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- 저자 : Changsong Zhao (검색결과 2 건)
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Yu, Changsong,Jia, Gang,Deng, Qiuhong,Zhao, Hua,Chen, Xiaoling,Liu, Guangmang,Wang, Kangning Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.5
Glucagon-like peptide-2 (GLP-2) is important for intestinal barrier function and regulation of tight junction (TJ) proteins, but the intracellular mechanisms of action remain undefined. The purpose of this research was to determine the protective effect of GLP-2 mediated TJ and transepithelial electrical resistance (TER) in lipopolysaccharide (LPS) stressed IPEC-J2 cells and to test the hypothesis that GLP-2 regulate TJ and TER through the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR) signaling pathway in IPEC-J2 cells. Wortmannin and LY294002 are specific inhibitors of PI3K. The results showed that $100{\mu}g/mL$ LPS stress decreased TER and TJ proteins occludin, claudin-1 and zonula occludens protein 1 (ZO-1) mRNA, proteins expressions (p<0.01) respectively. GLP-2 (100 nmol/L) promote TER and TJ proteins occludin, claudin-1, and zo-1 mRNA, proteins expressions in LPS stressed and normal IPEC-J2 cells (p<0.01) respectively. In normal cells, both wortmannin and LY294002, PI3K inhibitors, prevented the mRNA and protein expressions of Akt and mTOR increase induced by GLP-2 (p<0.01) following with the significant decreasing of occludin, claudin-1, ZO-1 mRNA and proteins expressions and TER (p<0.01). In conclusion, these results indicated that GLP-2 can promote TJ's expression and TER in LPS stressed and normal IPEC-J2 cells and GLP-2 could regulate TJ and TER through the PI3K/Akt/mTOR pathway.
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U-phosphate biomineralization induced by Bacillus sp. dw-2 in the presence of organic acids
Hong Tu,Guoyuan Yuan,Changsong Zhao,Jun Liu,Feize Li,Jijun Yang,Jiali Liao,Yuanyou Yang,Ning Liu 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.5
In this paper, we systematically investigated the influence of some selected ligands on the U-phosphateprecipitation induced by soil bacteria. These organics are widely ranging from acetate, lactate, salicylateand citrate to oxalate. The results revealed that uranium could be biomineralized on bacteria asUO2HPO4$4H2O or (UO2)3(PO4)2$4H2O. The influence of organic ligands on the biomineralization hadclear-cut correlations with its complexation abilities to uranyl. It was clearly found that the U-phosphatebiomineralization was affected noticeably by the strong ligands (oxalate and citrate). Further studydiscovered that when the organic ligands were uncompetitive with biotic PO4 3 for uranyl, the transformationof uranyl species from b-UO2(OH)2 colloidal particles to free UO2 2 þ-ligands ions could facilitatethe U-phosphate biomineralization. However, when the organic ligands competed with biotic PO4 3 foruranyl, the U-phosphate biomineralization were inhibited. Our results highlight the importance ofcomplex interactions of strong organic ligands with uranyl during the bacterial precipitation of UePcompounds and thus for the mobilization and immobilization of radio-nuclides in the nature.
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