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Foot Deformity in Charcot Marie Tooth Disease According to Disease Severity
So Young Joo,김덕용,Byung-Ok Choi,Soo Jin Hwang,Soo Jin Jung,Sun Young Cho 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.4
Objective To investigate the characteristics of foot deformities in patients with Charcot-Marie-Tooth (CMT) disease compared with normal persons according to severity of disease. Method Sixty-two patients with CMT disease were recruited for this study. The normal control group was composed of 28 healthy people without any foot deformity. Patients were classified into a mild group and a moderate group according to the CMT neuropathy score. Ten typical radiological angles representing foot deformities such as pes equinus and pes varus were measured. The CMT group angles were compared with those of the normal control group, and those of the mild group were also compared with those of the moderate group. Results Th e lateral (Lat.) talo-fi rst metatarsal angle, anteroposterior talo-fi rst metatarsal angle, Lat. calcaneal-fi rst metatarsal angle, Lat. naviocuboid overlap, Lat. calcaneal pitch, Lat. tibiocalcaneal angle, and Lat. talocalcaneal angle in the CMT group showed a signifi cant diff erence compared to the normal control group (p<0.05). These findings revealed CMT patients have pes cavus, forefoot adduction, midfoot supination and pes varus deformity. Compared to the mild group, the moderate group significantly showed an increased Lat. calcaneal pitch and decreased Lat. calcaneal-first metatarsal angle, Lat. tibiocalcaneal angle, Lat. talocalcaneal angle, and Lat. talofirst metatarsal angle (p<0.05). These findings revealed that the pes cavus deformity of CMT patients tend to be worse with disease severity. Conclusion The characteristic equinovarus foot deformity patterns in CMT patients were revealed and these deformities tended to be worse with disease severity. Radiographic measures may be useful for the investigation of foot deformities in CMT patients.
Prevalence of Bacterial Contaminations of Chicken Meat in South Korea 2014 - 2015
( Byung-kook Choi ),( Ok-mi Jeong ),( Chun-tae Lim ),( So-youn Youn ),( Na-young Kim ),( Byung-woo Jeon ),( Shin-ae Kim ),( Suk-chan Jung ),( Min-su Kang ) 대한인수공통전염병학회 2016 창립총회 및 학술대회 초록집 Vol.2016 No.1
Introduction: Food borne diseases are considered to begin from animal meat and meat products which are sometimes resulting to serious health problems due to the consumption of them. A two years study about bacteriological condition of chicken meat in South Korea, was carried out to investigate the occurrence of Salmonella spp., Staphylococcus aureus, Clostridium perfringens, Campylobacter coli, Campylobacter jejuni, Escherichia coli, Yersinia enterocolitica, and Listeria moncytogenes. Methods: Each solution of a hundred eighty samples of chicken carcasses was collected from the slaughter houses throughout the South Korea during 2014 -2015. The samples were analyzed for the presence of bacterial contaminations using Korean Food Standard Codex for meat and meat products. Results: In one hundred eighty chicken samples, Staphylococcus aureus (36.1%) is the most frequent pathogen in chicken meat for two years followed by Clostridium perfringens (31.7%), Campylobacter coli (23.3%), Salmonella spp. (13.3%), Campylobacter jejuni (10.0%), Escherichia coli: 0111 (3.9%), Escherichia coli: 0145 (2.2%), Escherichia coli: 026 (1.7%), Yersinia enterocolitica (1.1%), and Listeria monocytogenes (1.1%). Minor pathogens are Escherichia coli spp. (O45, O103, O104, O121 and O128). Conclusion: The bacteriological status of chicken meats from the slaughter houses showed that a variety of pathogens were able to transmit diseases to people especially high level of Staphylococcus aureus and Clostridium perfringens. Our findings suggest that farms and slaughter houses should more enforce hygiene system to reduce pathogens which are harmful for public health.
How useful are liver function tests in vitro in human hepatoma cell line (HepG2)?
Byung-Suk Jeon,Seong-Yun Hwang,So-Ryeon Hwang,Nam-Ju Kim,Hee Yi,Ji-Hyun Bang,Moon Her,Hyun-Ok Ku 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
In preclinical hepatotoxicity testing cell based are frequently relevant. However, prediction of drug induced liver injury remains a major challenge. Here we addressed the usefulness of frequently relevant markers of hepatocellular injury in human hepatocarcinoma cell line (HepG2) in response to treatment with either acetaminophen, amiodarone, etoposide, orphenadrine and/or lovastatin. The change in the cellular injury (AST, ALT and LDH) were determined toxicity and above drug concentrations as to evaluate the utility of these markers in vitro systems. Initially, treatment of HepG2 with any of the drugs caused a statistically significant reduction in enzyme activities to suggest a switch from basic amino acid metabolism towards induced detoxification. However, treatment for prolonged periods of time caused cytolysis, as evidenced by the significant rise in extracellular LDH and the concomitant increase in ALT and AST activity. Notably, among the various endpoints studied, LDH was best to determined dose dependent cytotoxicity, while other markers of hepatocellular injury were variable. Taken collectively, LDH measurement proofed to be robust in predicting hepatocellular toxicity; therefore, it should be included in preclinical testing strategies for an improved prediction of hepatotoxicity.