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Decaschistia intermedia Craib 추출물의 멜라닌 합성 억제 효능
임리진,추병삼,이상우,Bounleuane Douangdeuane,송희상 한국생약학회 2020 생약학회지 Vol.51 No.3
The purpose of this study was to investigate the anti-melanogenic effects of the extracts from Decaschistia intermedia craib (EDI). In this study, we examined the effects of EDI on mushroom tyrosinase activity in in vitro, melanin contents, and expression levels of mRNA and proteins of melanogenesis-related genes in B16F10 melanoma cells. The treatment of EDI significantly decreased both tyrosinase activity and melanin contents in B16F10 cells with dose-dependent manner. In addition, we found that the expression of mRNA or proteins of melanogenic proteins, such as, a-melanocyte-stimulating hormone (a-MSH)-induced microphthalmia associated transcription factor (MITF), tyrosinase, tyrosinase related protein-1 (TRP-1), and TRP-2 was significantly downregulated with dose-dependent manner in the EDI-treated B16F10 cells compared to controls. Our results suggest that the EDI inhibits cellular melanogenesis through downregulation of a-MSH-stimulated melanin synthesis. Thus EDI may potentially be an effective whitening agent.
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Su Jin Lee,Ji Eun Kim,Yun Ju Choi,Jeong Eun Gong,So Hae Park,Bounleuane Douangdeuane,Onevilay Souliya,Ju Min Park,Hee Seob Lee,Bae-Hwan Kim,Dae Youn Hwang 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Natural products with antioxidant activity have received a great attention for photoaging therapy because this disease is well known as premature skin changes after continuous and long-term repeated exposure to chronic ultraviolet (UV)A and UVB. To investigate therapeutic effects of methanol extracts of Dipterocarpus tuberculatus Roxb. (MED) against UV-induced photoaging, alterations on antioxidant activity, anti-apoptotic effects, ECM modulation, skin appearances and anti-inflammatory response were assessed in normal human dermal fibroblasts (NHDFs) cells and nude mice treated with MED. MED showed the high level of tannin content (879.27 mg/g) and high free radical scavenging activity to DPPH (IC50 = 7.06 μg/ml). UV-induced alterations on NO concentration, SOD activity and expression, and Nrf2 phosphorylation were remarkably recovered by MED treated NHDF cells. The number of apoptotic cells, Bax/Bcl-2 ratio and cleaved Cas-3/Cas-3 ratio were significantly decreased in UV+MED treated group, while G2/M phase arrest was increased in the same group. Also, similar recoveries after MED treatment were detected on b-galactosidase, MMP-2/9 expression and intracellular elastase activity. MED treatment induced the suppressing COX-2 induced iNOS mediated pathway, expression of inflammatory cytokines and inflammasome activation in UV-radiated NHDF cells. Furthermore, anti-photoaging effects observed in NHDF cells were measured in UV+MED treated nude mice although there are differences in the level of change. The skin phenotypes including wrinkle score, hydration, TEWL, melanin index and erythema index as well as histopathological structure were significantly improved UV+MED treated mice. Thus, these results suggest that MED has therapeutic effects against photoaging induced by UV, and that it presents the potential for development as a treatment for photoaging in the future.
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