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A case of oxaliplatin-induced immune-mediated thrombocytopenia
서성은,장문주,정소영,Richard H. Aster,Brian R. Curtis,오도연 대한혈액학회 2014 Blood Research Vol.49 No.1
Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-in-duced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemo-therapy with oxaliplatin.
Kim, Jinchae,Paek, Un-Chul,Lee, Byeong Ha,Hu, Jonathan,Marks, Brian,Menyuk, Curtis R Optical Society of America 2006 Optics letters Vol.31 No.9
<P>We have investigated the spectral properties of a band rejection filter made with a long-period fiber grating written in photonic crystal fiber that has interstitial air holes. Experiments showed that only one mode was coupled strongly to the fundamental core mode over a 600 nm spectral range. The central wavelength of the filter could be tuned over that range without being appreciably affected by any other mode. By using the multipole method, we found that the interstitial air holes of the photonic crystal fiber played a critical role in limiting the number of modes that could strongly interact with the fundamental mode and in obtaining well-separated resonance peaks. Excellent agreement between theory and experiment was obtained.</P>
A case of oxaliplatin-induced immune-mediated thrombocytopenia
Suh, Seong Eun,Jang, Moon Ju,Chong, So Young,Aster, Richard H.,Curtis, Brian R.,Oh, Doyeun Korean Society of Hematology; Korean Society of Bl 2014 Blood Research Vol.49 No.1
<P>Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-induced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemotherapy with oxaliplatin.</P>