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Photobiomodulation Therapy in the Treatment of Salivary Dysfunction
Celine DG. Abueva 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.1
Photobiomodulation therapy, owing to its photobiological anti-inflam-matory and wound healing effects, has been suggested as a non-invasive, safe, and effective approach in treating salivary dysfunctions. Xerostomia or dry mouth and hyposalivation are challenging conditions, and patients suffer oral problems and a poor quality of life. Several studies have demonstrated the potential of photobiomodulation in reducing xerosto-mia and hyposalivation. However, there is a lack of synthesis of available evidence to establish whether it is an efficient, safe, and cost-effective method. In addition, the challenges include the lack of consensus on the optimal PBM dosage, as well as the variability of the findings in published studies.
Photo-triggered Theranostic Nanoparticles in Cancer Therapy
Celine DG. Abueva 대한의학레이저학회 2021 MEDICAL LASERS Vol.10 No.1
In cancer therapy, it is often desirable to use precision medicine that involves treatments of high specificity. One such treatment is the use of photo-triggered theranostic nanoparticles. These nanoparticles make it possible to visualize and treat tumors specifically in a controlled manner with a single injection. Several novel and powerful photo-triggered theranostic nanoparticles have been developed. These range from small organic dyes, semiconducting and biopolymers, to inorganic nanomaterials such as iron-oxide or gold nanoparticles, carbon nanotubes, and upconversion nanoparticles. Using photo-triggered theranostic nanoparticles and localized irradiation, complete tumor ablation can be achieved without causing significant toxicity to normal tissue. Given the great advances and promising future of theranostic nanoparticles, this review highlights the progress that has been made in the past couple of years, the current challenges faced and offers a future perspective.