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RISS 인기검색어
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- 저자 : Boo-Sung Kim (검색결과 1,490 건)
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Combination treatment of Cetuximab and photodynamic therapy in SNU-1041 squamous cancer cell line
Kim, Sun Gon,Hong, Ji Won,Boo, Sung Hyun,Kim, Myung Gu,Lee, Kang Dae,Ahn, Jin Chul,Hwang, Hee Jun,Shin, Jang-In,Lee, Sang Joon,Oh, Jang Keun,Chung, Phil Sang Spandidos Publications 2009 ONCOLOGY REPORTS Vol.22 No.4
<P>Cetuximab (Erbitux) has been highlighted for its anti-proliferative effects in solid tumors and it is currently used as an adjuvant modality with other anti-cancer treatments. Photodynamic therapy (PDT) is used widely in many specialties of medicine. This study evaluated the efficacy of a combination treatment of two modalities (Cetuximab, PDT) both in vivo and in vitro. The SNU-1041 cell line was used for both the in vitro and in vivo studies. The in vivo and in vitro experiments were each classified into four groups, control group, Cetuximab applied group, PDT applied group and combined modality group. A migration study was performed to determine the anti-migration effect of Cetuximab, and a MTT assay was performed to compare the anti-proliferative effect of the modalities in vitro. For the in vivo study, the cells were implanted into 5-week-old nude mice. The measured volume of the tumor for each group was compared as a function of time. In the migration study, the control group showed a longer migration length than the Cetuximab applied group. In the MTT assay, the combination modality group showed less survival than the uni-modality groups. The measured tumor size after treatment showed that the combination treatment was more effective than the single modalities. PDT and Cetuximab are treatment modalities that target different molecular pathways. A combination of these two treatment modalities was found to more effective than an individual treatment. However, further studies will be needed to determine the optimal dose of the photosensitizer and Cetuximab.</P>
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A dual mechanism of 4-hydroxy-5-methyl-3[2H]-furanone inhibiting cellular melanogenesis.
Kim, Hyo Jung,An, Sang Mi,Boo, Yong Chool Society of Cosmetic Chemists 2008 Journal of cosmetic science Vol.59 No.2
<P>In previous studies, 4-hydroxy-5-methyl-3[2H]-furanone (HMF) was shown to have potent antioxidative and antimelanogenic effects, suggesting its potential use as a depigmenting agent. The present study investigated its mechanism of action on murine melanoma B16F10 cells stimulated by theophylline, an activator of the cyclic AMP/protein kinase A signaling leading to tyrosinase gene expression. When the cells were stimulated with theophylline, there were dose-dependent increases in cellular tyrosinase protein content and melanin formation, as expected. HMF inhibited the theophylline-stimulated melanin formation as effectively as arbutin, one of the most widely used depigmenting agents in cosmetics. HMF appeared to reduce tyrosinase mRNA and protein content in the cells stimulated by theophylline, indicating it inhibited tyrosinase gene expression. HMF also effectively inhibited tyrosinase-catalyzed melanin formation from dihydroxyphenylalanine in the cells as well as in vitro. Therefore, the antimelanogenic effects of HMF were best explained by a dual mechanism inhibiting tyrosinase gene expression and the enzyme activity of pre-existing tyrosinase.</P>
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Distribution and Biosynthesis of 20-Hydroxyecdysone in Plants of <i>Achyranthes japonica</i> Nakai
BOO, Kyung Hwan,LEE, Doseung,JEON, Gyeong Lyong,KO, Seung Hee,CHO, Somi K.,KIM, Jae Hoon,PARK, Se Pill,HONG, Quanchun,LEE, Sang-Han,LEE, Dong-Sun,RIU, Key Zung Japan Society for Bioscience, Biotechnology, and A 2010 Bioscience, biotechnology, and biochemistry Vol.74 No.11
<P>There is increasing interest in phytoecdysteroids (PEs) because of their potential role in plant defense against insects. To understand the mechanism regulating their levels in plants, the fluctuation, distribution, and biosynthesis of PE 20-hydroxyecdysone (20E) examined in <I>Achyranthes japonica</I>. The total amount of 20E per individual plant initially remained at a constant level, and increased markedly after the first leaf pair (LP) stage, while the concentration of 20E in a given plant decreased rapidly during vegetative growth. In addition, the incorporation of [2-<SUP>14</SUP>C]-mevalonic acid into 20E did not differ significantly depending on plant organs and developmental stages, suggesting that biosynthesis of 20E is not restricted to particular organs or growth stages.</P>
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Kim, Gun-Duk,Lee, Hak-Soon,Park, Chang-Hyun,Lee, Sang-Shin,Lim, Boo Tak,Bae, Hee Kyoung,Lee, Wan-Gyu The Optical Society 2010 Optics express Vol.18 No.21
<P>An ultra-small integrated photonic temperature sensor has been proposed and demonstrated which incorporates a silicon ring resonator linked to a vertical grating coupler. It was manufactured using a 0.18 관m standard CMOS process, rendering a homogeneous integration into other electrical/optical devices. The temperature variation was measured by monitoring the shift in the resonant wavelength of the silicon resonator, which was induced by the thermo-optic effect and the thermal expansion effect. The dependence of its sensing capability upon the waveguide width of the resonator was intensively probed both theoretically and experimentally. The best achieved sensitivity was about 83 pm/°C for a waveguide width of 500 nm, while the sensitivity was boosted by ~10 pm/°C by adjusting the waveguide width from 300 nm to 500 nm. Finally, the response speed of the sensor was as fast as ~6 관s.</P>
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BOO, SUNG MIN,KIM, HAN SOON,SHIN, WOONGGHI,BOO, GA HUN,CHO, SUNG MI,JO, BOK YEON,KIM, JEE-HWAN,KIM, JIN HEE,YANG, EUN CHAN,SIVER, PETER A.,WOLFE, ALEXANDER P.,BHATTACHARYA, DEBASHISH,ANDERSEN, ROBERT Blackwell Publishing Ltd 2010 Molecular ecology Vol.19 No.19
<P>Abstract</P><P>The global distribution, abundance, and diversity of microscopic freshwater algae demonstrate an ability to overcome significant barriers such as dry land and oceans by exploiting a range of biotic and abiotic colonization vectors. If these vectors are considered unlimited and colonization occurs in proportion to population size, then globally ubiquitous distributions are predicted to arise. This model contrasts with observations that many freshwater microalgal taxa possess true biogeographies. Here, using a concatenated multigene data set, we study the phylogeography of the freshwater heterokont alga <I>Synura petersenii sensu lato</I>. Our results suggest that this <I>Synura</I> morphotaxon contains both cosmopolitan and regionally endemic cryptic species, co-occurring in some cases, and masked by a common ultrastructural morphology. Phylogenies based on both proteins (seven protein-coding plastid and mitochondrial genes) and DNA (nine genes including ITS and 18S rDNA) reveal pronounced biogeographic delineations within phylotypes of this cryptic species complex while retaining one clade that is globally distributed. Relaxed molecular clock calculations, constrained by fossil records, suggest that the genus <I>Synura</I> is considerably older than currently proposed. The availability of tectonically relevant geological time (10<SUP>7</SUP>–10<SUP>8</SUP> years) has enabled the development of the observed, complex biogeographic patterns. Our comprehensive analysis of freshwater algal biogeography suggests that neither ubiquity nor endemism wholly explains global patterns of microbial eukaryote distribution and that processes of dispersal remain poorly understood.</P>
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X-linked inhibitor of apoptosis protein controls α5-integrin-mediated cell adhesion and migration
Kim, Jongmin,Ahn, Sunyoung,Ko, Young-Gyu,Boo, Yong Chool,Chi, Sung-Gil,Ni, Chih-Wen,Go, Young-Mi,Jo, Hanjoong,Park, Heonyong American Physiological Society 2010 American journal of physiology, Heart and circulat Vol.299 No.2
<P> The association of integrins with caveolin-1 regulates cell adhesion. However, the vascular ramifications of this association remain to be clearly determined. We recently reported that the X chromosome-linked inhibitor of apoptosis protein (XIAP)-caveolin-1 interaction is critical to endothelial cell survival. Thus, we hypothesized that XIAP performs a crucial function in integrin/caveolin-1-mediated endothelial cell survival. In this study, we demonstrated that XIAP is recruited into the α5-integrin complex via caveolin-1 binding and mediates cell adhesion. We also determined that XIAP is critical to shear stress-stimulated ERK activation in an α5-integrin-dependent manner but is not important to VEGF-induced ERK activation. This differential activation of ERK is partly attributable to unique localizations of the receptors. Furthermore, we confirmed that XIAP is an essential molecule in the efficient recruitment of focal adhesion kinase (FAK) into the α5-integrin-associated complex. This α5-integrin-caveolin-1-XIAP-FAK multicomplex regulates endothelial cell migration via a mechanism that involves shear-dependent ERK activation. Together, our results indicate that XIAP stabilizes the α5-integrin-associated focal adhesion complex, thereby further regulating endothelial cell adhesion and migration. The findings of this study provide us with greater insight into the molecular mechanisms underlying the control of vascular function by integrins. </P>
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Morphological and Molecular Classifications of Genus Pholis
Sung-Hoon Lee,장요순,Chung-Boo Baik,Kyeong-Ho Han,Jung-Goo Myung,Jin-Hee Lee,Sang-Duk Choi,Seon-Jae Kim,김종오,황재호 한국통합생물학회 2009 Animal cells and systems Vol.13 No.4
Morphological and molecular classifications were attempted in an effort to establish species-specific classifications of three species of the genus Pholis in Korea; these species were subjected to morphological and molecular methodologies using body measurements, RFLP, RAPD, and phylogenetic trees using the nucleotide sequences of mitochondrial 16S and 12S ribosomal DNAs, cytochrome c oxidase I, and cytochrome b. The data demonstrated that the three species of genus Pholis are distinct from each other, both morphologically and genetically.
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