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Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice
Byun, S.H.,Lee, J.H.,Jung, N.C.,Choi, H.J.,Song, J.Y.,Seo, H.G.,Choi, J.,Jung, S.Y.,Kang, S.,Choi, Y.S.,Chung, J.H.,Lim, D.S. Pergamon Press 2016 Biochemical pharmacology Vol.115 No.-
<P>Rosiglitazone is a selective ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which serves diverse biological functions. A number of autoimmune disease models have been used to examine the anti-inflammatory and immunosuppressive effects of tolerogenic dendritic cells (tDCs). The aim of the present study was to investigate whether rosiglitazone-mediated DC (Rosi-DC) therapy suppressed arthritis in a collagen-induced arthritis (CIA) mouse model. Rosi-DCs were generated by treating immature DCs with TNF-alpha, type II collagen, and rosiglitazone. CIA mice then received subcutaneously (s.c.) two injections of Rosi-DCs. The severity of arthritis was then assessed histopathologically. The phenotypes of the DC and regulatory T (Treg) cell populations in CIA mice were determined by flow cytometry and the effect of Rosi-DCs on the secretion of autoimmunity-inducing cytokines was examined by ELISA. Rosi-DCs expressed lower levels of DC-related surface markers than mature DCs. Histopathological examination revealed that the degree of inflammation in the paws of Rosi-DC-treated mice was much lower than that in the paws of PBS-treated CIA mice. Taken together, these results clearly show that rosiglitazone-mediated DCs ameliorate CIA, most likely via the induction of antigen-specific Treg cells. (C) 2016 Elsevier Inc. All rights reserved.</P>
On confinement characteristics of the newly developed sawtooth-free plasmas in KSTAR tokamak
Byun, C.s.,Na, Y.S.,Kim, H.S.,Kim, S.H. Elsevier 2014 Current Applied Physics Vol.14 No.1
Development of advanced scenarios, an important experimental goal of the Korea superconducting tokamak advanced research (KSTAR) project, has just begun. The safety factor (q) profile is a key to achieve these advanced scenarios. Particularly the hybrid scenario, one of the advanced scenarios, can be established generally with low magnetic shear (s) at the center with central q-value above unity so to avoid sawtooth instability. This q-profile was successfully produced using early divertor formation during a plasma current ramp-up phase in KSTAR. Auxiliary heating was also employed during the current ramp-up phase to delay the inductive current diffusion to the center of the plasma. In addition to the early divertor formation method, the target q-profile was attempted to be achieved by modifying the plasma current waveform using the so-called, 'current-overshoot' method and the timing of L-mode to H-mode transition. In this work, the confinement characteristics of these sawtooth-free regimes are investigated. The global energy confinement time is calculated and compared with that of conventional H-modes in KSTAR. The confinement enhancement factor reveals that the newly developed discharges are not improved over H-modes contrary to results of other tokamaks. To investigate the reason, transport modeling is performed self-consistently with an integrated simulation package incorporating plasma equilibrium, transport, and heating and current drive. The current ramp-up phase is simulated and impact of early divertor formation, current-overshoot, and early L-H transition on the target q-profile and s/q profile is addressed. The s/q profile is found to be not improved in these discharges compared with hybrid scenarios reported in other tokamaks. Based on these results, future experimental directions are addressed to access the hybrid regimes in KSTAR.
Chae, S.Y.,Jin, C.H.,Shin, J.H.,Son, S.,Kim, T.H.,Lee, S.,Youn, Y.S.,Byun, Y.,Lee, M.S.,Lee, K.C. Elsevier Science Publishers 2010 Journal of controlled release Vol.142 No.2
Alterations in the physicochemical characteristics of peptide drugs can transform their biological and pharmaceutical features. In the present study, we explored the potentials of lithocholic acid (LCA)-modified exendin-4 derivatives as novel long-acting GLP-1 receptor agonists. Exendin-4 was modified with lithocholic acid at two lysine residues to produce three derivatives that were obtained by reverse-phase HPLC separation, namely, Lys<SUP>12</SUP>-LCA-exendin-4 (LCA-M2), Lys<SUP>27</SUP>-LCA-exendin-4 (LCA-M1), and Lys<SUP>12,27</SUP>-LCA-exendin-4 (LCA-Di)). The biological, pharmacological, and physicochemical characteristics of these three exendin-4 analogues were then investigated. Although slight reductions in the GLP-1 receptor binding capacity and insulinotropic activity of exendin-4 were observed after derivatization, the mono-LCA substitutions, especially LCA-M1, well-preserved antidiabetic activity in type 2 diabetic mice when administered subcutaneously or intraperitoneally. Furthermore, the pharmacokinetic characteristics were dramatically enhanced, that is, absorption was delayed and elimination half-life was increased (1.6+/-0.4 and 9.7+/-1.4h by exendin-4 and LCA-M1, respectively). The enhanced long-acting characteristics of the derivative was found to be due to albumin binding and nanoparticle formation, and these were verified by the restoration of normoglycemia in type 2 diabetic mice after single injection (>24h, >10nmol/kg, s.c.) and daily injections (15nmol/kg/day) maintained normoglycemia for the 4-week administration period. Furthermore, antidiabetic potentials, such as, glucose clearance kinetics and percentage areas occupied by pancreatic β-cells were also enhanced by long-term LCA-M1 administration. The present study demonstrates that the derivatization of exendin-4 with LCA offers a possible means of producing a long-acting GLP-1 receptor agonist.
강민경,김소정,김유미,박수민,변고영,송은혜,신지혜,이은별,이은서,정진선,김건희,이수연 이화여자대학교 간호과학대학 2019 이화간호학회지 Vol.- No.53
Purpose: This study aimed to identify the relationship among sleep, resilience, and interpersonal relations of college students. Methods: Data were collected by using a structured questionnaire consisting of Korean Sleep Scale, Connor-Davidson Resilience Scale-10, and Relationship Change Scale between September 21st, 2018 to September 30th, 2018. Subjects were 185 college students who currently attend universities in a city. Collected data were analyzed using descriptive statistics, t-test, one-way ANOVA, Tukey’s test and Pearson’s correlation coefficient using the SPSS 25.0 program. Results: The mean score of sleep was 34.93±6.35, the mean score of resilience was 23.17±6.95, and the mean score of interpersonal relations were 3.65±0.38. In sleep, there were significant differences according to grade and major. In resilience, there were significant differences according to gender and grade. Sleep was negatively related to resilience (r=-.319, p<.001) and interpersonal relations (r=-.226, p=.002). Interpersonal relations were positively correlated to resilience (r=.348, p<.001). Conclusion: The results suggest that concrete measures to promote interpersonal relations need to be sought in consideration of the relations among college students' sleep, resilience, and interpersonal relations. Also, it is expected that the study will be used as basic data to improve the interpersonal relations of college students in the desirable direction by improving the sleep and resilience of college students.
鄭元采,盧載榮,安長憲,卞珠燮 충북대학교 엽연초연구소 1974 煙草硏究 Vol.2 No.-
This works has been carried out in order to study the influence of different condition of soil moisture on the growth and yield of tobacco leaves. It was investigated the soil moisture on the cultivating farm of tobacco for the study on the variation in soil moisture. The results are summarized as follow; 1.In the deficient supply of soil moisture, S1 treatment at the setting stage caused the delay of growth, and S3 treatment at the period vigrous growth influenced eriousely on the yield. Dry leaf weight decreased gradually in order S1>S6>S2>S3>S5>S4. 2.The dry leaf weight was decreased according to the increase of treatment duration, the results showed as T1=T2=T3<C 3.In the excessive supply of soil moisture, 90% (maximum water holding capacity) treatment during 10~20 days was damaged at early stage more than latter stage treatment in the growth. 4.In the deficient or excessive supply of soil moisture, excessive supply treated plots in long period and the replication plots in the deficient supply treated influenced on the yields.