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A 60-GHz LTCC SiP with Low-Power CMOS OOK Modulator and Demodulator
Byeon, Chul-Woo,Lee, Jae-Jin,Kim, Hong-Yi,Song, In-Sang,Cho, Seong-Jun,Eun, Ki-Chan,Lee, Chae-Jun,Park, Chul-Soon The Institute of Electronics and Information Engin 2011 Journal of semiconductor technology and science Vol.11 No.4
In this paper, a 60 GHz LTCC SiP with low-power CMOS OOK modulator and demodulator is presented. The 60 GHz modulator is designed in a 90-nm CMOS process. The modulator uses a current reuse technique and only consumes 14.4-mW of DC power in the on-state. The measured data rate is up to 2 Gb/s. The 60 GHz OOK demodulator is designed in a 130nm CMOS process. The demodulator consists of a gain boosting detector and a baseband amplifier, and it recovers up to 5 Gb/s while consuming low DC power of 14.7 mW. The fabricated 60 GHz modulator and demodulator are fully integrated in an LTCC SiP with 1 by 2 patch antenna. With the LTCC SiP, 648 Mb/s wireless video transmission was successfully demonstrated at wireless distance of 20-cm.
Human Serum Albumin-TRAIL Conjugate for the Treatment of Rheumatoid Arthritis
Byeon, Hyeong Jun,Min, Sun Young,Kim, Insoo,Lee, Eun Seong,Oh, Kyung Taek,Shin, Beom Soo,Lee, Kang Choon,Youn, Yu Seok American Chemical Society 2014 Bioconjugate chemistry Vol.25 No.12
<P>Albumin conjugation is viewed as an effective means of protracting short in vivo lifespans of proteins and targeting rheumatoid arthritis (RA). In this study, we present a human serum albumin (HSA) conjugate linked with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a bifunctional PEG derivative (HSA-TRAIL). Prepared HSA-TRAIL was found to have a larger molecular size (∼240 kDa, 15.4 nm) than TRAIL (∼66 kDa, 6.2 nm), and its bioactivity (apoptosis, cytotoxicity, and antiproliferation) was well preserved in Mia Paca-2 cells and mouse splenocytes. The enhanced therapeutic efficacy of HSA-TRAIL was demonstrated in collagen-induced arthritis (CIA) mice. The incidence and clinical scores, expressed as degree of erythema and swelling in HSA-TRAIL-treated mice, were remarkably lower than those of TRAIL-treated mice. The serum levels of pro-inflammatory cytokines IFN-γ, TNF-α, IL-1β, and IL-2 in HSA-TRAIL-treated mice were significantly lower than those of TRAIL-treated mice. Furthermore, HSA-TRAIL accumulated in the hind paws of CIA mice, not in naïve TRAIL mice. Pharmacokinetic profiles of HSA-TRAIL were greatly improved in comparison to those of TRAIL (AUC<SUB>inf</SUB>: 844.1 ± 130.0 vs 36.0 ± 1.2 ng·h/mL; <I>t</I><SUB>1/2</SUB>: 6.20 ± 0.72 vs 0.23 ± 0.01 h, respectively). The HSA-TRAIL conjugate, which presents clear advantages of targeting RA and long systemic circulation by HSA and unique anti-inflammatory efficacy by TRAIL, has potential as a novel treatment for rheumatoid arthritis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bcches/2014/bcches.2014.25.issue-12/bc500427g/production/images/medium/bc-2014-00427g_0011.gif'></P>
PEGylated apoptotic protein-loaded PLGA microspheres for cancer therapy
Byeon, Hyeong Jun,Kim, Insoo,Choi, Ji Su,Lee, Eun Seong,Shin, Beom Soo,Youn, Yu Seok Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P>The aim of the current study was to investigate the antitumor potential of poly (D,L-lactic-<I>co</I>-glycolic acid) microspheres (PLGA MSs) containing polyethylene glycol (PEG)-conjugated (PEGylated) tumor necrosis factor–related apoptosis-inducing ligand (PEG-TRAIL). PEG-TRAIL PLGA MSs were prepared by using a water-in-oil-in-water double-emulsion method, and the apoptotic activities of supernatants released from the PLGA MSs at days 1, 3, and 7 were examined. The antitumor effect caused by PEG-TRAIL PLGA MSs was evaluated in pancreatic Mia Paca-2 cell-xenografted mice. PEG-TRAIL PLGA MS was found to be spherical and 14.4±1.06 μm in size, and its encapsulation efficiency was significantly greater than that of TRAIL MS (85.7%±4.1% vs 43.3%±10.9%, respectively). The PLGA MS gradually released PEG-TRAIL for 14 days, and the released PEG-TRAIL was shown to have clear apoptotic activity in Mia Paca-2 cells, whereas TRAIL released after 1 day had a negligible activity. Finally, PEG-TRAIL PLGA MS displayed remarkably greater antitumor efficacy than blank or TRAIL PLGA MS in Mia Paca-2 cell-xenografted mice in terms of tumor volume and weight, apparently due to increased stability and well-retained apoptotic activity of PEG-TRAIL in PLGA MS. We believe that this PLGA MS system, combined with PEG-TRAIL, should be considered a promising candidate for treating pancreatic cancer.</P>
Park, Jun Chul,Yoon, Deok-Seo,Byeon, Eunjin,Seo, Jung Soo,Hwang, Un-Ki,Han, Jeonghoon,Lee, Jae-Seong Elsevier 2018 Aquatic toxicology Vol.204 No.-
<P><B>Abstract</B></P> <P>To investigate the adverse effect of two widely used pharmaceuticals, paracetamol (acetaminophen [APAP]) and oxytetracycline (OTC) on the marine rotifer <I>Brachionus rotundiformis</I> (<I>B. rotundiformis</I>), the animals were exposed to various environmentally-relevant concentrations. Up to date, acetaminophen and oxytetracycline have been considered as toxic, if used above threshold concentration, <I>i.e.</I> overdosed. However, this study demonstrated these two pharmaceuticals even at low concentration (<I>i.e.</I>, μg/L scale) elicited oxidative stress through the generation of reactive oxygen species (ROS) along with the increased glutathione <I>S</I>-transferase activity, despite no-observed effect in <I>in-vivo</I> population growth. To validate the adverse effects of the two pharmaceuticals at relatively low concentrations, mRNA expression analysis was performed of the entire set of genes encoding 26 cytochrome P450s (CYPs) of phase I and 19 glutathione <I>S</I>-transferases (GSTs) of phase II of the rotifer <I>B</I>. <I>rotundiformis</I>. The mRNA expression analysis suggested specific genes <I>CYP3045A2</I> and <I>GSTσ1</I>, <I>GSTσ4</I>, and <I>GSTω1</I> take part in detoxification of APAP and OTC, resulting in no significant changes in the population growth and undetermined no observed effect concentration (NOEC) in the marine rotifer <I>B. rotundiformis</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Low concentrations of two pharmaceuticals APAP and OTC elicited oxidative stress through the generation of ROS.. </LI> <LI> Low concentrations of two pharmaceuticals APAP and OTC increased glutathione S-transferase activity. </LI> <LI> APAP and OTC have no-observed effect in in-vivo population growth. </LI> <LI> <I>CYP3045A2</I> and <I>GSTs1</I>, <I>GSTs4</I>, and <I>GSTo1</I> were responsible in detoxification of APAP and OTC. </LI> <LI> These led no significant changes in the population growth and undetermined NOEC in rotifer. </LI> </UL> </P>