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Superantigen-mediated differentiation of bovine monocytes into dendritic cells
Seo, K. S.,Park, J. Y.,Davis, W. C.,Fox, L. K.,McGuire, M. A.,Park, Y. H.,Bohach, G. A. Wiley (John WileySons) 2009 Journal of Leukocyte Biology Vol.85 No.4
<P>Although many effects of staphylococcal superantigens (SAg) on T cells are well established, less is known about their effects on APC. In this study, bovine PBMC were stimulated with a low dose of staphylococcal enterotoxin C1 (SEC1). The phenotype of adherent cells (Ac) derived from bovine PBMC cultured with SEC1 [SEC1-stimulated Ac (sAc)] for 192 h was CD14(-), CD68(-), CD163(-), dendritic cell (DC)-specific ICAM-3-grabbing nonintegrin(+), MHC class II (MHC II)(high), CD11a(low), CD11b(high), CD11c(high), and CD1b(high), suggesting these cells were dendritic cells (DC). SEC1 also induced transcription of the CXCL1, -2, and -3 family, CXCL6, CCL2, and CCL5 genes in sAc, which increased rapidly but returned to basal levels by 48 h. In contrast, increased transcription of CCL3, CCL8, and CXCL12, responsible for mononuclear cell migration and chronic inflammation, was sustained. In vitro cell migration assays showed vigorous migration of granulocytes, followed by migration of mononuclear cells. The autologous MLR showed that sAc induced a dose-dependent proliferation of CD4(+) T cells and an even stronger proliferation of CD8(+) T cells. This effect was inhibited or reduced by pretreatment with mAb to CD11b, MHC II, or MHC II plus CD18. These results indicate that stimulation of bovine PBMC by SAg induces differentiation of monocytes into DC.</P>
Ma, L D,Wang, J,WEI, C,Kuroiwa, T,Narukawa, T,Ito, N,HIOKI, A,CHIBA, K,Yim, Y H,Lee, K S,Lim, Y R,Turk, G C,Davis, C W,Mester, Z,Yang, L,McCooeye, M,Maxwell, P,Cankur, O,Tokman, N,Coskun, F G BUREAU INTERNATIONAL DES POIDS ET MESURES 2017 METROLOGIA -BERLIN- Vol.54 No.-
<P></P> <P>The CCQM-K97 key comparison was organized by the inorganic analysis working group (IAWG) of CCQM as a follow-up to completed pilot study CCQM-P96 and P96.1 to test the abilities of the national metrology institutes to accurately quantitate the mass fraction of arsenobetaine (AsB) in standard solution and in fish tissue. A pilot study CCQM-P133 was parallelized with this key comparison. National Institute of Metrology (NIM), China and National Metrology Institute of Japan (NMIJ) acted as the coordinating laboratories.</P> <P>Six NMIs participated in CCQM-K97 and two institutes participated in CCQM-P133, and all of them submitted the results. Some NMIs submitted more than one results by different methods. The results were in excellent agreement with each other, and obviously better than those of previous P96 and P96.1. Therefore the calibrant which each NMI used was comparable. It shows that the capabilities of some of the participants have been improved after the previous pilot studies.</P> <H2>Main text</H2> <P> To reach the main text of this paper, click on <A HREF='http://www.bipm.org/utils/common/pdf/final_reports/QM/K97/CCQM-K97.pdf'>Final Report</A>. Note that this text is that which appears in Appendix B of the BIPM key comparison database <A HREF='http://kcdb.bipm.org/'>kcdb.bipm.org/</A>.</P> <P>The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).</P>
Friesen, Melissa C,Locke, Sarah J,Zaebst, Dennis,Viet, Susan,Shortreed, Susan,Chen, Yu-Cheng,Koh, Dong-Hee,Pardo, Larissa,Schwartz, Kendra L,Davis, Faith G,Stewart, Patricia A,Colt, Joanne S,Purdue, M BMJ Publishing Group Ltd 2014 Occupational and environmental medicine Vol.71 No.suppl1
<P><B>Objectives</B></P><P>We applied machine learning approaches to efficiently assist multiple experts to transparently estimate occupational lead exposure in a case-control study of renal cell carcinoma.</P><P><B>Method</B></P><P>We used hierarchical cluster models to classify the 7154 study jobs with occupational history and job/industry questionnaires into 360 groups with similar responses. Each group was reviewed independently by two or three experts and was assigned probabilities of lead exposure (<5%, ≥5– <50%, ≥50%) for three time periods (<1980, 1980–1994, ≥1995). When the group’s mean response pattern suggested within-group exposure variability, experts identified programmable conditions that defined the rating differences where possible or flagged the group for further review. After splitting jobs that overlapped time periods at the calendar cut point, the 9992 job/time periods were assigned their relevant expert/group/time period estimate. Classification and regression tree (CART) models were developed to predict each expert’s expected assignment, based on previous decisions, to assign estimates for jobs in groups that expert had not assessed and for jobs requiring further review.</P><P><B>Results</B></P><P>In preliminary analyses, CART models predicted 91–96% of the experts’ pre-1995 estimates and 77–96% of ≥1995 estimates. CART estimates were assigned to 3–48% of the job/time periods, varying by expert. Overall, 92% of the job/time periods were assigned the same estimate by at least two experts.</P><P><B>Conclusions</B></P><P>Our framework reduced the number of exposure decisions needed from each expert compared to job-by-job assessment. Future work will use CART models to identify differences between experts to be resolved and incorporate frequency and intensity of lead exposure estimates.</P>
Multi-component diffusion analysis and assessment of GAMMA code and improved RELAP5 code
No, H.C.,Lim, H.S.,Kim, J.,Oh, C.,Siefken, L.,Davis, C. North-Holland Pub. Co 2007 Nuclear engineering and design Vol.237 No.10
A loss-of-coolant accident (LOCA) has been considered a critical event for very high temperature gas-cooled reactor (VHTR). Following helium depressurization, it is anticipated that unless countermeasures are taken, air will enter the core through the break by molecular diffusion and ultimately by natural convection leading to oxidation of the in-core graphite structure. Thus, without any mitigating features, a LOCA will lead to an air ingress event, which will lead to exothermic chemical reactions of graphite with oxygen, potentially resulting in significant increases of the core temperature. New and safer nuclear reactors (Generation IV) are now in the early planning stages in many countries throughout the world. One of the reactor concepts being seriously considered is the VHTR. To achieve public acceptance, these reactor concepts must show an increased level of inherent safety over current reactor designs (i.e., a system must be designed to eliminate any concerns of large radiological releases outside the site boundary). A computer code developed from this study, gas multi-component mixture analysis (GAMMA) code, was assessed using a two-bulb experiment and in addition the molecular diffusion behavior in the prismatic-core gas-cooled reactor was investigated following the guillotine break of the main pipe between the reactor vessel and the power conversion unit. The RELAP5 code was improved for the VHTR air ingress analysis and was assessed using inverse U-tube and NACOK natural circulation data.
Excitons in Motion in CdTe, ZnTe and ZnSe
J. J. Davies,L. C. Smith,D. Wolverson,H. Boukari,R. T. Cox,H. Mariette,J. Cibert 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
We report remarkable changes in the magnetic properties of excitons as they acquire kinetic energy in wide (001) quantum wells of CdTe, ZnSe, ZnTe and GaAs. In particular, the magnetic moments (g-values) when magnetic fields are applied in the growth direction are shown to have a strong dependence on the translational wavevector Kz. The dependence is particularly marked when Kz is of the order of the inverse of the exciton Bohr radius or, equivalently, when the translational kinetic energy becomes comparable with the exciton Rydberg. The behaviour is ascribed to motionallyinduced mixing between the 1S hydrogenic exciton ground state and excited nP states and is describable by what appears to be a universal formula.
The SAMI Galaxy Survey: observing the environmental quenching of star formation in GAMA groups
Schaefer, A L,Croom, S M,Scott, N,Brough, S,Allen, J T,Bekki, K,Bland-Hawthorn, J,Bloom, J V,Bryant, J J,Cortese, L,Davies, L J M,Federrath, C,Fogarty, L M R,Green, A W,Groves, B,Hopkins, A M,Konstant Oxford University Press 2019 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.483 No.3
Sarzi, Marc,Shields, Joseph C.,Schawinski, Kevin,Jeong, Hyunjin,Shapiro, Kristen,Bacon, Roland,Bureau, Martin,Cappellari, Michele,Davies, Roger L.,Tim de Zeeuw, P.,Emsellem, Eric,Falcó,n-Barroso Blackwell Publishing Ltd 2010 Monthly notices of the Royal Astronomical Society Vol.402 No.4
<P>ABSTRACT</P><P>Following our study on the incidence, morphology and kinematics of the ionized gas in early-type galaxies, we now address the question of what is powering the observed nebular emission. To constrain the likely sources of gas excitation, we resort to a variety of ancillary data we draw from complementary information on the gas kinematics, stellar populations and galactic potential from the <SMALL>SAURON</SMALL> data, and use the <SMALL>SAURON</SMALL>-specific diagnostic diagram juxtaposing the [O <SMALL>III</SMALL>]λ5007/Hβ and [N <SMALL>I</SMALL>]λλ5197, 5200/Hβ line ratios. We find a tight correlation between the stellar surface brightness and the flux of the Hβ recombination line across our sample, which points to a diffuse and old stellar source as the main contributor of ionizing photons in early-type galaxies, with post-asymptotic giant branch (pAGB) stars being still the best candidate based on ionizing balance arguments. The role of AGN photoionization is confined to the central 2–3 arcsec of an handful of objects with radio or X-ray cores. OB-stars are the dominant source of photoionization in 10 per cent of the <SMALL>SAURON</SMALL> sample, whereas for another 10 per cent the intense and highly ionized emission is powered by the pAGB population associated to a recently formed stellar subcomponent. Fast shocks are not an important source of ionization for the diffuse nebular emission of early-type galaxies since the required shock velocities can hardly be attained in the potential of our sample galaxies. Finally, in the most massive and slowly or non-rotating galaxies in our sample, which can retain a massive X-ray halo, the finding of a spatial correlation between the hot and warm phases of the interstellar medium (ISM) suggests that the interaction with the hot ISM provides an additional source of ionization besides old ultraviolet-bright stars. This is also supported by a distinct pattern towards lower values of the [O <SMALL>III</SMALL>]/Hβ ratio. These results lead us to investigate the relative role of stellar and AGN photoionization in explaining the ionized gas emission observed in early-type galaxies by the Sloan Digital Sky Survey (SDSS). By simulating how our sample galaxies would appear if placed at further distance and targeted by the SDSS, we conclude that only in very few, if any, of the SDSS galaxies which display modest values for the equivalent width of the [O <SMALL>III</SMALL>] line (less than ∼2.4 Å) and low-ionization nuclear emission-line region like [O <SMALL>III</SMALL>]/Hβ values the nebular emission is truly powered by an AGN.</P>