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      • KCI등재

        레크리에이션 활동이 정신지체아의 사회적 기술과 문제행동에 미치는 효과

        강병일,추근도,최경훈,박기용,박병규 한국특수체육학회 2004 한국특수체육학회지 Vol.12 No.3

        The purpose of this study was to identify the effect of recreation program applied to the mentally retarded children on their social skill and problem behavior. The subjects of the study were the mentally retarded children who were attending at J middle school for special education in Andong-city, Kyungpook Province and the children were divided into two groups; experimental and comparative groups. Research design was as follows; the input of recreation activities was designated as independent variables, male and female mentally retarded children group was determined as object variables, and social skill and problem behavior was subject variables. After the pre-tests on the scales of the sampling children's social skill and problem behavior were carried out, experimental group was applied to the recreation program and comparative group was taught as a usual time and then the post-tests was performed. t Examination was used to identify the differences according to the results from post-tests and the data were processed by SPSS 10.0(Statistical Package for the Science) statistics program. The results from the above research were as follows; First, the mentally retarded children applied to the recreation program had a positive effect on their social skill. Second, the application of the program also had a positive effect on their problem behavior. From the results of this study, my suggestions were First, the follow-up research should be provided to identify the effect of recreation program on the children being various levels. Second, the range of research should be expanded, so the consistent research on children of kindergarten or after-elementary school should be followed. Third, the succeeding research on the long-term transfer of the program's effect should be continued. Forth, other programs(or strategies) could attribute to the promotion of the mentally children's social skill and the improvement of their problem behavior. Fifth, the research capable of inducing their activities after understanding the students' traits, interest degree on the subjects and so on should be made. Finally, each agencies or schools should develop and apply more systematic recreation program and also try to develop a system which could be classified and applied to recreation fields suitable for the individuals' traits.

      • KCI등재

        잔존 봉합사에 의해 발생한 점액종

        이제호,최병재,서원건,최형준 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4

        점액종이란 소타액선 분비관의 폐쇄 또는 파열로 인한 타액의 저류로 나타나는 종창에 대한 임상적인 용어이다. 점액종은 조직학적으로 삼출형과 잔류낭종형으로 분류되어, 삼출형은 외상등으로 소타액선 분비관이 파열된 후 점액이 조직내로 유출되어 조직간격에 고여있는 상태이기 때문에 상피 피복을 볼 수 없고 낭종벽은 육아조직으로 둘러싸여있다. 그리고 잔류낭종형은 소타액선 분비관이 작은 타석에의해 폐쇄되거나 분비관 주위 반흔조직의 협착으로 발생하며 낭종강은 원주상피 또는 위중층 편평상피로 피개되어있다. 본 증례는 3년전 하순의 열창 치료를 위해 봉합된 후 발사되지 않은 silk 봉합사에 의해 발생한 점액종의 치험례로, 발사되지 않은 봉합사가 하순 소타액선의 분비관을 관통하여 파열시켜서 점액이 결체조직으로 유출되어 점액종이 발생하였다. Mucocele is clinical term used to describe swelling caused by the pooling of saliva at the site of a severed or obstructed minor salivary gland duct. Mucoceles are categorized into two subgroups, extravasation type and retention cyst type. The etiology of extravasation type mucocele is related to mechanical trauma to the minor salivary gland excretory duct, resulting in extravasation of mucus into the fibrous connective tissue so that a cystlike cavity is produced, but the epithelial lining is absent. Retention cyst type mucocele results from obstruction of minor salivary gland excretory duct, and cystic cavity is lined by epithelial cells. This case report presents a mucocele occurred on the lower lip, and caused by suture silk unremoved for 3 years. Suture silk penetrated and tore the minor salivary gland duct on the lower lip with subsequent extravasation of mucus into the fibrous connective tissue.

      • KCI등재후보

        조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

        김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

        Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

      • SCOPUSSCIEKCI등재

        두개인두종의 치료성적과 조직학적 유형 및 PCNA지수의 연관성에 대한 연구

        김기정,오창완,조병규,김정선,지제근,최길수 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

        Craniopharyngiomas exhibit benign histologic features. However, such tumors have a relative high incidence of recurrence after surgical removal. In order to device reliable and efficient methods in identifying craniopharyngiomas with increased risk for recurrence after surgical removal, proliferating cell nuclear antigen(PCNA) expression as well as histological characteristics of the tumor were analyzed. There were 43 patients who had been surgically confirmed and had paraffin-embedded tissue from June, 1984 to May, 1993 avaliable for analysis from our department. Of the 43 patient, eighteen cases were in children(age of 15 years or less) and 25 cases were in adults. The mean follow-up period was 42.7 months. The histologic types were adamantinous in 30 cases, squamous papillary in 9 cases and mixed in 4 cases. There was no case of tumor recurrence in the squamous papillary group, while the recurrence rate was about 55% in the adamantinous group after surgical removal alone. The mean age of the adamantinous group was younger than that of the squamous papillary group(17.5 vs. 37.9 years old. P=0.0012), and the squamous papillary type was found only in adults(age over 20). In the group of 30 patients treated by surgical removal without radiation, the PCNA labelling index, calculated by counting the basal cell layer only, was significantly higher in the group with recurrence than without recurrence(9.51 vs. 6.58, P=0.001). However, the PCNA labelling index obtained by counting all cells in the four high-power (×400) fields failed to demonstrate any correlation with tumor recurrence. With a reference value of 8, PCNA index of the basal cell layer demonstrated the predictive sensitivity of 81.8% and specificity of 84.2% for tumor recurrence. There was no significant difference in PCNA labelling indices between adamantinous and squamous papillary types. As PCNA labelling index of the basal cell layer, as well as the histologic type, are sensitive indicators for prediction of tumor recurrence after surgical removal of craniopharyngiomas, therefore they should be considered as an index for biologic behavior of the tumor.

      • SCIESCOPUSKCI등재

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