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蔡鴻遠,李敏炯,申榮吉,金基學,李秀川,金正子 慶北大學校 體育科學硏究所 1990 체육과학연구지 Vol.6 No.-
In order to study the postures of Korean students, 4,448 students who lives in urban and rural community were participated as subjects and examined by using New York State Posture Rating Test Method with taking photographs. The results were subdivied into postures of body parts, total posture score, leg types, and lateral deviation and analysed as follows. 1. Postures of body parts 1) Head Tilt For elementary and middle school students, the cases of tilted head were shown more frequently in urban than rural and the ratio of the case of the tilted head was increased as grade was higher. On the other hand, high school studends had the opposite tendency. 2) Uneven Shoulder Height For elementary school childs, higher grades had better condition than lower grades, however, for high school students, those in urban had more cases of uneven shoulder than those in rural and girls showed more deviations than boys. 3) Scoliosis Rural childs had more cases of scoliosis than urban childs, but there were no differences of middle and high school students. 4) Uneven Hip Height Urban and rural childs showed some cases of uneven hip which belonged to normal ranges. Middle and high school studedns werw nearly perfect in the hip height, therefore the condition seems to change as they grow older. 5) Pronated Ankles For this part, those in rural showed better conditions than those in ruban in all age groups and, especially high school third grade students were more satisfactory in rural than urban(84% vs 50%) 6) Forward Head Elementary and middle school students appeared to be satisfactory regardless of age, sex and district, however 32% of high school girl students had forward head. 7) Round Shoulders Many students had round shoulders and some of them revealed severe conditions, There were large differences between urban and rural students. 8) Trunk Hyperextension Generally, girls showed better conditions than boys in trunk posture and, for high school boy students, conditions were differed according to their grades. 9) Sagging Abdomen More cases of sagging abdomen were revealed in ruban that rural for elementary girl students(30% vs 14%). For middle and high school students, there were differences between sex, boys showing more cases than girls in middle school and girls in high school. 10) Lordosis There were differences between urban and rural for elementary childs and high school boy students, however no differences were detected in other groups. Mean degrees of lordosis had a tendency of increasing as the age grew. 2. Total Posture Score For elementary childs, both boys and girls showed differences between urban and rural(75.95 vs 70.73, 75.16 vs 82.42), and, in rural girls seems to be more satisfactory than boys in comparison between boys and girls(p<. 001). In middle school group, rural students appeared to be significantly(p<.05) better than urban students for both sex(83.88 vs 81.93, 75.93 vs 75.02) and the result was same for the high school group(86.52 vs 84.03, 80.07 vs 78.10) 3. Leg types For elementary childs, girls revealed more cases of bowlegs and knock-knee than boys(6% vs 8.2%, 20.5% vs 30.3%). In high school group, the girls in rural showed more cases of bowlegs than those in urban(29.7% vs 13.0%) and, the knokc-knee, the result was opposite(19.3% vs 28.4%). 4. Lateral deviation 1) Head Tilt In elementary group, 11% of boys and 6.3% of girls had lateral deviation and, for high school students, 3.6% of boys and 5.4% of girls showed the deviations revealing girls had more cases of deviation than boys. 2) Uneven Shoulder Height 1.8% of elementary boys and 0.5% of girls had uneven shoulder and totally 1.5% of high school students showed uneven shoulder height. 3) Scoliosis 15.5% and 17.4% of elementary boys and 21.6% and 20.7% of girls deviated to right and left respectively. Urban students showed general trends to leftward deviation while rural students showed rightward deviation. 4) Uneven Hip Height In this part of posture, they showed good conditions in all age, sex, and district.
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이춘희,김세진,전상식,이택후,조영래,채종민 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1
Various clinical and histopathologic characteristics are currently used to obtain prognostic information about cervical carcinoma, but they do not predict the outcome for any individual patients. Thus, there is a need to identify additional tumor characteristics that are able to predict more accurately the outcome for an individual patient with cervical cancer. In this study, we explored the relationship between cathepsin-D expression and progression of the cervical neoplasia, the correlation between response to neoadjuvant chemotherapy and cathepsin-D expression, and we investigated if tumor cell cathepsin-D expression could serve as a prognostic factor in cervical carcinoma. Tumor tissues were obtained from 14 patients with cervical intraepithelial neoplasia and 52 patients with squamous cell carcinoma of the cervix. Cathepsin-S expression was identified by immunohistochemical methods using monoclonal antibody cathepsin-D (BioGene). Positive cathepsin-D immunoreaction in greater than 30% of carcinoma cells was scored as high expression. High cathepsin-D expression was seen in 15 of 52 invasive cancer but was absent in cervical intraepithelial neoplasia. It was shown that cathepsin-D expression was independent of the rumor grade, tumor size, lymph node involvement, depth of invasion, parametrial invasion, and response to chemotherapy. In disease free survival analysis by log-rank test, cathepsin-D expression was not significantly associated with survival. These results show that cathepsin-D expression is not a clinically useful adjunct to assessment of prognosis in invasive squamous cell carcinoma of the cervix.
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Chae-lim Kim,Sun-yeong Cha,Min Young Chun,Bumsoo Kim,Min Young Choi,Yong-Pil Cheon 한국발생생물학회 2015 발생과 생식 Vol.19 No.3
Diphlorethohydroxycarmalol (DPHC) is a known to modulate the expression of extracellular matrix (ECM) components in 3T3-L1. However, the possible role of DPHC in integument stability during obesity induction is not clear yet. We evaluated the effects of DPHC on collagen or elastic fiber quantity in integument during obesity induction with high-fat diet. The dorsal back integument sections were stained with hematoxylin–eosin, Masson trichrome, and Verhoff-Van Gieson. The intensities of collagen fibers and elastin fibers were analyzed with ImageJ. The number of fibroblasts was counted at ×1,000 fields. The number of fibroblast was increased by obesity induction, but DPHC suppressed it in a concentrationdependent manner both in lean and obese mice. On the other hand, the intensities of collagen fibers were increased by DPHC treatment in obese mice groups but not in lean mice groups. The intensities of collagen fibers of obese mice were lower than that of the lean mice in 0% group. However, the number became similar between lean and obese mice by the treatment of DPHC. The intensity of elastic fibers was increased in the lean mice with the concentration of DPHC. In the obese mice group, there were increasing patterns but only significant at 10% DPHC group. The intensity of elastic fibers of obese mice was higher than lean mice in 0%, 1%, and 10% groups. Histologically epithelial cells and follicle cells which were diffused nuclear staining forms were increased by DPHC treatment. The results suggest that the activity of integument cells during obesity induction can be modulated by DPHC.
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Sung Chun Chae,Kyung Il Min,Hyung Soo Kim,Nam-Jin Kim,Jun-Ran Kim,Bong Ki Son,Young-Joon Ahn 한국응용곤충학회 2012 한국응용곤충학회 학술대회논문집 Vol.2012 No.05
An assessment was made of the biological control potential of mud loaches, Misgurnus mizolepis, toward Culex pipiens molestus, in laboratory condition and septic tank and rainwater storage tank (RST) systems. Results were compared with those of temephos 20% emulsifiable concentrate (EC) and Bacillus thuringiensis israelensis (BTI). In the laboratory tests, all M. mizolepis survived on waters from the settling tank of aerobic septic tank (AST), sump tank of AST, and RST. However, all M. mizolepis died within 3 h after introduction in the settling tank and sump tank waters of anaerobic septic tank (AnAST). Gill or dorsal fin inflammation was detected in the dead mud loaches. M. mizolepis consumed an average of 968–1087, 901–986, and 993–1087 of 1500 third instars of Cx. p. molestus in AST settling tank, AST sump tank, and RST waters, respectively. In the AST and RST systems, predation of Cx. p. molestus by mud loaches at a release rate of 900 larvae/fish resulted in complete mosquito control from the first wk after treatment through the end of the survey period for 16 wk. The average mosquito reduction rates by temephos 20% EC and BTI treatments were 28.6 and 2.1% 2 wk post-treatment, respectively. Mud loaches merit further study as a potential biological control agent for the control of mosquito populations in light of global efforts to reduce the level of highly toxic synthetic insecticides in the aquatic environment.
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Hee-Jin Hong,Na-Ra Son,Ji-Su Kim,Min-Ji Kim,Chae-Hee Kim,Su-Yeon Hong,Do-Eun Kim,Ji-Eun Lee,In-Young Chun,Kyu-Won Kim,Seoul-Hee Nam 한국자기학회 2019 Journal of Magnetics Vol.24 No.4
In modern society, drinking is becoming a culture while alcohol consumption continues to increase. Studies show that alcohol consumption in the oral cavity averages 2 hours, and alcohol consumption seems to have a high effect on tooth damage. Therefore, this study was conducted to evaluate the possibility of dental erosion due to intake of some alcoholic beverages in the market. Six types of alcoholic beverages were immersed in 1 ml of each alcohol for 10 min, 60 min, and 120 min to obtain only enamel of the tooth and observe changes over time. The crystal structure of the enamel surface was observed by scanning electron microscopy (SEM), and the changes in calcium and phosphorus, the major constituents of teeth, were analyzed by energy dispersive electromagnetic wave (X-ray) spectroscopy (EDS). Based on the results, the tooth showed a destructive pattern while and loss of calcium (Ca) and phosphorous (P) increased significantly as exposure time to the low pH alcoholic drinks increased. Since this causes the demineralization of inorganic components and greatly affects the risk of tooth erosion, long contact with alcohol should be avoided.
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A Bacterial Metabolite, Compound K, Induces Programmed Necrosis in MCF-7 Cells via GSK3β
( Chae Won Kwak ),( Young Min Son ),( Min Jeong Gu ),( Girak Kim ),( In Kyu Lee ),( Yoon Chul Kye ),( Han Wool Kim ),( Ki Duk Song ),( Hyuk Chu ),( Byung Chul Park ),( Hak Kyo Lee ),( Deok Chun Yang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.7
Ginsenosides, the major active component of ginseng, are traditionally used to treat various diseases, including cancer, inflammation, and obesity. Among these, compound K (CK), an intestinal bacterial metabolite of the ginsenosides Rb1, Rb2, and Rc from Bacteroides JY-6, is reported to inhibit cancer cell growth by inducing cell-cycle arrest or cell death, including apoptosis and necrosis. However, the precise effect of CK on breast cancer cells remains unclear. MCF-7 cells were treated with CK (0-70 μM) for 24 or 48 h. Cell proliferation and death were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, respectively. Changes in downstream signaling molecules involved in cell death, including glycogen synthase kinase 3β (GSK3β), GSK3β, β-catenin, and cyclin D1, were analyzed by western blot assay. To block GSK3β signaling, MCF-7 cells were pretreated with GSK3β inhibitors 1 h prior to CK treatment. Cell death and the expression of β-catenin and cyclin D1 were then examined. CK dose- and time-dependently inhibited MCF-7 cell proliferation. Interestingly, CK induced programmed necrosis, but not apoptosis, via the GSK3β signaling pathway in MCF-7 cells. CK inhibited GSK3β phosphorylation, thereby suppressing the expression of β-catenin and cyclin D1. Our results suggest that CK induces programmed necrosis in MCF-7 breast cancer cells via the GSK3β signaling pathway.
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