정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

가교제를 첨가시킨 BSA고정막의 합성 및 특성

김재훈,김민,김병식 한국공업화학회 2003 응용화학 Vol.7 No.1

Bovine serum albumin(BSA) as a chiral ligand was captured uniformly throughout a porous hollow-fiber membrane at a level of 250mg/g by the polymer chains grafted onto the membrane. Subsequetly, crosslinking of BSA with a 0.05%(w/w) of glutaraldehyde in a Tris-HCL buffer (pH 8) for 5 h was effective in stabilizing the amount of BSA immobilized at a level of 200 mg/g. A solution of 이-Tryptophan in Tris-HCI buffer asa mobile phasa permeated the crosslinked-BSA multilayered membrane. Therefore on experimentation is BAS immobilized hollow fiber is applicable for the chiral separation of enantiomers in a mobile phase with various pH values and organic modifiers.

Glutaraldehyde로 가교시킨 BSA고정막에 의한 DL-Tryptophan의 흡착특성

김재훈,김민,김병식 한국공업화학회 2004 응용화학 Vol.8 No.1

A DEA group-containing polymer chain grafted onto a porous PE membrane. BSA was immobilized by the permeation of a BSA solution through the pore of the DEA membrane. The immobilized BSA was cross-linking with glutaraldehyde to prevent leakage. DL-tryptophan solution was forced to permeate through the BSA immobilized membrane at a flow 50mL/h. As a result, Adsorption of D-L-tryptophan increase with increasing of BSA immobilized as a function of the degree of GMA grafting.

이성질체 분리를 위한 음이온교환재료의 합성

김재훈,김민,김병식 한국공업화학회 2003 응용화학 Vol.7 No.2

Anion exchange groups were introduced into porous hollow fiber membranes by radiation-induced ploymerization. The epoxy group produced in the GMA-grafted hollow fiber membrane was converted into anion-exchange groups by reaction with Diethylamine(DEA). Triethylamine(TEA). Ethanolamine(EtA). Diethanolamine(DEtA). The D-, L-Tryptophan solution was forced to permeate across the hollow fiber DEA, TEA, EtA, DEtA memberan. When measurements of anion-exchange capacity of the DEA, TEA, EtA, DEtA memberan, the DEA membrane having higher adsorption capacity than TEA, EtA, DEtA membrane.

Haloperidol, Lithium 및 Amitriptyline이 인체에서 HLA type에 미치는 영향에 대한 예비연구 : in vivo

김문두,강병조,정성훈 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.1

저자는 정신분열증 환자, 주요우울장애 환자, 양극성장애 환자들의 치료에 사용되는 haloperidol, amitriptyline 및 lithium이 이런 환자들에서 HLA type에 어떠한 영향을 미치는 지를 알아보고자 본연구를 시험하였다. 향정신성 약물을 사용한 경험이 없는 환자 4명을 대상으로하여, 약물을 투여하기 전에 말초 혈액을 채혈하여 HLA 항원형을 결정하였고, 상기의 약물을 2개월 이상 치료용량으로 사용한 후 다시 HLA 항원형을 조사하여 다음과 같은 결과를 얻었다. haloperidol에서는 약물투여전과 약물투여후의 HLA항원형의 변화가 없었다. lithium에서는 HLA B60, HLA Cwl 항원이 소실되었다. amitriptyline에서는 HLA B55 항원이 소실되었고, HLA B75 항원이 발현되었다. 이상의 결과는 인체에서도 amitriptyline 및 lithium이 치료적 용량으로 충분히 사용한 이후 HLA 항원형에 변화를 가져올 수 있다는 것을 알수 있었다. To examine the effects of haloperidol, amitnptyline and lithium on HLA type in vivo, the author conducted microlymphocytotoxicity test on lymphocytes drawn from 4 psychiatric disordered patients, including 2 schizophrenic patients, 1 bipolar disordered patient and 1 major depressive disordered patient before administration of haloperidol, lithium and amitriptyline. After 2 months later, drug therapy was done sufficiently, we reexamine the HLA type on lymphocytes drawn from same patients. The results were as follows : 1) There is no significant changes on HLA type before and after 2 months long halopendol therapy in 2 schizophrenic patients. 2) It was shown that the disappearance of HLA B60 and HLA Cw1 antigen after 2 months long lithium therapy in l bipolar I disordered patient. 3) It was shown that the revelation of HLA B75 antigen and the disappearance of HLA B55 antigen after 2 months long amitriptyline therapy in 1 ma]or depressive disordered patient From the results of present study, we may draw a conclusion that the lithium and amitriptyline therapy cause a revelation of new HLA type and loss of some existed HLA antigens so that these drugs have an effect on HLA typing in vivo experiment.

킬레이트 형성기로서 Ethylenediamine을 도입한 다공성 중공사막에 의한 금속이온의 흡착특성

김헌석,김민,이영기,김병식 동국대학교 산업기술연구원 1999 산업기술논문집 Vol.14 No.-

폐수나 초순수 중의 금속이온을 효율적으로 회수하기 위해 킬레이트 형성기로서 에틸렌디아민(EDA)을 방사선그래프트중합법에 의해 생성된 그래프트 체인에 도입하였다. 그래프트율에 따른 에틸렌디아민기의 밀도를 측정하였으며, 그래프트율 177%의 경우 4.25mol/kg으로 나타났다. 에틸렌디아민기가 도입된 중공사막의 금속이온에 대한 흡착용량은 투과법에 의해 측정되었다. 투과압력의 변화에 무관한 흡착용량을 나타내었으며, 흡착된 금속이온은 용리액에 의해 100% 용리가 되었다. 구리(Cu)와 카드뮴(Cd)의 2성분 흡착에서는 구리이온이 카드뮴이온을 치환흡착 하는 것을 알 수 있었다. An ethylenediamine(EDA)-group as a chelate forming group was appended onto a hollow fiber membrane for effective recovery of metal ion from waste water or ultra pure water by radiation-induced graft polymerization of an epoxy-group-containing monomer, glycidylmethacrylate(GMA), and subsequent chemical modification. The density of EDA-group was investigated as a function of the degree of GMA grafting(dg), and it was 4.25mol/kg in case of the dg 177%. The adsorption of metal-ion onto toe EDA-hollow fiber membrane was measured by the permeation method. The metal adsorption capacity during permeation of a copper solution through the EDA-hollow fiber at various flow rate demonstrated that a higher flow rate is not affected to the collection efficiency. In the binary adsorption of Cu^2+/Cd^2+, we could see that Cu^2+ ion was substituted for Cd^2+ ion and adsorbed finally.

BSA고정화를 위한 가교제의 첨가특성

김재훈,김민,김병식 한국공업화학회 2004 응용화학 Vol.8 No.2

Anion exchange groups(DEA) were introduced into porous hollow fiber membranes by radiation-induced ploymerization. A DEA group-containing polymer chain grafted onto a porous PE membrane. The BSA solution was forced to permeate across the hollow fiber DEA membrane. BSA was immobilized by the permeation of a BSA solution through the pore of the DEA membrane. The immobilized BSA was cross-linking with glutaraldehyde to prevent leakage. Afterwards, The GA 0.05 percent membrane having higher adsorption capacity than 0.025, 0.075, 0.1 percent GA concentration.

갑상선 기능항진증에 병발된 주기성 마비 3예

최지훈,최경숙,김기훈,박병현,조정구 圓光大學校 醫科學硏究所 2001 圓光醫科學 Vol.16 No.1-2

Thyrotoxic periodic paralysis is characterized by intermittent flaccid paralysis of skeletal muscle, lasting several hours. The underlying pathophysiology of the syndrome is not yet to be well characterized and remains controversal, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself. It occurs primarily in Asian populations with an overwhelming male preponderance and a higher association of specific HLA antigens. Precipitating factors include high carbohydrate ingestion, exercise, trauma, infection, alcohol ingestion, administration of epinephrine, thyroid hormone, or corticosteroid. If hypokalemia is present, potassium administration may help abort the attack, but the only definitive treatment is formation of euthyroid state. We discribed two patients with hypokalemic thyrotoxic periodic paralysis and one patient with normokalemic thyrotoxic periodic paralysis.

악교정 수술 환자에서 수술부 술전소독에 사용되는 소독제의 항균성에 대한 임상적인 비교 : POVIDONE-IODINE AND CHLORHEXIDINE

엄기훈,한세우,유준영,양병은,김용관 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

For prevention of bacteremia and surgical field contamination, various concentration are used in preoperative skin preparation. Of these, povidone(PVP)-iodine has been known as one having believable effect. But, application of PVP-Ⅰon pral and maxillofacial field has some problems-skin discoloration, hypersensitivity, corneal irritation,etc. Therefore chlorhexidine has been tried to replace PVP-Ⅰ. More recent studies of antibacterial effect of chlorhexidine and PVP-Ⅰ has been achieved on the other field. The purpose of this study was to compare the antibactreial effect of two kinds of skin disinfectants used in oral and maxillofacial surgical field.-chlorhexidine and PVP-Ⅰ. We studied the 40 patients who have taken operation of orthognathic surgery in Dept. of oral & Maxillofacial Surgery, Kangnam General Hospital Public Corp..Results of bacterial culture taken from facial skin and intraoral mucosa after application 10% PVP-Ⅰ and 0.5% chlorhexidine were compared.

알루미늄材의 彈塑性破壞靭性評價에 關한 硏究

邕章祐,金載勳,朴昞俊 충남대학교 공업교육연구소 1986 論文集 Vol.8 No.3

It has been very important to evaluate the J_IC in Elastic-Plastic Fracture toughness test and to develope the certain method that we can precisely obtain the J_IC from any material. In this study, R-curve Method, Stretch Zone Method, and Ultrasonic Method are used to evaluate the J_IC of Aluminums, i.e., Al 2024, Al 5083, Al 7075. The echo energy of Ultrasonic Method increased rapidly in the unstable crack growth stage and then it is decreased at less rapidly slope. Therefore, the value of J_IC exists between linearly decreased region and the point of deviation. J_IC can be obtained precisely by Stretch Zone Method and approximately obtained by Ultrasonic Method. Stretch Zone Method can be used to evaluate J_IC very quantitively, but we have the trouble with the method in measurement. Ultrasonic method is required that the research for the more exact evaluation about correlation between echo energy and the crack openning behavior of precrack tip will be continued.