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Choi,Byong-Seok,Lee,Joon-Hwa The Korea Science and Technology Center 2000 BMB Reports Vol.33 No.3
In contrast to the pyrimidine (6-4) pyrimidone photoproduct [(6-4) adduct], its Dewar valence isomer (Dewar product) is low mutagenic and produces a broad range of mutations with a 42% replication error frequency. In order to determine the origin of the mutagenic property of the Dewar product, we used experimental NMR restraints and molecular dynamics to determine the solution structure of a Dewar-lesion DNA decamer duplex, which contains a mismatched base pair between the 3'-T residue and an opposed G residue. The 3'-T of the Dewar lesion forms stable hydrogen bonds with the opposite G residue. The helical bending and unwinding angles of the DW/GA duplex, however, are much higher than those of the DW/AA duplex. The stable hydrogen bonding of the G15 residue does not increase the thermal stability of the overall helix. It also does nt restore the distorted backbone conformation of the DNA helix that is caused by the forming of a Dewar lesion. These structural features implicate that no thermal stability, or conformational benefits of G over A opposite the 3'-T of the Dewar lesion, facilitate the perferential incorporation of an A. This is in accordance with the A rule during translation replication and leads to the low frequent 3'-T -> C mutation at this site.
Choi, Byong Seok,Lee, Joon Hwa,Hwang, Geum Sook 생화학분자생물학회 2000 BMB Reports Vol.30 No.6
The 4'-aminomethyl-4.5',8-trimethylpsoralen (AMT) has been used as intercalating DNA binding drugs in the photo-chemotherapy of skin diseases. The conformation and stability of DNA octamer duplex, d (GGGTACCC)₂, cross-linked with AMT has been studied by NMR spectroscopy. All the proton resonances of the psoralen cross-linked octamer were assigned and meting temperature studies were carried out based on the assignment of the proton resonances. The aromatic proton chemical shift data suggest that the conformation of the helix cross-linked with psoralen is destabilized more to furanside of the psoralen. possibly due to the protrusion of the aminomethyl side chain of the psoralen.
Choi, Byong Seok,Lee, Joon Hwa 생화학분자생물학회 2001 BMB Reports Vol.33 No.3
In contrast to the pyrimidine (6-4)pyrimidone photoproduct [(6-4) adduct], its Dewar valence isomer (Dewar product) is low mutagenic and produces a broad range of mutations with a 42% replicating error frequency In order to determine the origin of the mutagenic property of the Dewar product, we used experimental NMR restraints and molecular dynamics to determine the solution structure of a Dewar-lesion DNA decamer duplex, which contains a mismatched base pair between the 3'-T residue and an opposed G residue. The 3'-T of the Dewar lesion forms stable hydrogen bonds with the opposite G residue. The helical bending and unwinding angles of the DW/GA duplex, however, are much higher than those of the DW/AA duplex. The stable hydrogen bonding of the G15 residue does not increase the thermal stability of the overall helix. It also does not restore the distorted backbone conformation of the DNA helix that is caused by the forming of a Dewar lesion. These structural features implicate that no thermal stability, or conformational benefits of G over A opposite the 3'-T of the Dewar lesion, facilitate the preferential incorporation of an A. This is in accordance with the A rule during translesion replication and leads to the low frequent 3'-T→C mutation at this site.
Choi,Byong-Seok,Lee,Joon-Hwa,Hwang,Geun-Sook The Korea Science and Technology Center 1997 BMB Reports Vol.30 No.6
The 4'-aminomethyl-4,5', 8-trimethylpsoralen (AMT) has been used as intercalating DNA binding drugs in the photo-chemotherapy of skin diseases. The conformation and stability of DNA octamer duplex, d(GGGTACCC)₂, cross-linked with AMT has been studied by NMR spectroscopy. All the proton resonances of the psoralen cross-linked octamer were assigned and meting temperature studies were carried out based on the assignment of the porton resonances. The aromatic proton chemical shift data suggest that the conformation of the helix cross-linked with psoralen is destabilized more to furanside of the psoralen, possibly due to the protrusion of the aminomethyl side chain of the psoralen.
NMR Studies of Lipid-Protein Interaction in Apolipoprotein B / Phosphatidylcholine Recombinants
Byong-Seok Choi,Cheal O Joe,Ke Won Kang Korean Chemical Society 1990 Bulletin of the Korean Chemical Society Vol.11 No.3
$^{31}P${$^1H$} nuclear Overhauser effects (NOEs) have been obtained for complexes formed between apolipoprotein B (apo B) and dipalmytoylphosphatidylcholine (DPPC) vesicles. NOE measurements have been conducted with broad-band irradiation of the entire $^1H$ spectrum in order to identify the proton source of the NOE. In a unilamellar vesicle formed spontaneously upon mixing aqueous suspensions of long-chain phospholipid with small amount of short-chain lecithin, the maximum NOE occurs at the N-methyl proton resonance position of the choline moiety. With addition of cholesterol to vesicles, the position of the NOE maximum shifts further away from the choline methyl frequency. For the ternary apo B-vesicle-cholesterol complex, the position of the maximum NOE lies halfway between those in vesicles with and without cholesterol.
Choi, Byong-Seok,Lee, Joon-Hwa,Park, Jin-Young The Korea Science and Technology Center 1998 BMB Reports Vol.31 No.1
The structures of the self-complementary decamer duplexes, d(ACGTATACGT)₂ (TATA-duplex) and D(ACGTTACGT)₂,(TTAA-duplex) has been obtained in solution by proton NMR spectroscopy and restrained moleecular dynamics. The duplexes are essentially B-type, with distortions apparent at the TATA and TTAA steps. These distortions and their effects on dynamics have been investigated by the measurement of imino proton exchange time of the base-pairs. The unusual opening kinetics of central A.T base-pairs could be correlated to the abnormal structural properties of the corresponding sequences.
Synthesis of the Molybdenum Precursor for Slurry-Phase Hydrocracking of Heavy Oil
Choi, Byong-Min,Son, Seok-Hwan,Noh, Min-Sub,Lee, Kwang-Seok,Lee, Chul-Wee,Park, Sun-Yeong,Chung, Min-Chul American Scientific Publishers 2018 Journal of Nanoscience and Nanotechnology Vol.18 No.2
<P>In this study, Molybdenum precursors were synthesized with butanoic acid, hexanoic acid, nonanoic acid, decanoic acid, and undecanoic acid. In order to determine chemical structure of Synthesized molybdenum precursors, H-1(C-13)-NMR, EA and ICP were used pyrolysis properties were measured TGA. The molybdenum precursors was used for Hydrocracking of Vacuum R(1)esidue (VR). It was shown that molybdenum nonanoate(3) was shown the lowerst Toluene Insoluble and Gas Product about 2.1 and 5.0 percent.</P>