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Control and Mechanism of Tumor Promotion in UV-Carcinogenesis
Ueda, Masato,Budiyanto, Arief,Ashida, Masashi,Bito, Toshinori,Ichihashi, Masamitsu Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Carcinogenesis can be theoretically divided to intiation step and promotion step. Intiation associates with genetic alterations including p53 tumor suppressor gene and ras oncogene. Promotion involves in clonal expansion of of an initiated cell by epigenetic mechanism, mainly through signal transduction and gene expression. Ultraviolet light (UV) acts as both initiator and promoter. Initiation is closely related with DNA damage induced by UV, including cyclobutane pyrimidine dimers, (6-4) photoproducts and 8-hydroxy-2'-deoxyguanosine. Cyclobutane pyrimidine dimers and (6-4) photoproducts are directly induced by UV, while 8-hydroxy-2'-deoxyguanosine is induced indirectly by the reactive oxygen species. Because initiation is an irreversal genetic event, while promotion is a reversal and epigenetic event, to know the molecular mechanisms of tumor promotion in UV-carcinogenesis is crucial to develop preventive medicine and suppress UV-carcinogenesis. Because ROS is also involved in signal transduction of the cell, anti-oxidant could be the good candidate of anti-promoting agent. Here, we describe the suppressive effect of UV-carcinogenesis by various anti-oxidant including olive oil. In addition, we discuss about the mechanism of UVB-induced expression of cyclooxygenase-2, which might be a representative molecule involved in promotion of UV-carcinogenesis.
The role of antioxidant and DNA damage in the UVB-induced skin tumors of hairless mice
Bito, Toshinori,Budiyanto, Arief,Ueda, Masato,Ichihashi, Masamitsu Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Oxidative stress evoked hy Ultraviolet (UV) exposure has been suggested to be involved in UV-induced skin carcinogenesis. In this study, the role of oxidative stress in UV-carcinogenesis was evaluated by applying N-Acetylcysteine (NAC) in animal model of hairless-mouse. NAC is known to be a precursor of glutathione, which was converted to glutathione in cytoplasm, acting as an intracellular free radical scavenger. The glutathione levels in hairless mouse skin after one time application of NAC increased significantly. With and without the pre-treatment of NAC, hairless-mice were exposed to UVB three times a week, at total dose 274.4 kJ in 80 times, and the timing of tumor-development, incidence of skin tumor and the histopathology of tumors were observed. 8-hydroxy-2'-deoxyguanosine (8-0HdG), a typical form of oxidative damage in DNA has been also investigated in the course of experiment. The decrease of 8-0HdG formation of UVB- exposed skin compared to controls was observed in the early stage of experiment in the NAC-treated mice. In addition, initial tumor development delayed significantly in NAC-treated group. Finally the number of the tumor developed in the NAC-treated mice was fewer though not significant. These results suggest that antioxidants may have inhibitory effect in the initial step of UVB-induced carcinogenesis of hairless mice.
Yohanes Widodo Wirohadidjojo,Arief Budiyanto,Hardyanto Soebono 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.5
To determine whether platelet-rich fibrin lysate (PRF-L) could restore the function of chronically ultraviolet-A (UVA)-irradiated human dermal fibroblasts (HDFs), we isolated and sub-cultured HDFs from six different human foreskins. HDFs were divided into two groups: those that received chronic UVA irradiation (total dosages of 10 J cm-2) and those that were not irradiated. We compared the proliferation rates, collagen deposition, and migration rates between the groups and between chronically UVA-irradiatedHDFs in control and PRF-L-treated media. Our experiment showed that chronic UVA irradiation significantly decreased (p<0.05) the proliferation rates, migration rates, and collagen deposition of HDFs, compared to controls. Compared to control media, chronically UVA-irradiated HDFs in 50% PRF-L had significantly increased proliferation rates, migration rates, and collagendeposition (p<0.05), and the migration rates and collagen deposition of chronically UVA-irradiated HDFs in 50% PRF-L were equal to those of normal fibroblasts. Based on this experiment, we concluded that PRF-L is a good candidate material for treating UVA-induced photoaging of skin, although the best method for its clinical application remains to be determined.
Institutional Model and Strategy for Downstream Development of Shallot Agroindustry in Indonesia
Noveria Sjafrina,Agus Budiyanto,Amos Lukas,Alvi Yani,Puji Astuti,Arief Arianto,Abdullah Bin Arif,Marimin,Faqih Udin,Elisa Anggraeni,I Gusti Ayu Putu Mahendri 대한산업공학회 2023 Industrial Engineeering & Management Systems Vol.22 No.4
Alexis Nzila,정병권,김민철,제랄드 콘라드 이발,Fitri Budiyanto,Musa M. Musa,Assad Thukair,김상준,신재호 한국미생물학회 2018 미생물학회지 Vol.54 No.3
Using pyrene as the enrichment nutrient, a bacterial strain10PY1A, was isolated by enrichment culture from oil-contaminatedsea sand of Arabian Gulf in Saudi Arabia, and this strainbelongs to the species Idiomarina piscisalsi, based on 16SRNA gene sequence analysis. The genome of I. piscisalsi strain10PY1A contains 2,346 protein-coding sequences and an averageGC content of 47.4% in its chromosome (2.59 Mbp). Genesencoding proteins related to the degradation of pyrene wereexisted in the strain 10PY1A genome, indicating that this straincan be used to degrade polycyclic aromatic hydrocarbons inoil-contaminated marine flora and soil.