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      • Vascular hemodynamics and blood pressure differences between young and older women

        Brantley K. Ballenger,Gary R. Hunter,Gordon Fisher 대한고혈압학회 2022 Clinical Hypertension Vol.28 No.1

        Cardiovascular disease is one of the main causes of death in the United States, and hypertension is a primary risk factor. Therefore, the primary causes of hypertension need to be identified so they may be addressed for treatment. The purpose of this study was to compare blood pressure with hemodynamic values and identify factors that may explain blood pressure differences between a cohort of healthy normotensive younger and older women. Participants were 49 young (age: 33.8 ± 5.9) and 103 old (age: 65.8 ± 4) who were non-hypertensive, had no previous history of heart disease or type 2 diabetes, body mass index less than 30 kg/m 2 , normal electrocardiography response at rest and during exercise, nonsmokers, and no use of medications known to affect cardiovascular or metabolic function. Body composition measured by dual-energy X-ray absorptiometry. Hemodynamic values measured by non-invasive pulse wave velocity through radial artery tonometry. Markers of inflammation measured through blood sample analysis. Significant differences exist between young and old groups in %fat ( P < 0.001), systolic blood pressure (SBP) ( P = 0.001), large artery elasticity ( P = 0.005), small artery elasticity ( P < 0.001), systemic vascular resistance ( P = 0.004), total vascular impedance ( P < 0.001), estimated cardiac output ( P < 0.001), and tumor necrosis factor-⍺ (TNF-⍺) ( P < 0.001). Using ANCOVA the difference in SBP between age groups was no longer significant after adjusting for small artery elasticity ( P < 0.001) and TNF-⍺ ( P = 0.041). These data demonstrate that blood pressure and vascular hemodynamic measures differ significantly between young and old women independent of body composition. Furthermore, these differences may be explained by the inflammation marker TNF-⍺ and/or small artery elasticity.

      • Hydroxyapatite precipitation on nanotube surfaces of Ti-35Ta-xNb alloys.

        Jo, Chae-Ik,Jeong, Yong-Hoon,Brantley, William A,Choe, Han-Cheol American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.10

        <P>Hydroxyapatite precipitation on nanotube surfaces of Ti-35Ta-xNb alloys was investigated using electrochemical methods. The alloys were prepared by arc-melting, heat treated at 1050 degrees C for 12 h in an Ar atmosphere, and quenched in 0 degrees C water. Nanotubes were created on the Ti-35Ta-xNb alloys in a 1 M H3PO4 + 1.2 wt.% NaF electrolyte at room temperature. Hydroxyapatite precipitation was carried out in a 0.03 M Ca(NO3)2 x 4H2O + 0.018 M NH4H2PO4 solution at 80 1 degrees C, using 10 deposition cycles. Information about morphology and composition was obtained by FE-SEM and EDS. The microstructure of the Ti-35Ta-xNb alloys was transformed from α phase to βphase as the Nb content increased. The HA precipitates had a plate-like morphology on bulk Ti-35Ta-xNb alloys and a flower-like morphology on nanotubular Ti-35Ta-xNb alloys.</P>

      • SCOPUS

        Mechanical Surface Behavior of ZrN and TiN Coated Dental Screw by Ion-Plating Method

        Choe, Han Cheol,Chung, Chae Heon,Brantley, William A. Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.345-346 No.-

        <P>The abutment screw loosening of dental implant system has been remained problem in restorative practices. Surface treatment of screw plays a role of preventing screw from loosening in implant screw mechanism. The purpose of this study was to investigate surface characteristics of ZrN and TiN coated dental gold-screw and Ti-screw by ion-plating method and to evaluate wear resistance, surface roughness, and film adhesion on the screw surface using field emission scanning electron microscopy(FE-SEM), energy dispersive x-ray spectroscopy(EDX), micro-diamond scratch tester, vickers hardness tester, and surface roughness tester. The surface of gold screw and GoldTite is more smoothly than ones of other kinds of non coated screw. The ZrN and TiN coated surface is more smoothly than ones of other kinds of screw. The hardness of TiN and ZrN coated surface showed higher than that of non coated surface. The TiN coated titanium screw and ZrN coated gold screw have a good wear resistance and adhesion on the surface. The surface of ZrN coated screw showed low surface roughness compared with the surface of TiN coated screw.</P>

      • Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of <i>Bacillus anthracis</i> Spores

        Kirchdoerfer, Robert ,N.,Herrin, Brantley ,R.,Han, Byung ,Woo,Turnbough Jr., Charles ,L.,Cooper Jr., Max ,D.,Wilson Jr., Ian ,A. Elsevier 2012 Structure Vol.20 No.3

        <P><B>Summary</B></P><P>Variable lymphocyte receptors (VLRs) are the adaptive immune receptors of jawless fish, which evolved adaptive immunity independent of other vertebrates. In lieu of the immunoglobulin fold-based T and B cell receptors, lymphocyte-like cells of jawless fish express VLRs (VLRA, VLRB, or VLRC) composed of leucine-rich repeats and are similar to toll-like receptors (TLRs) in structure, but antibodies (VLRB) and T cell receptors (VLRA and VLRC) in function. Here, we present the structural and biochemical characterization of VLR4, a VLRB, in complex with BclA, the immunodominant glycoprotein of <I>Bacillus anthracis</I> spores. Using a combination of crystallography, mutagenesis, and binding studies, we delineate the mode of antigen recognition and binding between VLR4 and BclA, examine commonalities in VLRB recognition of antigens, and demonstrate the potential of VLR4 as a diagnostic tool for the identification of <I>B</I>. <I>anthracis</I> spores.</P> <P><B>Graphical Abstract</B></P><P><ce:figure id='dfig1'></ce:figure></P><P><B>Highlights</B></P><P>► VLRBs use their C-terminal LRRs and the LRRCT-loop to interact with antigen ► Sequence-related VLRBs exhibit differential recognition of their BclA epitopes ► VLR4 binds a conserved protein epitope, yet is specific for <I>B</I>. <I>anthracis</I> spores</P>

      • SCISCIESCOPUS

        Electrochemical characteristics of Ti-6Al-4V after plasma electrolytic oxidation in solutions containing Ca, P, and Zn ions

        Hwang, In-Jo,Choe, Han-Cheol,Brantley, William A. Elsevier Sequoia 2017 Surface & coatings technology Vol.320 No.-

        <P><B>Abstract</B></P> <P>The electrochemical characteristics of Ti-6Al-4V after plasma electrolytic oxidation (PEO) in solutions containing Ca, P, and Zn ions were studied using various experimental techniques. A Ti-6Al-4V ELI disk was used as a substrate for plasma electrolytic oxidation. A pulsed DC power supply was used to apply a potential of 280V in the electrolyte for 3min. To analyze the electrochemical properties of the PEO film as a function of the Zn content, potentiodynamic and AC impedance tests were carried out with a potentiostat (Model 2273, EG&G Co., USA) using a 0.9% NaCl solution. To examine the bioactivity, the PEO films formed on the specimens and the untreated Ti-6Al-4V specimens were immersed in a simulated body fluid (SBF) for 12h. The PEO-treated and SBF-immersed surfaces were observed by X-ray diffraction, field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, and attenuated total reflectance Fourier transform infrared spectroscopy.</P> <P>The number of pores in the PEO films increased, whereas the pore size decreased slightly, as the Zn ion concentration increased. The corrosion potential of the PEO-treated films decreased, while the corrosion current density increased slightly, as the Zn content increased. As shown by the Nyquist plots, the semicircular region in the profile of the Ti-6Al-4V specimens increased compared to that of the other specimens. The films obtained after PEO treatment in the solution containing Zn showed Warburg impedance characteristics. Bone-like apatite was well-formed in specimens of PEO films treated in solutions containing Zn ions at concentrations of 0, 5, and 10mM%. However, formation of the bone-like apatite decreased in specimens of the PEO films treated in a solution containing Zn ions at a concentration of 20mM%.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Electrochemical behaviors of PEO-treated Ti-6Al-4V in solutions containing Zn ion were studied. </LI> <LI> Number of pores in the PEO-films increased, whereas the pore size decreased with Zn concentration. </LI> <LI> Corrosion potential of PEO-films decreased, and corrosion current density increased, as Zn ion increased. </LI> <LI> From Nyquist plots, the PEO-films containing Zn showed Warburg impedance characteristics. </LI> <LI> The bone-like apatite was formed for 0%–10% Zn, whereas the apatite formation in 20% Zn decreased. </LI> </UL> </P>

      • SCIESCOPUSKCI등재

        A study of fracture loads and fracture characteristics of teeth

        Sheen, Chang-Yong,Dong, Jin-Keun,Brantley, William Arthur,Han, David Seungho The Korean Academy of Prosthodonitics 2019 The Journal of Advanced Prosthodontics Vol.11 No.3

        PURPOSE. The purpose of this in vitro study was to investigate the fracture loads and modes of failure for the full range of natural teeth under simulated occlusal loading. MATERIALS AND METHODS. One hundred and forty natural teeth were taken from mandibles and maxillas of patients. There were 14 groups of teeth with 10 teeth in each group (5 males and 5 females). Each specimen was embedded in resin and mounted on a positioning jig, with the long axis of the tooth at an inclined angle of 30 degrees. A universal testing machine was used to measure the compression load at which fracture of the tooth specimen occurred; loads were applied on the incisal edge and/or functional cusp. RESULTS. The mean fracture load for the mandibular first premolar was the highest (2002 N) of all the types of teeth, while the mean fracture load for the maxillary first premolar was the lowest (525 N). Mean fracture loads for the mandibular and maxillary incisors, and the first and second maxillary premolars, had significantly lower values compared to the other types of teeth. The mean fracture load for the teeth from males was significantly greater than that for the teeth from females. There was an inverse relationship between age and mean fracture load, in which older teeth had lower fracture loads compared to younger teeth. CONCLUSION. The mean fracture loads for natural teeth were significantly different, with dependence on tooth position and the sex and age of the individual.

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