Bacteriology of chronic suppurative otitis media : a multicenter study

YEO, SEUNG GEUN,PARK, DONG CHOON,HONG, SEOK MIN,CHA, CHANG IL,KIM, MYUNG GU WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Conclusions. Bacterial predominance and antibiotic sensitivity have changed over time, making continuous and periodic surveillance necessary in guiding appropriate antibacterial therapy. Objectives. With the development and widespread use of antibiotics, the types of pathogenic microorganisms and their resistance to antibiotics have changed. Knowledge of the species and resistance rates of current pathogens is important for determining the appropriate antibiotics for patients with chronic suppurative otitis media. We investigated the current bacteriology of chronic suppurative otitis media. Subjects and methods. This was a retrospective study of 1102 patients with chronic suppurative otitis media seen at six hospitals in Korea from January 2001 to December 2005. Results. The most commonly identified pathogenic bacterial species was Pseudomonas, with the next most prevalent being methicillin-resistant Staphylococcus aureus (MRSA).

면역요법이 비점막 및 말초혈액 단핵구의 Interleukin-4와 Interferon-γ 생산에 미치는 영향

여승근,조중생,진영완,차창일,김기주,박경유 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.6

저강도 초음파 및 레이저를 이용한 장관골 불유합의 치료

전인호,오창욱,김성중,경희수,박일형,박병철,인주철,여준영 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 저강도 초음파는 인체 및 동물 실험에서 골조직에 낮은 미세한 물리적 압력을 가하여 골절의 치유에 유리한 영향을 주고, 레이저 (LASER)는 심부 조직에 혈류를 증가시키고, 세포 내 잠재된 에너지를 증가시키는 것으로 알려져 있다. 이에 저자들은 임상적으로 확진된 장관골 붕류합의 치료에 있어 펄스형 저강도 초음파와 레이저를 적용하고 그 효용성을 알아보고자 하였다. 대상 및 방법: 초음파/레이저의 치료 효과를 비교하기 위하여 장관골 불유합으로 확진된 16예 중 8예는 연구군으로 골이식술 후 저강도 초음파와 레이저 치료를 추가하였고 대조군 8예에 대해선 일반적인 골이식술만 시행하여 조사하였다. 남자가 11예, 여자가 5예, 평균 연령은 41.7세 (19~62세)였고, 불유합 부위는 대퇴골이 10예, 경골이 6예였다. 첫 수상으로 인한 골절 후 초음파/레이저 치료까지 시간(골절 연력)은 평균 502일이었다. 결 과: 8예의 연구군에서는 완전 골유합이 6예에서 이루어졌으며 유합까지의 시간은 평균 141일 (101~202일)로 나타난 반면, 8례ㅢ 대조군에서는 5예에서 골유합이 이루어졌고, 유합까지의 시간은 평균 240일 (183~283일)이었다. 결 론: 저강도 초음파/레이져 골절 치료기가 반복된 수술로 인한 난치성 장관골 불유합의 치료에 있어 골이식술과 함께 사용될 경우 긍정적인 효과가 있었고, 특히 최초 가골 형성에 있어 대조군에 비해 그 시간을 줄일 수 있었따. Purpose: Low-intensity, pulsed ultrasound (LIPUS) has demonstrated a stimulation and acceleration of the normal fracture-repair process in cellular bases as well in animal and human models. In this study, the adjunctive effect of LIPUS and LASER was investigated in established nonunion of the long bones. Materials and Methods: Study group consisted of eight patients to whom conventional bone graft and adjunctive LIPUS and LASER was applied. On the other hands, eight patients in the control group underwent bone graft only. Eleven men and five women were included in this study and the average age of the patients was 41.7 years (range, 19~62 years). Six of the tibias and ten of the femurs met the criteria for established nonunion. The average fracture age, the post-fracture period before the start of LIPUS/LASER treatment, was 502 days. Results: Seven of the ten nonunions who were treated by LIPUS and LASER healed completely in an average treatment time of 141 days (range, 101~202 days) and otherwise, in control group, five of the eight nonunions healed completely, in 240 days (range 183~283 days). Conclusion: This clinical study showed a positive effect of LIPUS and LASER on the rate of osseous repair, especially accelerated time to initial callus cortical bridging compared to that of conventional treatment.

원전 운전원의 직무 스트레스 검사 개발 및 타당화

안창일(Chang-Il Ahn),안귀여 루(Gwi-Yeo-Roo Ahn),윤선아(Seon-Ah Yoon) 대한스트레스학회 2008 스트레스硏究 Vol.16 No.1

The purpose of this research was to develop a stress inventory applying to nuclear power plant operators and explore various methods of improving job performance of the operators. The inventory constructed by this study consists of three parts. First, "job stress" which measures various stress sources such as individual, group, environment and task-specific factors. Second, "resulting behaviors" which measures various damages of physiological, psychological and behavioral aspects as well as the strength of social support system. Finally, "personality" which measures factors such as aggression, sensitivity and timidity. Reliabilities of the test varied with the sub-scales: .71∼.89 in job stress, .81∼.96 in resulting behaviors, and .60∼.91 in personality sub-scales. Factor analysis was conducted to find 3 factors. The first factor contains personality, the second resulting behaviors, and the third job stress. Relatively high correlations are calculated among the objective stress scores earned from the test and the subjective stress appraisal reported by the individuals and their job change wishes. Therefore it can be said that the test constructed in this study is validated.

Expression of Toll-like Receptors 2 and 4 and Immunoglobulins in Children wih Recurrent Otitis Media with Effusion

Cha, Chang-Il,Lee, Young-Chan,Park, Dong-Choon,Kim, Young-Il,Lee, Jin-Woo,Yeo, Seung-Geun The Korean Association of Immunobiologists 2008 Immune Network Vol.8 No.2

Background: Toll-like receptors (TLRs) detect microbial infection and can directly induce innate host defense responses, which are thought to play critical roles in protecting the tubotympanum from infection. However, little is known about the relationship between TLRs, which are related to innate immunity, and immunoglobulins, which are related to adaptive immunity, in recurrent otitis media with effusion (OME). We therefore investigated the expression of TLR2 and TLR4 and immunoglobulin in children with OME. Methods: The study population consisted of 72 children with OME, 31 with more than 4 episodes in 12 months or more than 3 episodes in 6 months (otitis-prone group), and 41 with fewer than 3 episodes in 12 months (non-otitis prone group). The expression in middle ear effusion of TLR2 and TLR4 mRNA, as determined by Real time- -polymerase chain reaction (RT-PCR), and the concentrations of IgG, IgA, and IgM, as determined by Enzyme-linked immunosorbent assay(ELISA), were compared between the two groups. Results: Expression of TLR2 and TLR4 mRNA was lower in the otitis prone than in the non-otitis prone group, but the difference was not statistically significant (p>0.05). Between group differences in the concentrations of IgG, IgA and IgM in effusion fluid were not significant (p>0.05), and there were no correlations between immunoglobulin concentration and the expression of TLR2 and TLR4. Conclusion: Although there was a trend toward lower expression of TLR2 and TLR4 in the otitis-prone group, the differences, and those in immunoglobulin concentration, did not differ significantly between the otitis-prone and non-prone groups.

정보 인권과 민주주의를 위한 입법 과제

장여경(Chang Yeo Kyung),오병일(Oh Byoung Il),정민경(Jeong Min Kyung) 서강대학교 법학연구소 2012 서강법률논총 Vol.1 No.2

Lee Myoungbak and previous administrations has focused on the introduction of new technologies and the promotion of related industries in the national IT policy. Now it’s time to change the policy paradigm from industry-centric to democracy-centric. It’s a change of the perspective in the design of institutions to improve the quality of civil life and promote democracy in the society rather than the efficiency and the development of the industries. On the other hand there comes up the policy agenda to construct the information democracy and the horizontal and participatory social IT system in national IT environment. It’s necessary to pay attention to human rights in digital age to realize those agenda.

Temporal Changes of the Calcium-binding Proteins in the Medial Vestibular Nucleus following Unilateral Labyrinthectomy in Rats

Hong, Seok-Min,Lee, Jae-Hee,Yeo, Seung-Geun,Cha, Chang-Il,Park, Byung-Rim The Korean Society of Pharmacology 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.3

Calcium ($Ca^{2+}$) is an intracellular second messenger associated with neuronal plasticity of the central nervous system. The calcium-binding proteins regulate the $Ca^{2+}$-mediated signals in the cytoplasm and buffer the calcium concentration. This study examined temporal changes of three calcium-binding proteins (calretinin, calbindin and parvalbumin) in the medial vestibular nucleus (MVN) during vestibular compensation after unilateral labyrinthectomy (UL) in rats. Rats underwent UL, and the changes in the expression of these proteins at 2, 6, 12, 24, 48, and 72 h were examined by immuno-fluorescence staining. The expression levels of all three proteins increased immediately after UL and returned to the control level by 48 h. However, the level of calretinin showed changes different from the other two proteins, being expressed at significantly higher level in the contralateral MVN than in the ipsilateral MVN 2 h after UL, whereas the other two proteins showed similar expression levels in both the ipsilateral and contralateral MVN. These results suggest that the calcium binding proteins have some protective activity against the increased $Ca^{2+}$ levels in the MVN. In particular, calretinin might be more responsive to neuronal activity than calbindin or parvalbumin.

열처리 시간에 따른 중적외선 투과 ZnS 세라믹의 합성과 특성

권태형,여서영,박창순,김창일,홍연우,백종후,Kwon, Tae-Hyeong,Yeo, Seo-Yeong,Park, Chang-Sun,Kim, Chang-Il,Hong, Youn-Woo,Paik, Jong-Hoo 한국센서학회 2017 센서학회지 Vol.26 No.5

In this study, a heat treatment process was applied to ZnS nano-powder to improve the optical properties of ZnS ceramic, and the characteristics of heat treatment time were studied. The ZnS nano-powders were synthesized by hydrothermal synthesis. The heat treatment was carried out at $550^{\circ}C$ for 0.5, 1, 2, and 4 hours in a vacuum atmosphere ($10^{-2}torr$). X-ray diffraction and scanning electron microscope analyzes confirmed the change of crystal phase and grain size to confirm the structural change with heat treatment time. The heat treated ZnS nano-powder was sintered by hot pressing, and the change of optical properties of the ZnS ceramic was analyzed by infrared spectroscopy.

비용에서 Eotaxin-mRNA의 발현양상

여승근,조중생,차장일,박경유,박미자,허영범,조정제 경희대학교 2000 慶熙醫學 Vol.16 No.2

절식이 쥐의 후구에서 Nitric Oxide의 발현에 미치는 영향

여승근,박동춘,한정욱,윤상원,허영범,안희영,차창일,조중생 경희대학교 2002 慶熙醫學 Vol.18 No.2