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Kim, E-K,Seo, H-S,Chae, M-J,Jeon, I-S,Song, B-Y,Park, Y-J,Ahn, H M,Yun, C-O,Kang, C-Y Macmillan Publishers Limited 2014 Gene therapy Vol.21 No.1
For successful clinical tumor immunotherapy outcomes, strong immune responses against tumor antigens must be generated. Cell-based vaccines compromise one strategy with which to induce appropriate strong immune responses. Previously, we established a natural killer T-cell (NKT) ligand-loaded, adenoviral vector-transduced B-cell-based anticancer cellular vaccine. To enhance tumor antigen delivery to B cells, we established a modified adenoviral vector (Ad-k35) that encoded a truncated form of the breast cancer antigen Her2/neu (Ad-k35HM) in which fiber structure was substituted with adenovirus serotype 35. We observed increased tumor antigen expression with Ad-k35HM in both human and murine B cells. In addition, an Ad-k35HM-transduced B-cell vaccine elicited strong antigen-specific cellular and humoral immune responses that were further enhanced with the additional loading of soluble NKT ligand KBC009. An Ad-k35HM-transduced, KBC009-loaded B-cell vaccine efficiently suppressed the in vivo growth of established tumors in a mouse model. Moreover, the vaccine elicited human leukocyte antigen (HLA)-A2 epitope-specific cytotoxic T-cell responses in B6.Cg (CB)-Tg (HLA-A/H2-D) 2Enge/Jat mice. These findings indicated that the Ad-k35 could be appropriate for the preclinical and clinical development of B-cell-based anticancer immunotherapies.
Potassium-based dry sorbents for removal of sulfur dioxide at low temperatures
Chae, H.J.,Lee, S.C.,Lee, S.J.,Cho, M.S.,Jung, S.Y.,Ryu, C.Y.,Kwon, Y.M.,Hwang, B.W.,Lee, J.B.,Kim, J.C. Korean Society of Industrial and Engineering Chemi 2016 Journal of industrial and engineering chemistry Vol.36 No.-
<P>The SO2 sorption properties of dry potassium -based sorbents, prepared by impregnation of various supports with potassium carbonate, were investigated at the various water vapor concentrations at a level of 5000 ppm of SO2. It was found that alkali metal -based sorbents promoted with potassium carbonate could be used as a sorbent for SO2 sorption at low temperatures (between 30 degrees C and 60 degrees C). In particular, the potassium-based sorbents showed an excellent SO2 sorption capacity of about 310 mg SO2/g sorbent in the presence of water vapor, while in the absence of water vapor, their SO2 sorption capacities decreased. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.</P>
Genotyping of Chimerical BCR-ABL1 RNA in Chronic Myeloid Leukemia by Integrated DNA Chip
Kang, J.H.,Goh, H.G.,Chae, S.H.,Kim, S.Y.,Kim, D.W.,Chae, C.B. American Society for Investigative Pathology and t 2012 The Journal of Molecular Diagnostics Vol.14 No.5
Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph<SUP>+</SUP>) acute lymphoblastic leukemia (ALL) are associated with fusion of the BCR and ABL1 genes by chromosome translocation. The chimerical BCR-ABL1 gene encodes different fusion proteins that vary in size, depending on the breakpoint in the BCR region. Different types of fusion genes in CML and Ph<SUP>+</SUP> ALL are thought to be related to the clinical course and outcome of each patient. Currently, the genotypes are determined by PCR, followed by gel electrophoresis or DNA sequencing (among other methodologies). Our major aim was to develop a diagnostic method for CML genotyping by means of an integrated process of DNA microarray. Here, we describe a method of integrated multiplex reverse transcription, asymmetric PCR, and hybridization, all in the same reaction mixture in a chamber assembled on the surface of capture oligonucleotide probes immobilized on a glass slide. The integrated system successfully identified the four predominant types of chimerical BCR-ABL1 RNA (b3a2, b2a2, e1a2, and c3a2), which together account for 98% of CML cases. The integrated multiplex system also had a high sensitivity of detection (as little as 200 molecules of target RNA molecules). The integrated process saves time and effort, and it also the advantage of minimizing the steps needed for automated detection of different types of chimerical CML RNA.
Behavior of maltose-neopentyl glycol-3 (MNG-3) at the air/aqueous interface
Yoo, B.,Lee, J.,Choi, S.,Ryu, J.,Lee, H.,Chae, P.S.,Lee, S.U.,Maeda, M.,Sohn, D. Elsevier 2015 Colloids and surfaces. A, Physicochemical and engi Vol.484 No.-
<P>Integral membrane proteins (IMPS) performing a variety of cell functions comprise a significant fraction of the proteins encoded in an organism's genome. Maltose-neopentyl glycol-3 (MNG-3) was invented as a novel detergent to extract IMPs from the cell membranes; MNG-3 has an inherent flexibility originating from its central carbon and its arms comprising alkyl chains and maltose groups. Herein, we demonstrate the reverse-scissoring behavior of MNG-3 through the use of different subphase conditions at the air/water interface. The origin of its high performance was investigated by means of Langmuir techniques, X-ray reflectivity (XRR) analysis of its Langmuir-Schaefer (LS) film, Brewster angle microscope (BAM) and atomic force microscope (AFM) and computational simulation. (C) 2015 Elsevier B.V. All rights reserved.</P>
박범영,조수현,유영모,김진형,채현석,안종남,김용곤,이종문,윤상기 한국동물자원과학회 2002 한국축산학회지 Vol.44 No.2
도축 후 돈육의 육질평가에 있어 중요한 요인인 사후 24시간 pH를 측정하여 pH가 5.31∼5.50, 5.51∼5.70, ≥5.71에 따른 육질을 조사한 결과, 사후 pH가 더 낮을수록 단백질 함량이 높고, 지방 함량이 낮았다(P<0.05). 사후 24시간 pH가 높을수록 보수력은 증가하였으며, 가열감량과 육즙감량은 유의적으로(P<0.05) 감소하였다. 육의 경도, 탄력성, 씹힘성과 지방경도 역시 사후 24시간 pH가 높을수록 유의적인 증가를 보였다(P<0.05). 육색특성 중 CIE L*값은 사후 24시간 pH가 낮을수록 유의적으로 높았으며, a*와 b*값, chroma 값은 최종 pH가 5.71이상의 돈육에서 유의적으로 낮게 나타났다(P<0.05). Hue 값은 pH 5.31∼5.70 범위에서 가장 높았으며, ΔE 값도 pH 5.31∼5.50에서 가장 높았다. 관능적 특성의 분석결과, 다즙성과 연도는 최종 pH가 높을수록 향상되었으나, 향미는 최종 pH 범위에 따른 차이가 인정되지 않았다. 따라서 본 연구결과, 도축 후 24시간 돈육의 pH 범위에 따라 육질의 차이를 보이기 때문에 사후 적정 pH를 유지할 수 있도록 도축전 관리, 도축방법, 도축 후 냉각 온도관리 등을 개선하는 것이 고품질 돈육생산에 있어 중요한 것으로 사료된다. Meat quality of the domestic pork loins(n=537) classified by 3 groups(5.31∼5.50, 5.51∼5.70 and ≥5.71) according to pH at 24hr post-mortem(pH_24) was investigated. In proximate chemical compositions, protein was highest and fat was lowest in the pork loins of pH_24 5.31∼5.50 group. Water holding capacity increased as pH_24 increased, whereas purge loss and cooking loss decreased as pH_24 increased. Meat color values(CIE L*, a*, b*, Chroma, Hue and ΔE) decreased as pH_24 increased. In texture traits, hardness and chewiness were lowest and fat hardness was highest in the pork loins of pH_24≥5.71 group when compared to the other pH_24 groups. However, Warner-Bratzler Shear force, springiness and cohesiveness were not significantly different among the pH_24 groups(P>0.05). In sensory properties, juiciness and tenderness were highest in pH_24≥5.71 group. From the results of this study, pork quality was highly related to pH_24. Therefore, the factors affecting the post-mortem pH, such as stress before slaughter, slaughtering methods, and cooling condition slaughter must be properly controlled and improved to produce high quality pork.
Noh, J.,Chae, B. J.,Ku, B. C.,Lee, T. S. John Wiley Sons, Ltd 2014 Journal of polymer science Part A, Polymer chemist Vol.52 No.13
Conjugated polymers containing triphenylamine group are synthesized via Suzuki coupling polymerization. Fluorescent-conjugated polymer nanoparticles (CPN) are prepared by reprecipitation method using the newly synthesized conjugated polymer. CPN can be encapsulated with polyarginine by electrostatic interaction. The CPN modified with polyarginine exhibit excellent interaction with graphene oxide (GO) which is chemically modified with hydrophilic groups that possesses negative charge, which, in turn, induces the quenching of the fluorescence of CPN upon formation of CPN-GO nanohybrid. Upon exposure to trypsin, the quenched fluorescence is recovered by release of CPN from the nanohybrid, because trypsin cleaves the polyarginine linkage, resulting in weakening of interaction between CPN and GO. (c) 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 1898-1904