had grown to 236.11 mm in TL, 217.68 mm in fork length, and 136.5 g in weight. The fish resembled their adult form, with a light yellow-green body color, loss of the pattern on the sides of their body, and a yellow coloration at the tip of the caudal fin.
( Chi Eun Hong ),( Haeyoung Jeong ),( Sung Hee Jo ),( Jae Cheol Jeong ),( Suk Yoon Kwon ),( Donghwan An ),( Jeong Mee Park ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.3
Rhodococcus species have become increasingly important owing to their ability to degrade a wide range of toxic chemicals and produce bioactive compounds. Here, we report isolation of the Rhodococcus sp. KB6, which is a new leaf-inhabiting endophytic bacterium that suppresses black rot disease in sweet potato leaves. We determined the 7.0 Mb draft genome sequence of KB6 and have predicted 19 biosynthetic gene clusters for secondary metabolites, including heterobactins, which are a new class of siderophores. Notably, we showed the first internal colonization of host plants with Rhodococcus sp. KB6 and discuss its potential as a biocontrol agent for sustainable agriculture.
A Study on the Deep Hole Drilling for Refractory Metals
Sung Bo Sim(심성보),Chi Ok Kim(김치옥),Cheol Kyu Kim(김철규) 한국해양공학회 1999 韓國海洋工學會誌 Vol.13 No.1
오늘날 기계공업 현장에서 심공드릴가공은 광범위한 응용과 양호한 생산성으로 인하여 그 요구가 증가 되고 있다. 그러므로, 본 연구는 난삭재인 SKDll고합금공구강을 여러가지 절삭 조건하에서 BTA드릴가공 하여 얻은 실험결과(표면조도, 진직도, 진원도, 원통도, 구멍확대량, 등 )를 다루었으며 이들의 이론적 배경과 실험을 비교 분석하였다. 프레스금형 부품과 기계부품으로 사용되고 있는 SKDll고합금공구강은 기계가공이 힘든 난삭재료로서 그 어려움이 크므로 본 연구는 생산현장에 보다 나은 심공드릴가공결과와 관련 지식을 제공 할수 있다고 사료된다.
Sang Geun Yang,Seung Cheol Ji,Sang Gu Lim,Sang Woo Hur,Minhwan Jeong,Chi Hoon Lee,Bong Seok Kim,Young-Don Lee 한국발생생물학회 2016 발생과 생식 Vol.20 No.2
This study describes results on sexual maturation and characteristics of natural spawned eggs to develop a method for the production of stable, healthy fertilized eggs from captive-reared yellowtail kingfish, Seriola lalandi. A total of 59 yellowtail kingfish were captured off the coast of Jeju Island, after which the broodstock was cultured in indoor culture tank (100 ㎥) until they were 6.1–14.9 kg in body weight. As part of the rearing management for induced sex maturation, the intensity of illumination was maintained at 130 lux. The photoperiod (light/dark; L/D) was set to a 12 L/12 D from October 2013 to January 2014, and 15 L/9 D from February 2014 to June 2014. Feeds comprised mainly EP (Extruded Pellets), with squid cuttlefish added for improvement of egg quality, and was given from April to June 2014. The first spawning of yellowtail kingfish occurred in May 3, 2014, at a water temperature of 17.0°C. Spawning continued until June 12, 2014, with the water temperature set at 20.5°C. Time of spawning was 26 times at this period. The total number of eggs that spawned during the spawning period was 4,449×10³. The buoyant rate of spawning eggs and fertilization rate of buoyant eggs during the spawned period were 76.1% and 100%, respectively. The diameters of the egg and oil globule were 1.388 ± 0.041 mm and 0.378 ± 0.029 mm, respectively, which was higher in early eggs than in those from late during the spawned period.
Chi-Min Park,Ho-Kyung Chun,Dae-Sang Lee,Kyeongman Jeon,Gee Young Suh,Jin Cheol Jeong 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.86 No.6
Purpose: An intensivist is a key factor in the mortality of patients admitted to the intensive care unit (ICU). The aim of this study was to evaluate the effect of an intensivist on clinical outcomes of patients admitted to a surgical ICU. Methods: During the study period, the surgical ICU was converted from an open ICU to an intensivist-directed ICU managed by an intensivist who was board certified in both general surgery and critical care medicine. We compared consecutive patients admitted to the surgical ICU before and after implementing the intensivist-directed care. The primary outcome was ICU mortality, and secondary outcomes were hospital mortality, 90-day mortality, length of hospital stay, ICU-free days, ventilator-free days, and ICU readmission rate. Results: A total of 441 patients were included in this study: 188 before implementation of the intensivist and 253 after implementation. Clinical characteristics were not different between the two groups. ICU mortality decreased from 11.7% to 6.3% (P = 0.047) after implementation, and 90-day mortality also decreased significantly (P = 0.008). The adjusted hazard ratio of the intensivist for ICU mortality was 0.43 (95% confidence interval, 0.22?0.87; P = 0.020). ICU-free days (P = 0.013) and the hospital length of stay (P = 0.032) were significantly improved after implementing the intensivist-directed care. Before implementation period, 16.0% of patients were readmitted, compared with only 9.9% after implementation (P = 0.05). Conclusion: Implementing intensivist-directed care in the surgical ICU was associated with significant improvements in ICU mortality and significant clinical outcomes.