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Choi, Sun-Hye,Shin, Tae-Joon,Lee, Byung-Hwan,Chu, Dae-hyun,Choe, Han,Pyo, Mi-Kyung,Hwang, Sung-Hee,Kim, Bo-Ra,Lee, Sang-Mok,Lee, Jun-Ho,Kim, Dong-Hyun,Kim, Hyoung-Chun,Rhim, Hye-whon,Nah, Seung-Yeol Elsevier 2010 european journal of pharmacology Vol.637 No.1
<P><B>Abstract</B></P><P>The slowly activating delayed rectifier K<SUP>+</SUP> channels (<I>I</I><SUB><I>Ks</I></SUB>) are one of the main pharmacological targets for development of drugs against cardiovascular diseases. Cardiac <I>I</I><SUB><I>Ks</I></SUB> consists of KCNQ1 plus KCNE1 subunits. Ginsenoside, one of the active ingredient of <I>Panax ginseng</I>, enhances cardiac <I>I</I><SUB><I>Ks</I></SUB> currents. However, little is known about the molecular mechanisms of how ginsenoside interacts with channel proteins to enhance cardiac <I>I</I><SUB><I>Ks</I></SUB>. In the present study, we investigated ginsenoside Rg<SUB>3</SUB> (Rg<SUB>3</SUB>) effects on human <I>I</I><SUB><I>Ks</I></SUB> by co-expressing human KCNQ1 plus KCNE1 subunits in <I>Xenopus</I> oocytes. Rg<SUB>3</SUB> enhanced <I>I</I><SUB><I>Ks</I></SUB> currents in concentration- and voltage-dependent manners. The EC<SUB>50</SUB> was 15.2±8.7µM. However, in oocytes expressing KCNQ1 alone, Rg<SUB>3</SUB> inhibited the currents with concentration- and voltage-dependent manners. The IC<SUB>50</SUB> was 4.8±0.6µM. Since Rg<SUB>3</SUB> acts opposite ways in oocytes expressing KCNQ1 alone or KCNQ1 plus KCNE1 subunits, we examined Rg<SUB>3</SUB> effects after co-expression of different ratios of KCNE1 and KCNQ1. The increase of KCNE1/KCNQ1 ratio converted <I>I</I><SUB><I>Ks</I></SUB> inhibition to <I>I</I><SUB><I>Ks</I></SUB> activations. One to ten ratio of KCNE1 and KCNQ1 subunit is required for Rg<SUB>3</SUB> activation of <I>I</I><SUB><I>Ks</I></SUB>. Mutations of K318 and V319 into K318Y and V319Y of KCNQ1 channel abolished Rg<SUB>3</SUB> effects on KCNQ1 or KCNQ1 plus KCNE1 channel currents. The docked modeling revealed that K318 residue plays a key role in stabilization between Rg<SUB>3</SUB> and KCNQ1 plus KCNE1 or KCNQ1 subunit. These results indicate that Rg<SUB>3</SUB>-induced activation of <I>I</I><SUB><I>Ks</I></SUB> requires co-assembly of KCNQ1 and KCNE1 subunits and achieves this through interaction with residues K318 and V319 of KCNQ1 subunit.</P>
Synthesis of Antineoplaston A10 Analogs as Potential Antitumor Agents
Choi, Bo-Gil,Kim, Ok-Young,Chung, Byung-Ho,Cho, Won-Jea,Cheon, Seung-Hoon,Choi, Sang-Un,Lee, Chong-Ock The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.2
Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. The in vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially, m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.
Caffeine Inhibits Cell Proliferation and Regulates PKA/GSK3β Pathways in U87MG Human Glioma Cells
Bo Mi Ku,Yeon Kyung Lee,Joo Yeon Jeong,Jinhyun Ryu,Jungil Choi,Joon Soo Kim,Yong Woon Cho,Gu Seob Roh,Hyun Joon Kim,Gyeong Jae Cho,Wan Sung Choi,Sang Soo Kang 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.3
Caffeine is the most commonly ingested methylxanthine and has anti-cancer effects in several types of cancer. In this study, we examined the anti-cancer effects of caffeine on gliomas, both in vitro and in vivo. In vitro, caffeine treatment reduced glioma cell proliferation through G_0/G_1-phase cell cycle arrest by suppressing Rb phosphorylation. In addition, caffeine induced apoptosis through caspase-3activation and poly(ADP-ribose) polymerase (PARP) cleavage. Caffeine also phosphorylated serine 9 of glycogen synthase kinase 3 beta (GSK3β). Pretreatment with H89, a pharmacological inhibitor of protein kinase A (PKA), was able to antagonize caffeine-induced GSK3β^(ser9) phosphorylation,suggesting that the mechanism might involve a cAMP-dependent PKA-dependent pathway. In vivo, caffeine-treated tumors exhibited reduced proliferation and increased apoptosis compared with vehicle-treated tumors. These results suggest that caffeine induces cell cycle arrest and caspase-dependent cell death in glioma cells,supporting its potential use in chemotherapeutic options for malignant gliomas.
Case Reports : A Case of Cicatricial Alopecia Associated with Erlotinib
( Bo Hee Yang ),( Chan Yl Bang ),( Ji Won Byun ),( Sung Hyub Han ),( Hee Jin Song ),( Seung Gyun In ),( Jeong Hyun Shin ),( Gwang Seong Choi ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3s
Erlotinib is a small-molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). Erlotinib has been used primarily to treat non-small cell lung cancer. In addition to its role in tumor cells, EGFR is also an important regulator of growth and differentiation in the skin and hair. Therefore, EGFR-TKIs have been associated with a number of cutaneous side effects including follicular acneiform eruptions, cutaneous xerosis, chronic paronychia, desquamation, seborrheic dermatitis, and hair texture changes. Herein, we report a rare case of a 61-year-old woman who was treated with erlotinib and experienced cicatricial alopecia. (Ann Dermatol 23(S3) S350~S353, 2011)
Electrochemical Behaviors of Sparteine-Copper (II) Dihalide
Sung-Nak Choi,Jin-Hyo Park,Young-In Kim,Yoon-Bo Shim Korean Chemical Society 1991 Bulletin of the Korean Chemical Society Vol.12 No.3
Electrochemical behaviors of optically active sparteine-Cu(II) dihalide complexes were investigated by polarography and cyclic voltammetry (CV). These Cu(II) complexes are rather easier to be reduced to Cu(I) states when comparison is made with other nonplaner copper complexes, We have assigned the CV peaks and polarographic waves related to the redox processes for these complexes. We could also observe the exchange reaction of Cu(II) ion in the complex with mercury metal in the cell having mercury pool. The redox mechanism of these complelxes is as follows; The 1st wave appeared at +0.47 V/+0.65 V corresponds to the reaction of $SpCuX_2+ e{\rightleftarrow}SpCuX_{2^-}$ and the 2nd one at +0.26 V/+0.21 V does the reaction of $SpCuX_{2 ^-} +e{\rightleftarrow}SpCuX_2^{2-}$. The 3rd one at -0.35 V/-0.27 V is dueto the reduction of mercury complex formed via exchange reaction. Where, X is chloride ion.
Cervical Disc Herniation as a Cause of Brown-S$\acute{e}$quard Syndrome
Choi, Kyeong-Bo,Lee, Choon-Dae,Chung, Dai-Jin,Lee, Sang-Ho The Korean Neurosurgical Society 2009 Journal of Korean neurosurgical society Vol.46 No.5
The possible causes of Brown-S$\acute{e}$quard Syndrome (BSS) have been frequently observed with spinal trauma and extramedullary spinal tumors, but the cervical disc herniation to cause BSS is rare. The authors present five cases of patients who were diagnosed with BSS resulting from cervical disc herniation, and the results of the literature in view of their distinctive symptoms and clinical outcomes. Postoperatively, the patients showed complete or almost complete recovery from their motor and sensory deficits. On the basis of our cases, it is important to diagnose it early by cervical magnetic resonance imaging, especially in the absence of the typical symptoms of cervical disc herniation or other obvious etiology of extremity numbness. Immediate surgical treatment is also essential for a favorable functional neurological recovery.
Pyogenic Spondylodiscitis after Percutaneous Endoscopic Lumbar Discectomy
Choi, Kyeong-Bo,Lee, Choon-Dae,Lee, Sang-Ho The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.48 No.5
We reviewed 9 cases of pyogenic spondylodiscitis following percutaneous endoscopic lumbar discectomy (PELD). Microbiologic cultures revealed 6 causative organisms. Five patients were managed conservatively and four were treated surgically. The mean follow-up period was 20.6 months and the average length of hospitalization was 24 days. Radiological evidence of spinal fusion was noted and infection was resolved in all patients. Although PELD is a safe and effective procedure, the possibility of pyogenic spondylodiscitis should always be considered.
Herniated Lumbar Disc Combined with Spinal Intradural Extramedullary Cysticercosis
Choi, Kyeong-Bo,Hwang, Byeong-Wook,Choi, Won-Gyu,Lee, Sang-Ho The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.48 No.6
Spinal cysticercosis is a very uncommon manifestation of neurocysticercosis which is caused by the larvae of Taenia solium. However, it can develop as a primary infection through blood stream or direct larval migration. It can result in high recurrence and severe neurologic morbidity if not treated appropriately. We report the case of a 43-year-old woman who presented with severe lower back pain and left leg radiating pain in recent 2 weeks. Magnetic resonance image (MRI) of lumbar spine demonstrated extruded disc at the L5-S1 level combined with intradural extramedullary cystic lesion. We performed the open lumbar microdiscectomy (OLM) at L5-S1 on the left with total excision of cystic mass. After surgery, the patient showed an improvement of previous symptoms. Diagnosis was confirmed by histopathological examination as intradural extramedullary cysticercosis. We discuss clinical features, diagnostic screening, and treatment options of spinal cysticercosis.