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- 저자 : Cao Wu (검색결과 223 건)
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Improved Switching Ripple Suppression Strategy for Multi-Paralleled Grid-Connected Inverters System
Wu Cao,Haotian Kang,Kangli Liu,Shunyu Wang,Jianfeng Zhao,Xiaochun Ji,Jun Zhao 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
The switching operations of inverters in the distributed system inevitably introduce high-frequency harmonics into grid, which may make influences on electrical devices. To address it, this paper proposes a ripple suppression strategy based on active cancellation combined with passive filtering. The active cancellation is realized by carrier-phase-shift (CPS) technique and the passive filtering is achieved by filters. Furthermore, two component-shared LCL-type filters improved by traditional LCL filters are studied from the points of resonance and accuracy of gridinjected current. To valid the effectiveness of the proposed strategy, simulations and experimental test are carried out. The results show that the proposed strategy can effectively suppress high-frequency harmonics and two componentshared LCL-type filters can become promising filters for the multi-paralleled grid-connected inverters.
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Cao, Yin,Yang, Yingbo,Wu, Hui,Lu, Yi,Wu, Shuang,Liu, Lulu,Wang, Changhong,Huang, Fei,Shi, Hailian,Zhang, Beibei,Wu, Xiaojun,Wang, Zhengtao The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.3
Backgroud: Sleep deprivation (SD) impairs learning and memory by inhibiting hippocampal functioning at molecular and cellular levels. Abnormal autophagy and apoptosis are closely associated with neurodegeneration in the central nervous system. This study is aimed to explore the alleviative effect and the underlying molecular mechanism of stem-leaf saponins of Panax notoginseng (SLSP) on the abnormal neuronal autophagy and apoptosis in hippocampus of mice with impaired learning and memory induced by SD. Methods: Mouse spatial learning and memory were assessed by Morris water maze test. Neuronal morphological changes were observed by Nissl staining. Autophagosome formation was examined by transmission electron microscopy, immunofluorescent staining, acridine orange staining, and transient transfection of the tf-LC3 plasmid. Apoptotic event was analyzed by flow cytometry after PI/annexin V staining. The expression or activation of autophagy and apoptosis-related proteins were detected by Western blotting assay. Results: SLSP was shown to improve the spatial learning and memory of mice after SD for 48 h, accomanied with restrained excessive autophage and apoptosis, whereas enhanced activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in hippocampal neurons. Meanwhile, it improved the aberrant autophagy and apoptosis induced by rapamycin and re-activated phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling transduction in HT-22 cells, a hippocampal neuronal cell line. Conclusion: SLSP could alleviate cognitive impairment induced by SD, which was achieved probably through suppressing the abnormal autophagy and apoptosis of hippocampal neurons. The findings may contribute to the clinical application of SLSP in the prevention or therapy of neurological disorders associated with SD.
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Cao, Wei,Wu, Xianjian,Jia, Gang,Zhao, Hua,Chen, Xiaoling,Wu, Caimei,Cai, Jingyi,Wang, Jing,Liu, Guangmang Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.8
Objective: This study investigated whether spermine supplementation could regulate cell cycle, apoptosis, and amino acid transporter-related genes expression in the thymus and spleen of early weaned piglets. Methods: Eighty female piglets were randomly distributed to receive adequate nutrients supplemented with spermine (0.4 mmol/kg body weight/24 h) or to be provided with restricted nourishment supplemented with normal saline for 7 h or 3, 6, or 9 d in pairs. Results: Regardless of administration time, spermine supplementation significantly up-regulated cyclin A2 gene expression but down-regulated p21 and cyclin D3 mRNA levels in the thymus and spleen and reduced cyclin E2 gene expression in the thymus of piglets (p<0.05). Irrespective of the treatment period, the reduced Bax and caspase-3 gene expressions and improved Bcl-2 mRNA level were observed in the thymus and spleen of spermine-administrated piglets (p<0.05). Regardless of supplementation time, spermine intake significantly enhanced the expressions of amino acid transporter-related genes (SLC1A1, SLC1A5, SLC7A1, SLC7A7, and SLC15A1) in both thymus and spleen, as well as SLC7A9 in the spleen of piglets (p<0.05). In addition, extended spermine administration also markedly promoted cell proliferation, depressed apoptosis and modulated amino acid transport (p<0.05), and such effects were the greatest during prolonged spermine supplementation (6 d) compared to the other time periods (p<0.05). Conclusion: Spermine supplementation may regulate cell cycle during the G1/S phase, suppress apoptosis and modulate amino acid transport. A period of 6 d of spermine supplementation is required to produce the optimal effects on nutritional implications.
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Wu Cao,Kangli Liu,Sheng Xu,Haotian Kang,Jianfeng Zhao 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.3
The frequent starting of large capacity lifting machines and other surge ship electrical loads will result in severe impacts on a shipboard power network, such as voltage and frequency fl uctuations. Therefore, a novel stabilization control strategy for shore power systems based on virtual synchronous generator is proposed in this paper, so as to improve the power quality and enhance the stability and reliability of shipboard power networks. In this strategy, a reactive power inertia component is embedded into the virtual synchronous generator aiming at shipboard surge reactive powers. On this basis, a voltage and frequency stability control method is presented to improve the static performances of shore power systems. In addition, a d-q decoupling control scheme in synchronous reference frame for the voltage and current double closed-loop control system is designed, and moreover, the infl uence of diff erent feedback voltages on the output characteristics of shore power supplies is studied. The theoretical analysis, simulation and experiment results show that, the proposed control strategy can eff ectively attenuate the frequency and voltage fl uctuations, eliminate the frequency and voltage steady-state errors, as well as realize the power distribution evenly for modular shore power supplies.
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Yin Cao,Yingbo Yang,Hui Wu,Yi Lu,Shuang Wu,Lulu Liu,Changhong Wang,Fei Huang,Hailian Shi,Beibei Zhang,Xiaojun Wu,Zhengtao Wang 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.3
Backgroud: Sleep deprivation (SD) impairs learning and memory by inhibiting hippocampal functioningat molecular and cellular levels. Abnormal autophagy and apoptosis are closely associated with neurodegenerationin the central nervous system. This study is aimed to explore the alleviative effect and theunderlying molecular mechanism of stemeleaf saponins of Panax notoginseng (SLSP) on the abnormalneuronal autophagy and apoptosis in hippocampus of mice with impaired learning and memory inducedby SD. Methods: Mouse spatial learning and memory were assessed by Morris water maze test. Neuronalmorphological changes were observed by Nissl staining. Autophagosome formation was examined bytransmission electron microscopy, immunofluorescent staining, acridine orange staining, and transienttransfection of the tf-LC3 plasmid. Apoptotic event was analyzed by flow cytometry after PI/annexin Vstaining. The expression or activation of autophagy and apoptosis-related proteins were detected byWestern blotting assay. Results: SLSP was shown to improve the spatial learning and memory of mice after SD for 48 h,accomanied with restrained excessive autophage and apoptosis, whereas enhanced activation of phosphoinositide3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in hippocampalneurons. Meanwhile, it improved the aberrant autophagy and apoptosis induced by rapamycinand re-activated phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling transductionin HT-22 cells, a hippocampal neuronal cell line. Conclusion: SLSP could alleviate cognitive impairment induced by SD, which was achieved probablythrough suppressing the abnormal autophagy and apoptosis of hippocampal neurons. The findings maycontribute to the clinical application of SLSP in the prevention or therapy of neurological disordersassociated with SD.
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Xinyu Cao,Yin Fang,Chunguang Yang,Zhenghao Liu,Guoping Xu,Yan Jiang,Peiyan Wu,Wenbo Song,Hanshuo Xing,Xinglong Wu 대한배뇨장애요실금학회 2024 International Neurourology Journal Vol.28 No.1
Purpose: Prostate cancer (PCa) is an epithelial malignancy that originates in the prostate gland and is generally categorized into low, intermediate, and high-risk groups. The primary diagnostic indicator for PCa is the measurement of serum prostate-specific antigen (PSA) values. However, reliance on PSA levels can result in false positives, leading to unnecessary biopsies and an increased risk of invasive injuries. Therefore, it is imperative to develop an efficient and accurate method for PCa risk stratification. Many recent studies on PCa risk stratification based on clinical data have employed a binary classification, distinguishing between low to intermediate and high risk. In this paper, we propose a novel machine learning (ML) approach utilizing a stacking learning strategy for predicting the tripartite risk stratification of PCa. Methods: Clinical records, featuring attributes selected using the lasso method, were utilized with 5 ML classifiers. The outputs of these classifiers underwent transformation by various nonlinear transformers and were then concatenated with the lasso-selected features, resulting in a set of new features. A stacking learning strategy, integrating different ML classifiers, was developed based on these new features. Results: Our proposed approach demonstrated superior performance, achieving an accuracy of 0.83 and an area under the receiver operating characteristic curve value of 0.88 in a dataset comprising 197 PCa patients with 42 clinical characteristics. Conclusions: This study aimed to improve clinicians’ ability to rapidly assess PCa risk stratification while reducing the burden on patients. This was achieved by using artificial intelligence-related technologies as an auxiliary method for diagnosing PCa.
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Limin Cao,Jin Si,Weiyu Wang,Xiaorong Zhao,Xiaomei Yuan,Huifen Zhu,Xiaolong Wu,Jianzhong Zhu,Guanxin Shen 한국분자세포생물학회 2006 Molecules and cells Vol.21 No.1
Gene therapy with nonviral vectors using the suicide gene/prodrug activating system of herpes simplex virus type-1 thymidine kinase (HSV1-TK)/ganciclovir (GCV) is inefficient in killing malignant tumor cells due to two major factors: (a) an unsatisfactory bystander effect; (b) short-lived expression of the protein. To study the capacity of the protein transduction domain (PTD) of HIV-1 TAT protein to enhance HSV1-TK/GCV cancer gene therapy, we constructed three fusion proteins TAT-TK, TK-TAT and TK. TATTK retained as much enzyme activity as TK, whereas that of TK-TAT was much lower. TAT-TK can enter HepG2 cells and much of it is translocated to the nucleus. The transduced HepG2 cells are killed by exogenously added GCV and have bystander effects on untransduced HepG2 cells. Most importantly, the introduced recombinant protein is stable and remains functional for several days at least, probably because nuclear localization protects it from the cytoplasmic degradation machinery and provides access to the nuclear transcription machinery. Our results indicate that TAT fusion proteins traffic intercellularly and have enhanced stability and prodrug cell killing activity. We conclude that TAT has potential for enhancing enzyme prodrug treatment of liver cancers.
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A Hybrid Self-Powered System Based on Wind Energy Harvesting for Low-Power Sensors on Canyon Bridges
Hao Cao,Xiaoping Wu,Hao Wu,Yajia Pan,Dabing Luo,Ali Azam,Zutao Zhang 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.1
Canyon cross wind has great potential to be transformed into electricity to power for low-power sensors of the health monitoring devices in bridge field. In this paper, a hybrid wind energy harvesting system (WEHS), integrating piezoelectric and electromagnetic mechanisms, is proposed to supply power for low-power sensors on canyon bridges. Firstly, the S-rotor embedded with a one-way bearing converts wind energy into rotational mechanical energy. Then, the piezoelectric cantilever beam and coils simultaneously convert mechanical energy into electricity under the excitation of the rotational magnet array. For the piezoelectric transducer, the symmetrical poles arrangement of tip magnet reduces the starting wind speed and resistance torque during energy harvesting. In addition, the relationship between different number of excitation magnets and the output of the piezoelectric transducer is explored. Finally, the output electricity is stored in the capacitors to supply power for low power sensors. The experimental results showed that the symmetrical poles arrangement of tip magnet could effectively reduce the starting resistance torque and improve the output power at low wind speeds. Given a wind speed of 6.5 m/s, the maximum output power of the WEHS can reach 19.24 mW with corresponding electrical energy of 75.714 mJ in one sweep period (6 s). The field test results demonstrated that the WEHS could effectively charge for the capacitors and power for a hundred LEDs. Furthermore, the mechanical durability and stability of the WEHS are verified by introducing a self-powered low power sensor system.
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