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Khandelwal Ankur,Chaturvedi Arvind,Sokhal Navdeep,Singh Akanksha,Sharma Hanjabam Barun 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.2
Study Design: This was a double-blind randomized study. Purpose: The primary purpose was to compare the effects of propofol and ketofol on amplitudes and latencies of transcranial motor evoked potentials (TcMEPs) during thoracolumbar spine surgery. In addition, intraoperative hemodynamics and muscle power were compared. Overview of Literature: Propofol is commonly used during intraoperative TcMEP monitoring. However, propofol inhibits TcMEP amplitudes and causes hypotension in a dose-dependent fashion. Methods: Amplitude and latency of TcMEPs were recorded bilaterally from the abductor pollicis brevis (APB) and abductor hallucis (AH) muscles in 38 adult American Society of Anesthesiologists I and II patients undergoing thoracolumbar spine surgery. Baseline recordings of TcMEPs in both groups were recorded under propofol infusion. Group X patients then received propofol and fentanyl (1 mcg/kg/hr), and group Y patients received ketofol and fentanyl (1 mcg/kg/hr). Bispectral index was maintained at 40–60 in both groups. Amplitude and latency were recorded at 30 minutes intervals for 2 hours. Results: Propofol caused no significant changes in amplitude and latency in any muscle. In contrast, amplitude increased significantly at all time points in the bilateral APB muscles and 60, 90, and 120 minutes in the left AH muscle without changes in latency in response to ketofol. When the two groups were compared, ketofol induced significantly higher amplitudes at 60, 90, and 120 minutes in the (left) APB, at all time points in the (right) APB, and at 120 minutes in both AH muscles, compared with propofol. Blood pressures were lower and fluid and vasopressor requirements were higher in group X. Muscle power was similar between the two groups. Conclusions: Ketofol facilitates TcMEP amplitudes without affecting latency. Use of ketofol resulted in a better and more stable hemodynamic profile than did use of propofol.
Bajpai, Ram,Chaturvedi, Himanshu,Jayaseelan, Lakshmanan,Harvey, Pauline,Seguy, Nicole,Chavan, Laxmikant,Raj, Pinnamaneni,Pandey, Arvind The Korean Society for Preventive Medicine 2016 Journal of Preventive Medicine and Public Health Vol.49 No.6
Objectives: The survival outcomes of antiretroviral treatment (ART) programs have not been systematically evaluated at the state level in India. This retrospective study assessed the survival rates and factors associated with survival among adult human immunodeficiency virus (HIV)-infected patients in Andhra Pradesh, India. Methods: The present study used data from 139 679 HIV patients aged ${\geq}15$ years on ART who were registered from 2007 to 2011 and were followed up through December 2013. The primary end point was death of the patient. Mortality densities (per 1000 person-years) were calculated. Kaplan-Meier and Cox-regression models were used to estimate survival and explore the factors associated with survival. Results: The overall median follow-up time was 16.0 months (2.0 months for the deceased and 14.0 months for those lost to follow-up). Approximately 13.2% of those newly initiated on ART died during follow-up. Of those deaths, 56% occurred in the first three months. The crude mortality rate was 80.9 per 1000 person-years at risk. The CD4 count (adjusted hazard ratio [aHR],4.88; 95% confidence interval [CI], 4.36 to 5.46 for < $100cells/mm^3$ vs. > $350cells/mm^3$), functional status (aHR, 3.05; 95% CI, 2.82 to 3.30 for bedridden vs. normal), and body weight (aHR, 3.69; 95% CI, 3.42 to 3.97 for <45 kg vs. >60 kg) were strongly associated with the survival of HIV patients. Conclusions: The study findings revealed that high mortality was observed within the first three months of ART initiation. Patients with poor baseline clinical characteristics had a higher risk of mortality. Expanded testing and counseling should be encouraged, with the goal of ensuring early enrollment into the program followed by the initiation of ART in HIV-infected patients.
Ojha, Amit,Chaturvedi, Pradyumn,Mittal, Arvind,Jain, Shailendra The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1
Common mode voltage (CMV) generation is a major problem in switching power converter fed induction motor drive systems. CMV is the zero sequence voltage generated due to the switching action of power converters. Even a small magnitude of CMV with a high rate of change may circulate large bearing currents which may damage a machine's bearings and shorten its life. There are several methods of controlling CMV. This paper presents 3-level sinusoidal pulse width modulation based techniques to control the magnitude and rate of change of CMV in multilevel AC-DC-AC drive systems. Simulation and experimental investigations have been presented to validate the performance of proposed technique to control CMV in 3-level neutral point clamped inverter based AC-DC-AC system.
Amit Ojha,Pradyumn Chaturvedi,Arvind Mittal,Shailendra Jain 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1
Common mode voltage (CMV) generation is a major problem in switching power converter fed induction motor drive systems. CMV is the zero sequence voltage generated due to the switching action of power converters. Even a small magnitude of CMV with a high rate of change may circulate large bearing currents which may damage a machine’s bearings and shorten its life. There are several methods of controlling CMV. This paper presents 3-level sinusoidal pulse width modulation based techniques to control the magnitude and rate of change of CMV in multilevel AC-DC-AC drive systems. Simulation and experimental investigations have been presented to validate the performance of proposed technique to control CMV in 3-level neutral point clamped inverter based AC-DC-AC system.
Ram Bajpai,Himanshu Chaturvedi,Lakshmanan Jayaseelan,Pauline Harvey,Nicole Seguy,Laxmikant Chavan,Pinnamaneni Raj,Arvind Pandey 대한예방의학회 2016 Journal of Preventive Medicine and Public Health Vol.49 No.6
Objectives: The survival outcomes of antiretroviral treatment (ART) programs have not been systematically evaluated at the state level in India. This retrospective study assessed the survival rates and factors associated with survival among adult human immunodeficiency virus (HIV)-infected patients in Andhra Pradesh, India. Methods: The present study used data from 139 679 HIV patients aged ≥15 years on ART who were registered from 2007 to 2011 and were followed up through December 2013. The primary end point was death of the patient. Mortality densities (per 1000 person-years) were calculated. Kaplan-Meier and Cox-regression models were used to estimate survival and explore the factors associated with survival. Results: The overall median follow-up time was 16.0 months (2.0 months for the deceased and 14.0 months for those lost to follow-up). Approximately 13.2% of those newly initiated on ART died during follow-up. Of those deaths, 56% occurred in the first three months. The crude mortality rate was 80.9 per 1000 person-years at risk. The CD4 count (adjusted hazard ratio [aHR],4.88; 95% confidence interval [CI], 4.36 to 5.46 for <100 cells/mm3 vs. >350 cells/mm3), functional status (aHR, 3.05; 95% CI, 2.82 to 3.30 for bedridden vs. normal), and body weight (aHR, 3.69; 95% CI, 3.42 to 3.97 for <45 kg vs. >60 kg) were strongly associated with the survival of HIV patients. Conclusions: The study findings revealed that high mortality was observed within the first three months of ART initiation. Patients with poor baseline clinical characteristics had a higher risk of mortality. Expanded testing and counseling should be encouraged, with the goal of ensuring early enrollment into the program followed by the initiation of ART in HIV-infected patients.