Ischemia-Related Changes in Galanin Expression in the Dentate Hilar Region after Transient Forebrain Ischemia in Gerbils

LEE, Hyeon Yong,HWANG, In Koo,KIM, Dae Ho,KIM, Jung Hwa,KIM, Chang Ho,LIM, Beong Ou,KANG, Tae-Cheon,BANG, Kyung Hwan,SEONG, Nak Sul,LEE, Hak Ju,KIM, Jong Dai,WON, Moo Ho Japanese Association for Laboratory Animal Science 2005 EXPERIMENTAL ANIMALS Vol.54 No.1

<P>Although galanin (GAL) protects hippocampal neurons from ischemic damage, no study has examined ischemia-related changes in endogenous GAL in the hippocampal dentate gyrus. We investigated the chronological changes of GAL, well-known as the potassium channel opener, expression in the dentate gyrus at various times after 5 min of transient forebrain ischemia in gerbils. A few GAL-immunoreactive (IR) neurons were found in the polymorphic layer of the sham-operated group. Three hours after ischemia-reperfusion, the pattern of GAL immunoreactivity was similar to that of the sham-operated group and the number of GAL-IR neurons and immunoreactivity were highest 12 h after ischemic insult. At this time, GAL-IR neurons in the polymorphic layer showed strong GAL immunoreactivity. Thereafter, GAL-IR neurons and immunoreactivity significantly decreased in the dentate hilar region. Four days after ischemic insult, GAL-IR neurons were not detectable. In addition, the results of a Western blot study showed a pattern of GAL expression similar to the immunohistochemical changes. GAL protein content also was highest 12 h after ischemia. In conclusion, the increased expression of endogenous GAL in the dentate gyrus after ischemia is related to response to the ischemic damage.</P>

영양표시정착화사업(Ⅱ) : 식품참고량설정에 관한 연구 Study on the Establishement of the Reference Amount in Foods

김대병,장영미,김인복,이혜영,장재희,김보영,이정구,김창민,정해랑 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 영양표시에서 1회분량 및 영양소함량표시의 기준으로 사용되는 "식픔창고량"에 관한 연구를 수행하므로써 합리적이고 일관성있는 영양표시기준 개선을 위한 기초자료로 활용코자 하였다. 이를 위하여 미국 및 캐나다를 중심으로 제외국의 현황 및 식품참고량 설정방법을 조사 ·연구 하으며 제도도입 및 개선 방안을 강구하였파. 또한, 시판 제품의 영양료시현황 및 음료류 둥의 포장단위 등을 피악하여 식품참고량설정을 위한 기초자료로 활용코자 하였다. 앞으로 국민건강 ·영양조사자료의 체계적인 통계분석, 가공식품의 섭취량조사 등을 통하여 우리나라 국민의 1인 1회 섭취량자료의 축적이 선행되어야 할 것이다. The purpose of this ?roject is to study on the reference amounts customarily consumed per eating occasion to improve the nutrition labelling standards. We Performed to study on the methodology to establish the reference amounts on the basis of the review on the advanced counITy's status. And we investigated the packaged unit ofprocessed foods. Further study is needed to establlsh the customarily consumed amount per eating occasionthrough the statistical analysis of nationwide food consumption data. Our results will be helpful information to improve nutrition labelling system in Korea.

HEC-GeoRAS 모형에 의한 침수면적산정 사례연구

김창수(Chang Soo Kim),이영대(Young Dai Lee),이환우(Hwan Woo Lee) 한국방재안전학회 2009 한국방재안전학회 논문집 Vol.2 No.4

지난 몇 년 동안 우리나라는 생명과 재산에 엄청난 피해를 준 홍수를 겪었다. 태풍에 의해 발생한 홍수는 가장 일반적인 자연 재해의 한 형태이다. 지구온난화로 인한 지구의 기온상승으로 인해 태풍의 발생 가능성도 증가하게 되었다. 홍수시 강우 도달시간이 감소됨과 함께 강의 수위상승이 일어나며 최대 유출량도 증가되어 왔다. 게다가, 국토 부족을 해결하기 위한 여러가지 국토정비사업과 함께 침수피해는 계속 증가되어 오고 있다. 1960년대에는 농경지, 1970년대에는 산업시설 및 공공시설에 각각 많은 피해가 있었으며, 1980년대에 는 많은 용수해 피해가 있었다. 그리고 1990년대에는 그 피해의 규모가 상당히 증가하였다. 따라서 자연재해에 대한 예방조치를 통해 태풍과 홍수로부터의 희생자와 재산 손실을 줄일 필요가 있다. 본 연구에서는 침수지역의 깊이와 양을 계산하여 홍수피해를 예측하고 예방하기 위해서 시뮬레이션 시스뎀이 도입되었다. 본 연구에서는 침수를 모의 할 수 있는 HEC-GeoRAS와 ArcView를 이용하여 침수면적 및 침수심을 산정하는데 그 목적이 있다. 이번 연구가 재해 관리 분야의 전문가들과 기관들에 유용한 정보를 제공할 것으로 기대한다. During the past few years, Korea has experienced extraordinary floods, which have caused many damagesof lives and properties. Flooding caused by typhoon is the most common disastrous phenomenon of nature among all catastrophes. As the average temperature of the earth has been increasing by global warming, the possibility of typhoon is also increased by abnormal climate changes. Along with the river improvement as a part of flood control, the time of concentration has been decreased, so the pick discharge has been increased. Moreover, with the land development activities, the area of storage has been diminishing, and the damages from inundation have been continuously increasing. There were a lot of damages to farmland in l960's, industrial and public facilities in l970's, and a lot of sufferings from the windstorm in l980's. In l990's, however, the amount of damages was increased substantially. So, there is need to decrease the number of the victims and loss of properties by applying preventive measures against natural calamities. This study has employed a simulation system to calculate the depth and amounts of inundation areas to forecast and prevent from flood damage by using rainfall-runoff model. In this study, a case study method is adopted to show inundation by using ra infall-runoff model, HEC-GeoRAS and Arcview. It is hoped that, this study would be conducive to professionals and organizations working in the field of disaster management.

S-상 심실중격의 임상적 고찰

이동민,장경식,양종태,장대용,김종오,서영욱,고영엽,홍순표 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background: The sigmoid septum described an anatomical variation in the contour of the left ventricular outlet. It is related to degenerative change with aging. We observed clinical significance of sigmoid septum in Korean. Methods: Echocardiographic examination was performed in 434 patients. Sigmoid septum is defined as discrete bulging of the proximal interventricular septum with that thickness is greater than 1.3cm or the thickness is grater 1.5 times than adjacent mid interventricular septum in apical 3 chamber view. Result: The incidence of patient with sigmoid septum(septum patient) is 24.8% (male 8.4%, female 16.3%) . The incidence increases with age and is more common in women. The patients with sigmoid septum were compared with targeted groups, there was no significant difference in blood pressure between them, but in height and weight, the former were lower. (p<001, p<03). In the patients with sigmoid septum, weight and the surface area of a body have an opposite correlation with increase of age (p<03, r=-0.34) (p<04, r=-0.31) , but no decrease of height was found according to age increase (p=0.47, r=-0.11) The main reason patients with sigmoid septum ask echocardiolography and its clinical symptoms were abnormal results of previous electrocardiography and/or usual chest pain. Compared with control group, interventricular septal thickness is larger in septum patients (p<001). The thickness of interventricular septum located in subaortic left ventricular outflow tract is 1.6±0.3cm. There is another web like structure that continued from interventricualr septum to anterior free wall of left ventricle and the width is 1.6±0.4cm. A sign of insignificant obstruction due to left ventricular outflow was observed from three sigmoid septum patients. Conculusion: Septum patient is largely found in older age group and the body weight and body surface area are lower than control group. The body weight and body surface area are opposite correlation with age. So sigmoid septum is considered as structural change by weight reduction with aging. It is assumed that septum patients are related with asymptomatic ischemia because they have more abnormal ECG finding such as T wave inversion on precordial leads or standard leads, nonspecific ST-T change, LBBB etc. Sigmoid septum is not only proximal interventricular septal bludging but also another web like structure continuing to anterior wall of left ventricle.

일부 시판세치제의 비교치아마모도 및 경과시간에 따른 유효불소농도변화에 관한 연구

장덕수,이병진,배광학,방금석,이원재,노정,백대일,김종배 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.3

The purpose of this study was to assess relative tooth abrasivity and to measure effective fluoride concentration of dentifrices selling in Korea for help consumer's selection of suitable dentifrice. Assessment of the abrasion on tooth produced by different dentifrices were carried out on bovine teeth in the laboratory and tested by radioactive dentin abrasion method. And total soluble fluoride concentrations within the dentifrices was determined using fluoride ion selective electrode with standard curve obtained from standard solutions of known fluoride concentration. 10 dentifrice samples were stored at 49t for 15 weeks and the measurements were made for each dentifrice in 1 week, 2 weeks, 3 weeks, 13 weeks and 15 weeks and 11 dentifrice samples were stored at 40.6C for 3 weeks and the measurements were made for each dentifrice in 1 week and 3 weeks. Tooth abrasivity of selling dentifrices is suitable for toothbrushing but dentifrice which recommended for patient who have tooth abrasion or erosion was somewhat high abrasivity level. Effective fluoride concentrations of selling dentifrices were maintained generally optimal level. But some dentifrices contaning CaCO_(3), as abrasive were decreased as time elapsed. It was suggested that relative tooth abrasivity must be marked on package and fluoride level should be maintained acceptable level in dentifrices for consumer's selection of suitable dentifrice.

연구기반 읽기교수가 학습장애아동의 읽기유창성 및 읽기이해에 미치는 효과

김의정,최혜승,장대준 국립특수교육원 2006 특수교육연구 Vol.13 No.2

본 연구의 목적은 연구기반 읽기교수가 학습장애아동의 읽기유창성과 읽기이해에 미치는 효과를 조사하는데 있었다. 본 연구에는 전라남도 Y시에 소재한 J초등학교 4, 5학년에 재학 중인 3명의 학습장애아동이 참여하였다. 중재의 효과를 조사하기 위하여 단일대상연구 설계의 하나인 대상자간 중다 간헐 기초선 설계(multiple probe design across participants)를 사용하였다. 연구기반 읽기교수를 실시한 결과 모든 참여자의 읽기유창성은 다소 향상되었으며 읽기이해는 상당히 향상되었다. 중재가 종료된 후, 참여자 중 두 명의 읽기유창성은 중재 단계보다 향상되었으나, 나머지 한 명은 감소되었고, 모든 참여자의 읽기이해는 중재단계에 비해 낮아졌으나 기초선 단계보다 향상되었다. 또한 본 연구에서 중재를 실시하지 않은 다른 교사가 연구기반 읽기교수를 실시하였을 때, 참여자 두 명의 읽기유창성과 읽기이해는 중재단계보다 향상되었으나, 한 명의 읽기유창성과 읽기이해는 다소 감소하였다. 마지막으로 본 연구의 제한점, 향후 연구방향 및 교육현장에 던지는 시사점에 대하여 논의하였다. This study examined the effects of research-based reading instruction on the reading fluency and reading comprehension of students with learning disabilities. Participants were three 4, 5th-grade students with learning disabilities attending J elementary school in Y city in Jeollanamdo. A single subject, multiple probe design across participants was employed to investigate the functional relationship between the research-based reading instruction and the reading fluency and reading comprehension of students with learning disabilities. The results of this study indicated that all participants made moderate gains in reading fluency and significant gains in reading comprehension upon the implementation of the research-based reading instruction. During the maintenance phase, two participants's reading fluency and reading comprehension scores were better than those of the intervention phase: however, one participant's reading fluency and reading comprehension scores was decreased, but these scores were better than those of the baseline phase. The results and limitations of this study, directions for future research, and implications were discussed.

우리나라 夫婦財産制에 있어서의 그 實態와 妻의 地位

高昌鉉,金柄大,金英坤 朝鮮大學校 社會科學硏究所 1981 社會科學硏究 Vol.4 No.-

지역사회 체육시설의 현황과 확충 방안 연구

이사겸,김명진,김창섭,김대진 경희대학교 사회체육연구소 1996 體育科學論叢 Vol.- No.9

This Study attempted to seek a method for revitalizing the community sports for al related to the sports facilities in order to encourage sports activity according with the regional property. In order to make al well-balanced distribution and untilization of sports for all facilities in Korea a comprehensive evaluation for the demand and trend in the future should be carried out. The expansion of sport facilities for the pubilc, private and one's place of work should be induced and a joint system with sport facilities for schools should be settled. The continuous investment and interacting is more important for the harmonious develolpment in each community than that of unbalanced investment.

중국거주 조선족 여성의 영적 안녕정도가 정신건강에 미치는 영향

정성덕,이종범,김진성,서완석,배대석,박순재,주열,염형욱,김승원,김구묘,안영록,황대홍,표미자,조창열,정태길 영남대학교 의과대학 2004 Yeungnam University Journal of Medicine Vol.21 No.2

자아초월 정신의학이 체계화되면서 영성(spirituality)은 인성의 한 부분이라는 이론이 대두되었는데 이 영성은 정신건강에 큰 영향을 미친다고 했다. 인간의 성향 중 영적 안녕 정도를 파악하여 그 정도가 정신건강 중 허위성 경향, 정신병적 경향 및 불안과 우울 경향 등에 어떠한 영향을 미치는지를 조사하고저 본 연구를 실시하였다. 대상은 중국의 연변 조선족 자치구에 거주하는 여성 400명을 대상으로 하여 한국판 영적 안녕척도를 사용하여 영적 안녕정도를 파악하였다. 영적 안녕척도의 총점과 이 척도의 2개 하위 척도인 종교적 안녕과 실존적 안녕 척도 양자로 평가한 성적이 불안-우울통합척도와 정신분열증 척도 및 허위성 척도로 평가한 성적에 미치는 영향을 검증하기 위하여 상관관계분석 및 회기분석을 실시하였다. 그 결과는 다음과 같다. 1) 영적 안녕척도로 평가한 조선족 여성의 총점은 68.29로 한국의 기독교 여성이 평가한 100.65보다 훨씬 낮은 점수였다. 2) 불안·우울통합척도로 평가한 총점은 44.88로 연변노인이 평가한 점수와 일개지역의 한국농촌주민이 평가한 점수와 비슷한 결과였다. 3) 허위성 척도로 평가한 성적은 평균 74.57로 70점 이상이 86%(344명)이었으나 영적 안녕 성적과 허위성 성적 간에는 유의한 상관이 없었다. 4) 영적 안녕총점은 정신분열증 척도로 평가한 정신병적 경향에 유의한 영향을 미치지 않았으나 종교적 안녕하위척도의 성적은 정신병적 경향을 높여준데 비하여 실존적 안녕하위척도의 성적은 정신병적 경향을 낮게 해주었다. 5) 영적 안녕척도의 총점 및 두 하위척도인종교적 안녕과 실존적 안녕은 불안과 우울에유의한 상관을 보였는데 영적 안녕총점이 높을수록 불안·우울 총점이 다소 낮아지는 경향을 보였다. 6) 종교적 안녕 하위척도와 불안과 우울과의 관계는 종교적 안녕점수가 높을수록 불안과 우울을 각각 다소 유의하게 높여주었으며 이에 비하여 실존적 안녕하위척도와 불안과 우울과의 관계는 실존적 안녕정도가 높을수록 불안 및 우울점수는 유의하게 낮아졌다. 이와 같은 성적을 미루어볼 때 연변에 거주하는 조선족 여성이 평가한 영적 안녕정도는 정신병적 경향과 불안 및 우울에 유의한 상관을 보였으면 이 척도의 하위 척도인 종교적 안녕정도는 정신건강에 부정적인 영향을 미치는 반면 실존적 안녕정도는 정신건강에 긍정적 영향을 미친 결과로 평가되었다. 이러한 결과는 공산주의 사회에서 실존적 안녕은 긍정적인 가치관으로 평가되는 반면 종교적 안녕은 정신건강에 부정적으로 작용한 것을 입증해 주었다고 하겠다. Background: Spirituality has been an important part of Transpersonal Psychology and is believed to have a large effect on the mental health because it has been systematized. The aim of this study was to determine the level of spiritual disposition on human beings along with its effects on one's mental health. Materials and Methods: The study targeted 400 women residing in Youn-Gil city of JiLin Prov., which is a district of the Cho-Sun tribe in China. Their spiritual well-being was studied using the Spiritual Well-being Scale-Korean Version. The spiritual well-being scale consists of 2 sub-scales of religious well-being and existential well-being. The study was evaluated using a lie scale, psychotic trend, and a combined anxiety-depression scale. The results were considered to be factors of one's mental health. The correlation between the spiritual well-being and each tendency was analyzed by regression analysis. Results: The total score of the Cho-Sun tribal women according to the spiritual well-being scale was 68.29 which was much less than the 100.65 of Korean Christian women. There was no significant correlation between the spiritual well-being and the Lie trend. However, it was found that 86%(344) of Cho-Sun tribal women scored above 70 in the Lie trend with a mean score of 74.57 which is higher than normal populations. Regarding the correlation between the spiritual well-being and psychotic trend, the psychotic trend became significantly higher when the religious well-being was at a high level. On the other hand, the psychotic trend became significantly lower when the existential well-being was at a high level. Regarding the correlation between the spiritual well-being and anxiety, the anxiety was significantly higher when the religious well-being was at a high level. However, the anxiety level was significantly low when the existential well-being was at a high level. Regarding the correlation between the spiritual well-being and depression, the depression level was somewhat significantly high when the religious well-being was at a high level. However, the depression level was significantly low when the existential well-being was at a high level. Conclusion: This study evaluated the effects of spiritual well-being on a person's mental health among Cho-Sun tribal women in Youn-Gil city of JiLIn Prov., P.R. of China. The results found that the religious well-being, which is a sub-scale of spiritual well-being, had negative effects while the existential well-being had positive effects on the mental health. These results proved that a person's religious disposition had negative effects on their mental health in a communitarian society.

주의력결핍 과잉행동장애 아동의 지적수준에 따른 정신병리와 실행기능의 차이

천은진,서완석,이종범,김진성,구본훈,송창진,성형모,배준용,배대석 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

To investigate psychopathoIogy and executive functions of attention deficit hyperactivity disorder (ADHD) children according to intelligence level, this study included 197 ADHD children who visited the outpatient department of neuropsychiatry of YeungNam University Medical Center, from July 2000 to June 2002. The children were divided into groups based on their intelligence levels. They were compared by the Personality Inventory for Children (PIC), Conncers' Continuous Performence Test (CPT), and Wisconsin Card Sorting Test (WCST). There were significant differences in PIC, on the subscales of verbal development, socialization and autism. In the CPT, there was no significant difference. In the WCST, there were significant differences in the total number of errors, the number of perseverative errors, the number of completed categories and the number of trials needed to complete the first category. Considering these results, the intelligence level of ADHD children is related to their disabilities and behavioral symptoms.Executive functions such as abstract thinking, categorization, working memory and flexibility had significant relationship to the intelligence levels of ADHD children. Therefore, the intelligence level of children with ADHD influences the higher executive functions of regulating attention and information processing rather than attentional functions and capacity alone.