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- 저자 : Chengwen Han (검색결과 2 건)
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Chengwen Han,Kyeong Bin Kim,Seok-Woo Lee,Martin Byung-Guk Jun,Young Hun Jeong 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.9
Currently, carbon fiber-reinforced plastic (CFRP) is a material with potential uses for various industries due to its excellent properties. However, the severe tool wear in its machining is an evitable problem because it deteriorates product quality and productivity at the same time. Timely replacement of the tool should be taken in advance to reduce the influences of this drawback. In sum, the accurate estimation of the tool wear plays a crucial role in CFRP machining. Therefore, in this study, a tool wear estimation in CFRP drilling is presented. The method used is based on discrete wavelet transformation (DWT) of the thrust force signal and an artificial neural network (ANN). Two valuable features related to tool wear are identified and then extracted using DWT. The tool wear is estimated by using an ANN with two features adapted from DWT. Consequently, the tool wear, especially flank wear, in CFRP drilling can be accurately estimated using the proposed method.
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BRG1 Promotes chromatin remodeling around DNA damage sites
Wenjing Qi,Hongyu Chen,Chengwen Lu,Qingpan Bu,Xiaoguang Wang,Liping Han 한국통합생물학회 2018 Animal cells and systems Vol.22 No.6
Chromatin remodeling complexes play important roles in various DNA metabolism processes, including DNA damage repair. BRG1 is the core subunit of the SWI/SNF complex, which plays critical roles in cell cycle regulation, cell development, cell differentiation, and tumorigenesis. In the present study, we report that BRG1 depletion increased the percentage of apoptotic cells in etoposide-treated cells. Moreover, western blotting and immunofluorescence data showed that BRG1 depletion decreased H2AX phosphorylation and caused defective phosphorylated histone H2AX (γH2AX) clearance. Furthermore, we found that in both SW13 and U2OS cells, BRG1 expression could increase the sensitivity of genomic DNA to micrococcal nuclease (MNase) and facilitate chromatin relaxation around DNA damage sites. Thus, the results provide evidence that BRG1 plays an important role in early DNA damage repair by remodeling the chromatin structure near DNA damage sites.
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