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RISS 인기검색어
- 검색키워드
- 저자 : Charles H. Cho (검색결과 14 건)
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Cho, Sung-Yup,Chae, Jeesoo,Na, Deukchae,Kang, Wonyoung,Lee, Ahra,Min, Seoyeon,Kang, Jinjoo,Choi, Boram,Lee, Jieun,Sung, Chang Ohk,Chuang, Jeffrey H.,Lee, Charles,Lee, Won-Suk,Park, Hansoo,Kim, Jong-Il American Association for Cancer Research 2019 Clinical Cancer Research Vol.25 No.9
<P><B>Purpose:</B></P><P>Genomic and transcriptomic alterations during metastasis are considered to affect clinical outcome of colorectal cancers, but detailed clinical implications of metastatic alterations are not fully uncovered. We aimed to investigate the effect of metastatic evolution on <I>in vivo</I> treatment outcome, and identify genomic and transcriptomic alterations associated with drug responsiveness.</P><P><B>Experimental Design:</B></P><P>We developed and analyzed patient-derived xenograft (PDX) models from 35 patients with colorectal cancer including 5 patients with multiple organ metastases (MOMs). We performed whole-exome, DNA methylation, and RNA sequencing for patient and PDX tumors. With samples from patients with MOMs, we conducted phylogenetic and subclonal analysis and <I>in vivo</I> drug efficacy test on the corresponding PDX models.</P><P><B>Results:</B></P><P>Phylogenetic analysis using mutation, expression, and DNA methylation data in patients with MOMs showed that mutational alterations were closely connected with transcriptomic and epigenomic changes during the tumor evolution. Subclonal analysis revealed that initial primary tumors with larger number of subclones exhibited more dynamic changes in subclonal architecture according to metastasis, and loco-regional and distant metastases occurred in a parallel or independent fashion. The PDX models from MOMs demonstrated therapeutic heterogeneity for targeted treatment, due to subclonal acquisition of additional mutations or transcriptomic activation of bypass signaling pathway during tumor evolution.</P><P><B>Conclusions:</B></P><P>This study demonstrated <I>in vivo</I> therapeutic heterogeneity of colorectal cancers using PDX models, and suggests that acquired subclonal alterations in mutations or gene expression profiles during tumor metastatic processes can be associated with the development of drug resistance and therapeutic heterogeneity of colorectal cancers.</P>
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Is Environmental Disclosure Good for the Environment? A Meta-analysis and Research Agenda
( Charles H. Cho ),( Jonathan Maurice ),( Emmanuelle Negre ),( Marie Anne Verdier ) 한국회계학회 2016 회계학연구 Vol.41 No.3
This paper reviews the literature on the association between environmental disclosure and environmental performance. Results from previous studies are mixed. While some studies conducted in an economic perspective document a positive association between these two environmental dimensions, other studies obtain a negative association that they mainly explain using arguments drawn from socio-political theories. Given these conflicting results, we conduct a meta-analysis to provide an average direction and magnitude of the association between environmental disclosure and environmental performance. The meta-analysis reveals that there is no association between the environmental disclosure and the environmental performance of the 2,672 companies of our cumulated sample, and that this non-association remains constant over time despite the continuous reinforcement of environmental regulations. Based on these results, we discuss theoretical and methodological issues associated with prior literature that could explain this overall non-association and we suggest avenues for future research.
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An Unusual Type of Cancer-associated Retinopathy in a Patient with Ovarian Cancer
Young H,Yoon,Eun H,Cho,Joon hong Sohn,Charles E,Thirkill 대한안과학회 1999 Korean Journal of Ophthalmology Vol.13 No.1
We studied a case of unusual retinopathy in a 35-year-old woman who presented with bilateral visual deterioration due to retinal pigmentary mottling and serous elevation in the posterior pole. Two years before, she had undergone hysterectomy and bilateral salphingo-oophorectomy for ovarian cancer. Her electroretinogram became subnormal, and her fluorescein angiogram exhibited multiple deep retinal pigment epithelial leakages and subretinal dye pooling in both eyes. Corticosteroid therapy failed to prevent visual loss. She was found to possess antibodies against retinal 45 kd protein. This led to a diagnosis of cancer-associated retinopathy with atypical protein profile. We report a rare variety of cancer-associated retinopathy in a patient with-ovarian cancer.
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IN DISTRUST OF MERITS: NEGATIVE EFFECTS OF ASTROTURFS ON PEOPLE'S PROSOCIAL BEHAVIORS
Jungyun Kang,Hakkyun Kim,Hosang Chu,Charles H. Cho 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7
Will information from astroturf organizations affect people’s trust toward overall nonprofit organizations and willingness to engage in prosocial behaviors? Astroturf organizations are defined as “fake grassroots organizations animated by a clever public relations campaign and a huge budget” (Hoggan and Littlemore 2009). In other words, an astroturf organization hides its true identity by using rhetorical language to convince the public. It can be inferred that large corporations sponsor astroturf organizations to employ deceptive and fraudulent tactics as propaganda. Prior research on astroturf organizations for climate change shows that people exposed to information from astroturf organizations denying global warming tend to become more uncertain about climate issues (e.g., causes of global warming or the existence of global warming) than people exposed to information from grassroots organizations (Cho et al. 2011). We propose that information from astroturf organizations may affect not only relevant issues or organizations, but also nonprofit organizations in general, which can then lower people's willingness to engage in prosocial behaviors (e.g., donations and volunteering). Darke and Ritchie (2007) found that deceptive advertisements engender distrust and undermine the trustworthiness of subsequent advertising. The process of defensive stereotyping can explain how initial deception activates general skepticism regarding advertising. Based on such an explanation, we suggest that exposure to astroturf organizations can make consumers more logically defensive and can decrease their trust toward messages from other nonprofit organizations. Therefore, we hypothesize that people who read messages from astroturf organizations will be more distrustful toward nonprofit organizations and will display lower willingness to engage in prosocial behaviors than people who read messages from grassroots organizations. To test this hypothesis, we conducted an experiment. We used a one-factor design with two levels of organization types (astroturf vs. grassroots). Participants (N = 72) were randomly assigned to one of the two conditions. Participants were told that they would read a message captured from a website of an organization (astroturf vs. grassroots) working on global warming. After viewing the advertisement, participants completed a questionnaire measuring their trust toward nonprofit organizations in general and willingness to engage in prosocial behaviors. We assessed whether viewing the advertisement from the astroturf organization had an impact on participants' trust toward nonprofit organizations and their willingness to engage in prosocial behaviors. An analysis of variance (ANOVA), with trust toward nonprofit organizations as the dependent variable and the type of organization as the independent variable, yielded a significant effect (F = 4.38, p < .05). The results showed that participants who viewed the advertisement from the astroturf organization were more likely to be distrustful of nonprofit organizations than those who viewed the advertisement from the grassroots organization (Mastroturf = 4.14, SD = 1.48 vs. Mgrassroots = 4.80, SD = 1.16). Thus, astroturf organizations may not only confuse people about a specific issue that the respective astroturf organizations aimed to attack, but they can also significantly weaken people's trust toward nonprofit organizations in general, which suggests severe detriment for the entire society. In addition, exposure to the message from an astroturf organization appeared to have an impact on people's willingness to engage in prosocial behaviors (F = 4.77, p < .05). To be specific, people who viewed the advertisement from the astroturf organization indicated that they were less likely to engage in prosocial behaviors, compared to those who viewed the advertisement from the grassroots organization (Mastroturf = 3.11, SD = .63 vs. Mgrassroots = 3.48, SD = .77). Taken as a whole, this research suggests that messages from astroturf organizations can frequently engender people’s distrust toward nonprofit organizations and can lower their willingness to engage in prosocial behaviors. Our results extend prior research demonstrating that information from astroturf organizations affects people’s trust and certainty levels regarding one specific issue (Cho et al. 2011) and suggest that the effects of exposure to astroturf messages are not limited to a specific issue. Rather, the effects can be far-reaching and diverse, since such messages can evoke skepticism toward benign intentions and programs of nonprofit organizations. Given that the insidious use of astroturf organizations is growing in popularity, this research provides meaningful insights into the influence of fake grassroots organizations and can forewarn the public of their undesirable effects on the community.
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IN DISTRUST OF MERITS: NEGATIVE EFFECTS OF ASTROTURFS ON PEOPLE'S PROSOCIAL BEHAVIORS
Jungyun Kang,Hakkyun Kim,Hosang Chu,Charles H. Cho 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.2
Will information from astroturf organizations affect people’s trust toward overall nonprofit organizations and willingness to engage in prosocial behaviors? Astroturf organizations are defined as “fake grassroots organizations animated by a clever public relations campaign and a huge budget” (Hoggan and Littlemore 2009). In other words, an astroturf organization hides its true identity by using rhetorical language to convince the public. It can be inferred that large corporations sponsor astroturf organizations to employ deceptive and fraudulent tactics as propaganda. Prior research on astroturf organizations for climate change shows that people exposed to information from astroturf organizations denying global warming tend to become more uncertain about climate issues (e.g., causes of global warming or the existence of global warming) than people exposed to information from grassroots organizations (Cho et al. 2011). We propose that information from astroturf organizations may affect not only relevant issues or organizations, but also nonprofit organizations in general, which can then lower people's willingness to engage in prosocial behaviors (e.g., donations and volunteering). Darke and Ritchie (2007) found that deceptive advertisements engender distrust and undermine the trustworthiness of subsequent advertising. The process of defensive stereotyping can explain how initial deception activates general skepticism regarding advertising. Based on such an explanation, we suggest that exposure to astroturf organizations can make consumers more logically defensive and can decrease their trust toward messages from other nonprofit organizations. Therefore, we hypothesize that people who read messages from astroturf organizations will be more distrustful toward nonprofit organizations and will display lower willingness to engage in prosocial behaviors than people who read messages from grassroots organizations. To test this hypothesis, we conducted an experiment. We used a one-factor design with two levels of organization types (astroturf vs. grassroots). Participants (N = 72) were randomly assigned to one of the two conditions. Participants were told that they would read a message captured from a website of an organization (astroturf vs. grassroots) working on global warming. After viewing the advertisement, participants completed a questionnaire measuring their trust toward nonprofit organizations in general and willingness to engage in prosocial behaviors. We assessed whether viewing the advertisement from the astroturf organization had an impact on participants' trust toward nonprofit organizations and their willingness to engage in prosocial behaviors. An analysis of variance (ANOVA), with trust toward nonprofit organizations as the dependent variable and the type of organization as the independent variable, yielded a significant effect (F = 4.38, p < .05). The results showed that participants who viewed the advertisement from the astroturf organization were more likely to be distrustful of nonprofit organizations than those who viewed the advertisement from the grassroots organization (Mastroturf = 4.14, SD = 1.48 vs. Mgrassroots = 4.80, SD = 1.16). Thus, astroturf organizations may not only confuse people about a specific issue that the respective astroturf organizations aimed to attack, but they can also significantly weaken people's trust toward nonprofit organizations in general, which suggests severe detriment for the entire society. In addition, exposure to the message from an astroturf organization appeared to have an impact on people's willingness to engage in prosocial behaviors (F = 4.77, p < .05). To be specific, people who viewed the advertisement from the astroturf organization indicated that they were less likely to engage in prosocial behaviors, compared to those who viewed the advertisement from the grassroots organization (Mastroturf = 3.11, SD = .63 vs. Mgrassroots = 3.48, SD = .77). Taken as a whole, this research suggests that messages from astroturf organizations can frequently engender people’s distrust toward nonprofit organizations and can lower their willingness to engage in prosocial behaviors. Our results extend prior research demonstrating that information from astroturf organizations affects people’s trust and certainty levels regarding one specific issue (Cho et al. 2011) and suggest that the effects of exposure to astroturf messages are not limited to a specific issue. Rather, the effects can be far-reaching and diverse, since such messages can evoke skepticism toward benign intentions and programs of nonprofit organizations. Given that the insidious use of astroturf organizations is growing in popularity, this research provides meaningful insights into the influence of fake grassroots organizations and can forewarn the public of their undesirable effects on the community.
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