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RISS 인기검색어
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- 저자 : Changyi Li (검색결과 4 건)
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The Functional Properties of Preserved Eggs: From Anti-cancer and Anti-inflammatory Aspects
Changyi Mao,Zhihui Yu,Chengliang Li,Yongguo Jin,Meihu Ma 한국축산식품학회 2018 한국축산식품학회지 Vol.38 No.3
Preserved egg, a kind of alkaline-fermented food, is a traditional egg product in China. Here, we investigated the nutritional functions of preserved eggs by in vivo and in vitro experiments. The results of in vivo studies showed that the levels of triglycerides (TG), total cholesterol (TCHO) and low-density lipoprotein cholesterol/high density lipoprotein cholesterol (LDL-C/HDL-C) were significantly decreased (p<0.05) in the liver of rats treated with preserved eggs. Meanwhile, the levels of two important cancer markers, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), were also significantly decreased (p<0.05) in treated rats. In vitro studies were performed on Caco-2 cells, a human epithelial colorectal adenocarcinoma cell line. It demonstrated that the gastrointestinal (GI) digests of preserved eggs significantly accelerated (p<0.05) the apoptosis by upregulating caspase-3 in the Caco-2 cells. Besides, after treated with preserved eggs, the half maximal inhibitory concentration (IC50) of preserved eggs digests to Caco-2 cells was 5.75 mg/mL, indicating the significant inhibition of cell proliferation provided by preserved eggs (p<0.05). The results shown in this study demonstrated that preserved eggs may be a novel functional food involved with antilipemic, anti-inflammatory activity as well as the effect on accelarating the apoptosis of Caco-2 cells.
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Frequency and Length Adjustment of A PEFP Low-Beta Dumbbell
Changyi, Gao,An, Sun,Liping, Zhang,Yazhe, Tang,Yingmin, Li,Kim, Han-Sung,Cho, Yong-Sub The Korean Society of Superconductivity and Cryoge 2008 한국초전도저온공학회논문지 Vol.10 No.2
Superconducting RF cavities are being considered for accelerating a proton beam at 700 MHz in the linac of the Proton Engineering Frontier Project (PEFP) and its post-project. Dumbbell fabrication is a mid-process for manufacturing an elliptical superconducting RF cavity. During the dumbbell fabrication, control of the dumbbell length and the $TM010\;{\pi}$ mode frequencies is necessary to build up a desired cavity. A new formula with a perturbation measurement method is used to measure and calculate the frequencies of the individual half-cells of a PEFP low-beta dumbbell, and to tune the frequency and length of the half-cells. In this article, the tuning method and results of the PEFP low-beta dumbbells have been presented.
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Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis
Lin Zhang,Changyi Li,Min Yu,Jiayin Deng,Xing Lv,Jun Liu,Yu Xiao,Wenjie Yang,Yuru Zhang 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.4
Purpose: Rheumatoid arthritis (RA) is an inflammatory joint disorder, the progressionof which leads to the destruction of cartilage and bone. Chemokines are involvedin RA pathogenesis. In this study, we investigated the chemokine signaling pathway associated with CCL2 in peripheral blood (PB) and synovial tissues (ST) of RA patients based on our previous work about chemokine signaling pathway involvedin the activation of CCL2 production in collagen-induced arthritis rat ST. Materials and Methods: Total RNA was isolated from PB leukocytes and synoviumof the knee joint in both RA patients and control populations. Real-time polymerasechain reaction was used to determine CCL4, CCR5, c-Jun, c-Fos, and CCL2 expressions. Serum level of CCL2 was assessed by enzyme-linked immunosorbent assay, and the production of CCL2 in ST was analyzed immunohistochemically. Results: The expressions of CCL4, CCR5, c-Jun, c-Fos, and CCL2 messenger RNA in RA patients were significantly higher than those in healthy controls, both in ST and on PB leukocyte. Serum CCL2 levels were elevated in RA patients. Histological examination of rheumatoid joints revealed extensive CCL2 expression in RA ST. Conclusion: CCL2, CCL4, c-Jun, c-Fos, and CCR5 may play an important role in the recruitment of PB leukocytes into the RA joints. These data provide evidence that the chemokine signaling pathway is involved in CCL2 expression in RA patient tissues, which may contribute to chronic inflammation associated with RA. Targetingthis signaling pathway may provide a novel therapeutic avenue in RA.
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Cheng Zhiping,Wang Kaifang,Li Zhongwen,Wu Haotian,Zhi Changyi,Zhang Jinbin 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1
In this paper, distributed secondary control of AC microgrid (MG) is studied and the infuence of communication delay on its control performance is analyzed and verifed. Firstly, a secondary control strategy for the MG is designed to achieve frequency recovery and proportional active power dispatch. Secondly, the stability of the MG system is analyzed in the frequency domain and a rigorous formula is derived to calculate the delay margin for the stability of the distributed secondary control with communication delays. The theoretical calculation results of the stability margin are approximately consistent with the simulation results, with an error of only 1.27%. The efects of the algorithm gains, communication topology, and connection weights on the delay margin are discussed based on the derived formula. The results demonstrate that the algorithm gain is inversely proportional to the delay margin. Changes in the communication topology and connection weights lead to changes in the maximum eigenvalue of the adjacency matrix L, which in turn afects the delay margin. Moreover, the infuence of time-varying delays is considered. The system can tolerate greater time-varying delays than fxed delays. Simulation and experimental results validate the efectiveness and feasibility of the proposed method.
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