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- 저자 : C hul-Ho Shin (검색결과 1 건)
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Antitumor activity of spinasterol isolated from Pueraria roots
Gook-Che Jeon,Myoung-Soon Park,윤도영,C hul-Ho Shin,Hong-Sig Sin,엄수종 생화학분자생물학회 2005 Experimental and molecular medicine Vol.37 No.2
We purified phytoestrogens from Pueraria root (Pueraria mirifica from Thailand and Pueraria lobata from Korea), which is used as a rejuvenat-ing folk medicine in Thailand and China. Dried, powdered plant material was extracted with 100% ethanol and further separated by concentration, filtration, and thin layer silica gel chromatogra-phy. Using the fractions obtained during separa-tion, we first investigated their cytotoxicity in se-veral cancer cel lines from various tissues. The ethanol-extracted components (PE1, PE4) had sig-nificant antiproliferative efects on breast cancer cel lines, including MCF-7, ZR-75-1, MDA-MB-231, SK-BR-3, and Hs578T. Second, we compared flavonoids, sterols, and coumarins from Pueraria root. The known compounds were not as efec-tive, and occured in a diferent polarity region on HPLC. Third, further separation resulted in the isolation of eight diferent components (Sub PE-A to -H). One of these, PE-D, affected the growth of some breast cancer cel lines (MCF-7, MDA- MB-231) in a dose- and time-dependent maner, as wel as the growth of ovarian (2774) and cervical cancer cels (HeLa). Finaly, a transfec-tion assay showed that this component had an estrogenic effect similar to 17βactivates both estrogen receptor α (ERα) and ERβ. The NMR analysis determined that spin-asterol (stigmasta-7, 22-dien-3beta-ol) is an active cytotoxic component of Pueraria root.
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