Effect of Total Hip Arthroplasty on Ipsilateral Lower Limb Alignment and Knee Joint Space Width: Minimum 5-Year Follow-up

Choi Yun Seong,Park Jung-Wee,Kim Tae Woo,Kang Kee Soo,Lee Young-Kyun,Koo Kyung-Hoi,Chang Chong Bum 대한의학회 2023 Journal of Korean medical science Vol.38 No.20

Background: This study aimed to 1) assess the effect of total hip arthroplasty (THA) on coronal limb alignment, namely, the hip–knee–ankle angle (HKA), 2) identify factors that determine changes in the HKA, and 3) determine whether alignment changes influence the knee joint space width. Methods: We retrospectively evaluated 266 limbs of patients who underwent THA. Three types of prostheses with neck shaft angles (NSAs) of 132°, 135°, and 138° were used. Several radiographic parameters were measured in the preoperative and final radiographs (at least 5 years after THA). A paired t-test was used to confirm the effect of THA on HKA change. Multiple regression analysis was performed to identify radiographic parameters related to HKA changes following THA and changes in knee joint space width. Subgroup analyses were performed to reveal the effect of NSA change on the HKA change, and the proportion of total knee arthroplasty usage and changes in radiographic parameters between maintained joint space and narrowed joint space groups were compared. Results: The preoperative mean HKA was 1.4° varus and increased to 2.7° varus after THA. This change was related to changes in the NSA, lateral distal femoral angle, and femoral bowing angle. In particular, in the group with a decrease in NSA of > 5°, the preoperative mean HKA was largely changed from 1.4° varus to 4.6° varus after THA. The prostheses with NSA of 132° and 135° also led to greater varus HKA changes than those with an NSA of 138°. Narrowing of the medial knee joint space was related to changes in the varus direction of the HKA, decrease in NSA, increase in femoral offset. Conclusion: A large reduction in NSA can lead to considerable varus limb alignment after THA, which can have adverse effects on the medial compartment of the ipsilateral knee.

Projections of summertime ozone concentration over East Asia under multiple IPCC SRES emission scenarios

Lee, Jae-Bum,Cha, Jun-Seok,Hong, Sung-Chul,Choi, Jin-Young,Myoung, Ji-Su,Park, Rokjin J.,Woo, Jung-Hun,Ho, Changhoi,Han, Jin-Seok,Song, Chang-Keun Elsevier 2015 Atmospheric environment Vol.106 No.-

<P><B>Abstract</B></P> <P>We have developed the Integrated Climate and Air Quality Modeling System (ICAMS) through the one-way nesting of global–regional models to examine the changes in the surface ozone concentrations over East Asia under future climate scenarios. Model simulations have been conducted for the present period of 1996–2005 to evaluate the performance of ICAMS. The simulated surface ozone concentrations reproduced the observed monthly mean concentrations at sites in East Asia with high R<SUP>2</SUP> values (0.4–0.9), indicating a successful simulation to capture both spatial and temporal variability. We then performed several model simulations with the six IPCC SRES scenarios (A2, A1B, A1FI, A1T, B1, and B2) for the next three periods, 2016–2025 (the 2020s), 2046–2055 (the 2050s), and 2091–2100 (the 2090s). The model results show that the projected changes of the annual daily mean maximum eight-hour (DM8H) surface ozone concentrations in summertime for East Asia are in the range of 2–8 ppb, −3 to 8 ppb, and −7 to 9 ppb for the 2020s, the 2050s, and the 2090s, respectively, and are primarily determined based on the emission changes of NO<SUB>x</SUB> and NMVOC. The maximum increases in the annual DM8H surface ozone and high-ozone events occur in the 2020s for all scenarios except for A2, implying that the air quality over East Asia is likely to get worse in the near future period (the 2020s) than in the far future periods (the 2050s and the 2090s). The changes in the future environment based on IPCC SRES scenarios would also influence the change in the occurrences of high-concentrations events more greatly than that of the annual DM8H surface ozone concentrations. Sensitivity simulations show that the emissions increase is the key factor in determining future regional surface ozone concentrations in the case of a developing country, China, whereas a developed country, Japan would be influenced more greatly by effects of the regional climate change than the increase in emissions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Change in ozone level is determined by the combination of NO<SUB>x</SUB> and NMVOC emissions. </LI> <LI> Ozone level over East Asia would get worse in the near future (the 2020s) than far future. </LI> <LI> A high-concentration event generally increases and more frequently occurs in the future. </LI> <LI> Change in ozone air quality in a developing country depends more on emissions change. </LI> <LI> Change in ozone air quality in a developed country depends more on climate change. </LI> </UL> </P>

Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice

Yoon, Hye Eun,Kim, Eun Nim,Kim, Min Young,Lim, Ji Hee,Jang, In-Ae,Ban, Tae Hyun,Shin, Seok Joon,Park, Cheol Whee,Chang, Yoon Sik,Choi, Bum Soon Hindawi Publishing Corporation 2016 Oxidative medicine and cellular longevity Vol.2016 No.-

<P><I>Background</I>. This study evaluated whether the change in the renin-angiotensin system (RAS) is associated with arterial aging in mice.<I> Methods</I>. Histologic changes and expressions of transforming growth factor-<I>β</I> (TGF-<I>β</I>), collagen IV,<I> fibronectin</I>, angiotensin II (Ang II), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), prorenin receptor (PRR), Mas receptor (MasR), endothelial nitric oxide synthase (eNOS), NADPH oxidase 2 and oxidase 4 (Nox2 and Nox4), 8-hydroxy-2′-deoxyguanosine (8-OHdG),<I> 3-nitrotyrosine</I>, and superoxide dismutase 1 and dismutase 2 (SOD1 and SOD2) were measured in the thoracic aortas from 2-month-old, 12-month-old, and 24-month-old C57/BL6 mice.<I> Results</I>. Twenty-four-month-old mice showed significantly increased aortic media thickness and expressions of TGF-<I>β</I>, collagen IV, and fibronectin, compared to 2-month-old and 12-month-old mice. The expressions of PRR, ACE, and Ang II, and AT1R-positive area significantly increased, whereas expressions of ACE2 and MasR and AT2R-positive area decreased with age. The expressions of phosphorylated serine<SUP>1177</SUP>-eNOS, SOD1, and SOD2 decreased, and the 8-OHdG-positive area and the 3-nitrotyrosine-positive area increased with age. The expression of Nox2 significantly increased with age, but that of Nox4 did not change.<I> Conclusions</I>. The enhanced PRR-ACE-Ang II-AT1R axis and reduced ACE2-MasR axis were associated with arterial aging in mice. </P>

한ㆍ일 도시가스산업의 생산성 비교분석

최인수(In Su Choi),도범성(Bum Sung Do),박창수(Chang Soo Park),박중구(Jung Gu Park) 한국가스학회 2009 한국가스학회지 Vol.13 No.2

본고는 21세기 들어 고유가와 기후변화협약에 대응하여 중요성이 더해지고 있는 한국과 일본의 도시가스기업의 생산성을 분석하였다. 맘퀴스트 생산성 지수(Malmquist Productivity Index: MPI)를 통해 1997년부터 2005년까지 한국 30개, 일본 5개 기업들의 재무제표를 활용하여 기간 전체로, 그리고 수요의 구조변화를 나타내었던 2000년을 기준으로 이전과 이후의 생산성을 평가하였다. 분석의 결과, 첫째, 1996년~2005년 전체 기간의 MPI 누적지수에서 한국의 도시가스산업이 일본보다 상위에 있는 것으로 분석되었다. 그러나 기간별로 본 MPI 개선효과는 일본의 경우 1997~2000년 동안 -1.03%에서 2001~2005년 동안에는 -1.72%로 근소한 차이를 나타낸 반면, 한국의 경우에는 전반기 0.37%(금융외환위기를 경험한 98년 제외시 0.80%)이었지만 후반기에 -0.60%로 악화된 것으로 나타났다. 둘째, 후반기 한국의 MPI 악화는 기술적 효율성 지수보다는 기술변화 지수가 전반기 -0.88%(98년 제외시 0.29%)에서 후반기 -1.29%로 크게 악화된 것에 기인하는 것으로 분석되었다. 이에 따라 한국의 도시가스사업은 2001년 이후 악화되고 있는 생산성 증가율과 악화의 요인이 되고 있는 기술변화를 개선하는 정책적 노력이 필요하다. This article makes a comparative analysis on the productivity in gas distribution industry between Korea and Japan, using Malmquist productivity index(MPI). The estimated MPI during 1997~2005 shows that the productivity of Korean gas distribution industry has been generally higher than that of Japanese gas distribution industry. But Korean MPI made a drastic change from positive improvement (+ 0.37) during 1997~2000 to severe deterioration (-0.60) during 2001~2005, while Japan MPI has seldom changed. This change of Korean MPI is analyzed to result from the worsening of technical change rather than technical efficiency change. According to this result, Korean gas distribution industry needs to improve the technical change.

요추 추간판탈출증 수술 후 임상 증상의 회복

신병준,김준범,조영훈,권희,서유성,김연일,나수균,최창욱 대한척추외과학회 1997 대한척추외과학회지 Vol.4 No.2

Study Design : The authors retrospectively analysed the recovery of clinical symptoms after surgical treatment of lumbar HIVD. Objectives : To investigate the incidence of clinical symptoms, the recovery rate and time after surgical treatment and the difference between L4-5 and L5-S1 lesion. Summary of Literature Review : There are many reports concerning the clinical result of surgical treatment for the HIVD. They usually describe the result as excellent, good, fair and poor. We can't get any information about the recovery rate and recovery time of each clinical symptom from the reports. Materials and Methods : Thirty-eight patients were treated by one level open discectomy from march 1991 to december 1995. The clinical symptoms and signs including SLR, motor deficit, sensory deficit, change of DTR and severity of radiating pain were periodically followed up on the predesigned protocol, Results : In preoperative examination, SLR was positive in 82%, motor deficit in 76%, sensory deficit in 74%, DTR change in 50%, and radiating pain in 100%. The recovery rate of SLR was 96.8%, motor deficit ; 93.6%, sensory deficit ; 78.6%, DTR change ; 21 % and radiating pain ; 84.2%. The average recovery time of SLR was 3.4 months, motor deficit ; 1.9 months, sensory deficit ; 5.3 months, DTR change ; 4.1 months and radiating pain ; 3.2 months. Motor and sensory deficit was more frequent in L4-5 lesion but DTR change was usually noted in L5-S] lesion. The recovery rate and time showed no great difference between the two level. Conclusions : The recovery rate was higher in SLR, motor deficit and radiating pain rather than sensory deficit and DTR change. The recovery time was fastest in radiating pain but variable nature was noted in sensory deficit. Above results may be helpful to explain the prognosis of the lumbar HIVD.

다양한 골 이식재의 임상 효과에 대한 고찰

이승범,연제영,채경준,정의원,김창성,이용근,조규성,채중규,김종관,최성호,Lee, Seung-Bum,Yon, Je-Young,Chae, Gyung-Joon,Jung, Ui-Won,Kim, Chang-Sung,Lee, Yong-Geun,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.4

Purpose: Various bone graft materials are being used for periodontal tissue regeneration. Th materials are being developed continuously for ideal clinical effects. Therefore, it is necessary to identify the clinical characteristics of each bone graft material through comparing the various bone graft materials statistically and in doing so, proposing a more efficient bone graft material. In this study, the following results were attained through comparing the clinical effects among the bone graft materials, using the statistical method based on the clinical studies published at the department of periodontology of Yonsei hospital. Materials and Method: 6 selected studies of department of Periodontology at Yonsei University Hospital were based on clinical study of bone grafting in intrabony defects. It was compared the clinical parameters among the 6 clinical studies, using the statistical META analysis. Result: When comparing the probing depth reduction, there was a relatively great amount of decease when using the xenograft, Anorganic Bovine Derived Hydroxapatite Bone Matrix/Cell Binding Peptide(ABM/P-15: PepGen $P-15^{(R)}$) and the autogenous bone and absorbable membrane, d, 1-alctide/glycolide copolymer(GC: $Biomesh^{(R)}$). The allogfrafts showed a relatively low decrease in the probing depth and clinical attachment change. It also showed a slight decrease in the bone probing depth. The allografts showed various results according to different bone graft materials. When comparing the ABM/P-15 and bovine bone $powder(BBP^{(R)})$, ABM/P-15 showed a relatively high clinical attachment level and the bovine bone powder showed a relatively high clinical attachment level. The probing depth change and gingival recession change showed a lower value than the mean value between the two bone graft materials. The synthetic bone showed a relatively high decrease in clinical attachment level and periodontal probing depth change. There was a relatively larger amount of gingival recession when using Bioactive Glass(BG) but a relatively low bone regeneration effect was seen. Conclusion: Good restorative results of the periodontal tissue can be attained by applying the various bone graft materials being used today after identifying the accurate clinical effects.

공공체육시설의 활용방안

최종환,김창범,이규문,김태완,김현준,박종진 忠北大學校 平生體育硏究所 1995 平生體育硏究所 論文集 Vol.7 No.-

An effective use of public facilities for life sports was studied. The purpose of this study was 1) to examine the present management and sport programs of the public sport facilities, and 20 to provide more effective and productive sports management and programs for Cheongju-city community, which will be resulting in an independence of Chungbuk Athletics Association and the enhancement of level of citizens' health and physical fitness. After the investigation on the present situations of managing public sport facilities, this study showed the following results and suggestions. First, this study found several problems (e.g, a few numbers of sport experts and programs, ineffective opening and closing time for each facility, etc..) and suggested new plans on the management of public facilities for sport activities. Second, this study provided more practical sport programs for each age group, regarding to each public sport facility. In addition, these sport facilities were also used for cultural activities and resting places for the community. Third, this study also suggested that an indepence of Chungbuk Athletic Association and the enhancement of level of citizens' health and physical fitness should be consequently accomplished by activation of effective management on sport programs and facilities.

東國大學校 雲吉山 然習林의 植物相(Ⅱ)

崔相範,金昌浩 동국대학교 1985 論文集 Vol.24 No.-

The area of Mt. Ungil in which the experiment forest of Dongguk University is situated has abundant rainfall as well as proper amount of moisture and humidity due to the nearby flowing Han River and Jin-joong Cheon. This climatic and geographic factors provide the forest with an ideal condition for tree-growing, which has resulted in the growth of a variety of trees in that area. Since the Kwang-joo mountains stretch toward north-east, the school forest is well connected with the surrounding forests, and thus various wild trees and plants are evenly distributed in the area. The range of plants living in the area was surveyed from summer to autumn of 1983, and it was found that is consists of 64 families, 259 genera, 397 species, 60 varieties and 3 kinds.

편측안면경련에 대한 미세혈관압술시 수술시야 확보를 위한 방법으로서 소뇌피질동맥 박리술 - 수 술 수 기 -

김범태,임수빈,장재칠,신윈한,최순관,변박장 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.11

정신분열병 환자의 반응시간

최형식,정범석,김한규,송현주,이재원,김창윤 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구배경: 주의력은 인지적인 정보처리과정(information processing)의 가장 기본적인 단계이다. 반응시간 (reaction time)은 주의력을 가장 잘 반영하는 검사 중 하나로서, 자극이 제시된 후 반응이 시작되기까지 반응 여부를 결정하는데 걸리는 시간인 판단 시간(decision time)과 반응이 시작되면서 목표에 도달할 때까지 시간인 운동시간(motor time)으로 나누어 볼 수 있다. 기존의 연구결과로는, 정신분열병 환자군에서 반응시간의 수행이 떨어져 있다는 보고는 많이 되어왔으나 차이가 없다는 보고도 있으며, 판단시간과 운동시간 중 어느 부분에 장애가 있는지 명확하지 않다. 또한 반응시간 측정값은 질병의 진단적 유형(diagnostic subtype), 증상, 경과 등의 영향을 받으며 개체간의 변동(inter-individual variation)이 크고, 같은 피험자라도 측정시점이 다를 때마다 차이를 보이는 개체내 변동(intra-individual variation)이 커서 검사결과마다 차이를 보이고 있는 상태이다. 목적: 환자군은 개체간 변동이 크고 다른 임상적 요소에 의해 영향받는 점을 고려하여, 임상적으로 안정적인 경과에 있는 정신분열병 환자만을 대상으로 정상인 군과 반응시간의 차이를 비교하고자 하였다. 또한 반응시간을 판단시간과 운동시간으로 나누어 측정하여 각각을 비교분석 하고자 하였고, 개체내 변동이 큰점을 고려하여 25회 반복 측정을 실시하고 이에 따른 변동의 경향성을 조사하고자 하였다. 방법: DSM-Ⅳ에 의해 '정신분열병'으로 진단된 환자로서, 급성기 이후 항정신병약물을 유지하고 있으며BPRS(brief psychiatric rating scale) 30점 이하의 임상적으로 안정적인 상태가 3개월 이상 유지된10명이 환자군으로 포함되었고, 정상인은 자원자 10명이 포함되었다. 검사도구는 비엔나 테스트 시스템 반응유닛(Reation Unit) 파라미터 S8을 이용하였다. 총 6가지의 자극이 무작위로 1측정시기(session) 당 총 32회 주어지고, 피험자는 이중 특정 자극에 8번만 반응하도록 되어 있다. 시작 전 1회 연습 후 총 25측정시기를 5분 간격으로 반복하였다. 반응 시간을 판단시간과 운동시간의 합으로 정의하고 세 가지 모두 컴퓨터를 이용하여 자동 측정되었다. 반응·판단·운동 시간의 비교에는 반복 측정을 고려한 분산분석(repeated measures analysis of variance)을 사용하였다. 결과: 환자군은 정상인에 비하여 유의하게 반응시간의 수행속도가 저하되어 있었다(p<0.01). 판단시간과 운동시간으로 나누어 볼 때, 환자군에서 판단시간이 유의하게 느렸고(p<0.01), 운동시간은 수행저하의 경향을 보였으나 통계적으로 유의하지는 않았다. 25회 반복측정시 양군 모두 측정시기에 따른 유의한 변화를 보였고(p<0.01), 환자군의 반응시간은 개체간의 차이뿐 아니라 개체내 변동이 큰 경향을 보였다. 옳게 반응한 횟수(correct response)는 환자군에서 저하되는 경향을 보였으나 통계적으로 유의하지는 않았다. 고찰: 정신분열병 환자군에서 판단시간이 유의하게 저하된 것은, 반응시간의 저하가 운동요소 보다는 인지적 요소에 의한 것임을 시사하는 것으로, 정보처리과정의 기본적인 단계인 주의력 장애를 보여주는 것으로 생각된다. 비교적 안정적이고 임상적인 특성이 동일한 환자군에서도 반응시간이 대조군에 비해 큰 개체간 차이와 개체내 변동성의 경향을 보였으며, 이는 단순한 측정오차라기 보다는 정신분열병 환자군의 인지기능의 특성을 반영하는 것으로 생각된다. 중심단어:정신분열병·반응시간·판단시간·운동시간·개체간 변동·개체내 변동. The reaction time(RT) has been known to reflect attention that controls the flow of information processing. Extensive research has demonstrated cognitive impairment in schizophr-enia subjects using RT taske. However, little work has been done examining the relative contribution of DT(decision time) and MT(motor time) to slowed RT in schizophrenics. Also, recent investigators have observed that schizophrenic patients exhibit larger intra-individual variability in RT than do normal comparison subjects. The purpose of this study, using multi-stimulus convergent RT task, was to explore the speed of RT, relative contribution of decision time(DT) and motor time(MT) to slowed RT, overall sequential profile in 25 repeated-time measurements in 10 schizophrenic out-patients and 10 normal control subjects. Overall reaction time and decision time were slower in schizophrenic subjects than in normal controls. The motor time was not shown to be significantly different between the two groups with 0.05 significance level, although there was some trend indicating schizophrenic subjects were slower consistently in repreated measurements over time. These results suggested that the slower reaction time in schizophrenic subjects was mostly determined by cognitive component, decision time rather than motor time. Sequential profile of repeated measurements showed greater intraindividual and interindividual variations in schizphrenics than in normal controls. These results indicate that high variabilities are not merely measurement errors but characteristic of schizophrenic psychopathology. KEY WORDS: Schizophrenia·Reaction time·Decision time·Motor time·Inter-individual variation·Intra-individual variation.