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( Dong Il Park ),( Tadakazu Hisamatsu ),( Minhu Chen ),( Siew Chien Ng ),( Choon Jin Ooi ),( Shu Chen Wei ),( Rupa Banerjee ),( Ida Normiha Hilmi ),( Yoon Tae Jeen ),( Dong Soo Han ),( Hyo Jong Kim ) 대한장연구학회 2018 Intestinal Research Vol.16 No.1
Because anti-tumor necrosis factor (anti-TNF) therapy has become increasingly popular in many Asian countries, the risk of developing active tuberculosis (TB) among anti-TNF users may raise serious health problems in this region. Thus, the Asian Organization for Crohn’s and Colitis and the Asia Pacific Association of Gastroenterology have developed a set of consensus statements about risk assessment, detection and prevention of latent TB infection, and management of active TB infection in patients with inflammatory bowel disease (IBD) receiving anti-TNF treatment. Twenty-three consensus statements were initially drafted and then discussed by the committee members. The quality of evidence and the strength of recommendations were assessed by using the Grading of Recommendations Assessment, Development, and Evaluation methodology. Web- based consensus voting was performed by 211 IBD specialists from 9 Asian countries concerning each statement. A consensus statement was accepted if at least 75% of the participants agreed. Part 1 of the statements comprised 2 parts: risk of TB infection Recommenda-during anti-TNF therapy, and screening for TB infection prior to commencing anti-TNF therapy. These consensus statements will help clinicians optimize patient outcomes by reducing the morbidity and mortality related to TB infections in patients with IBD receiving anti-TNF treatment. (Intest Res 2018;16:4-16)
Dong Il Park,Tadakazu Hisamatsu,Min-Hu Chen,Siew Chien Ng,Choon Jin Ooi,Shu Chen Wei,Rupa Banerjee,Ida Normiha Hilmi,Yoon Tae Jeen,한동수,Hyo Jong Kim,Zhi Hua Ran,Kaichun Wu,Jiaming Qian,Pin-Jin Hu,Katsu 대한장연구학회 2018 Intestinal Research Vol.16 No.1
Because anti-tumor necrosis factor (anti-TNF) therapy has become increasingly popular in many Asian countries, the risk of developing active tuberculosis (TB) among anti-TNF users may raise serious health problems in this region. Thus, the Asian Organization for Crohn’s and Colitis and the Asia Pacific Association of Gastroenterology have developed a set of consensus statements about risk assessment, detection and prevention of latent TB infection, and management of active TB infection in patients with inflammatory bowel disease (IBD) receiving anti-TNF treatment. Twenty-three consensus statements were initially drafted and then discussed by the committee members. The quality of evidence and the strength of recommendations were assessed by using the Grading of Recommendations Assessment, Development, and Evaluation methodology. Web- based consensus voting was performed by 211 IBD specialists from 9 Asian countries concerning each statement. A consensus statement was accepted if at least 75% of the participants agreed. Part 2 of the statements comprised 3 parts: management of latent TB in preparation for anti-TNF therapy, monitoring during anti-TNF therapy, and management of an active TB infection after anti-TNF therapy. These consensus statements will help clinicians optimize patient outcomes by reducing the morbidity and mortality related to TB infections in patients with IBD receiving anti-TNF treatment.
음성 및 지문인식에 기초한 스마트홈 환경에서의 대화시스템에 관한 연구
박일천(Il-Chen Park) 산업기술교육훈련학회 2011 산업기술연구논문지 (JITR) Vol.16 No.4
This paper, we discuss the user-customized interaction for smart home environments. The dialog system based upon the integrated techniques using speech recognition, speech synthesis and fingerprint verification. For essential modules, the speech recognition and synthesis were basically used for a interaction between the user and the proposed system. In experiments, particularly, the real-time speech recognizer based on the HM-Net(Hidden Markov Network) was incorporated into the integrated system. Besides, the fingerprint verification was adopted to customize home environments for a specific user. In experimental evaluation, the results presented that the performance of real-time speech recognition in the proposed system was not better than the simulation results owing to the ambient noisy environments. Nevertheless, the results from the questionnaire showed an affirmative possibility for building smart system that might give us much more convenient and comfortable living environments.
Chen, Meilian,Nam, Seung-Il,Kim, Ji-Hoon,Kwon, Young-Joo,Hong, Sungwook,Jung, Jinyoung,Shin, Kyung-Hoon,Hur, Jin Elsevier BV 2017 Science of the Total Environment Vol.599 No.-
<P><B>Abstract</B></P> <P>The seawater samples from the Chukchi and East Siberian Seas were collected along a shelf-slope-basin gradient and analyzed for chromophoric and fluorescent DOM (i.e., CDOM and FDOM, respectively). Unexpected high protein-like FDOM (0.35±0.40 and 0.24±0.34 RU for peaks B and T, respectively) levels were identified, which corresponded to 1–2 orders of magnitude higher than those documented by previous reports. This unique phenomenon could be attributed to a fall phytoplankton bloom. The seawater chl-<I>a</I> data, estimated from in situ fluorescence measurements and satellite remote sensing data, showed the subsurface chl-<I>a</I> maximum of up to 1.52mgm<SUP>−3</SUP> at ~25–70m depths and the surface monthly average values (August 2015) up to 0.55 to 0.71mgm<SUP>−3</SUP>, which fall in the range of ~0.5–2.0mgm<SUP>−3</SUP> during fall phytoplankton blooms in this area. Meanwhile, the depth profile of DOM parameters revealed subsurface maxima of protein-like fluorescence peaks along the shelf-slope gradient. The positive correlations between the protein-like peaks and biological index implied the lateral transport of DOM and nutrients from the shelf to the slope and basin. Despite still being a largely ice-covered environment, potential shifts in the ecosystem appear to make progress in response to changing climate in the Arctic Ocean.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Importance of CDOM dynamics in the fast-changing Arctic ecosystem is highlighted. </LI> <LI> Optical properties of DOM were spatially examined in the Arctic Ocean area. </LI> <LI> High levels of protein-like fluorescence were newly found in the region. </LI> <LI> All observed data including remote sensing data supported fall phytoplankton bloom. </LI> <LI> A lateral spreading of nutrients and DOM was suggested along shelf-slope-basin. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Chen, Bai Hui,Park, Joon Ha,Lee, Tae-Kyeong,Song, Minah,Kim, Hyunjung,Lee, Jae Chul,Kim, Young-Myeong,Lee, Choong-Hyun,Hwang, In Koo,Kang, Il Jun,Yan, Bing Chun,Won, Moo-Ho,Ahn, Ji Hyeon Elsevier 2018 Chemico-biological interactions Vol.285 No.-
<P><B>Abstract</B></P> <P>Animal models of scopolamine-induced amnesia are widely used to study underlying mechanisms and treatment of cognitive impairment in neurodegenerative diseases such as Alzheimer's disease (AD). Previous studies have identified that melatonin improves cognitive dysfunction in animal models. In this study, using a mouse model of scopolamine-induced amnesia, we assessed spatial and short-term memory functions for 4 weeks, investigated the expression of myelin-basic protein (MBP) in the dentate gyrus, and examined whether melatonin and scopolamine cotreatment could keep cognitive function and MBP expression. In addition, to study functions of melatonin for keeping cognitive function and MBP expression, we examined expressions of brain-derived neurotrophic factor (BDNF) and tropomycin receptor kinase B (TrkB) in the mouse dentate gyrus. Scopolamine (1 mg/kg) and melatonin (10 mg/kg) were intraperitoneally treated for 2 and 4 weeks. Two and 4 weeks after scopolamine treatment, mice showed significant cognitive impairment; however, melatonin and scopolamine cotreatment recovered cognitive impairment. Two and 4 weeks of scopolamine treatment, the density of MBP immunoreactive myelinated nerve fibers was significantly decreased in the dentate gyrus; however, scopolamine and melatonin cotreatment significantly increased the scopolamine-induced reduction of MBP expression in the dentate gyrus. Furthermore, the cotreatment of scopolamine and melatonin significantly increased the scopolamine-induced decrease of BDNF and TrKB immunoreactivity in the dentate gyrus. Taken together, our results indicate that melatonin treatment exerts anti-amnesic effect and restores the scopolamine-induced reduction of MBP expression through increasing BDNF and TrkB expressions in the mouse dentate gyrus.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Long-term treatment of scopolamine (Sco) induces cognitive deficits. </LI> <LI> Long-term treatment of melatonin improves Sco-induced cognitive deficits. </LI> <LI> Sco significantly decreases MBP, BDNF, and TrkB in the dentate gyrus. </LI> <LI> Melatonin restores scopolamine-induced decreases in MBP, BDNF, and TrkB. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Encapsulation of Single Small Gold Nanoparticles by Diblock Copolymers
Chen, Hong Y.,Abraham, Sinoj,Mendenhall, Juana,Delamarre, Soazig C.,Smith, Kahli,Kim, Il,Batt, Carl A. WILEY-VCH Verlag 2008 CHEMPHYSCHEM -WEINHEIM- Vol.9 No.3
<B>Graphic Abstract</B> <P>Hairy micelles are obtained by using amphiphilic diblock copolymers with long hydrophilic blocks which favor single encapsulation of Au nanoparticles (ca. 5 nm, see figure). Antibody molecules can be attached to the hydrogel layers of the encapsulated Au nanoparticles to give nanoparticle/biomolecule conjugates. <img src='wiley_img/14394235-2008-9-3-CPHC200700598-content.gif' alt='wiley_img/14394235-2008-9-3-CPHC200700598-content'> </P>
Spatial Distribution of Lead Iodide and Local Passivation on Organo-Lead Halide Perovskite
Chen, Sheng,Wen, Xiaoming,Yun, Jae S.,Huang, Shujuan,Green, Martin,Jeon, Nam Joong,Yang, Woon Seok,Noh, Jun Hong,Seo, Jangwon,Seok, Sang Il,Ho-Baillie, Anita American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.7
<P>We identify nanoscale spatial distribution of PbI2 on the (FAPbI(3))(0.85)(MAPbBr(3))(0.15) perovskite thin film and investigate the local passivation effect using confocal based optical microscopy of steady state and time-resolved photoluminescence (PL). Different from a typical scanning electron microscope (SEM) morphology study, confocal based PL spectroscopy and microscopy allow researchers to map the morphologies of both perovskite and PbI2 grains simultaneously, by selectively detecting their characteristic fluorescent bands using band-pass filters. In this work, we compare the perovskite samples without and with excess PbI2 incorporation and unambiguously reveal PbI2 distribution for the PbI2-rich sample. In addition, using the nanoscale time-resolved PL technique we show that the PbI2-rich regions exhibit longer lifetime due to suppressed defect trapping, compared to the PbI2-poor regions. The measurement on the PbI2-rich sample indicates that the passivation effect of PbI2 in perovskite film is effective, especially in localized regions. Hence, this finding is important for further improvement of the solar cells by considering the strategy of excess PbI2 incorporation.</P>