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RISS 인기검색어
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- 저자 : Cheal-Wung Huh (검색결과 22 건)
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Cheal Wung Huh,Young Hoon You,Da Hyun Jung,Ra Ri Cha,Yeon Ji Kim,Kyoungwon Jung,Kyung Ho Song,Ki Bae Bang,Chung Hyun Tae,Soo In Choi,Cheol Min Shin 대한소화기 기능성질환∙운동학회 2024 Journal of Neurogastroenterology and Motility (JNM Vol.30 No.3
Background/AimsAcid-suppressive drugs, such as proton pump inhibitors (PPIs), are treatment options for functional dyspepsia (FD). However, the efficacy of potassium-competitive acid blockers (P-CABs) in treating FD has not yet been established. This prospective multicenter clinical trial-based study aimed to assess the efficacy and safety of tegoprazan as a P-CAB treatment in patients with FD. MethodsFD was diagnosed using the Rome IV criteria. All patients received tegoprazan 50 mg once daily for 8 weeks. Dyspeptic symptoms were assessed using a dyspepsia symptom questionnaire (5-point Likert scale, Nepean Dyspepsia Index-Korean [NDI-K], and gastroesophageal reflux disease–health-related quality of life [GERD-HRQL]). The main outcome was satisfactory symptom relief rates at 8 weeks. ResultsIn this study, from the initial screening of 209 patients, 173 were included in the per-protocol set analysis. Satisfactory symptom relief rates at 8 and 4 weeks were 86.7% and 74.6%, respectively. In addition, the NDI-K and GERD-HRQL scores significantly improved at 8 and 4 weeks compared with the baseline scores. The efficacy of tegoprazan was not influenced by the FD subtype or Helicobacter pylori status. In patients with overlapping FD and GERD, there was a greater improvement in the NDI-K and GERD-HRQL scores than in patients with FD symptoms only. No serious drug-related adverse events occurred during this study. ConclusionTegoprazan (50 mg) administered once daily provided satisfactory symptom relief for FD.
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Cheal Wung Huh,Gi Jun Kim,Byung-Wook Kim,Myeongsook Seo,Joon Sung Kim 거트앤리버 소화기연관학회협의회 2019 Gut and Liver Vol.13 No.5
Background/Aims: The risk of peritoneal seeding following perforation after endoscopic resection in patients with early gastric cancer is unclear. The purpose of this study was to investigate long-term clinical outcomes including peritoneal seeding and overall survival rate following gastric perforation during endoscopic submucosal dissection (ESD). Methods: Between January 2002 and March 2015, 556 patients were diagnosed with early gastric cancer and underwent ESD. Among them, 34 patients (6.1%) experienced gastric perforation during ESD. Clinicopathological data of these patients were reviewed to determine the clinical outcome and evidence of peritoneal seeding. Results: Among 34 patients with perforation, macroperforations occurred during ESD in 17 cases (50%), and microperforation was identified in the remaining 17 cases (50%). All patients except one who underwent emergency surgery due to severe panperitonitis were managed successfully by endoscopic clipping (n=27) or conservative medical treatment (n=6). No evidence of peritoneal seeding after perforation associated with ESD was found in our cohort. Cumulative survival rates did not differ between the perforation and non-perforation groups (p=0.691). Furthermore, mortality was not associated with perforation. In addition, multivariate analysis showed that tumor size and achievement of curative resection were related to cancer recurrence. Perforation was not associated with cancer recurrence and survival. Conclusions: Perforation associated with ESD does not lead to worse clinical outcomes such as peritoneal seeding or cumulative survival rate. Therefore, periodic follow-up might be possible if curative resection was achieved even if perforation occurred during ESD.
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Cheal Wung Huh,윤영훈 대한연하장애학회 2017 대한연하장애학회지 Vol.7 No.1
Dysphagia is one of the common symptoms that are encountered in clinical practice. However, dysphagia is still crucial and must be thoroughly investigated because it may be a key symptom of several malignancies. There are two types of dysphagia, oropharyngeal and esophageal dysphagia. Esophageal dysphagia can be caused by esophageal neuromuscular motility disorder, various inflammatory disorders, and also extrinsic or intrinsic structural lesions such as esophageal cancer. This article focuses on malignant esophageal dysphagia, including its causes, risk factors, clinical symptoms, and management.
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( Cheal Wung Huh ),( Da Hyun Jung ),( Jie Hyun Kim ),( Yong Chan Lee ),( Hyunki Kim ),( Hoguen Kim ),( Sun Och Yoon ),( Young Hoon Youn ),( Hyojin Park ),( Sang In Lee ),( Seung Ho Choi ),( Jae Ho Che 대한내과학회 2011 대한내과학회 추계학술발표논문집 Vol.2011 No.1
Background: Signet ring cell carcinoma (SRC) of the stomach has been known to have different microscopic and biologic characteristics compared to non-SRC. Thus, a pathologic report has documented partly SRC component with other main histologies in gastric cancer. However, the clinical significance of SRC mixture has not been reported. The aim was to investigate clinicopathologic features of mixed-SRC histology in early gastric cancer (EGC). Methods: Between 1999 and 2005, 2208 patients were diagnosed with EGC and underwent surgery at Severance and Gangnam Severance Hospital. Among them, 156 patients were diagnosed with adenocarcinoma with partly SRC (mixed-SRC group), 1,512 with only adenocarcinoma (adenocarcinoma group), and 540 with SRC (SRC group). Clinicopathologic characteristics among the mixed-SRC, adenocarcinoma, and SRC groups were analyzed. Results: The SRC group was more significantly associated with younger age, female, mid-body location, mucosa-confined, depressed type, lower lymph node metastasis (LNM), lower lymphovascular invasion, and a better survival rate than the adenocarcinoma group. The mixed-SRC group was more significantly associated with younger age, female, upper-body location, and depressed type than the adenocarcinoma group, similar to the SRC group. However, the mixed-SRC group showed more submucosal invasion, larger size, and higher LNM than SRC and adenocarcinoma groups. Also, a mixed-SRC component was one of the independent risk factors of LNM. Conclusions: The mixed-SRC group displayed different clinicopathologic characteristics from other groups. Mixed-SRC histology in EGC showed more aggressive biologic characteristics than SRC and adenocarcinoma. Thus, clinical considerations of mixed-SRC histology may be helpful to decide on a specific cancer treatment.
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Cheal-Wung Huh,Dae Won Ma,Byung-Wook Kim,Joon Sung Kim,Seung Jae Lee 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.2
Background/Aims: The use of endoscopic submucosal dissection (ESD) for treating undifferentiated-type early gastric cancer iscontroversial. The objective of this study was to perform a meta-analysis to compare the long-term outcomes of ESD and surgery forundifferentiated-type early gastric cancer. Methods: The PubMed, Cochrane Library, and EMBASE databases were used to search for relevant studies comparing ESD andsurgery for undifferentiated-type early gastric cancer. The methodological quality of the included publications was evaluated usingthe Risk of Bias Assessment tool for Nonrandomized Studies. The rates of overall survival, recurrence, adverse event, and completeresection were determined. Odds ratios (ORs) and 95% confidence intervals (CIs) were also evaluated. Results: This meta-analysis enrolled five studies with 429 and 1,236 participants undergoing ESD and surgery, respectively. Nosignificant difference was found in the overall survival rate between the ESD and surgery groups (OR, 2.29; 95% CI, 0.98–5.36;p=0.06). However, ESD was associated with a higher recurrence rate and a lower complete resection rate. The adverse event rate wassimilar between the two groups. Conclusions: ESD with meticulous surveillance esophagogastroduodenoscopy may be as effective and safe as surgery in patientswith undifferentiated-type early gastric cancer. Further large-scale, randomized, controlled studies from additional regions arerequired to confirm these findings.
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Cheal Wung Huh,Nak Hoon Son,Young Hoon Youn,Da Hyun Jung,Min Kyung Kim,Eun Jeong Gong,Kyu Chan Huh,Seung Young Kim,Moo In Park,Ju Yup Lee,Joong Goo Kwon,Jae Hak Kim,Cheol Min Shin,Kee Wook Jung,Su Jin 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.4
Background/AimsGastroesophageal reflux disease (GERD) is a common chronic gastrointestinal disorder that typically requires long-term maintenance therapy. However, little is known about patient preferences and satisfaction and real-world prescription patterns regarding maintenance therapy for GERD. MethodsThis observational, cross-sectional, multicenter study involved patients from 18 referral hospitals in Korea. We surveyed patients who had been prescribed proton pump inhibitors (PPIs) for GERD for at least 90 days with a minimum follow-up duration of 1 year. The main outcome was overall patient satisfaction with different maintenance therapy modalities. ResultsA total of 197 patients were enrolled. Overall patient satisfaction, patient preferences, and GERD health-related quality of life scores did not significantly differ among the maintenance therapy modality groups. However, the on-demand therapy group experienced a significantly longer disease duration than the continuous therapy group. The continuous therapy group demonstrated a lower level of awareness of potential adverse effects associated with PPIs than the on-demand therapy group but received higher doses of PPIs than the on-demand therapy group. The prescribed doses of PPIs also varied based on the phenotype of GERD, with higher doses prescribed for non-erosive reflux disease than erosive reflux disease. ConclusionAlthough overall patient satisfaction did not significantly differ among the different PPI maintenance therapy modality groups, awareness of potential adverse effects was significantly different between the on-demand and continuous therapy groups.
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허철웅 ( Cheal Wung Huh ),김병욱 ( Byung-wook Kim ) 대한소화기학회 2018 대한소화기학회지 Vol.72 No.5
Accurate diagnosis of Helicobacter pylori (H. pylori) infection is mandatory for the effective management of many gastroduodenal diseases. Currently, various diagnostic methods are available for detecting these infections, and the choice of method should take into account the clinical condition, accessibility, advantage, disadvantage, as well as cost-effectiveness. The diagnostic methods are divided into invasive (endoscopic-based) and non-invasive methods. Non-invasive methods included urea breath test, stool antigen test, serology, and molecular methods. Invasive methods included endoscopic imaging, rapid urease test, histology, culture, and molecular methods. In this article, we provide a review of the currently available options and recent advances of various diagnostic methods. (Korean J Gastroenterol 2018;72:229-236)
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허철웅 ( Cheal Wung Huh ),윤영훈 ( Young Hoon Youn ),정다현 ( Da Hyun Jung ),김도환 ( Do Whan Kim ),고보건 ( Bo Gun Kho ),김지현 ( Jie Hyun Kim ),박효진 ( Hyo Jin Park ),이상인 ( Sang In Lee ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.4
Cytomegalovirus (CMV) colitis is common among immunocompromised patients, and often diagnosed by pathologic confirmation because it is associated with a diverse spectrum of clinical and endoscopic features. However, Crohn`s disease has no definitive diagnostic criteria, but longitudinal ulcers and cobble stone appearance are accepted as typical endoscopic features of Crohn`s disease. An 83 year-old male with a history of radiotherapy for hypopharyngeal cancer visited our hospital with a complaint of melena for 1 week. His colonoscopic exam showed multiple longitudinal ulcers along the entire colon. Most of the ulcers were longer than 4 cm, these endoscopic findings were suspected as typical endoscopic features of Crohn`s disease. Pathologic reports revealed multiple inclusion bodies with CMV on immunohistochemistry. He was finally diagnosed as having CMV colitis, and received a 3 week-course of intravenous ganciclovir. A colonoscopic follow-up showed complete healing of the multiple longitudinal ulcers, and he is doing well now without further treatment. (Korean J Gastroenterol 2012;59:303-307)
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허철웅 ( Cheal Wung Huh ),김병욱 ( Byung-wook Kim ) 대한소화기학회 2017 대한소화기학회지 Vol.70 No.3
Gastric adenoma (dysplasia) is a precancerous lesion. Therefore, managements of gastric adenomas are important for preventing the development of gastric cancers and for detecting gastric cancers at earlier stages. The Vienna classification divides gastric adenomas into two categories: high-grade dysplasia and low-grade dysplasia. Generally, endoscopic resection is performed for adenoma with high-grade dysplasia due to the coexistence of carcinoma and the potential of progression to carcinomas. However, the treatments of adenoma with low-grade dysplasia remain controversial. Currently two treatment strategies for the low-grade type have been suggested; First is the `wait and see` strategy; Second is endoscopic treatment (e.g., endoscopic mucosal resection, endoscopic submucosal dissection, or argon plasma coagulation). In this review, we discuss the current optimal strategies for endoscopic management of gastric adenoma. (Korean J Gastroenterol 2017;70:115-120)
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