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Wyche, Thomas P.,Ruzzini, Antonio C.,Beemelmanns, Christine,Kim, Ki Hyun,Klassen, Jonathan L.,Cao, Shugeng,Poulsen, Michael,Bugni, Tim S.,Currie, Cameron R.,Clardy, Jon American Chemical Society 2017 ORGANIC LETTERS Vol.19 No.7
<P>Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosynthetic gene cluster accounts for the observed structural diversity.</P>
Macrotermycins A–D, Glycosylated Macrolactams from a Termite-Associated <i>Amycolatopsis</i> sp. M39
Beemelmanns, Christine,Ramadhar, Timothy R.,Kim, Ki Hyun,Klassen, Jonathan L.,Cao, Shugeng,Wyche, Thomas P.,Hou, Yanpeng,Poulsen, Michael,Bugni, Tim S.,Currie, Cameron R.,Clardy, Jon American Chemical Society 2017 ORGANIC LETTERS Vol.19 No.5
<P>Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39's sequenced genome revealed the macrotermycin's putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.</P>