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앵엽(櫻葉) 에탄올 추출물의 혈관이완 효능 및 작용기전에 대한 연구
이경진 ( Kyung Jin Lee ),김광우 ( Kwang Woo Kim ),허희승 ( Hee Seung Heo ),함인혜 ( In Hye Ham ),이미화 ( Mi Hwa Lee ),김범정 ( Bum Jung Kim ),부영민 ( Young Min Bu ),김호철 ( Ho Cheol Kim ),최호영 ( Ho Young Choi ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.4
Objectives : The purpose of present study was to investigate the vasorelaxant activities and mechanisms of action of the ethanol extract of P. yedoensis leaf (PYL) on isolated rat aortic rings. Methods : Dried P. yedoensis leaves were extracted 3 times with 100% ethanol for 3 h in a reflux apparatus. Isolated rat aortic rings were suspended in organ chambers containing 10 ml Krebs-Henseleit (K-H) solution. The rings were maintained at 37℃ and aerated with a mixture of 95% O2 and 5% CO2. Changes in their tension were recorded via isometric transducers connected to a data acquisition system. Results : PYL relaxed the contraction of aortic rings induced by phenylephrine (PE, 1 μM) or KCl (60 mM) in a concentration dependent manner. However, the vasorelaxant effects of PYL on endothelium-denuded aortic rings were lower than endothelium-intact aortic rings. And the vasorelaxant effects of PYL on endothelium-intact aortic rings were reduced by pre-treatment with Nω-Nitro-L-arginine methyl ester (10 μM), methylene blue (10 μM), 1-H-[1,2,4]-oxadiazolo-[4,3-α]-quinoxalin-1-one (10 μM), tetraethylammonium (5 mM). In addition, PYL inhibited the contraction induced by extracellular Ca2+ in endothelium-denuded aortic rings pre-contracted by PE or KCl in Ca2+-free K-H solution. Conclusions : These results suggest that PYL exerts its vasorelaxant effects via the activation of Nitric Oxide (NO) formation by means of L-arginine and NO-cGMP pathways and via the blockage of receptor operated calcium channels, voltage dependent calcium channels and calcium-activated potassium channels.
Cheol Min Jo(조철민),So Min lee(이소민),Bum Jung Kim(김범정),Kyung Jin Lee(이경진),Ho Young Choi(최호영) 한국약용작물학회 2021 한국약용작물학회 학술대회논문집 Vol.2021 No.1
Background : The purpose of this study was to investigate the vasorelaxant activity and action mechanism of the ethanol extract of Prunus mume (Siebold) Siebold & Zucc. branch (PMB). Methods and Results : PMB (2 –30 μg/㎖) activity on endothelium-intact and endothelium-denuded aortic rings pre-contracted by PE (1 μM) was determined. PMB caused concentration-dependent vasorelaxation on endothelium-intact but did not cause vasorelaxation on endothelium-denuded aortic rings. Pre-incubation with NG-nitro-L-arginine methyl ester (L-NAME), indomethacin, L-NAME + indomethacin, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), methylene blue (MB), atropine, tetraethylammonium chloride (TEA), glibenclamide, 4-aminopyridine (4-AP), and barium chloride(BaCl<sub>2</sub>) significantly reduced the EC50 values. All inhibitors used in the mechanism study significantly inhibited vascular relaxation. Conclusion : PMB caused endothelium-dependent vasorelaxation in rat aortic rings. The vasorelaxant activity of PMB were related to (1) NO-cGMP pathway, (2) PGI2 pathway, (3) muscarinic receptor pathway, and (4) potassium channels such as KV channel, K<sub>ATP</sub> channel, and K<sub>IR</sub> channel. Our study explains that PMB may be another approach to hypertension treatment to reduce the burden of cardiovascular disease.