8q24 rs4242382 Polymorphism is a Risk Factor for Prostate Cancer among Multi-Ethnic Populations: Evidence from Clinical Detection in China and a Meta-analysis

Zhao, Cheng-Xiao,Liu, Ming,Xu, Yong,Yang, Kuo,Wei, Dong,Shi, Xiao-Hong,Yang, Fan,Zhang, Yao-Guang,Wang, Xin,Liang, Si-Ying,Zhao, Fan,Zhang, Yu-Rong,Wang, Na-Na,Chen, Xin,Sun, Liang,Zhu, Xiao-Quan,Yuan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Evidence supporting an association between the 8q24 rs4242382-A polymorphism and prostate cancer (PCa) risk has been reported in North American and Europe populations, though data from Asian populations remain limited. We therefore investigated this association by clinical detection in China, and meta-analysis in Asian, Caucasian and African-American populations. Materials and Methods: Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=335) and from age-matched normal controls (n=347). The 8q24 (rs4242382) gene polymorphism was genotyped by polymerase chain reaction-high-resolution melting analysis. We initially analyzed the associations between the risk allele and PCa and clinical covariates. A meta-analysis was then performed using genotyping data from a total of 1,793 PCa cases and 1,864 controls from our study and previously published studies in American and European populations, to determine the association between PCa and risk genotype. Results: The incidence of the risk allele was higher in PCa cases than controls (0.222 vs 0.140, $P=7.3{\times}10^{-5}$), suggesting that the 8q24 rs4242382-A polymorphism was associated with PCa risk in Chinese men. The genotypes in subjects were in accordance with a dominant genetic model (ORadj=2.03, 95%CI: 1.42-2.91, $Padj=1.1{\times}10^{-4}$). Presence of the risk allele rs4242382-A at 8q24 was also associated with clinical covariates including age at diagnosis ${\geq}65$ years, prostate specific antigen >10 ng/ml, Gleason score <8, tumor stage and aggressive PCa, compared with the non-risk genotype ($P=4.6{\times}10^{-5}-3.0{\times}10^{-2}$). Meta-analysis confirmed the association between 8q24 rs4242382-A polymorphism and PCa risk (OR=1.62, 95%CI: 1.39-1.88, $P=1.0{\times}10^{-5}$) across Asian, Caucasian and African American populations. Conclusions: The replicated data suggest that the 8q24 rs4242382-A variation might be associated with increased PCa susceptibility in Asian, Caucasian and African American populations. These results imply that this polymorphism may be a useful risk biomarker for PCa in multi-ethnic populations.

A Collaborative Filtering Recommendation Algorithm Fusing Rating and Time Interval Similarity on Item Attributes

Xiao-hui Cheng,Yu Wu,Yun Deng 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.12

Traditional methods UBCF have limitations of poor recommendation quality and problems of data sparsity. To alleviate these problems, a novel collaborative filtering algorithm is designed, which firstly get the users’ ratings and time intervals for each attribute from the users’ ratings for items, then produce two methods to calculate the similarity between users, introduce a weighting parameters to control the weight between the two similarity methods in order to get a fusion similarity between two users. The results show that this method is able to improve the accuracy of predicted values, resulting in improving recommendation quality of the collaborative filtering recommendation algorithm.

Construction and Differential Screening of a cDNA Library Specific to Osmotic Stress of Haloxylon ammodendron Seedlings

( Xiao Cheng Jiang ),( Xin Hong Guo ),( Xiao Ling Pan ),( Song Quan Song ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.5

A subtracted cDNA library specific to osmotic stress of Haloxylon ammodendron (Mey.) Bge seedlings was constructed by suppression subtractive hybridization (SSH) and T/A cloning. SSH was performed between two groups of H. ammodendron seedlings, one was cultivated in Hoagland (H) solution as a driver and the other group was treated with osmotic stress of the Hoagland solution by the addition of 400 mM mannitol (M), as a tester. The library consisted of about 400 recombinant clones, with the average size being of 500 bp, ranging from 300 bp to 1500 bp. Using a PCR-select differential screening kit, 100 recombinant clones were randomly chosen from the subtracted cDNA library and hybridized with forward,reverse subtracted and unsubtracted probes for two rounds. As a result, 21 positive clones specific to osmotic stress were obtained and some of them were verified by Northern blot analysis. The sequencing analysis of 6 positive clones and the following homology comparison to GenBank [blastx] non-redundant databases characterized that two sequences obtained in this experiment may contribute to novel drought-related genes.

Serviceability reliability analysis of cable-stayed bridges

Cheng, Jin,Xiao, Ru-Cheng Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.20 No.6

A reliability analysis method is proposed in this paper through a combination of the advantages of the response surface method (RSM), finite element method (FEM), first order reliability method (FORM) and the importance sampling updating method. The accuracy and efficiency of the method is demonstrated through several numerical examples. Then the method is used to estimate the serviceability reliability of cable-stayed bridges. Effects of geometric nonlinearity, randomness in loading, material, and geometry are considered. The example cable-stayed bridge is the Second Nanjing Bridge with a main span length of 628 m built in China. The results show that the cable sag that is part of the geometric nonlinearities of cable-stayed bridges has a major effect on the reliability of cable-stayed bridge. Finally, the most influential random variables on the reliability of cable-stayed bridges are identified by using a sensitivity analysis.

Application of inverse reliability method to estimation of cable safety factors of long span suspension bridges

Cheng, Jin,Xiao, Ru-Cheng Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.23 No.2

An efficient and accurate algorithm is proposed to estimate cable safety factor of suspension bridges satisfying prescribed reliability levels. Uncertainties in the structure and load parameters are incorporated. The proposed algorithm integrates the concepts of the inverse reliability method and deterministic method for assessing cable safety factors of suspension bridges. The unique feature of the proposed method is that it offers a tool for cable safety assessment of suspension bridges, when the reliability level is specified as a target to be satisfied by the designer. After the accuracy and efficiency of the method are demonstrated through two numerical examples, the method is used to estimate cable safety factors of suspension bridges with span length ranging from 2000 to 5000 m. The results show that the deterministic method overestimates cable safety factor of suspension bridges because of neglecting the parameter uncertainty effects. The actual cable safety factor of suspension bridges should be estimated based on the proposed method.

Experimental investigation on the behaviour of UHPC-steel composite slabs under hogging moment

Xiao-Long Gao,Jun-Yan Wang,Chen Bian,Ru-Cheng Xiao,Biao Ma 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.42 No.6

Ultra high performance concrete (UHPC) can be used in the UHPC-steel composite structures especially for bridge structures to achieve high stiffness and high fatigue resistance with low self-weight. The structural performances of UHPC-steel composite slabs subjected to hogging moment have a significant influence on the global stiffness and durability of UHPC-steel composite structures. In order to study the structural behaviors of non-steam-cured UHPC-steel composite slabs subjected to negative moment, five composite slabs combined the thin UHPC layers to steel plates via shear stud connecters with the diameter of 16mm were fabricated and tested under negative moment. The test program aimed to investigate the effect of stud spacing and longitudinal reinforcement ratios on the failure mode, load-deflection behaviors, cracking patterns, bond-slips, and carrying capacities of composite slabs subjected to negative moment. In addition, direct tensile tests for the dog-bone UHPC specimens with longitudinal reinforcement bars were carried out to study the effect of reinforcement bars on the tensile strength of UHPC in the thin structure members. Based on the experimental results, analytical models were also developed to predict the cracking load and ultimate load of UHPC-steel composite slabs subjected to negative moment.

Probabilistic shear-lag analysis of structures using Systematic RSM

Cheng, Jin,Cai, C.S.,Xiao, Ru-Cheng Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.21 No.5

In the shear-lag analysis of structures deterministic procedure is insufficient to provide complete information. Probabilistic analysis is a holistic approach for analyzing shear-lag effects considering uncertainties in structural parameters. This paper proposes an efficient and accurate algorithm to analyze shear-lag effects of structures with parameter uncertainties. The proposed algorithm integrated the advantages of the response surface method (RSM), finite element method (FEM) and Monte Carlo simulation (MCS). Uncertainties in the structural parameters can be taken into account in this algorithm. The algorithm is verified using independently generated finite element data. The proposed algorithm is then used to analyze the shear-lag effects of a simply supported beam with parameter uncertainties. The results show that the proposed algorithm based on the central composite design is the most promising one in view of its accuracy and efficiency. Finally, a parametric study was conducted to investigate the effect of each of the random variables on the statistical moment of structural stress response.

Application of artificial neural networks to the response prediction of geometrically nonlinear truss structures

Cheng, Jin,Cai, C.S.,Xiao, Ru-Cheng Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.26 No.3

This paper examines the application of artificial neural networks (ANN) to the response prediction of geometrically nonlinear truss structures. Two types of analysis (deterministic and probabilistic analyses) are considered. A three-layer feed-forward backpropagation network with three input nodes, five hidden layer nodes and two output nodes is firstly developed for the deterministic response analysis. Then a back propagation training algorithm with Bayesian regularization is used to train the network. The trained network is then successfully combined with a direct Monte Carlo Simulation (MCS) to perform a probabilistic response analysis of geometrically nonlinear truss structures. Finally, the proposed ANN is applied to predict the response of a geometrically nonlinear truss structure. It is found that the proposed ANN is very efficient and reasonable in predicting the response of geometrically nonlinear truss structures.

Copy Detection Technique with Enhanced Efficiency by using Substring Comparison Algorithm

Xiao-hui Cheng,Meng Hu,Tong Wang,Yun Deng 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.12

As the information was being overloaded from time to time, a significant technique should be accomplished by several search engines that exists will use from the databases to eradicate the replicas of data which was available in articles and to present the outcomes of the search to users in terms of percentage of the amount of the data copied from the original file. Plagiarism is the process of bestowing one’s creative ideas as our individual conception. It is does not meant that anybody cannot use other’s considerations or workings, anybody can use their data by giving the actual credit the original users by stating their names in literature or in references and also by giving special note on acknowledgements. Copying the content of the others work is mainly considered to be a big crime in terms of research and in terms of the owning the idea of the others. The main idea of this work is to identify the extent of the data that was being copied or to identify the amount of data that was being copied from other peoples work or their own credited work. Performance of plagiarizing a document is not limited to word files or pdf files, it is possible to plagiarize even images and other files too. Hence, we were focused on finding the plagiarism in word files which includes academics and research articles.

Advanced aerostatic stability analysis of suspension bridges

Xiao, Ru-Cheng,Cheng, Jin Techno-Press 2004 Wind and Structures, An International Journal (WAS Vol.7 No.1

Aerostatic instability of a suspension bridge may suddenly appears when the deformed shape of the structure produces an increase in the value of the three components of displacement-dependent wind loads distributed in the structure. This paper investigates the aerostatic stability of suspension bridges using an advanced nonlinear method based on the concept of limit point instability. Particular attention is devoted to aerostatic stability analysis of symmetrical suspension bridges. A long-span symmetrical suspension bridge (Hu Men Bridge) with a main span of 888 m is chosen for analysis. It is found that the initial configuration (symmetry or asymmetry) may affect the instability configuration of structure. A finite element software for the nonlinear aerostatic stability analysis of cable-supported bridges (NASAB) is presented and discussed. The aerostatic failure mechanism of suspension bridges is also explained by tracing aerostatic instability path.